No abstract available.
Child ; Male ; Female ; Humans

No abstract available.
Humans

This study was done to determine the correlation between body image and depression among women with urinary incontinence. The ultimate goal was to contribute to the planning of nursing intervention towark the establishment of a positive body image and the prevention of depression in women with urinary incontinence. The data were collected from Jan. 10 to May. 30, 1998 from 98 adult women, who lived in Cheonan City, Korea. The insturments were Hendrickson's Stress Incontinence Scale, physical self-image items out of Fitts' Tennessee self concept Scale, Osgood's Semantic Differential Scale, and Zung's self-rating Depression Scale. The data were analyzed using the SAS computerized program and include percentage, t-test, ANOVA, and the Pearson correlation coefficient. The results of this study are summarized as follows, 1. It was reported that 61.2% of the subjects experienced urinary incontinence. The level of body image perceived by urinary incontinent women had a mean of 58.56(SD=7.02) ; women with urinary incontinence showed mild depression. 2. The level of depression and body image was not significantly different between the incontinent or continent. There were significant differences in depression levels according to the severity of urinary incontinence of the subjects. 3. Severity of urinary incontinence and body image was negatively correlated (r=-0.300, p<0.01) ; correlation between depression and body image was negative (r=-0.578, p<0.01). 4. There are significant differences in body image according to use of medication, itching, and sensitivity of the vagina. 5. There are significant differences in depression with discharges from the vagina, itching, and sensitivity of the vagina. In conclusion, as urinary incontinence in women proved mildly depressive, health care providers need to develop and provide nursing intervention for the urinary incontinent with the goal of helping clients establish a positive body image and prevent depression.
Adult ; Body Image* ; Chungcheongnam-do ; Depression* ; Female ; Health Personnel ; Humans ; Korea ; Nursing ; Pruritus ; Self Concept ; Semantic Differential ; Tennessee ; Urinary Incontinence* ; Vagina

No abstract available.
Korea* ; Rotavirus*

No abstract available.
Genetic Therapy*

Bioequivalence is defined as the absence of a significant difference in the rate and extent to which the active ingredient or active moiety in pharmaceutical equivalents or pharmaceutical alternatives becomes available at the site of drug action when administered at the same molar dose under similar experimental conditions in either a single dose or multiple doses in an appropriately designed study. If a drug is to be bioequivalent to the reference drug, the confidence interval for both pharmacokinetic parameters, AUC(area under the plasma concentration-time curve) and Cmax(maximal plasma concentration), must be entirely within the 80% to 125% of those of the reference drug. Underlying the concept of bioequivalence is the thesis that, if a drug product contains a drug substance that is chemically identical and is delivered to the site of action at the same rate and extent as another drug product, then it is equivalent and can be substituted for that drug product. The primary concern from the regulatory point of view is the protection of the patient against approval of products that are not bioequivalent. In this paper the general concept and the practical significance of the bioequivalence is described. The recently revised Korean guideline for bioequivalence test is also discussed.
Drug Substitution ; Humans ; Molar ; Plasma ; Therapeutic Equivalency*

No abstract available.
Emergencies* ; Emergency Medicine* ; Korea*

No abstract available.

Antibiotics are prescribed to prevent infection and to treat established or presumptive infections. In choosing the appropriate antibiotics, a number of factors must be considered. First, the identity of the infecting organism must be known. Second, the information about the antibiotic susceptibility of the infecting organism must be as accurate as possible. Finally, host factors must be taken into consideration. The pharmacokinetics and pharmacodynamics of antibiotics in children are different from those in adults and are important host factors. The antibiotics may be classified into several groups : the beta-lactams (i.e., penicillins, cephalosporins, carbacephems, and monobactam), glycopeptides (i.e., vancomycin), aminoglycosides, macrolides, and quinolones. This article describes the clinical application of selected antibiotics to infectious diseases with newly available agents in children. The development of new oral agents prescribed as once or twice per day achieves enhanced compliance. These include cefprozil, cefpodoxime, loracarbef, azithromycin, clarithromycin, and fluoroquinolones. Meropenem is also a newly available carbacephem approved for use in children. Antibiotics available but not approved for use in children are imipenem-ci-lastatin, aztreonam, quinolones, and several cephalosporins including "fourth"-generation such as cefipime. Recently the use of once-daily dosing of aminoglycosides has been evaluated in pediatric populations, which appears to be safe and effective, although further studise are warranted. The emergence of antibiotic-resistant bacteria has generally been correlated with the rise of specific antibiotic use in clinical practice. Although the development of resistance may be inevitable, the rate at which it develops may be diminished by the rational use of antibiotics.
Adult ; Aminoglycosides ; Anti-Bacterial Agents ; Azithromycin ; Aztreonam ; Bacteria ; beta-Lactams ; Cephalosporins ; Child ; Clarithromycin ; Communicable Diseases ; Compliance ; Fluoroquinolones ; Glycopeptides ; Humans ; Macrolides ; Penicillins ; Pharmacokinetics ; Quinolones

PURPOSE: The purpose of this study was to review the articles and theses on the patient safety culture of clinical nurses for identifying overall research trends regarding patient safety culture among hospital nurses, and to suggest strategies for improving nursing work environment related to patient safety culture. METHODS: The subjects for this study were 17 articles selected according to inclusion criteria from five databases in Korea. RESULTS: Seven articles were collected from nursing journals and ten from master's theses. The studies on the 17 articles were conducted at 66 hospitals from seven regions of Korea. The tools for patient safety culture were selected among the three tools from AHRQ and two Korean translation tools. The mean score of patient safety culture was 3.43. CONCLUSION: The findings from the article review indicate that, in order to improve nursing work environment for patient safety culture, the hospital and nursing manager should emphasize the education for patient safety, communication and open-minded reporting, and cooperation among the departments of hospital.
Education ; Korea ; Nursing* ; Patient Safety* ; Review Literature as Topic