A case of hypohidrotic ectodermal dysplasia was seen at the Dermatological Clinic of Chosun Univeraity Hospital, with a classical symptom triad consisting of hypohidrosis to anhidroais, hypotrichosis and hypodontia, and characteristic facial appearance. He was a 20 year-old male patient who presented, in addition, milium-like papules of sebaceous hyperplasia located on the nose and cheeks, supernumerary nipples of right breast, ceruminosis since childhood, and absence of apocrine glands on the axilla and pubic area, all of which are not frequently observed in hypohidrotic ectodermal dysplasia. Dermatoglyphics of this patient revealed that the axial triradius of the left palm was t, its atd angle was 42 degree, and the total ridge count of finger print was 5. This patient has no relatives showing the symptoms of hypohidrotic ectodermal dysplasia and the genetics was discussed in relation to this disease.
Anodontia ; Apocrine Glands ; Axilla ; Breast ; Cheek ; Dermatoglyphics ; Ectodermal Dysplasia 1, Anhidrotic* ; Fingers ; Genetics ; Humans ; Hyperplasia ; Hypohidrosis ; Hypotrichosis ; Male ; Nipples ; Nose ; Young Adult

Daily topical sequential triple therapy(tretinoin, betamethasone valerate and hydroquinone), as proposed by Kligman et al and Gano et al, has been performed on 29 Korean female patients with melasma. After 4 weeks treatment with 2% hydroquinone cream, only three of eight patients (37. 5%) showed good to excellent results. However, after 4 weeks treatment with 4% hydroquinone cream, twelve of twentyone patients (57. 1%) showed good to excellent results and its therapeutic effects appeared more rapidly than the former group. Overall, after 4 weeks treatment. 96.6% of the total group showed fair to excellent results of which 57. 7% had a good to excellent rating. The fair-com- plexioned Koreans had a better response than dark-complexioned.
Betamethasone Valerate* ; Betamethasone* ; Female ; Humans ; Melanosis* ; Tretinoin*

No abstract available.

Primary cutaneous monomorphous lymphoma is rare compared to the more usual involvement of skin secondary to internal monomorphous lymphoma. The histopathological diagnosis of the primary cutaneous monomorphous lymbhoma (PCML) requires differentiation from cutaneous lymphoid hyperplasia. The authors observed 3 cases of PCML. Case 1 was 21 year-old woman, who had an initial lesion on her left arm. Histopathologically it was diagnosed as poorly differentiated. lymphocytic lymphoma and was treated by surgical excision. Six months after onset she developed new lesions on her skin elsewhere, histopathologically diagnosed as well differentiated lymphocytic lymphoma. She died of infiltration of the bone marrow 19 months after the initial onset, even though combination of radiotherapy and chemotherapy resulted in clinical improvernent. Case 2 was a 70 year-old woman having an unusual cutaneous manifestation of an adult palm sized ulcerative, indurated tumor on her right forearm, histopathologically diagnosed as histiocytic lymphoma. There was no evidence of extracutaneous in volvement except right axillary lymphadenopathy. Case 3 was 72 year-old man, who had a clinical manifestation to that of case 2, histopathologically diagnosed as histiocytic lymphoma and received radiotherapy with good improvement. The patient did not show any evidence of extracutaneous involvement five months after the onset.
Adult ; Aged ; Arm ; Bone Marrow ; Diagnosis ; Drug Therapy ; Female ; Forearm ; Humans ; Hyperplasia ; Leukemia, Lymphocytic, Chronic, B-Cell ; Lymphatic Diseases ; Lymphoma* ; Lymphoma, Large B-Cell, Diffuse ; Radiotherapy ; Skin ; Ulcer ; Young Adult

A case of Ramsay Hunt syndrome, though more often seen at the ENT clinic because of the patients' concern with symptoms in the ear, was seen and treated at the Dermatologic Clinic of Chosun University. A 29 year old male patient presented earache, pinhead to rice sized erythematous vesicular eruption on the external auditory canal, auricle and superior auricular area, and facial paralysis, all involving the right side of the face, duration of which were 7 days, 5 days and 1 day respectiveIy. High doses of prednisolone alone made it possible to remit the otalgia, control the vesicular eruption and resolute the facial paralysis almost completely within 18 days in the order of their appearance, indicating that this is one of the more easily treated diseases for dermatologists, The 22 cases of this syndrome reported in Korean literature were reviewed and the conceptual development of its pathogenesis and definition was described.
Adult ; Ear ; Ear Canal ; Earache ; Facial Paralysis ; Herpes Zoster Oticus* ; Humans ; Male ; Prednisolone

No abstract available.
Humans ; Incidence* ; Infant, Low Birth Weight* ; Infant, Newborn ; Mortality* ; Statistics as Topic*

No abstract available.
Hemoperitoneum*

DNA isolated from human tumor cells can induce malignant transfarmation of tissue culture cells. The DNA is then called an oncogene. Its protein produets have been detected in animal and human tumors and are considered to play a significant role in carcinogenesis. In order to evaluate whether the oncogenes are involved in development of tumors of epidermis and whether they could be used as tumor markers, immunoperoxidase staining was performed for the ras product in sections of squamous cell carcinoma, Bowen's disease, actinic keratosis, keratoacanthoma and seborrheic keratosis. Three cases of sgamous cell carcinoma showed 10~20 positive cells per high power field(HPF). Three cases of Bowen's disease revealed 1-9 positive cells per HPF, whereas the actinic keratosis 1~9 or no positive cells per 10 HPF in all three cases. The keratoacanthoma and seborrheic keratosis showed 1~9 or no positive cells in all observed cases. The positive staining was observed in the cytoplasm. The increasing positivity in parallel with the increase of malignant potential strongly suggests that the ras oncogene is closely related to development of epidermal malignancy and also point out the possibility of ras as a cancer marker.
Animals ; Bowen's Disease ; Carcinogenesis ; Carcinoma, Squamous Cell ; Cytoplasm ; DNA ; Epidermis* ; Genes, ras* ; Humans ; Keratoacanthoma ; Keratosis, Actinic ; Keratosis, Seborrheic ; Oncogenes ; Biomarkers, Tumor

Papulonecrotic tuberculid (PNT) and Pityriasis lichenoides et varioliformis acuta (PLEVA) have been in controversy in their pathogeneses and entity itselves. Authors reviewed litera,tures of the two dermatoses with observation of nine casea of PNT from 1979 to 1981 and evaluated whether PNT could be also classified as PLEVA. The results were a,s follows: 1. By the review of literatures PNT and PLEVA showed great similarities in their clinical aspects including shape of cutaneous lesions, course, favorite age and subjecive symptoms. Histopathological overlappings were also found. 2. Of the nine cases of PNT authors observed, seven cases were histopathologically PLEVA and four cases could be thought PLEVA also clinically. But way six cases were treated by anti-tuberculous drugs. 3. The incidence of other tuberculous signs and results of tuberculin skin tests were all significant in the nine cases above. With the above observations it seems that PNT is one of the causes of PLEVA and thus could be a kind of PLEVA.
Child* ; Dermatitis* ; Humans ; Incidence ; Pityriasis Lichenoides ; Skin Diseases ; Skin Tests ; Tuberculin ; Tuberculosis, Cutaneous

No abstract available.
Keratosis, Seborrheic*