1.Ultrastructural study of basement membrane of choleastoma epithelium.
Kyung You PARK ; Joong Saeng CHO ; Chang Il CHA
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(4):649-658
No abstract available.
Basement Membrane*
;
Epithelium*
2.Clinical Efficacy of Carvedilol in Patients with Moderate to Severe Congestive Heart Failure.
Dong Hoon CHA ; Young Soo CHA ; Jin Hwan KOOK ; Kyung Wha WHANG ; Hyung Tae KIM ; Sang Wook LIM ; Tae Yong KIM ; Yun Kyung CHO ; Pil Won PARK
Korean Circulation Journal 1998;28(4):523-531
BACKGROUND: Clinical trials have shown that b-adrenergic blocking drugs are effective and well tolerated in patients with mild to moderate congestive heart failure. Carvedilol is a mild b1-selective adrenergic blocking agent with vasodilating properties due to a blocker and antioxidant and anti-proliferative properties. This study assessed the efficacy and safety of carvedilol in patients with moderate to severe congestive heart failure caused by idiopathic dilated cardiomyopathy. METHODS: We enrolled 27 patients with moderate to severe congestive heart failure with a left ventricular ejection fraction of 35% by MUGA scan. Each patient was randomly assigned to either control (n-9) or carvedilol (n-18, target dose 25 mg bid) for 6 months while background therapy with digoxin, diuretics, and ACE inhibitor remained constant. RESULTS: Compared to the control group, patients in the carvedilol group showed significant increase of left ventricular ejection fraction (p<0.05). In addition, patients in the carvedilol group had a tendency to show a decrease in left ventricular end-diastolic dimension and heart rate. Also, the carvedilol group had a greater frequency of symptomatic improvement than the control group. There was neither serious side effects nor hospitalization. CONCLUSION: These finding indicate that carvedilol produces important clinical benefits in patients with moderate to severe heart failure treated with digoxin, diuretics, and ACE inhibitor without serious side effects.
Cardiomyopathy, Dilated
;
Digoxin
;
Diuretics
;
Heart Failure*
;
Heart Rate
;
Hospitalization
;
Humans
;
Stroke Volume
3.Higher Prevalence and Progression Rate of Chronic Kidney Disease in Elderly Patients with Type 2 Diabetes Mellitus.
Kyung Soo KIM ; Seok Won PARK ; Yong Wook CHO ; Soo Kyung KIM
Diabetes & Metabolism Journal 2018;42(3):224-232
BACKGROUND: To evaluate the prevalence of chronic kidney disease (CKD) and progression rate to CKD in elderly patients with type 2 diabetes mellitus (T2DM). METHODS: We investigated the medical records of 190 elderly patients (65 years or older) with T2DM from 2005 to 2011 in 6-month increments. Mean follow-up duration was 64.5 months. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m² and/or the presence of albuminuria. RESULTS: The mean age was 70.4 years and mean diabetes duration was 10.6 years. Among all the participants, 113 patients (59.5%) had CKD. The eGFR was significantly decreased between baseline (65.7±15.0 mL/min/1.73 m²) and the end of follow-up (52.7±17.5 mL/min/1.73 m², P < 0.001). At the end of follow-up, the prevalence of eGFR < 60 mL/min/1.73 m² had increased by 61.6% (at baseline, 44.2%). Furthermore, in patients with eGFR ≥60 mL/min/1.73 m², the progression rate to more than CKD stage 3 was 39.6% at the end of follow-up; 30.2% of elderly diabetic patients had progressed to albuminuria from normoalbuminuria. Kaplan-Meier analysis showed that the time interval to worsening nephropathy was significantly shorter in elderly patients with diabetes duration ≥10 years than in those with diabetes duration < 5 years (P=0.018). CONCLUSION: CKD was commonly observed in older patients with T2DM, and the progression rate to CKD is also high. Consequently, it is important to identify and manage CKD as early as possible in elderly patients with T2DM, especially in those with diabetes duration ≥10 years.
