Previous observations have demonstrated that fibronectia (FN) is deposited high abundance in basal cell carcinoma (BCC) stroma. Since FN is a glycoprotein which promotes interaction between cells and extracellular matrix, it may been important component of slowly expansile carcinoma such as BCC. Furthermore, BCCs aggressiveness varies with it's histologic appearance. The authors investigated distribution of plasma FN (pFN) in 8 BCC cases with various histologic types (3 nodulocystic type, 2 infiltrative type, 2 keracotic type, 1 adenoid type) and 4 squamous cell carcinomas (SCC), which have a more aggrcisive biologic behavior than BCC using immunohistochemical staining. In normal skin, pFN was strongly positive at the clenzoepidermal junction and perivascular area with a linear pattern, and in the papillary dermis with a reticular pattern, and was weakly positive in the reticular dermis. In BCC, pFN was strongly positive in nodulocystic BCC, with the highest concentration along the periphery of the tumor island in a filamentous pattern, .hereas, it was moderately positive in adenoid, keratotic, infiltrative BCC stroma. In SCC, pFN was weakly positive around tumor the margins with a thin, coarse deposition These results show that with epidermal tumors, the degree of the pFN expression in stroma is propotional to their aggressiveness.
Adenoids ; Carcinoma, Basal Cell* ; Carcinoma, Squamous Cell ; Dermis ; Extracellular Matrix ; Fibronectins* ; Glycoproteins ; Plasma* ; Skin

The prevalence of low serum urea nitrogen concentrations (<6 mg/dL) in our patient population was 3.8% (452 per 11,911 determinations), representing 372 individual cases. Of these, 323 of the patients' charts were located, reviewed, and classified into disease groups. Malignant tumor was found in 25.1% of the 323 patients, the remaining patients without malignant tumor had various clinical conditions; pregnancy (19.5%), infectious diseases (12.1%), trauma (10.2%), cerebrovascular accident (6.2%), hepatopathy (5.3%), and miscellaneous conditions (21.6%). The prevalence in female and young aged patients under 5 years was considered due to the lower reference range in these groups than in that of female adult groups, and moreover pregnancy in another superimposing factor in the former group. In regards to the causes of this condition, our study corresponded well to the textbook cited etiology of the low serum nitrogen concentration, although malnutrition and hepatopathy were inverted in their incidental order. We postulated, through the present study, that the low serum urea nitrogen concentration is not pathognomonic findings to suggest specific disease or conditions, but rather to reflect patient's general conditions such as hydration, nutrition, or administration of certain drugs.
Adult ; Communicable Diseases ; Female ; Humans ; Malnutrition ; Nitrogen* ; Pregnancy ; Prevalence ; Reference Values ; Stroke ; Urea*

No abstract available.

Bowens disease is generally regarded as a premalignant dermatosis. If untreated, 3% to 5% of patients may develop squamous cell carcinoma. However, sebaciou carcinoma arising from Bowens disease is very rare. We presented a case of quarnous cell carcinoma and sebaceous circ s disease in a 68 year-old male. He had multiple bowenoid skin lesi nsties. A bean-sized nodule as developed on the bowenoid lesion of the he had a large yellow crust.ed exudative tumor on the Rt. thigh. We took a biopsy specimen of these three discrete lesions. The nu lipid stain of frozen section revealed Bowens disease, squarnous concllnoma arising from Bowen on the trunk and extremi Rt. lower abdomen. Almost of routine histology and carcinoma, and sebaceous carcinoma, respectively.
Abdomen ; Aged ; Biopsy ; Bowen's Disease ; Carcinoma, Squamous Cell* ; Frozen Sections ; Humans ; Male ; Skin ; Skin Diseases ; Thigh

This study was performed to guide the effective utilization of blood and optimal blood ordering schedule for various elective surgeries, based on the analysis of 1,462 transfused surgical procedures and 5,933 blood units transfused during operation in the period of two years through January, 197 to December, 1988 at Yeungnam University Hospital. The frequency of transfusion, and mean transfused units were evaluated and recommended blood unit for each surgical procedure was proposed. We assure that the successful establishment of this guideline can lead to substantial monetary saving, reduced blood outdating, and a decreased blood bank workload with a more appropriate allocation of the technician's time and effort.
Appointments and Schedules ; Blood Banks

