Intraperitoneal adminstration of radioisotopes is suggested to treat the metastatic ovarian cancer in the pertioneal cavity. Administering beta-emitting radioisotopes into the pertioneal cavity allows the maximum energy delivery to the cancerous cells of the pertioneal wall surface while sparing the normal cells located in deep site of the peritoneal wall. In this study, dose estimates of the peritoneal wall are provided to be used for prescribing the amount of 166Ho-chitosan complex administered. The 166Ho-chitosan complex diffused in the peritoneal fluid may attach to the peritoneal wall surface. The attachment fraction of 166Ho-chitosan complex to the peritoneal wall surface is obtained by simulating the ascites with Fischer rats. Both volume source in the peritoneal fluid and the surface source over the peritoneal wall surface are counted for the contribution to the peritoneal wall dose. The Monte Carlo code EGS4 is used to simulate the energy transfer of the beta particles emitted from 166Ho. A plane geometrical model of semi-infinite volume describes the peritoneal cavity and peritoneal wall. A semi-infinite plane of 10 micrometer in thickness at every 1 mm of depth in the peritoneal wall is taken as the target in dose estimation. Greater han 98 percents of attachment fraction has been observed from the experiments with Fischer rats. Given 1.3 microcurie/cm2 and 2.4 microcurie/ml of uniform activity density, absorbed dose is 123 Gy, 8.59 Gy, 3.00 Gy, 1.03 Gy, and 327 Gy at 0 mm, 1 mm, 2 mm, 3 mm, and 4 mm in depth to the peritoneal wall, respectively.
Ascites ; Ascitic Fluid ; Beta Particles ; Energy Transfer ; Ovarian Neoplasms ; Peritoneal Cavity ; Radioisotopes ; Rats, Inbred F344

No abstract available.
Stomach Neoplasms* ; Stomach*

Dermal wound healing is a complex process that involved inflammation leading to re-epithelialization, granulation tissue, and tissue remodeling. Previous studies from our laboratory have shown that polysaccharides isolated from fungus, Phellinus gilvus (PG) have various anti-inflammatory activities. In present study, we have assessed the effect of polysaccharides from PG on the dermal wound healing of polysaccharides from PG in streptozotocin-induced diabetic rat model. Six of 6-mm circular wounds were created with biopsy punch on the 4th day after induction of diabetes. After 24 hours, each test substance was applied to the wound twice a day for next 5 days. Circular wounds treated with PG showed significantly reduced wound contraction and complete reepithelialization, as compared to wounds of non-treated (p < 0.05). These results show that polysaccharides isolated from PG enhanced wound repair in diabetic impaired healing, and could be developed as a wound healing agent in such clinical settings.
Administration, Cutaneous ; Animals ; Anti-Inflammatory Agents/pharmacology ; Basidiomycota/*metabolism ; Diabetes Mellitus, Experimental/*pathology ; Histocytochemistry ; Male ; Polysaccharides/isolation&purification/*pharmacology ; Rats ; Rats, Sprague-Dawley ; Skin/*injuries ; Streptozocin ; Wound Healing/*drug effects ; Wounds, Penetrating/*drug therapy

Primary pulmonary tuberculosis is one of the common pulmonary disease affecting children in Korea. Simple chest film is essential in diagnosis of primary pulmonary tuberculosis, but it is difficult to interpret the findings in some cases. Authors reviewed chest films of 162 cases of clinically confirmed primary pulmonary tuberculosis from April 1978 to June 1981 at Seoul National University Hospital. The results are as follows; 1. Lymph node enlargement, either hilar or mediastinal, was found in 82.7% and pulmonary parenchymal infiltration in74%. 2. Incidence of unilateral and bilateral hilar lymph node enlargement is about 50% (81cases) and 30% (49cases) respectively. Incidence of unilateral and bilateral mediastinal lymph node enlargement is about 21% (34cases) and 4.3% (7 cases), more common in right side. 3. Pulmonary parenchymal lesion is demonstrated in 74% (120cases). The pattern of primary focus is as follows in order; patchy infiltration 47% (76 cases) linear-streaky infiltration 15% (25 cases), lobar or segmental homogenous infiltration 9% (14 cases), nodular infiltration 4% (7cases). The primary focus of right lung is two times as common as that of left. 4. Calcification in primary focusis noted in about 27% in pulmonary parenchyma and 49% in hilum. 5. Plerual effusion is identified in 10%, but pleural effusion without pulmonary parenchymal lesion or lymph node enlargement is noted in only 2% (3 cases).
Child ; Diagnosis ; Humans ; Incidence ; Korea ; Lung ; Lung Diseases ; Lymph Nodes ; Pleural Effusion ; Seoul ; Thorax ; Tuberculosis, Pulmonary