Aged*
;
Albuminuria
;
Diabetes Mellitus, Type 2*
;
Follow-Up Studies
;
Glomerular Filtration Rate
;
Humans
;
Kaplan-Meier Estimate
;
Medical Records
;
Prevalence*
;
Renal Insufficiency, Chronic*
4.Vitamin D Deficiency at Mid-Pregnancy Is Associated with a Higher Risk of Postpartum Glucose Intolerance in Women with Gestational Diabetes Mellitus
Kyung Soo KIM ; Seok Won PARK ; Yong Wook CHO ; Soo Kyung KIM
Endocrinology and Metabolism 2020;35(1):97-105
BACKGROUND:
To evaluate the association between serum 25-hydroxyvitamin D (25(OH)D) at mid-pregnancy and postpartum glucose intolerance in women with gestational diabetes mellitus (GDM).
METHODS:
We enrolled 348 pregnant women diagnosed with GDM from August 2012 to October 2016. We measured serum 25(OH)D levels at mid-pregnancy and carried out a 75-g oral glucose tolerance test at 6 to 12 weeks after delivery. Vitamin D deficiency was defined as serum 25(OH)D <20 ng/mL.
RESULTS:
The prevalence of vitamin D deficiency was 76.7% (n=267). Women with vitamin D deficiency had a higher prevalence of postpartum glucose intolerance than did those without vitamin D deficiency (48.7% vs. 32.1%, P=0.011). Serum 25(OH)D level was negatively correlated with hemoglobin A1c at antepartum and postpartum period (antepartum: r=−0.186, P=0.001; postpartum: r=−0.129, P=0.047). Homeostasis model assessment of β-cell function was positively correlated with serum 25(OH)D level only postpartum (r=0.138, P=0.035). The risk of postpartum glucose intolerance was 2.00 times (95% confidence interval, 1.13 to 3.55) higher in women with vitamin D deficiency than in those without vitamin D deficiency (P=0.018).
CONCLUSION
In women with GDM, vitamin D deficiency at mid-pregnancy is associated with an elevated risk of postpartum glucose intolerance.
5.The Protective Effect of Marly SkinR on Housewife' s Eczema.
Mi Kyung CHA ; Yeon Ho PARK ; Tae Yoon KIM ; Hyung Ok KIM ; Chung Won KIM
Korean Journal of Dermatology 1994;32(4):675-681
BACKGROUND: It is important to avoid the direct contact with water of detergents as possible for the treatment and prevention of hand eczema. OBJECTIVE: The purpose of this study is to evaluate the protective effect of skin protector, Marly skin on housewifes eczema, METHODS: The patients with hand eczema apply skin protector, Maly skin, four times a day on their both hands. They are evaluated with the scores of subjective symptor is(itch, dryness, smarting) and objective signs(erythema, scaling, fissures), and skin replica which are taken from the specified site are analysed by using an image analyser and, scanning electron micrascipe. RESULTS: 4 weeks after application of skin protector, there are statstically significant decrease of total clinical symptom scores. Scanning electron microscopic findings of the skin replicas show marked changes between the beginning and the end of the study. On quantive image analysis of the skin replicas, the length of fissure is a little decreased and the depth of rrows is slightly increased than before application of skin protector, but these are not statistically significant. CONCLUSION: Skin protector, Marly skin, has a protective effect on the development of hand eczema.
Detergents
;
Eczema*
;
Hand
;
Humans
;
Mali
;
Skin
6.Artifacts in MR imaging caused by air and fat: an experimental study.
Kyung Joo PARK ; Byung Ihn CHOI ; Kee Hyun CHANG ; Sang Hoon CHA ; Sang Joon KIM
Journal of the Korean Radiological Society 1992;28(3):321-326
To investigate the nature of artifacts caused by air and chemical shift by fat, a test tube phantom study was performed in 2.0T and 0.5T superconducting magnetic resonance imaging systems in various imaging sequences. Spatial mismapping and signal change made image distortion in spin echo images of the air-column and severe signal voids in gradient echo images. Chemical shift artifacts appeared in the planes of frequency-encoding axis as crescent-shaped signal voids and summated bright signals, Both artifacts were more prominent in high field strength, Images at 0.5T showed more severe artifacts in the T2-weighted images than those in the other sequences. As the acquisition matrix increased, truncation artifacts decreased and susceptibility artifacts in gradient echo images diminished. Familiarity with causes, appearances and mechanisms of various artifacts will help radiologists for interpretation of MRI.
