OBJECTIVE: To determine a guideline on the cytologic diagnosis of ASCUS and to develope the relationship between cervical ASCUS and the eating habits in asymptomatic women. STUDY DESIGN: A total of 222 women with a cytologic diagnosis of ASCUS favoring either reactive change or squamous intraepithelial lesion(SIL) were evaluated by repeated Pap smear and colposcopy directed biopsy respectively. At the same time, eating habits of them were obtained by the questionnaire. RESULTS: Among the 157 women who had a cervical cytologic diagnosis of ASCUS favoring reactive change, 133 women(84.7%) were normal by repeated smear and/or cervical tissue biopsy. Twenty four(15.3%) of 157 women had squamous intraepithelial lesion. Among the 65 women who had a cervical cytologic diagnosis of ASCUS favoring SIL, 26(40%)were normal by repeated smear and/or cervical tissue biopsy. Thirty nine(60%) of 65 women had SIL. The confirmed SIL group showed the eatig habits of increased intake of processed food(6.67%).The other reactive group was lower(2.56%). CONCLUSION: A cytologic diagnosis of ASCUS favoring reactive change was associated with a very low risk of haboring SIL. But the woman whose initial smear showed ASCUS favoring SIL was associated with a relatively high risk of harboring SIL(p<0.001). Therefore, the woman whose smear showed ASCUS favoring SIL requires further active management even in the presence of a normal repeated pap smear. The ASCUS group favoring SIL showed the habits of increased dietary intake of processed food(P<0.05). Further study with large number of patients seems warranted.
Biopsy ; Colposcopy ; Diagnosis ; Eating* ; Female ; Humans ; Surveys and Questionnaires

The evaluation of urinary calculi was done in 84 patients of paraplegia and quadriplegia due to traumatic spinal cord injury. These patients were diagnosed by KUB and intravenous urography at National Veterans Hospital during 6 years from Jan. 1975 to Dec. 1980. The results were as follows; 1. Overall incidence of urinary calculi was 38.1 %; Incidence of renal calculi was 8.3%, ureteral calculi 4.8%, and urinary bladder claculi 32.1%. 2.Relation of neurological level and incidence of urinary calculi were as follows; Cervical injury in 34.8% upper thoracic injury in 40.0%, lower thoracic injury in 45.0%, and lumbar injury in 36.5%. 3. Laterality was not toplay a role information of urinary claculi. 4. The urinary calculi were developed 62.5% during the first 36 months following spinal cord injury. 5. The recurrence of urinary calculi was 40.6%; True recurrence was 15.6% and pseudo recurrence was 25.05.
Hospitals, Veterans ; Humans ; Incidence ; Kidney Calculi ; Paraplegia ; Quadriplegia ; Recurrence ; Spinal Cord Injuries ; Spinal Cord ; Thoracic Injuries ; Ureteral Calculi ; Urinary Bladder ; Urinary Calculi ; Urography

The present study was designed to estimate the seroprevalence of NLVs among diarrheagenic children and in healthy adults in Seoul and its vicinity with the use of an EIA and an Western blot (WB) based on recombinant Norwalk virus capsid protein (rNV) and crude virus preparations as antigen. Seroconversion was observed in 34 (83%) of 41 tested using the EIA and in 21 (54%) of 39 using the WB, suggesting that the NLVs with epitopes common to rNV are prevalent in Seoul area. Diarrheal children who were known to have been infected with several other strains of the NLVs showed no significant antibody response to the rNV. Infection with rNV occurred earlier in life: primary infections with rNV were common before the age of 6 months and over 91% of children had evidence of infection by that age by the EIA. Since the amount of the NLV antigens available for seroepidemiologic surveys is limited, we tried to detect NLV antibody by using crude virus preparations as antigen. One crude virus preparation of a child whose stool yielded genetically distinct NLV revealed the presence of the plural number of bands upon SDS-PAGE, but precipitated only one band (62 kDa) after the WB with a serum (collected 10 days after the onset of symptoms) of another diarrheal child. The WB assay we present in this report revealed that the NLVs are prevalent among Korean population and that the sera contained antibody to a single major structural protein, with molecular sizes of 58 to 62 kDa, compatible with the sizes reported for the Norwalk virus and Snow Mountain agent proteins, respectively. When the results of the WB were compared with those obtained by the EIA, the EIA antibody assay was sensitive enough to detect an antibody rise of as much as 4096-fold but not as specific as the WB. The WB assay presented in this paper will provide a powerful tool to elucidate not only antigenic structures of the NLVs but also seroepidemiology of the NLV infection. The availability of an unlimited source of antigen will enable a large scale serologic studies that will greatly increase our understanding of the role of NLVs in human enteric illness.
Adult ; Antibody Formation ; Blotting, Western ; Capsid Proteins ; Capsid* ; Child ; Electrophoresis, Polyacrylamide Gel ; Epitopes ; Humans ; Norovirus* ; Norwalk virus* ; Seoul* ; Seroepidemiologic Studies* ; Snow

