1.Renin Release by Adenosine Agosists and Antagonists in Two-Kidney One Clip Goldblatt Hypertensive Rats.
Young Jin CHOI ; Sun Hee KIM ; Kyoung Woo CHO ; Jong HUH ; Kyung Hwan SEOL
Journal of Korean Society of Endocrinology 1998;13(1):67-76
BACKGROUND: In two-kidney one clip Goldbaltt hypertensive rats(2K1C GHR), clipped kidney may be exposed to low pressure and unclipped kidney to high pressure. In addition, both kidneys may have a different amount of adenosine which is increased by ischemia and plays an important role for renin release. The aim of this study was to invstigate the responsmiveness for renin release to adenosine agonists and antagonist in clipped and unclipped kidney of 2K1C GHR. METHODS: Emplying kidney slices from both unclipped and unclipped kidney of 2K1C GHR, the alteration by adenosine agonists and antagonist of renin release was studied. RESULTS: The renal renin content and basal renin release from unclipped kidney slices were suppressed, whereas those from clipped kidney were augmented Adenosine Al receptor agonist, cyclohexyladenosne(CHA), phenylisopropyl adenosine(PIA) and adenosine caused a decrease in renin release from clipped kidney slices. Adenosine A2 receptor agonist, NECA, and nonspecific adenosine receptor aganist, 2-chloroadenosine(CA) caused an increase in renin release from clipped kidney slices. Adenosine receptor antagonist, 8-phenyltheophylline(8-PT) caused an increase in renin release from clipped kidney slices. In unclipped kidney, however, the renin release in response to NECA, CA or 8-PT was reversed and the decreasing effect of renin release to CHA and adenosine was slightly inereased. CONCLUSION: These results suggest that the responsiveness of adenosine receptors, which may participate in renin release is modified in clipped and unclipped kidney of 2K1C GHR.
Adenosine*
;
Adenosine-5'-(N-ethylcarboxamide)
;
Animals
;
Hypertension, Renovascular
;
Ischemia
;
Kidney
;
Rats*
;
Receptors, Adenosine A2
;
Receptors, Purinergic P1
;
Renin*
3.Skin Lesion after Repeated Fluoroscopically Guided Procedures: A Case Report.
Hee Sang KIM ; Kyung Hoi AHN ; Dong Hwan YUN ; Jin Ju OH ; Yong Seol JEONG ; Dong Hwan KIM
Journal of the Korean Academy of Rehabilitation Medicine 2001;25(4):729-733
The radiation exposure has multiple complication of various organs. Especially, the Food and Drug Administration has recently issued a bulletin warning of the risks of acute skin injury occurring during fluoroscopically guided procedures. Physicians need information about typical radiation doses during fluoroscopically guided various procedures and estimates of entrance skin dose must be monitored using thermoluminescent dosimetry, film badge dosimetry, pocket dosimetry and on-line computer system. Current National Council on Radiation Protection and Measurements recommended are that yearly total body dose should not exceed 50 mSv (5 rem) and that life time dose measured in millisieverts should not exceed one's age in years multiplied by 10. Types of skin injury are erythema, alopecia, dry desquamation, invasive fibrosis, dermal atropy, telangiectasia, moist desquamation, skin necrosis and secondary ulcer. Also, long-term exposure caused skin cancer. We experienced personally pigmentation on the finger nail and the hand after repeated fluoroscopically guided procedures. Thus, we report this case for giving warning to the physiatrist by the complications due to frequent exposure during procedures.
Alopecia
;
Computer Systems
;
Erythema
;
Fibrosis
;
Film Dosimetry
;
Fingers
;
Fluoroscopy
;
Hand
;
Humans
;
Necrosis
;
Pigmentation
;
Radiation Protection
;
Skin Neoplasms
;
Skin*
;
Telangiectasis
;
Thermoluminescent Dosimetry
;
Ulcer
;
United States Food and Drug Administration
4.Evaluation of Foodservice Managers' Perception on Safety Management in Childcare Centers and Kindergartens.
