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Basement membrane zone gene expression by fibroblast cultures was examined by molecular hybridizations with human sequence specific cDNAs corresponding to type 1V procollagen and laminin subunit polypeptides. Northern transfer analysis with total RNA revealed the presence of specific mRNA transcripts for al (IV) and a2 (1V) chains of type 1V procollagen as well as Bl and B2 chains of laminin. Laminin A chain mRNAs were not detected using the same RNA preparations. The molecular size of al (1V) and a2 (1V) procollagen mRNA revealed 6.8kb and 6.7kb, respectively. The molecular size of Bl chain of laminin revealed 5.6kb, and B2 chain revealed 8.2 and 5.5kb polymorphic transcripts. In slotblot analysis using densitometer, steady-state levels of type IV procollagen and laminin mRNAs indicated that they were in relatively low abunclance, as compaired with type I procollagen mRNA. Quantitative levels of al (IV) and laminin Bl chaii mRNAs were more abundant than those of a2 (IV) and laminin B2 mRNAs. The mRNA ratio of al (IV)/a2 (lV) and laminin Bl/B2 were 1.9 and 1.5, respectively. These results demonstrate evidence for differential regulation of the expression of different basement membrane zone molecules during the formation of basement membrane.
Basement Membrane ; Collagen Type I ; Collagen Type IV* ; DNA, Complementary ; Fibroblasts* ; Gene Expression ; Humans ; Laminin* ; Peptides ; Procollagen ; RNA ; RNA, Messenger ; Skin*

6.Comparative analysis of operative procedures in rectal prolapse between perineal and abdominal approach.

Ho Jin PARK ; Byung Jo SO ; Kyu Young JUN

Journal of the Korean Surgical Society 1991;40(3):354-359

7.Primary Cutaneous Cryptococcosis Successfully Treated With Fluconazole.

Jun Hyoung PARK ; Young Wook RYOO ; Kyu Suk LEE

Annals of Dermatology 2000;12(2):148-151

We report a case of primary cutaneous cryptococcosis on Rt. forehead and perioral area of 57 year old woman with non-insulin dependent diabetes mellitus and Lt. cerebral infarction. She had large ulcers with yellowish purulent exudates on Rt. forehead and perioral area for 2months. A histopathological examination from the lesion showed numerous encapsulated, round spores and the organisms were identified as Cryptococcus neoformans in a series of fun-gal studies. The patient received a 5-week course of IV and oral fluconazole with resolution of her skin lesion. The patient is free of any lesion several months after completing therapy. This experience supports the use of fluconazole as initial and single therapy in primary cutaneous cryptococcosis.
Cerebral Infarction ; Cryptococcosis* ; Cryptococcus neoformans ; Diabetes Mellitus ; Exudates and Transudates ; Female ; Fluconazole* ; Forehead ; Humans ; Skin ; Spores ; Ulcer

1.The clinical reviews of the diverticular diseases.

2.Expression of type IV collagen and laminin genes by skin fibroblasts in culture.

3.Multiple polyposis coli.

4.Strangulated obturator hernia.

5.Hepatic resection for metastases from colorectal carcinoma.

6.Comparative analysis of operative procedures in rectal prolapse between perineal and abdominal approach.

7.Primary Cutaneous Cryptococcosis Successfully Treated With Fluconazole.

8.A clinical analysis of 311 cases of hemorrhoids.

9.Histopathological review of low anterior resection for rectal cancer.

10.A clinical analysis of 311 cases of hemorrhoids.

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