The fifty gastrointestinal polyps, which were removed endoscopically frorn 47 patients at the Seoul National Univeraity. Hospital from January, 1978 to September, 1983, were reviewed with regard to the clinical and pathological features. The observed data are as follows; 1) Fifty polyps were reoved from 10 patients with gastric polyps and 37 patients with colonic polyps. Out of 37 patients 26 were male and 21 female, the sex ratio being 1.2: 1. 2) The gastric polyps were located in the body and antrum and 90 per cent of the colonic polyps were found in the left colon, especially in the rectosigmoid colon. 3) Out of the 10 gastric ployps snared, 8 could be retrivevd, 2 being lost. The histological examination showed that 3 were hyperplastic polyps, 2 gastritis verrucosa, 1 inflammatory polyp and the remaining 1 revealed intramucosel carcinoma with borderline epithelium. 4) Fourty polypectomies were performed in 37 patients with colonic polyps. Histological examination revealed that 24(60%) were adenomatous polyps, 9(22.5%) retention polyp, 4 (10.0%) inflammatory polyp and 3(7. 5%) Peutz-Jegher's poIyps. Among the adenomatous polys, 4 cases were complicated with focal adenocarcinoma. 5) Except the 2 cases of post-polypectomy bleeding, no other complication was encountered. The one case of hemorrhage after gastric polypectomy was treated with transfusion of 2 pints of whole blood, and the other case after colonic polypectomy required exploratory laparotomy because of inability of bleeding control by electrocoagulation.
Adenocarcinoma ; Adenomatous Polyps ; Colon ; Colonic Polyps ; Electrocoagulation ; Epithelium ; Female ; Gastritis ; Gastrointestinal Tract* ; Hemorrhage ; Humans ; Laparotomy ; Male ; Polyps* ; Seoul ; Sex Ratio ; SNARE Proteins

The athors have presented recently treated 4 cases of malignant tumors of the eye and adnexa. 1. All of them were rapidly aggrevated after previous incompleted surgical management (3 cases) or postponement 01 operation (1 case). 2. Three cases of them except adenoid cystic Ca. were recurred after orbital exenteration. 3. The authors were concluded that the poor prognosis is due to its nature of malignancy and delayed radical surgical management.
Adenoids ; Melanoma* ; Orbit ; Prognosis

No abstract available.
Clone Cells* ; Cloning, Organism* ; DNA* ; Genome* ; Nucleopolyhedrovirus* ; Plasmids*

No abstract available.
Cushing Syndrome*

Bone morphogenetic protein-2/4 are members of Transforming Growth Factor-beta(TGF-beta) superfamily and they may induce formation of cartilage and bone in vivo. This study was performed to investigate the cellular target and period of action of BMP-2/4 and understanding of actions of BMP-2/4 at cellular level. The appearance of BMP-2/4 during healing of mandibular and periodontal defect in rat was evaluated immunohistochemically. 40 Sprague-Dawley strain white male rats, each weighing about 300gm were used. Bony defect was performed in the mandible and they were sacrificed at the day of 3rd, 10th, 20th, 30th after operation. The specimens were harvested and examined histologically and immunohistochemically by localization of anti-BMP-2/4. The results were as follows: 1. Woven bone was observed at 10th day and perfect healing of defect with compact bone and periodontal ligment space at 30th day. 2. Osteoprogenitor cells, osteoblastic cells and periosteum were positive reaction to immunohistochemical stain at 10th day. 3. Cells of bone marrow space and surface cells of osteocytes and cementoblasts were positive reaction to immunohistochemical stain at 20th day. 4. Newly formed osteocytes and cementocytes were positive reaction to immunohistochemical stain at 30th day. From the above findings, we could conclude that BMP-2/4 acted significant roles as factors of induction, proliferation and differentiation during bone healing process.
Animals ; Bone Marrow ; Cartilage ; Dental Cementum ; Humans ; Male ; Mandible ; Osteoblasts ; Osteocytes ; Periosteum ; Rats* ; Rats, Sprague-Dawley

