No abstract available.
Blood Platelets* ; Humans* ; Membranes* ; Plasminogen*

No abstract available.
Disseminated Intravascular Coagulation* ; Plasma* ; Scrub Typhus*

No abstract available.
Liver Transplantation* ; Liver*

Low dose finasteride(1mg/d, Propecia(R)) has been widely used as an effective treatment for male androgenetic alopecia. Finasteride is an inhibitor of 5-alpha-reductase, the enzyme responsible for testosterone metabolism to dihydrotestosteron(DHT). We report a case of painful, unilateral idiopathic gynecomastia aggravated by low dose finasteride for male androgenetic alpopecia. A 23-year-old man started treatment with Propecia(R), 1 mg per day. Two months later he presented with a painful enlargement of his right breast. Treatment was stopped and two months later the clinical manifestration had disappeared.
Alopecia ; Breast ; Finasteride* ; Gynecomastia* ; Humans ; Male ; Metabolism ; Testosterone ; Young Adult

Multiple gastric caner, now considered to be a sort of multiple primary cancer by Moertel's classification, is a special type of cancer in which two or more tumor lesions arise independently from the stomach. Although its incidence is rare and it has never been reported in Korea yet, the report of multiple gastric cancer is increasing with lengthened life survival and improved diagnostic method. We recently experienced two cases of triple gastric cancer, the one in 53-years-old male who had well differentiated adenocarcinoma(EGC IIb+c) on antrum, poorly differentiated adenocarcinoma on cardia and moderately differentiated adenocarcinoma on mid-body, and the other in 65-years-old female who had two poorly differentiated adenocarcinoma on cardia and anterior wall of low body and moderately differentiated adenocarcinoma (EGCIIc) on posterior wall of low body. Triple gastric cancer is rare, so we reported 2 cases of triple gastric cancer.
Adenocarcinoma ; Cardia ; Classification ; Female ; Humans ; Incidence ; Korea ; Male ; Stomach ; Stomach Neoplasms*

Blue nevi are usually solitary, but they may be multiple and form a plaque composed of multiple papules or nodules with an intervening flat area of blue coloration. It looks like a benign and asymptomatic lesion. However, because of its rarity, no definitive prognosis can be given. An 18-year-old male presented with a 5 x 4 cm-sized, speckled blue-black tumor on his posterior neck, which had existed since birth. Histopathologic examination showed clumps of melanocytes intermingled with irregularly arranged collagen bundles in the mid and lower dermis, with some extending to the subcutaneous tissue. We diagnosed the lesion as a plaque-type blue nevus, based on histopathologic findings of common blue nevus.
Adolescent ; Collagen ; Dermis ; Humans ; Male ; Melanocytes ; Neck ; Nevus, Blue* ; Parturition ; Prognosis ; Subcutaneous Tissue

In the previous studies, we found that lumbrokinase an, extract from Korean earthworm, had a strong in vitro thrombolytic effect, and that when added to thrombin had a significant effect in reducing fatality rate in thrombin-induced lung infarction mice model. To determine whether it also has in vivo thrombolytic effect in cerebral embolism model using 9 Spraw Dawly male rats of 200 to 300gm, we cannulated the extemal carotid artery lene tubes and occluded the pterygopalatine arteries. Via the extemal carotid artery, we injected 1 mm3 of human blood clots which were previously mixed with Tc-99m sulfur colloid. After confirming the intracranially situated clot by camera, we injected 3cc of following fiuids to each group of three rats: saline, urokinase, lumbrokinase fraction m Then using Gamma camera of 64*64 m obtained for 1 minute in every 30 minutes. After 150 minutes radioactivities of the clots in the brain were 3.02%, 21 02% urokinase, and lumbrokinase treated animals respectively. In the liver, the uptake of radioactivities was accordingly increased. Brain sections showed no Significant intracranial bleeding in any of the treated animals. Therefore, we conclude that lumbrokinase has in vivo thromboembolism model without producing significant intracranial bleeding. However, compared with its in vitro effects the in vivo effects appear to be less potent. Futher experiments with better designed animal models are warranted.
Animals ; Arteries ; Brain ; Carotid Arteries ; Gamma Cameras ; Hemorrhage ; Humans ; Infarction ; Intracranial Embolism ; Liver ; Lung ; Male ; Mice ; Models, Animal ; Oligochaeta ; Radioactivity ; Rats* ; Technetium Tc 99m Sulfur Colloid ; Thrombin ; Thromboembolism* ; Urokinase-Type Plasminogen Activator