Hyung Soo PARK ; Kyung Mi LEE ; Hye Rin SEOL ; Ki Hwan PARK ; Kyung RYU
Korean Journal of Community Nutrition 2009;14(1):87-99
The purpose of this study was to investigate the perception of foodservice managers in childcare centers and kindergartens for identifying the vulnerable areas of safety management. The foodservice managers in 1,144 of nationwide childcare centers and kindergartens were surveyed from May to October 2007 to answer a total 72 questions in areas of general characteristics, actual practice of foodservice management and safety management perception. Meals were served in 97.7% of surveyed facilities and 91.0% among them were self-operated. The hiring rate (27.8%) of dietitians in childcare centers was significantly lower than the rate (82.0%) of kindergartens. The needs of dietitian employment between childcare centers and kindergartens differed as 44.9% and 87.5%, respectively. In knowledge on food-borne illnesses, they have the wrong information in the field of season for frequent outbreak, major pathogens and foods causing food-borne illnesses. The food-borne illnesses (36.2%) were indicated as the major problem in foodservice facilities and the degree of risk exposure was considered as safe (70.1%). More than 70% of both facilities answered as sanitary in the status of personal hygiene. Only 38.0% recognized the Facility and Equipment Standard in the Childcare Law and Early Childhood Education Law. In preparation of meals and management of cooking processes, kindergarten scored significantly high compared to childcare centers (p < 0.05 or p < 0.01) while the necessity of standards was not different in both facilities. Among managers surveyed, 28.8% had taken food safety education from professional institutions and more than 80% in both facilities indicated the need of professional educations. These results suggest that it is necessary for the systematic sanitary education of foodservice managers by developing the sanitary management standard as well as the amendment of laws related foodservice in childcare centers and kindergartens.
Cooking
;
Employment
;
Food Safety
;
Foodborne Diseases
;
Humans
;
Hygiene
;
Jurisprudence
;
Meals
;
Safety Management
;
Seasons
5.Five Cases of Polypectomy using Endoscopic " O " -ring Ligation.
Jung Myung CHUNG ; Sang Hyuk LEE ; Sang Yong SEOL ; Dae Sik KOO ; Kyung Seok OH ; Hyen Jung JANG ; Chan Hwan KIM
Korean Journal of Gastrointestinal Endoscopy 1994;14(4):442-449
Endoscopic polypectomy was firstly introduced by Tsuneoka in 1969, and till now this method has been widely used for the treatment of benign and malignant polyps with the advent of technical improvement. This method is a very important modality as secondary prevention of malignancy because polyps in gastraintestinal tract are now being considered as precancerous lesion. Polypectomy with snare and electrocautery is mainly used for pedunclated polyps (eg. Yamada Class III, IV), but sessile polyps pose technical difficulty and occasionally cause serious gastrointestinal hemorrhage when resection margin adjacent polyp base. We performed polypectomy with "O"-ring used in endocopic variceal ligation (EVL) to make sessile polyp as semipedunclated form, and also to control bleeding, and then successfully remove it with conventional snare polypectomy. We report these 5 cases with the review of the literature.
Electrocoagulation
;
Gastrointestinal Hemorrhage
;
Hemorrhage
;
Ligation*
;
Polyps
;
Secondary Prevention
;
SNARE Proteins
6.The Relationship between Quality of Life and Psychosocial Characteristics in Patients with Schizophrenia.
Kyung Jin KIM ; Jee Hwan SEOL ; Young Suk PAIK ; Jae Hyun KIM
Journal of Korean Neuropsychiatric Association 2004;43(5):603-610
OBJECTIVES: This study was to identify the relationship between quality of life and psychosocial characteristics in patients with schizophrenia. METHODS: The subjects were eighty nine patients with schizophrenia according to DSM-IV. The Korean Quality of Life Scale (K-QLS) and the Korean modified Scale to measure Subjective Well-being under Neuroleptic treatment (KmSWN) were used to assess quality of life. The psychopathology of each patient was assessed by the Positive and Negative Syndrome Scale (PANSS). The Scale to Assess Unawareness of Mental Disorder (SAUMD) was used for differentiating presence and absence of insight. The Social and Occupational Functioning Assessment Scale (SOFAS), the Scale of Social Support (SSS), and the Family Adaptability and Cohesion Evaluation Scale (FACES) were used for assessing psychosocial characteristics. The correlation between the scores of each quality of life scale and other scales was examined, and multiple regression analysis was performed to assess the contribution of the scores of each quality of life scale to other scales. RESULTS: The K-QLS score was significantly related to the scores of the PANSS, the SAUMD, the social conflict domain of the SSS, and the SOFAS. The KmSWN score was significantly related to the scores of the PANSS, the SOFAS, the social conflict domain of the SSS, and the FACES. In multiple regression analysis, the scores on the PANSS (32.9%), the SAUMD (5.8%), and the FACES (4.0%) were contributed to the score on the K-QLS, and the scores on the social conflict domain of the SSS (17.3%) and the FACES (12.9%) were contributed to the score on the KmSWN. CONCLUSION: The relation between the K-QLS score and the scores of other scales means that the objective quality of life increases according to decreased the severity of symptom, the high level of insight and the socio-occupational function. And the relation between the KmSWN score and the scores of other scales means that the subjective quality of life increases according to the perceptions to the high level of social support, the low level of social conflict, and the high level of family adaptability and cohesion. The objective quality of life assessed by the K-QLS is affected primarily by the severity of symptoms, and the subjective quality of life assessed by the KmSWN is affected by the subjective perceptions of social conflict, family adaptation and cohesion. These findings suggest that the treatment of symptoms is important in the treatment of schizophrenic patients, but that it is also important to approach to the psychosocial characteristics to increase subjective satisfaction from the quality of life in them
Diagnostic and Statistical Manual of Mental Disorders
;
Family Conflict
;
Humans
;
Mental Disorders
;
Psychopathology
;
Quality of Life*
;
Schizophrenia*
;
Weights and Measures
7.The Relationship between Quality of Life and Psychosocial Characteristics in Patients with Schizophrenia.