No abstract available.
Iron*

PURPOSE: The purpose of this study is to analyze the smoking behaviors and to identify the impacts of depression, temperament, and characteristic on smoking experience in the female adolescents. METHODS: This study surveyed 691 highschool girls in the Gangwon area using self-administered questionnaires. Data were analyzed by SPSS 12.0. using Pearson correlation coefficient and multiple regression. RESULTS: The smoking rate of the highschool girls was lower than that of the national average. Depression was observed to be seriously in the highschool girls. There were a positive correlations among smoking experience, the school records and novelty seeking and a negative correlation between smoking and cooperativeness. The significant predictors of smoking experience were the type of school, the satisfaction with school, the school records, novelty seeking, reward dependence and cooperativeness. CONCLUSION: These results suggest that femalel adolescents who have the factors identified in this study are considered to have the potential for smoking. These results provide the basis for developing smoking prevention and cessation programs.
Adolescent* ; Depression* ; Female ; Gangwon-do ; Humans ; Reward ; Smoke* ; Smoking* ; Temperament* ; Surveys and Questionnaires

A clinico-pathologic study with an immunohistochemical examination for c-erbB-2 expression in 54 cases of ductal carcinoma in situ and 16 cases of Paget's disease of the breast was performed. c-erbB-2 oncoprotein overexpression was observed in 45% (24/54) and 88% (14/16) of ductal carcinoma in situ and Paget's disease, respectively. The overexpression of c-erbB-2 oncoprotein was significantly correlated with the nuclear grade of tumors and inversely with the status of the estrogen receptor. c-erbB-2 was positive in 4 out of 5 patients with metastasis to axillary lymph nodes and 3 out of 4 patients who died of the disease. Prognostic significance of c-erbB-2 oncoprotein in ductal carcinoma in situ was highly suggested. The expression of c-erbB-2 oncoprotein in Paget's disease was well correlated with coexisting infiltrating or in situ ductal carcinoma. The high positive rate of c-erbB-2 oncoprotein in ductal carcinoma with Paget's disease could be understood with a recent hypothesis that c-erbB-2 oncoprotein is involved in promotion of cell motility and the spread of carcinoma cells.
Neoplasm Metastasis

PURPOSE: To determine whether triple negative (TN) early stage breast cancers have poorer survival rates compared with other molecular types. MATERIALS AND METHODS: Between August 2000 and July 2006, patients diagnosed with stage I, II early stage breast cancers, in whom all three markers (estrogen receptor, progesterone receptor, and human epidermal growth factor receptor [HER]-2) were available and treated with modified radical mastectomy or breast conserving surgery followed by radiotherapy, were retrospectively reviewed. RESULTS: Of 446 patients, 94 (21.1%) were classified as TN, 57 (12.8%) as HER-2 type, and 295 (66.1%) as luminal. TN was more frequently associated with young patients younger than 35 years old (p = 0.002), higher histologic grade (p < 0.0001), and nuclear (p < 0.0001). The median follow-up period was 78 months (range, 4 to 130 months). There were 9 local relapses (2.0%), 15 nodal (3.4%), 40 distant metastases (9.0%), and 33 deaths (7.4%) for all patients. The rates of 5-year OS, DFS, LFS, and DMFS for all patients were 95.5%, 89.9%, 95.4%, and 91.7%, respectively. There were no significant differences in OS, DFS, LFS, and DMFS between triple negative and other subtypes (p > 0.05). CONCLUSION: We found that patients with TN early stage breast cancers had no difference in survival rates compared with other molecular subtypes. Prospective study in homogeneous treatment group will need for a prognosis of TN early stage breast cancer.
Breast ; Breast Neoplasms ; Disease-Free Survival ; Follow-Up Studies ; Humans ; Mastectomy, Modified Radical ; Mastectomy, Segmental ; Neoplasm Metastasis ; Phenobarbital ; Prognosis ; Receptor, Epidermal Growth Factor ; Receptors, Progesterone ; Recurrence ; Retrospective Studies ; Survival Rate ; Treatment Outcome