This sutdy was designed to localize the distribution of basic fibroblast growth factor(bFGF) in the developing rat condylar region and to elucidate the associated function of bFGF in the condyle development. The condyles of temporomandibular joint of Sprague-Dawley rats (27g of weight) were used. The tissues were examined with electron microscope and immunohistochemical method. The results were as follows: 1. The developing condylar region are divided in to 5 zones apparently: proliferative, maturation, hypertrophic, calcifying, and ossification zones. 2. The cells in the proliferative zone are condensed and have under-developed cell organells in the cytoplasm. This zone shows a strong immunoreactivity of bFGF. 3. The cells in the maturation zone are typical chondroblasts showing well-developed cell organells and round nucleus. The cartilaginous matrix does not show the immunoreactivity of bFGF, while the chondroblasts show the immunoreactivity. 4. The cells in the hypertrophic zone show hypertrophic change having the degenerated cell organelles and small nucleus. There are no immunoreactivity of bFGF in this zone except the nucleus and endoplasmic region showing mild immunoreactivity. 5, The cells in the calcifying zone show hypertrophic change and cell organelles are disappeared. The cells are surrounded by the calcified cartilaginous matrix. There are no immunoreactivity of bFGF in this zone except the endoplasmic region showing mild immunoreactivity. 6. In the zone of bone formation, chondroblasts are disappeared. Newly differentiated osteoblasts secreting osteoid around the calcified cartilaginous matrix. The bone marrow shows the immunoreactivity of bFGF, while the bone matrix does not show the immunoreactivity of bFGF.
Animals ; Bone Marrow ; Bone Matrix ; Chondrocytes ; Cytoplasm ; Fibroblasts* ; Joints* ; Organelles ; Osteoblasts ; Osteogenesis ; Rats* ; Rats, Sprague-Dawley ; Temporomandibular Joint

No abstract available.
Mediastinitis*

No abstract available.
Mediastinitis*

This study was performed to observe the effect of ultrasound(1.0MHz, 0.75W/cm2 and 1.0W/cm2) irradiation on cultured MC3T3-E1 cell, osteoblastic like cell with respect to the proliferation, protein synthesis, and alkaline phosphatase activity of the cells. The results were as follows: 1. The proliferation of MC3T3-E1 cells was increased on ultrasound irradiated group compared with control group. 2. The protein synthesis was not apparently increased on ultrasound irradiated group compared with control group. 3. The alkaline phosphatase activity level was not apparently increased on ultrasound irradiated group compared with control group. From the above results and other literatures, we could suggest that the ultrasound with the appropriate intensity and frequency may have important roles in stimulation of cell proliferation. Therefore the ultrasound may be used in the acceleration of the bone regeneration and bone fracture healing.
Acceleration ; Alkaline Phosphatase ; Bone Regeneration ; Cell Proliferation ; Fractures, Bone ; Osteoblasts ; Ultrasonography

Conegenital anomalies of the ribs are common but rarely result in shadow which might be mistaken forpathological lesions. Careful inspection of the bony parts, which should be a routine, will usually be sufficientto avoid mistakes. Authors reviewed 6,921(5,865 male, 1,056 female) chest P-A films in adult (older than 16years), and radiolographic findings of congenital anomalies of the ribs were analized. The result were as follows;1. Congenital anomalies of the ribs were present in 193 patients. The incidence of congenital anomalies of theribs were 2.7% in male, 3.3% in female. 2. Among the 193 cases of congenital rib anomalies, 7 cases(0.1%) ofcervical ribs, 31 cases (0.4%) of underdeveloped ribs, 81 cases (1.2%) of anterior bifurcation, 34 cases (0.5%) ofbroadned ribs, 19 cases (0.3) of complete fusion and 21 cases (0.3%) of pseudathrosis were included. 3. 11.4% ofthe cases were bilateral, and right to left was 4:3 in unilateral involvement. 4. The location of the ribanomalies were as follows; (1) Underdeveloped ribs; 1st rib 31 case (79.5%), 2nd rib 3 cases(7.7%), 4th rib 3cases(7.7%), 5th rib 2 cases(5.1%). (2) Anterior bifurcation; 3rd rib 37 cases. 4th rib 29 cases, 5th rib 12cases, 6th rib 6cases, 2nd rib 2 cases. (3) Broadened ribs; 3rd 17 cases, 4th rib 15 cases, 5th rib 4 cases, 2ndrib 1 case. (4) Complete fusion; 1st-2nd rib 13 cases (68.4%), 5-6th ribs 4 cases (21.0%), 4-5th ribs 1case(5.3%), 6-7 ribs 1case(5.3%). The fusion occur in the posterior portion of 1st-2nd and 4-5th ribs,and in theposterior portion of 5-6th and 6-7ribs. (5) Pseudarthrosis; 1st-2nd and 2nd-3rd ribs, and in the posterior portionof 3-4th, 4-5 and 5-6th ribs. 5. In the cases of anterior bifurcation, the rib bifurcates almost in its anterior2.1-5.0 cm and most common in 3.1-4.0cm. 6. The characteristic radiographic findings in anterior bifurcation wereas follow;
Adult ; Female ; Humans ; Incidence ; Male ; Pseudarthrosis ; Ribs ; Thorax