No abstract available.
Humans ; Infertility* ; Infertility, Male* ; Male ; Male*

No abstract available.
Chancre ; Lip

A relationship between preceding acute paralytic poliomyelitis and the later development of motor neuron disease has only occasionally been suggested since it was first postulated by Charcot in 1875. The authors recently experienced a 20-year-old male who was considered to have postpoliomyelitis muscular atrophy. We report this case in view of its rarity and necessity of differential diagnosis from other neuromuscular disorders. Clinical presentation included slowly progressive muscle wasting of left thigh for 4 years, mild weakness of left arm and both thigh, intermittent fasciculation, and previous history of acute paralytic poliomyelitis. Electromyographic findings showed fibrillation potentials, positive sharp waves, fasciculations, giant motor unit potentials and reduced interference patterns. Muscle biopsy revealed scattered small angulated fibers, individual myofiber degeneration and mild inflammatory cell infiltration.
Arm ; Biopsy ; Diagnosis, Differential ; Fasciculation ; Humans ; Male ; Motor Neuron Disease ; Poliomyelitis ; Postpoliomyelitis Syndrome* ; Thigh ; Young Adult

A strictly right handed patient showed aphasia and left hemiplegia following a deep infarct of the right hemisphere. He had no personal or family history o{ left-handedness. His aphasia was persistent and global in nature without right limb apraxia which was tested by serial Modified Western Aphasia Battery There was a deep subcortical infarc tion of the territoy supplied by the right middle cerebral artery without any lesion or .perfusion defect in the left hemisphere on brain CT and SPECT. The frequency of persistent aphasia in the right hemispheric lesion in dextrals has been known to be very low and there was no reported case in Korea So we report a case of crossed aphasia in a dextral with review of literature.
Aphasia* ; Apraxias ; Brain ; Extremities ; Hand ; Hemiplegia ; Humans ; Korea ; Middle Cerebral Artery ; Perfusion ; Tomography, Emission-Computed, Single-Photon

Polymerase chain reaction (PCR) method is a proced.ure for in vitro enzymatic ampli fication of a specific segment of DNA. PCR method was used to detect any M. tuberculi DNA in the 16 cerebrospinal fluid specimens from 6 patients clinically diagnosed as tuberculous meningitis. We synthesized two oligonucleotide primers derived from the sequence of a gene that codes for the 65-kilodalton antigen of M. tuberculosis. The amplified 165bp genomic DNA of M. tuberculosis was detected in 3 specimens (18.5%) with polyacrylamide gel electrophoresis. A following southem blot analysis confirmed these mycobacterial DNAs and detected another amplified DNA (25%) that was not seen on the polyacrylamide gels. Conventional detection methods such as smear and culture for M. tuberculosis found these specimens to be negative. Now we recommend PCR and combined southem blot analysis as a useful tool for early and rapid diagnosis of tuberulous meningitis.
Cerebrospinal Fluid ; Diagnosis* ; DNA ; DNA Primers ; Electrophoresis, Polyacrylamide Gel ; Gels ; Genes, vif ; Humans ; Meningitis ; Polymerase Chain Reaction* ; Tuberculosis ; Tuberculosis, Meningeal*

The effects of 1-methyl-4-phenyl-1, 2. 3, 6-tetrahydropyridine (MPTP) on behavioral and histochemical changes were investigated in C57BL/6 mice. For immunocytochemis try, one group of mice received a dose of 2X30mg/kg of MPTP given 12hours apart and the other group 30mg/kg/day of MPTP for 7days. Locomotor activit,v was measured during 120minutes after a single injection of 30mg/kg of MPTP. We compared the numbers of tyrosine hydroxylase (TH)-positive cell bodies using immunocytochemical technique in the substantia nigra, ventral tegmental area and locus ceruleus 10 days after the last injection of MPTP. There was a significant decrease in locomotor activity during 100minutes after injection of MPTP and the number of TH-positive cell bodies in the substantia nigra of the mice which received the dose of 30mg/kg/day for 7 days, but not in the ventral tegmental area or the locus ceruleus. But 30mg/kg of MPTP given 12 hours apart failed to produce a significant decrease in the number of TH-positive cell bodies in any three catecholamine nuclei examined. It is concluded that MPTP-treated C57BL/6 mice provide a useful model for studying characteristics of Parkinson's disease and the dose of 30mg/kg/day for 7 days is more effective in the animal model for Parkinson s disease in C57BL/6 mice.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Animals ; Locus Coeruleus ; Mice* ; Models, Animal ; Motor Activity ; Parkinson Disease* ; Substantia Nigra ; Tyrosine 3-Monooxygenase ; Ventral Tegmental Area

