It is the purpose of this study to determine the alterations of the metabolism on the feline spinal cord following trauma. Cats were anesthetized with ketamine hydrocloride and injured with a 400 gm-cm impact injury to L-2 level of spinal cord. Biochemical analysis of the injured segment revealed signicifant depletion in the concentrations of adenosine triphosphate(ATP) for the entire 24-hour postinjury period. Glucose concentrations were elevated significantly for the entire 24-hour period, and especially marked elevated between 8 and 24 hours. Lactate concentrations were elevated at 1 hour and between 1 and 4 hours. but especially significantly declined between 8 and 24 hours. This sequence of the metabolic changes suggested that anaerobic metabolism likely predominated for the initial 4 hours, and between 8 and 24 hours there appeared to be an increasing percentage of oxidative metabolism in the remaining metabolically viable tissues.
Adenosine ; Adenosine Triphosphate ; Animals ; Cats ; Energy Metabolism* ; Glucose ; Ketamine ; Lactic Acid ; Metabolism ; Spinal Cord Injuries* ; Spinal Cord*

In a double-blind clinical study, single-dose lumbar epidural blockade was instituted in 45 healthy patients undergoing cesarean section. Patients were randomly assigned to one of three groups. Each group received treatment with a different local anesthetic solution used were 2.0% Lidocaine HCL 20 ml in group I, 0.5% Bupivacaine HCL 20 ml in group II and Lidocaine-Bupivacaine Mixture in the ratio of 1:1 20 ml in group III The injections were made at the third lumbar interspace. The local anesthetic was injected directly through 176 Tuohy needle at 1 ml/s with the bevel directed cephalad(11 ml) and caudad(9 ml), The onset times were fastest in group I and slowest in group III. The durations were shortest in group L The times reguired to reach the highest level in group I and III were shorter than group II. The Apgar scores and blood pressure changes were similar in the diifferent groups. The frequency of pain sense was highest in group II. It is concluded that Lidocaine and Lidocaine-Bupivacine Mixture are superior to Bupivacaine for lumbar epidural blockade for cesarean section.
Blood Pressure ; Bupivacaine* ; Cesarean Section* ; Female ; Humans ; Lidocaine* ; Needles ; Pregnancy

No abstract available.
Coronary Vessels ; Multidetector Computed Tomography ; Sinus of Valsalva

A five-year-old boy received a blunt trauma on chest by a kindergarten bus on Feb. 29, 1996. Pulmonary hemorrhage and pericardiac effusion were developed, followed by multi-organ failure threatening his life. All symptoms were improving when pansystolic harsh murmur (III/IV) originating from a tiny ventricular rupture with a blood leak to the pericardial space was auscultated on the 12th day after the trauma. This murmur disappeared with the left ventricular healing and progressive aneurysmatic formation. Howeve, on the 61st day after the trauma a continuous murmur (II/III) of aortic dissecting aneurysm on the left upper sternal border and dorsum was newly auscultated. Two-dimensional color doppler echocardiogram and aortogram by femoral artery catheterization revealed aneurysmatic dilatations of both the left ventricular free wall and descending aorta immediately after the origin of the subclavian artery with mild mitral regugitation. The patient underwent successful corrective surgery.
Aneurysm* ; Aneurysm, Dissecting ; Aorta, Thoracic* ; Automobiles* ; Catheterization ; Catheters ; Dilatation ; Femoral Artery ; Heart Ventricles* ; Hemorrhage ; Humans ; Male ; Rupture ; Subclavian Artery ; Thorax

No abstract available.
Diagnosis* ; Hemangioma* ; Tomography, Emission-Computed, Single-Photon*

There are still many limitations on fabricating dentures using digital method while computerized production of fixed prostheses utilizing intraoral scanner and CAD/CAM technology has propagated rapidly. Recently the digital solution of fabricating removable partial denture by applying haptic input device, electronic surveying, and rapid prototyping was introduced. In this case presentation, five patients were treated with surveyed crown and removable partial dentures by this digital solution. Fit of dentures was excellent except for one case which showed morphological difference between the actual teeth and that of master cast by the erroneous impression process. There also was not any problem of stability and retention after adaptation in the clinical setting.
Crowns ; Denture, Partial, Removable ; Dentures ; Electronics ; Electrons ; Humans ; Prostheses and Implants ; Retention (Psychology) ; Tooth

We successfully rescued a patient whose coronary artery perforated following implantation of a drug-eluting stent (DES), by deploying a stent-graft in symptomatic myocardial bridging. Our case demonstrated that coronary perforation could be handled without difficulty when perforated myocardial bridging is confined to the interventricular groove
Angioplasty, Balloon, Coronary ; Coronary Vessels ; Drug-Eluting Stents ; Humans ; Myocardial Bridging ; Stents

BACKGROUND: It is known that some opioids protect the myocardial tissue from myocardial ischemia-reperfusion (I/R) injury. The aim of this study was to investigate whether remifentanil, at a clinically relevant concentration that's during the peri-ischemic period, has a protective effect against a regional I/R injury in an in vivo rat heart model. METHODS: Rats were subjected to 25 minutes of coronary artery occlusion and this was followed by 24 hours of reperfusion. A microcatheter was advanced into the left ventricle and the hemodynamic function was evaluated after 24 hours of reperfusion. The infarct size was determined by triphenyltetrazolium staining. The serum level of cardiac troponin-I (cTnI) was determined by ELISA (enzyme-linked immunosorbent assay). RESULTS: Remifentanil administration during the peri-ischemic period didn't show any identifiable protective effects for the hemodynamic function or to reduce the infarct size. In the control group, the peak rate of the ventricular pressure increase (+dP/dt(max)) (P < 0.05) and the peak rate of the intraventricular pressure decline (-dP/dt(max) P < 0.05) were significantly decreased as compared to those values for the sham group. In the remifentanil group, the +dP/dt(max) and -dP/dt(max) were not improved compared to those values of the control group. The infarct size was 45.6% of the area at risk in the control group, and the infarct size was reduced by administration of remifentanil to 43.2% in the remifentanil group. The I/R-induced serum level of cTn-I was not reduced by remifentanil infusion during the peri-ischemic period. CONCLUSIONS: Remifentanil, at a clinically relevant concentration that's infused during the peri-ischemic period, has no myocardial protective effect after regional myocardial I/R injury in an in vivo rat heart model.
Analgesics, Opioid ; Animals ; Coronary Vessels ; Enzyme-Linked Immunosorbent Assay ; Heart ; Heart Ventricles ; Hemodynamics ; Piperidines ; Rats ; Reperfusion ; Reperfusion Injury ; Salicylamides ; Tetrazolium Salts ; Troponin I ; Ventricular Pressure

The prevalence of colorectal cancer is increasing now in Korea and the principal strategy of its management is early detection and surgical resection. Current discussion of the topic of colorectal polyps and cancer is largely based on the concept of the adenoma-carcinoma sequence, which is thought to be the most probable pathogenesis for colorectal cancer. But the case reports about colonic adenocarcinoma arising from adenoma in clinical practice between short interval are rare in Korea. We experienced two cases of colon cancer, which were transformed from small adenoma can not be removed because of patients' refusal, 3 years ago. So we present these cases with a review of relevant literatures.
Adenocarcinoma* ; Adenoma* ; Colon* ; Colonic Neoplasms ; Colorectal Neoplasms ; Disulfiram ; Korea ; Polyps ; Prevalence