1.Brain Atrophy and its C.T.Criteria.
Choong Suh PARK ; Kyung Chan CHAE ; Kyung Yoon O
Journal of the Korean Neurological Association 1987;5(2):213-229
Since opening of the Yeungnam University Hospital in March 1983 till the end of 1986, total 156 cases of brain atrophy and encephalopathy (control) diagnosed at the neurology department were investigated, adopting C.T. criteria of brain atrophy. Among the 156 only 77 cases had available C.T. films. Of the 77,35 cases were normal (control) and 42 had brain atrophy. The following results are obtained: 1. A new C.T. criteria of brain atrophy and its degree were devised. (Table 8.9) 2. As the age increased, number of brain atrophy cases increased. 3. Degree of EEG abnormalities were not parallel with the degree of brain atrophy. 4. The most frequent EEG abnormalities with or without brain atrophy were moderate abnormalities. 5. The EEG abnormalities were improved with treatment in most of the cases. 6. The group with suspected organic brain lesions had 69% cases of brain atrophy, whereas the group with only headache or dizzines had 57% of no atrophy. 7. There exists a clinical entity of "Cryptogenic Brain Atrophy". (Park) 8. Recent literatures of Brain Atrophy were reviewed.
Atrophy*
;
Brain*
;
Electroencephalography
;
Headache
;
Neurology
2.Bacterial growth in artificially contaminated packed red cells following room temperature exposure.
Bo Chan JEONG ; Chae Hoon LEE ; Kyung Dong KIM ; Chung Sook KIM ; Dal Hyo SONG
Korean Journal of Blood Transfusion 1993;4(1):89-95
No abstract available.
3.A Case of Vanishing Bile Duct Syndrome Associated with Ibuprofen Overuse.
Gook Chan JANG ; Kyung Rye MOON ; Chae Hong SUH
Korean Journal of Pediatric Gastroenterology and Nutrition 2006;9(2):262-268
Ibuprofen is currently widely prescribed in the pediatric population and has potentially very severe adverse events, even in the absence of an overdose. We treated a four year-old male who presented with severe jaundice, skin rash, xanthoma, eosinophilia and decreased hepatic function after overuse of ibuprofen for fever control. The liver biopsy revealed the vanishing bile duct syndrome. We report a case of vanishing bile duct syndrome associated with Ibuprofen overuse for the first case in Korea.
Bile Ducts*
;
Bile*
;
Biopsy
;
Eosinophilia
;
Exanthema
;
Fever
;
Humans
;
Ibuprofen*
;
Jaundice
;
Korea
;
Liver
;
Male
;
Xanthomatosis
4.Effects of Verapamil and Propranolol on Hemodynamic Responses to Laryngoscopy and Tracheal Intubation in Hypertensive Patients.
Dong Hoon CHAE ; Kyung Yeon YOO ; Chan Jin PARK ; In Ho HA
Korean Journal of Anesthesiology 1990;23(3):366-372
Laryngoscopy and endotracheal intubation in patients undergoing general anesthesia causes hypertension and tachycardia with concomitant increases in plasma catecholamine concentration. These transient stress responses are greatly exaggerated in patients with hypertension and cardiovascular disease and can lead to cardiac arrhythmia, pulmonary edema, cardiac failure and cerebral hemorrhage. Therefore, several attempts have been made to attenuate the hypertensive and tachycardiac responses, but none have been satisfactory. This study was designed to evaluate verapamil or propranolol as a valuable adjuvant in attenuating hemodynamic responses to tracheal intubation in 53 patients with hypertension. They were randomly divided into three groups according to premedication used. Group 1 (n=19) was without pretreatment, and group 2 (n=18) and group 3 (n=16) were pretreated with verapamil (0.1 mg/kg) iv and verapamil (0. 1 mg/kg)-propranolol (0.01 mg/kg) mixture iv, respectively, just prior to the intubation. Mean arterial pressure (MAP) and heart rate (HR) were measured, just prior to intubation (baseline), after induction, and at 1, 2, 3, 4, 5 and 7 minutes following intubation. The results were as follows. 1) In the control group. tracheal intubation produced increases in MAP (27% average increase from baseline) and heart rate (31% increase) at one minute after the procedure. 2) In group 2, verapamil abolished pressor response to tracheal intubation, but did not affect tachycardiac responses. 3) In group 3, the verapamil-propranolol mixture attenuated both pressor and tachycardiac responses to tracheal intubation. 4) The rate-pressure product increased after tracheal intubation by 61% and 31% in group 1 and group 2, respectively, but it remained unchanged in group 3. These findings suggest that intravenous verapamil-propranolol mixture is a valuable adjuvant in attenuating hypertensive and tachyeardiac responses to tracheal intubation.
Anesthesia, General
;
Arrhythmias, Cardiac
;
Arterial Pressure
;
Cardiovascular Diseases
;
Cerebral Hemorrhage
;
Heart Failure
;
Heart Rate
;
Hemodynamics*
;
Humans
;
Hypertension
;
Intubation*
;
Intubation, Intratracheal
;
Laryngoscopy*
;
Plasma
;
Premedication
;
Propranolol*
;
Pulmonary Edema
;
Tachycardia
;
Verapamil*
5.Transient Pancytopenia and SIADH associated with Administration of Carbamazepine.