Artifacts*
;
Magnetic Resonance Imaging*
;
Recognition (Psychology)
7.A Case of Autoimmune Hemolytic Anemia Associated with Chronic Hepatitis in Children.
Kwan Mo CHOI ; Kyeong Hun CHA ; Eun Yeong KWAK ; Kyung Rae MOON ; Yeong Bong PARK
Journal of the Korean Pediatric Society 1990;33(9):1288-1293
No abstract available.
Anemia, Hemolytic, Autoimmune*
;
Child*
;
Hepatitis, Chronic*
;
Humans
8.Immunoelectron Microscopic Analysis of Human Cytomegalovirus ( HCMV ) Antigens Reacting with Specific Monoclonal Antibodies.
Eung Soo HWANG ; Chang Yong CHA ; Hae Kyung PARK ; Ju Young SEOH
Journal of the Korean Society for Microbiology 1997;32(5):601-610
For the purpose of morphologic analysis of human cytomegalovirus (HCMV) antigens reacting with specific monoclonal antibodies, we observed HCMV particles after immunogold staining. HCMV was cultured in human fetal lung fibroblasts to be concentrated by polyethylene glycol 6,000. The HCMV stock was dropped onto Formva-coated grids and was fixed by 2% glutaraldehyde. The grids were reacted with MCMVA57, 93, 135 or with SCMVM1, 6, 14, 49 monoclonal antibodies (MoAbs) follwed by gold (10 nm)-conjugated goat anti-mouse IgG. Then the grids were stained with 2.5% uranyl acetate to be observed under Hitachi 500 or Jeol 1,200 electron microscope. When HCMV was reacted with SCMVM14 and SCMVM49 MoAbs, gold particles were adsorbed to virion envelopes, suggesting that the reactive antigens were envelope proteins. In cases of MCMVA135 and SCMVM6 MoAbs, gold particles were adsorbed to dense bodies as well as to virion envelope. These results, together with the previous results of immunologic and genetic characterization, suggested that the reactive antigens of MCMVA135 and SCMVM6 MoAbs were gB homologue and structural protein, respectively. In case of SCMVM1 MoAb, gold particles were adsorbed to capsids, envelopes, and dense bodies, suggesting that the reactive antigen was structural protein. In case of SCMVM8 MoAb, gold particles were observed between the envelopes and capsids, which space was supposed to be the tegument, suggesting that the reactive antigen was carbohydrate moiety of glycoprotein or its polymer. In cases of MCMVA57 and MCMVA93 MoAbs, gold particles were adsorbed to only dense bodies, suggesting that the reactive antigens were precursors of structural proteins.
Antibodies, Monoclonal*
;
Capsid
;
Cytomegalovirus*
;
Fibroblasts
;
Glutaral
;
Glycoproteins
;
Goats
;
Humans*
;
Immunoglobulin G
;
Lung
;
Polyethylene Glycols
;
Polymers
;
Virion
9.A Case of Cloacal Exstrophy.
Kyung Hwan OH ; Joon Soo PARK ; Hak Joo CHA ; Sang Jhoo LEE
Journal of the Korean Pediatric Society 1990;33(11):1574-1578
No abstract available.
10.Two Cases of Collodion Baby.
Seung Hoon CHA ; Seok Don PARK ; Yon Kyun OH ; In Kyung KANG ; Kyu Chul CHOI
Korean Journal of Dermatology 1997;35(1):129-134
A collodion baby is born with a tough, inelastic parchment-like membrane covering the whole body surface. As the meinbrane fissures and peels, a more characteristic ichthyosiform change is evident beneath the collodion membrane. Uncommonly, normal skin is found under it. We herein present two cases af collodion baby, which were confirmed as a sporadic case of lamellar ichthyosis and a case of lamellar exfoliation of the newborn, respectively, after long-term clinical observation. It is necessary that detailed genetical and molecular biological studies should be perforrned in order to elucidate the fur:damental, molecular changes that cause these dramatic cutaneous changes.
Collodion*
;
Humans
;
Ichthyosis, Lamellar
;
Infant, Newborn
;
Membranes
;
Skin