No abstract available.
Anemia, Iron-Deficiency* ; Humans ; Infant* ; Iron*

BACKGROUND: Left ventricular hypertrophy is a major cardiovascular risk factor for sudden death, acute myocardial infarction and congestive heart failure. The left ventricle is generally thought to adapt to sustained arterial hypertension with increased total peripheral resistance by developing concentric hypertrophy. In recent years, the echocardiogrphy has been developed as a noninvasive method for evaluation of left ventricular geometry and left ventricular mass. However, left ventricular adaptation to hypertension has been shown to be more complex than expected. In fact, many patients with mild to moderate hypertension exhibit normal left ventricular mass and wall thickness, other hypertensive patients have eccentric ventricular hypertrophy that is not related to systolic dysfunction, but rather to increased cardiac output and preload and in some hypertensive patients absolute and relative wall thickness is increased with normal ventricular mass(concentric remodeling). There are differences in the hemodynamics, systolic function and diastolic function in each group. METHODS: From september 1992 to August 1994, in 144 patients with untreated essential hypertension and 50 age and gender matched normal adults studied by two-dimensional, M-mode and Doppler echocardiography. In the present study we used echocardiographically derived left ventricular mass and relative wall thickness to assess the patterns of ventricular geometric adaptation to systemic hypertension and their relations to systemic hemodynamics, left ventricular load and contractile performance. RESULTS: Hypertensive group was 144 cases(M:F=68:76), the mean age 56+/-13years. Normotensive group was 50 cases(M:F=22:28), the mean age 52+/-9years. Among hypertensive patients, left ventricular mass index and relative wall thickness were normal in 42 cases(29%), 24 cases(17%) had increased relative wall thickness with normal ventricular mass(concentric remodelin),48 cases(33%) had both increased relative wall thickness and ventricular mass(concentric hypertrophy), 30 cases(21%) had increased left ventricular mass with normal relative wall thickness(eccentric hypertrophy). Concentric hypertrophy and normal left ventricle group are more common in untreated hypertensive patients in Korea. Systemic hemodynamics showed tendency to paralleled ventricular geomety. In groups with concentric remodeling and hypertrophy, perpheral resistance was increased. Cardiac index was midly increased in eccentric hypertrophy. Diastolic dysfunction was prominent tn concentric hypertrophy. CONCLUSION: Each patterns of left ventricular geometry had different systemic hemodynamics, ventricular pressure overload and ventricular volume overload. Therefore, appropriate selection of antihypertensive agent for the patients with each patterns of hypertrophy reduce the left ventricular hypertrophy and may improve the prognosis.
Adult ; Cardiac Output ; Death, Sudden ; Echocardiography ; Echocardiography, Doppler ; Heart Failure ; Heart Ventricles ; Hemodynamics ; Humans ; Hypertension* ; Hypertrophy ; Hypertrophy, Left Ventricular* ; Korea ; Myocardial Infarction ; Prognosis ; Risk Factors ; Vascular Resistance ; Ventricular Pressure

PURPOSE: The specific aims of the present study were to compare Kirogi children's mental distress and psychosocial factors between short-term (ST) and long-term groups (LT), and to identify predictors of mental distress in the two groups. METHODS: A sample of 107 Kirogi children living in the U.S. participated in this cross-sectional study and completed the following questionnaires: Center for Epidemiologic Studies Depression Scale, State-Trait Anxiety Inventory for Children, Somatic Symptom Scale, Self-Esteem Scale, Parent-Child (P-C) Relationship Satisfaction Scale, Parent-Adolescent Communication Inventory Social, Attitudinal, Familial, and Environmental Scale, and Social Support Scale. RESULTS: The LT group reported higher scores on depression and anxiety, and lower scores on self-esteem and P-C relationship than the ST group. Higher scores on somatic symptoms were found in the ST group. Problematic mother-child communication and dissatisfaction with father-child relationship were significant predictors for mental distress. Self-esteem predicted depression and anxiety in the ST group; particularly self-esteem was a significant predictor for anxiety in both groups. Discrimination and process-oriented stress were significant predictors for depression and anxiety in the ST group. CONCLUSION: Results of the present study reveal the needs for school-based mental health programs for the increasing number of Kirogi children vulnerable to mental distress.
Adolescent ; Anxiety ; Anxiety Disorders ; Child* ; Cross-Sectional Studies ; Depression ; Discrimination (Psychology) ; Father-Child Relations ; Humans ; Mental Health ; Parent-Child Relations ; Psychology ; Surveys and Questionnaires