Kyung Jin KIM ; Jee Hwan SEOL ; Young Suk PAIK ; Jae Hyun KIM
Journal of Korean Neuropsychiatric Association 2004;43(5):603-610
OBJECTIVES: This study was to identify the relationship between quality of life and psychosocial characteristics in patients with schizophrenia. METHODS: The subjects were eighty nine patients with schizophrenia according to DSM-IV. The Korean Quality of Life Scale (K-QLS) and the Korean modified Scale to measure Subjective Well-being under Neuroleptic treatment (KmSWN) were used to assess quality of life. The psychopathology of each patient was assessed by the Positive and Negative Syndrome Scale (PANSS). The Scale to Assess Unawareness of Mental Disorder (SAUMD) was used for differentiating presence and absence of insight. The Social and Occupational Functioning Assessment Scale (SOFAS), the Scale of Social Support (SSS), and the Family Adaptability and Cohesion Evaluation Scale (FACES) were used for assessing psychosocial characteristics. The correlation between the scores of each quality of life scale and other scales was examined, and multiple regression analysis was performed to assess the contribution of the scores of each quality of life scale to other scales. RESULTS: The K-QLS score was significantly related to the scores of the PANSS, the SAUMD, the social conflict domain of the SSS, and the SOFAS. The KmSWN score was significantly related to the scores of the PANSS, the SOFAS, the social conflict domain of the SSS, and the FACES. In multiple regression analysis, the scores on the PANSS (32.9%), the SAUMD (5.8%), and the FACES (4.0%) were contributed to the score on the K-QLS, and the scores on the social conflict domain of the SSS (17.3%) and the FACES (12.9%) were contributed to the score on the KmSWN. CONCLUSION: The relation between the K-QLS score and the scores of other scales means that the objective quality of life increases according to decreased the severity of symptom, the high level of insight and the socio-occupational function. And the relation between the KmSWN score and the scores of other scales means that the subjective quality of life increases according to the perceptions to the high level of social support, the low level of social conflict, and the high level of family adaptability and cohesion. The objective quality of life assessed by the K-QLS is affected primarily by the severity of symptoms, and the subjective quality of life assessed by the KmSWN is affected by the subjective perceptions of social conflict, family adaptation and cohesion. These findings suggest that the treatment of symptoms is important in the treatment of schizophrenic patients, but that it is also important to approach to the psychosocial characteristics to increase subjective satisfaction from the quality of life in them
Diagnostic and Statistical Manual of Mental Disorders
;
Family Conflict
;
Humans
;
Mental Disorders
;
Psychopathology
;
Quality of Life*
;
Schizophrenia*
;
Weights and Measures
8.Hemodynamic Change by Portal Tumor Thrombus in Hepatocellular Carcinoma: Evaluation by Combined Spiral CT Hepatic Arteriography and CT Arterial Portography.
Mee Ran LEE ; Yun Hwan KIM ; Kyung A KIM ; Hae Young SEOL ; Kyoo Byung CHUNG ; Won Hyuk SUH
Journal of the Korean Radiological Society 1996;34(1):81-87
PURPOSE: To evaluate the hemodynamic change by portal tumor thrombus in hepatocellular carcinoma(HCC). MATERIALS AND METHODS: We reviewed 35 cases of combined spiral CTHA and CTAP in 25 HCC patients with portal tumorthrombus from April 1993 to October 1994, regarding to portal tumor thrombus, the involved area of arterioportal(AP) shunt and the development of cavernous transformation of portal vein, in comparison with hepaticand superior mesenteric arteriography. RESULTS: Spiral CTHA showed hyperattenuating tumor, portal tumor thrombus and hyperattenuating peritumoral parenchymal area. Spiral CTAP showed perfusion defect area including tumor, portal tumor thrombus and peritumoral area distal to portal vein obstruction. In 15 cases, portal tumor thrombus showed intraluminal and marginal hyperattenuating linear structures on CTHA due to transvasal AP shunt and tumor feeding arteries, which were corresponding to thread and streaks sign on hepatic arteriography. Cavernous transformation of portal vein was demonstrated in 15 cases as irregular periportal hyperattenuating collateral vessels on spiral CTAP. In 32 cases, portal vein was visualized on CTHA due to AP shunt. And according to shunt amount, we classified AP shunt into 4 grades. Grade I means only the presence of portal tumor thrombus without AP shunt, grade II with segmental AP shunt, grade III with one lobar AP shunt, and grade IV with both lobar AP shuntor the presence of cavernous transformation of portal vein. Grade I was seen in 3, grade II in 4, grade III in 13 and grade IV in 15 cases. CONCLUSION: Variable CTHA and CTAP findings were shown in HCC patients with portal tumor thrombus according to the amount of AP shunt and the presence of cavernous transformation of portal vein. Combined CTHA and CTAP are useful to differentiate the tumor thrombus from simple thrombus and are very sensitive method for detecting AP shunt. Understanding these findings related with portal tumor thrombus is important topredict patient}s prognosis and to decide treatment method.