Ho Joong JEONG ; Ghi Chan KIM ; Heung Chae CHUNG ; Kyung Hwan ROH
Journal of the Korean Academy of Rehabilitation Medicine 2001;25(1):173-176
Carbamazepine is widely used to manage of seizures and symptomatic treatment of trigeminal neuralgia and central pain. We experienced two cases of exceedingly rare but potentially fatal side effects following carbamazepine administration. One traumatic brain injured patient developed pancytopenia 3 weeks after beginning to take carbamazepine for prophylactic management of seizure and the other C6 incomplete spinal cord injured patient receiving carbamazepine for the management of central pain sequentially developed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 1 week after administration. Because of more frequent indications of carbamazepine, these side effects must be borne in mind and cautious administration will be desirable.
Brain
;
Carbamazepine*
;
Humans
;
Inappropriate ADH Syndrome*
;
Pancytopenia*
;
Seizures
;
Spinal Cord
;
Trigeminal Neuralgia
6.Detection of mecA, blaZ and aac(6')-aph(2") gene of staphylococci by PCR.
Ho Chan LEE ; Eun Hae KIM ; Hee Soon CHO ; Chae Hoon LEE ; Kyung Dong KIM ; Bo Chan JUNG
Korean Journal of Clinical Pathology 2001;21(6):505-511
BACKGROUND: Staphylococci are major nosocomial pathogens and reveal an increase in resistant strains such as methicillin-resistant Staphylococcus aureus. For treatment of infection and prevention of dissemination, rapid and reliable identification methods are required but the conventional bacterial identification and susceptibility tests require at least 24 hours. In this study, we evaluated the polymerase chain reaction (PCR) of the antibiotic resistant genes by comparing with the disk diffusion susceptibility test for the detection of resistance to penicillin, oxacillin and gentamicin. METHODS: A hundred-thirty-five staphylococci including 95 S. aureus and 40 S. epidermidis were from clinical specimens from June to December 2000. Antimicrobial susceptibility tests were done using the NCCLS disk diffusion method. PCRs were performed with primer sets specific for mecA, blaZ and aac(6')-aph(2"). The species-specific PCR was also used to identify S. aureus and S. epidermidis. RESULTS: All four penicillin-susceptible staphylococci were negative for blaZ and 108 of 131 penicillin resistant-staphylococci were positive for blaZ. The concordance rate for PCR of the blaZ gene and penicillin disk diffusion test was 83.0%. 110 of 115 oxacillin-resistant staphylococci were positive for mecA and all five mecA negative oxacillin-resistant strains were positive for blaZ and have the phenotype beta-Lactamase hyperproducer. One of the oxacillin-susceptible S. aureus was positive for mecA. The concordance rate of PCR for the mecA gene and oxacillin disk diffusion test and those of the aac(6')-aph(2") gene and gentamicin disk diffusion test was 95.6% and 97.8%, respectively. CONCLUSTIONS: The disk diffusion tests misdiagnosed 25% of the mecA negative staphylococci as methicillin-resistant staphylococci (MRS) and lost one of the mecA positive strain. We considered that the detection of the mecA and blaZ gene using the PCR was more useful than the disk diffusion test for detection of methicillin-resistant staphylococci.
beta-Lactamases
;
Diffusion
;
Gentamicins
;
Methicillin Resistance
;
Methicillin-Resistant Staphylococcus aureus
;
Oxacillin
;
Penicillins
;
Phenotype
;
Polymerase Chain Reaction*
7.Fires and Burns Occurring in an Electrocautery after Skin Preparation with Alcohol during a Neurosurgery.
Sang Bae CHAE ; Woo Kyung KIM ; Chan Jong YOO ; Cheol Wan PARK
Journal of Korean Neurosurgical Society 2014;55(4):230-233
While there are reports regarding burns occurring to patients during the surgery, there are little reports concerning the incidents of the burns related to neurosurgical operations. Moreover, in Korea, even surveys and statistics on the incidents of burns in operating rooms are not known. This report explores burns occurring to a patient in an electrocautery scenario after disinfecting the surgical site with alcohol during the preparation of a neurosurgical operation in an operating room where there is much exposure to oxygen. The authors show a case of a 33-year-old male patient who undergoing evacuation of hematoma on occipital lesion, suffered second degree burns as a result of surgical fires.
Adult
;
Burns*
;
Electrocoagulation*
;
Fires*
;
Hematoma
;
Humans
;
Korea
;
Male
;
Neurosurgery*
;
Operating Rooms
;
Oxygen
;
Skin*
8.Paraplegia following cervical epidural catheterization using loss of resistance technique with air: a case report.