Using immunohistochemical methods, the authors investigated the distribution of tubulin in normal skin and 31 skin tumors, including 11 benign skin tumors and 20 malignant skin tumors, In normal skin, tubulin was strongly expressed in basal cells of the epidermis, sebaceus celis and dermal nerves. Myoepithelial cells, ductalI cells of sveat ducts and outer root sheath cells of hair follicles stained moderat,ely. Lermal fi broblasts showed no staining. In benign tumors including keratoacanthoma, trichoepithelioma, and nevocellular nevus the strornal fibroblast.s were entirely tubulin negative as well as the turnor cells. In basal cell carcinoma, the stromal fibroblasts were negative',whereas tumor cells were weakly positive. In squarnous cell carcinoma(SCC), tumor cells weri, tubulin positive weakly, the degree of tubulin expression of its stroma1 fibroblasts tencied to be in proportional to the grade of malignanr.u. Tumor cells of malignant melanoma and nevocellular nevus were tubulin positive moderately bist the stromal fibrobla.sts were strongly positive only in the cases of malignant melanoma. These results show that the degree of the tubulin; expression in adjacent, stromal cells of epidermal tumors is in proportiona.l to that of their malignancy, These suggest that the expression of tubulin in fibroblasts surrounding tumor cells of malignant melanoma and SCC reflects a stromal alt,eration that might contribute to tumor in vasion, and play a role for cellular motility.
Carcinoma, Basal Cell ; Epidermis ; Fibroblasts ; Hair Follicle ; Keratoacanthoma ; Melanoma ; Nevus ; Skin* ; Stromal Cells ; Tubulin*

No abstract available.
Bronchogenic Cyst*

The total 223 cases of tetralogy of Fallot is analysed angiographically, in which selective biplanecinecardioangiography with axial projection has been done at the Departement of Radiology, Seoul National University Hopital, in recent 2 year and 4 months, with specific refrence to the location of pulmonic stenosis,and associated cardiac anomalies. The summary of the analysis is as follow; 1. Left ventriculogram (long axialoblique view) was necessary to detect the ventricular septal defects including anterior marginal VSD, and washelpful to identify the coronary artery anatomy and presence of PDA and evaluate the size of left ventricle. 2.Right ventriculogram(elongated RAO view) was the best projection for the demonstration of pulmonic infundibulumand was essential to differenciate and localize the ventricular septal defects. 3.In the right ventriculogram(4chamber view), well demonstrated the right ventricular outflow tract, pulmonary valve, and pulmonaryarteries(main, right, left and peripheral), and also perimitted the detection of ASD in levophase. 4. The positionof ventricular septal defects was perimembranous in 199 cases(89.2%), subarterial in 15 cases(6.8%) andinfundibular (intracristal) in 9 cases(4%). Multiple ventricular septal defects (perimembranous& marginal ) werefound in 11 cases(4.5%). 5. In 35 cases(15.5%), pulmonary stenosis is found only in pulmonary infundibulum. Thecombination of its components was most commonly anterior wall and conus septum hypertrophy in 24 cases(68.6%) 6.Combined pulmonary stenosis was identified in 188 cases(84.3%). The most common combination was infundibular andpulmonary valvular stenosis in 56 cases(29.8%) 7. Associated cardiac anomalies were right aortic arch in 53 cases(23.8%), persistent left SVC in 17 cases (7.7%), ASD in 13 cases (5.9%), PDA in 9 cases(4.1%), aberrant subclavianartery in 5 cases(2.2%), IVC interruption with azygos continuation in 2 cases, single coronary artery in 2 cases,and anterior descending artery from right coronary artery in 1 case, etc. 8. Selective biplanecinecardioangiography with axial projection is essential to evaluate the size of left ventricle and to localizethe ventricular septal defects and pulmonary stenosis, and to detect associated cardiac anomalies in T.O.F. Sometimes aortography is necessary when anomaly of coronary arteries is suspected.
Aorta, Thoracic ; Aortography ; Arteries ; Constriction, Pathologic ; Conus Snail ; Coronary Vessels ; Heart Septal Defects, Ventricular ; Heart Ventricles ; Hypertrophy ; Pituitary Gland ; Pulmonary Valve ; Pulmonary Valve Stenosis ; Seoul ; Tetralogy of Fallot

No abstract available.
Choriocarcinoma* ; Female ; Pregnancy

No abstract available.
Colorectal Neoplasms*