Angiography*
;
Arteries
;
Carcinoma, Hepatocellular*
;
Hemodynamics*
;
Humans
;
Perfusion
;
Portal Vein
;
Portography*
;
Prognosis
;
Thrombosis*
9.Postoperative Complications and Cost-effectiveness of Simultaneous and Staged Bilateral Total Hip Arthroplasty Using a Modified Minimally Invasive Two-incision Technique.
Jong Hwan SEOL ; Kyung Soon PARK ; Taek Rim YOON
Hip & Pelvis 2015;27(2):77-82
PURPOSE: To compare the postoperative complications and cost-effectiveness of simultaneous and staged bilateral total hip arthroplasty (THA), using a minimally invasive two-incision technique. MATERIALS AND METHODS: All 206 patients who underwent simultaneous or staged bilateral THA using a modified, minimally invasive two-incision between January 2004 and November 2009 were registered and divided into a simultaneous bilateral THA group (group A, 147 patients) and staged bilateral THA group (group B: 59 patients). Staged THA was performed on group B with interval of at least 2 months between the initial and second surgery. Clinical evaluations, amount of blood loss, need for transfusion, complications and costeffectiveness were compared. RESULTS: Perioperative morbidity rates were similar in the two groups (P=0.546) and overall complications were not significant between the groups. Average length of hospital stay was significantly shorter in group A than in group B (average 14.6 days vs. 25.3 days; P<0.001). Total medical cost was significantly higher in group B than in group A (average 9,236 US dollars vs. 11,163 US dollars). Patients in group A required more blood transfusions than those in group B (3.02 vs. 1.90 units; P=0.003), although blood loss in the two groups were similar (892 vs. 917 ml P=0.613). CONCLUSION: Comparison of intra- and postoperative complications support the conclusion that simultaneous bilateral THA compares favorably with staged THA in terms of outcomes, complications and cost-effectiveness.
Arthroplasty, Replacement, Hip*
;
Blood Transfusion
;
Humans
;
Length of Stay
;
Methods
;
Postoperative Complications*
10.A Clinical Review of 11 Cases of a Laparoscopic Adrenalectomy Comparison with an open adrenalectomy.
Jeong Yoon SONG ; Sang Mok LEE ; Suck Hwan KOH ; Sung Wha HONG ; Young Seol KIM
Journal of the Korean Surgical Society 2000;58(3):369-374
PURPOSE: The laparoscopic adrenalectomy has become the golden standard procedure for adrenal tumors because of its many advantages. The purpose of our study was to compare the outcomes for patients who underwent a transperitoneal laparoscopic adrenalectomy with those of patients who had a conventional open adrenalectomy. Similar to the open adrenalectomy, the laparoscopic adrenalectomy was divided into anterior (LA: Laparoscopic anterior) and posterior (LP: Laparoscopic posterior) approaches. METHODS: Between January 1991 and September 1998, a retrospective review of consecutive ad renalectomies performed at Kyung Hee University Hospital was done. Outcome measurements of operative indications, tumor size, operation time, first oral intake, postoperative stay, and postoperative complications were reviewed. RESULTS: Eleven(11) laparoscopic adrenalectomies (4 LAs and 7 LPs) were performed in 11 patients and 47 open adrenalectomies [24 with an anterior, OA (Open anterior), approach and 23 with a posterior, OP (Open posterior), approach] in 43 patients. The LA approach showed a significantly shorter time to first oral intake (1.8 vs 3.4 days p=0.001) and postoperative hospital stay (5.5 vs 12.8 days p=0.001) compared to the OA approach. The LP approach also showed a significantly shorter time to first oral intake (0.9 vs 1.6 days p=0.046) and postoperative hospital stay (5.9 vs 9.9 days p=0.004) compared to the OP approach. There were no differences in tumor size, operation time, and postoperative complications between laparoscopic adrenalectomies and open adrenalectomies. CONCLUSION: The laparoscopic adrenalectomy is superior to the open adrenalectomy when performed by appropriately trained and skilled surgeons.
Adrenalectomy*
;
Humans
;
Length of Stay
;
Postoperative Complications
;
Retrospective Studies