The effect of MPTP on catecholamine neurons in young (4-6 weeks) and aging (10-12 months) C57BL/6 mice was studied using immunocytochemical techniques. Both groups of mice received 4 repeated dosages of 10mg/kg of MPTP given 12 hours apart. We compared the number of tyrosine hydroxylase (TH)-positive cell bodies using immunocytochemical technique in substantia nigra (SN), ventral tegmental area(VTA) and locus ceruleus (LC) 7 days after the last injection of MPTP. There was a significant decrease in the number of TH-positive cell bodies in the SN of young mice, but not in VTA or LC. In aging mice, there was a significant decrease in the number of TH-positive cell bodies in VTA as well as in SN. It is concluded that aging mice are more sensitive to MPTP and show more widespread damage in the catecholamine neurons than young mice, suggesting that MPTP-treated aging mice provide a more useful model for studing anatomical characteristics of Parkinson's disease than young mice.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine* ; Aging* ; Animals ; Brain* ; Locus Coeruleus ; Mice* ; Neurons ; Parkinson Disease ; Substantia Nigra ; Tyrosine 3-Monooxygenase

A 45-year-old male with meningeal neurocysticercosis presented with mesence-phalothalamic syndrome as a variant of lacunar syndrome. Brain magnetic resonance imaging showed bilateral paramedian thalamic and mesencephalic infarction with cystic dilatation of the third ventricle. Cerebrospinal fluid analysis confirmed the diagnosis as it showed active inflammation and positive immunologic reactions to cysticercosis.
Brain ; Cerebrospinal Fluid ; Cysticercosis ; Diagnosis ; Dilatation ; Humans ; Infarction ; Inflammation ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neurocysticercosis* ; Stroke, Lacunar* ; Third Ventricle

PURPOSE: Forty patients who maintained a clear cornea for at least 20 years after receiving penetrating keratoplasty (PKP) were evaluated to determine favorable prognostic factors of PKP. METHODS: Among 78 patients who underwent PKP before 1986, 40 patients continue to maintain clear corneas in 2008. Demographic features of the recipients and the donors, along with underlying diseases causing blindness, the trephine size of the donor and recipient corneas, suturing methods, preoperative and postoperative visual acuity, and cause of death of the donors were evaluated retrospectively. The criteria of clear cornea maintenance was based on patient medical records. RESULTS: Among those patients maintaining clear corneas 20 years after PKP, females outnumbered male patients by 25 patients more. Patients who underwent the operation in their twenties had the highest success rates. The most common condition necessitating PKP was keratoconus, followed by traumatic corneal opacity and herpes keratitis in descending order of frequency. Female donors exceeded male donors in number. Most donors were aged 60 years or older, and the most common cause of donor death was accident. The most frequently used trephine size was 7.0 mm for the recipient and 7.5 mm for the donor, and continuous suture was used more often than interrupted suture. Patients who preserved clear corneas for at least 20 years after PKP displayed a preoperative visual acuity of counting fingers at 30 cm, which improved to 0.11 after the operation. CONCLUSIONS: We propose favorable prognostic factors of PKP based on our analysis of the characteristic features of patients who maintained clear corneas for at least 20 years after receiving a penetrating keratoplasty.
Aged ; Blindness ; Cause of Death ; Cornea ; Corneal Opacity ; Female ; Fingers ; Humans ; Keratitis ; Keratoconus ; Keratoplasty, Penetrating ; Male ; Medical Records ; Retrospective Studies ; Sutures ; Tissue Donors ; Visual Acuity

No abstract available.
Hand