No abstract available.
Congenital Abnormalities* ; Osteotomy* ; Recurrence*

No abstract available.
Arthroplasty* ; Knee*

BACKGROUND: Urography(IVU) is considered the best first investigation in patient with suspected urinary calculi, but recently ultrasonography(USG), combined with a plain film of the abdomen, has been suggested as an alternative. METHODS: We undertaken study to see if this approch can be used in emergency patients and outpatients by radiologists with different amounts of ultrasound experence. Some 192 patients with suspected urinary colic presenting to Koo Hospital Emergency Department and Youngnam Universith Hospital outward Department(IM, URO, FM) over 12-month period were studied. They had a plain abdominal film(KUB) and USG examination of the kidney, ureter, bladder following hydration and subsequently underwent IVU. Of these, 22 patients passed a stone before their IVU. The data analysis was performed on the remaining 170 patients. Urography was used as the gold standard. RESULTS: Some 170 patients subsequently underwent IVU at a mean interval of 1.8 days after the ultrasound examination. In 91 of 170 patients the IVU was positive. In 97 of 170 patients the combination of JUB plus USG was positive, leaving three false negative KUB plus USG. Thus the sensitivity of KUB plus USG was 97%, specificity was 89%, positive predictive value was 91%, and negative predictive value was 96%. CONCLUSIONS: Our findings in this study suggest that in the hydrated patient the combination of KUB plus US is a very sensitive and relative specific screening test. Because of the high negative predictive value of KUB plus US, urography is not likely to be helpful when KUB plus US are negative. Urography is indicated only if KUB plus US findings are equivocal or if intervention is necessa.ry.
Abdomen ; Colic ; Emergencies ; Emergency Service, Hospital ; Humans ; Kidney ; Mass Screening ; Outpatients ; Sensitivity and Specificity ; Statistics as Topic ; Ultrasonography* ; Ureter ; Urinary Bladder ; Urinary Calculi* ; Urography*

No abstract available.
Para-Aortic Bodies* ; Paraganglioma*

PURPOSE: To analyse the survival rate and influencing factors and evaluate functional results in total knee arthroplasty. MATERIALS AND METHODS: The survival of total knee replacement between 1982 and 1997 with a follow-up period of up to 16 years was estimated by Kaplan-Meier method. We analyzed clinically and radiologically 852 patients (1294 knees) who were followed up for more than one year (average 10 years, 3 months) . The average age at operation was 59.6 years. The patients had osteoarthritis in 913 knees (70.5%) and rheumatoid arthritis in 287 knees (22.2%) . Also, the knee function was evaluated according to the Functional Knee Scores of Hospital for Special Surgery. RESULTS: The HSS knee score was improved from an average of 57.7 points preoperatively to an average of 90.2 points postoperatively. The results were satisfactory in 1189 knees (91.8%) . Revision surgery was performed in 53 knees of the 1294 knees (4.1%) . The survival rate with reliability, 13 years after operation, was 88.2%. CONCLUSION: Factors influencing the survival rate were the diagnosis of disease, kind of implant and postoperative tibiofemoral angle. Total knee replacement is an effective and satisfying procedure which can relieve pain, correct deformity, restore function, improve quality of life and achieve long-term survival.
Arthritis, Rheumatoid ; Arthroplasty ; Arthroplasty, Replacement, Knee* ; Congenital Abnormalities ; Diagnosis ; Follow-Up Studies ; Humans ; Knee ; Osteoarthritis ; Quality of Life ; Survival Rate

OBJECTIVES: The purpose of this study is to provide the basic data for anatomy of proximal tibia by real measurement, to determine the morphologic fitness between the proximal tibia of Korean and the tibial prosthesis in total knee arthroplasty, and consequently to provide basic data for development of prosthesis that appropriate to Korean. MATERIALS AND METHODS: The anteroposterior length and mediolateral length of proximal tibia were measured for 173 knees of 117 patients who underwent total knee arthroplasty. Also, obtained data from intraoperative measure of proximal tibia were analysed according to patient's age, sex and disease. RESULTS: The results show that average mediolateral length of proximal tibia is 72.7 +/- 4.0mm, average anteroposterior length of medial plateau is 48.0 +/- 3.1mm, and average anteroposterior length of lateral plateau is 39.8 +/- 2.9mm. The mediolateral length of proximal tibia and the anteroposterior length of medial tibial plateau are significantly larger than tibial prosthesis designed by 5 different companies. The morphological differences according to disease entity are significantly larger in osteoarthritic patient group than in other disease entity. The significant difference according to patient's age is not found. CONCLUSION: The results of this study show the morphologic discrepancy between the proximal tibia of Korean and the tibial prostheses, and the development of design of tibial prosthesis for Korean should be considered.
Arthroplasty* ; Humans ; Knee* ; Prostheses and Implants* ; Prosthesis Design ; Tibia*