Yun Jeong CHAE ; Kyung Ream HAN ; Hyung Bae PARK ; Chan KIM ; Si Gweon NAM
Korean Journal of Anesthesiology 2016;69(1):66-70
We report a case of paraplegia without neurologic deficit of upper extremities following cervical epidural catheterization using air during the loss of resistance technique. A 41-year-old woman diagnosed with complex regional pain syndrome had upper and lower extremity pain. A thoracic epidural lead was inserted for a trial spinal cord stimulation for treating lower extremity pain and cervical epidural catheterization was performed for treating upper extremity pain. Rapidly progressive paraplegia developed six hours after cervical epidural catheterization. Spine CT revealed air entrapment in multiple thoracic intervertebral foraminal spaces and surrounding epidural space without obvious spinal cord compression before the decompressive operation, which disappeared one day after the decompressive operation. Her paraplegia symptoms were normalized immediately after the operation. The presumed cause of paraplegia was transient interruption of blood supply to the spinal cord through the segmental radiculomedullary arteries feeding the spinal cord at the thoracic level of the intervertebral foramen caused by the air.
Adult
;
Arteries
;
Catheterization*
;
Catheters*
;
Epidural Space
;
Female
;
Humans
;
Lower Extremity
;
Neurologic Manifestations
;
Paraplegia*
;
Spinal Cord
;
Spinal Cord Compression
;
Spinal Cord Ischemia
;
Spinal Cord Stimulation
;
Spine
;
Upper Extremity
9.Gianturco Metallic Biliary Stent in Malignant Biliary Obstruction: Results of Follow-up in Dead Patients.
Kyung Soo LEE ; Kwon Mook CHAE ; Byung Suk ROH ; See Sung CHOI ; Jong Jin WON ; Chan Soo KIM ; Haak Cheul KIM
Journal of the Korean Radiological Society 1994;30(4):659-664
PURPOSE: In order to study the patency, restenosis, efficacy, and complications of the metallic stent in the course of treatment of malignant biliary obstruction,the results of follow up of the dead patients after stent insertion were reviewed. MATERIALS AND METHODS: Self-expandable Gianturco metallic stent with 10-mm diameter was successfully inserted in 33 patients :10 with Klatskin tumor, 7 with common bile duct cancer, 7 with gallbladder cancer, 5 with pancreatic cancer, 2 with recurred stomach cancer, one with periampullary cancer, one with hepatocellular carcinoma. RESULTS: The overall duration of survival and patency of the stents in 33 patients were 5.2 months(1-12 months) and 4.9 months(1.14 months), respectively. Restenosis of metallic stents was found in 9 cases(27%), after 6.1 months in average. Causes of stent occlusion were overgrowing of tumor in 5, overgrowing and ingrowing of tumor in 3, extraductal dislodgement in one case. Two cases of symptomatic cholangitis after stent placement were successfully treated with percutaneous cholecystostomy. Three cases of destruction and migration of metallic stents were found after 6 months. CONCLUSION: On the basis of our experience, insertion of Gianturco metallic biliary stent is an acceptable treatment method in the malignant biliary obstruction, especially for whom short term survival is expected.
Carcinoma, Hepatocellular
;
Cholangitis
;
Cholecystostomy
;
Common Bile Duct
;
Follow-Up Studies*
;
Gallbladder Neoplasms
;
Humans
;
Klatskin's Tumor
;
Pancreatic Neoplasms
;
Stents*
;
Stomach Neoplasms
10.Effectiveness of Cold Stress Thermography in the Diagnosis of Complex Regional Pain Syndrome Type 1.
Eun Jung PARK ; Kyung Ream HAN ; Yun Jeong CHAE ; Won Ho JEONG ; Chan KIM
The Korean Journal of Pain 2006;19(2):159-163
BACKGROUND: Despite the enormous amount of basic research on neuropathic pain, there is the lack of an objective diagnostic test for complex regional pain syndrome (CRPS). The aim of this study was to evaluate the usefulness of cold stress thermography in the diagnosis of CRPS. METHODS: The study involved 12 patients with CRPS type 1, according to the IASP criteria, who were compared with 15 normal healthy volunteers. All subjects underwent thermographic examination under baseline conditions at 21degrees C. A cold stress test (CST; 10degrees C water for 1 minute) was then applied to both hands below the wrists, immediate, and after 10 and 20 minutes. RESULTS: The temperature asymmetry between the patients with CRPS and the volunteers showed significant discrimination at the baseline and after a 20 minute recovery period from the CST. Among the study subjects having temperature asymmetry of both hands of less than 1degrees C (8 out of 12 CRPS patients and 14 out of 15 volunteer), 7 (87.5%) of the 8 CRPS patients and 3 (21%) of the 14 volunteers showed a temperature difference of more than 1degrees C after the 20 minute recovery period. The actual temperature values during the four periods did not discriminate between the patients with CRPS and the volunteers. CONCLUSIONS: Thermography, under the CST, could be a more objective test for the diagnosis of CRPS. A temperature asymmetry greater than 1degrees C during the 20 minute recovery period following CST provides strong diagnostic information about CRPS, with both high sensitivity and specificity.
Diagnosis*
;
Diagnostic Tests, Routine
;
Discrimination (Psychology)
;
Exercise Test
;
Hand
;
Healthy Volunteers
;
Humans
;
Neuralgia
;
Sensitivity and Specificity
;
Thermography*
;
Volunteers
;
Water
;
Wrist