BACKGROUND: Menopause is an independent risk factor in metabolic syndrome which induced an alteration of the lipid metabolism by hormonal changes. Apolipoprotein A5 gene (APOA5) was related to the regulation of triglyceride and high density lipoprotein cholesterol (HDL-C) level with biosynthesis and decomposition. This study was conducted to investigate the relationship between APOA5 polymorphism and metabolic syndrome in Korean postmenopausal women. METHODS: This study included 307 postmenopausal women with anthropometric and biochemical measurement in 2010-2011. The polymorphism of APOA5 was analyzed by polymerase chain reaction-restriction fragment length polymorphism method with MseI restriction enzyme. RESULTS: The metabolic syndrome prevalence with TT genotype was significantly lower than the frequency in those with TC/CC (27.09%, 38.46%, and 45.71% for TT, TC, and CC, respectively; P < 0.05). Multiple regression analysis of metabolic syndrome risk factors indicated that postmenopausal women with CC genotype had a higher risk with 3 times than that in TT genotype (P < 0.05). APOA5 C carriers showed an increased risk of triglyceride level (odd ratio, 2.93 and 1.85 for CC and TC+CC, respectively; P < 0.05). Interestingly, HDL-C was related to triglyceride directly in comparison to APOA5. CONCLUSION: The results of this study indicate that APOA5 has an influence on serum triglyceride and HDL-C, which contribute to metabolic syndrome in Korean postmenopausal women.
Apolipoproteins ; Apolipoproteins A ; Cholesterol ; Cholesterol, HDL ; Female ; Genotype ; Humans ; Lipid Metabolism ; Lipoproteins ; Menopause ; Metabolic Syndrome X ; Polymorphism, Single Nucleotide ; Prevalence ; Risk Factors ; Triglycerides

No abstract available.
Classification* ; von Willebrand Diseases* ; von Willebrand Factor*

BACKGROUND: It is well recognized that thyroid hormone stimulates bone turnover, increasing bone resorption, thus affecting bone mineral density, but few data are available on untreated subclinical hypothyroidism. The aim of this study was to examine whether bone mineral density is increased in postmenopausal subclinical hypothyroidism patients compared with postmenopausal normal thyroid function women, and to evaluate the relationship between thyroid hormones (TSH, FT(4)) and bone mineral density or various biochemical markers of bone metabolism. METHODS: This was a cross sectional study of 132 postmenopausal women aged from 51 to 70 who undertook health screening program in Pundang CHA general hospital from 1996 to 2001. They were divided into two groups; subclinical hypothyroidism group (n=52) and normal thyroid function group (n=80) matched by age. RESULTS: The total bone mineral density was significantly increased in the subclinical hypothyroid group than in the normal group (P<0.05). The serum osteocalcin was lower in the subclinical hypothyroidism group (P<0.05), but neither the alkaline phosphatase nor the deoxypyridinoline showed any significance. For all participants in this study, TSH, but not FT(4), exhibited significant correlation with the total bone mineral density (r=0.188, P<0.05), and with the osteocalcin (r=-0.191, P<0.05). Multiple regression analysis identified the TSH as an independent predictor of the total bone mineral density (beta=0.0410; P< 0.05). CONCLUSION: This study indicated that subclinical hypothyroidism is one of the factors which can elevate bone mineral density in postmenopausal women.
Aged ; Alkaline Phosphatase ; Amino Acids ; Biomarkers ; Bone Density ; Bone Resorption ; Female ; Hospitals, General ; Humans ; Hypothyroidism ; Mass Screening ; Osteocalcin ; Thyroid Gland ; Thyroid Hormones