1.The Risk Factors of Septic Shock in Childhood Cancer Patients with Neutropenic Fever.
Ji Eun BAN ; Kyu Tae NOH ; Young Ho LEE
Korean Journal of Pediatric Hematology-Oncology 2001;8(2):281-289
PURPOSE: We evaluated the easily-assessable risk and prognostic factors of septic shock in children with neutropenic fever (NF) which developed after anticancer chemotherapy. METHODS: We retrospectively reviewed the medical records and laboratory data of 97 children who received anticancer chemotherapy at Dong-A University Hospital and had NF between March, 1993 and February, 2001. RESULTS: There were 223 episodes of NF in 97 children, of which 71 episodes (31.8%) of bacteremia and 18 episodes (8.1%) of septic shock developed. The incidence of septic shock was associated with fever duration (> 5 days, odds ratio=7.367, P=0.0159), tachycardia (odds ratio=11.857, P=0.0001), and serum bicarbonate level (<24 mEq/L, odds ratio=6.235, P=0.0378), whereas not with the underlying disease, age, sex, causative organisms, absolute neutrophil count, absolute monocyte count, absolute phagocyte count, the presence of central venous catheter, the accompanied focal infection, and the use of hematopoietic growth factor. Septic shock developed 3.2 (1~11) days after NF. The prognosis of septic shock patients was not associated with the therapeutic timing, antibiotics, fever duration, tachycardia, or serum bicarbonate level. CONCLUSION: We suggest that the fever duration, tachycardia, and serum bicarbonate level could be important risk factors of septic shock in children with NF. Although We could not reveal the prognostic factors in children with septic shock, further studies will be required.
Anti-Bacterial Agents
;
Bacteremia
;
Central Venous Catheters
;
Child
;
Drug Therapy
;
Fever*
;
Focal Infection
;
Humans
;
Incidence
;
Medical Records
;
Monocytes
;
Neutropenia
;
Neutrophils
;
Phagocytes
;
Prognosis
;
Retrospective Studies
;
Risk Factors*
;
Shock, Septic*
;
Tachycardia
2.A Case of Acute Necrotizing Encephalopathy with a Thalamic Hemorrhage.
Sang Soo PARK ; Kyu Tae NOH ; Sun Seob CHOI ; Kyu Geun HWANG
Journal of the Korean Child Neurology Society 2004;12(2):223-228
Acute necrotizing encephalopathy predominantly affects young children and infants living in Japan and Taiwan, and is characterised by acute encephalopathy with seizures and decreased level of consciousness. The Hallmark of the disease is diffuse and symmetrical CNS lesions of both thalami, brainstem tegmentum, cerebral periventricular white matter and cerebellar medula. The clinical, radiological and pathological features of this disease, a disease entity established recently, is proposed by Masashi Mizuguchi et al in 1995. The aetiology is unknown but infectious or parainfectious process seems likely. The diagnosis can be made without difficulty on the basis of the combination of a typical clinical figures and characteristic radiologic findings. There is no specific therapy or prevention. The prognosis was poor in the 1980s but has improved recently. We experienced a case of 6-month-old female infant with acute necrotizing encephalopathy and a thalamic hemorrhage. We report this case with a review of the related literatures.
Brain Stem
;
Child
;
Consciousness
;
Diagnosis
;
Female
;
Hemorrhage*
;
Humans
;
Infant
;
Japan
;
Prognosis
;
Seizures
;
Taiwan
3.Studies of the Change of Antibody Titers after Vaccination of Haemophilus Influenzae PRP-T Conjugate Vaccine.
Pil Soon YANG ; Jeong Il SEO ; Kyu Tae NOH ; Jae Ho YOO ; Kwang Soo HWANG ; Kyu Geun HWANG
Journal of the Korean Pediatric Society 2002;45(8):987-993
PURPOSE: This study was carried out to survey the serum anti-PRP titers after the completion of a primary series with 3 doses of the PRP-T conjugate vaccine(ACT-HIBTM), to evaluate the necessity of booster vaccination. METHODS: One hundred twenty healthy infants who went for consultations at Moon Hwa hospital between December 1999 to May 2001 were vaccinated at two, four and six months after birth. The serum antibody levels were measured at 7-8 months and 19-20 months of age by the "Farr" type of radioimmunological method at Aventis Pasteur International in France. RESULTS: The geometric mean of Anti-PRP titers were 24.6 microgram/mL at 7-8 months and then fell to 2.10 microgram/mL at 19-20 months. Minimum Anti-PRP titer was 0.75 microgram/mL at 7-8 months, and 0.1 microgram/mL at 19-20 months. Maximum Anti- PRP titer was 99.2 microgram/mL at 7-8 months, and 9.1 microgram/mL at 19-20 months. Subjects of Anti-PRP titers more than 0.15 microgram/mL were 100% at 7-8 months, and 97.0% at 19-20 months, and subjects of Anti-PRP titers more than 1.0 microgram/mL were 98.3% at 7-8 months, and 61.6% at 19-20 months. CONCLUSION: The Anti-PRP titers at 7-8 months were very high but rapidly decreased at 19-20 months of age, so the necessity of booster vaccination could be considered in Korean children.
Child
;
France
;
Haemophilus influenzae*
;
Haemophilus*
;
Humans
;
Infant
;
Parturition
;
Referral and Consultation
;
Vaccination*
4.Retroperitoneal Fibrosis; Diagnosed as an Aderenal Gland Orgin Tumor Preoperatively.
Tae Hoon KIM ; Do Joong PARK ; Dong Young NOH ; Yeo Kyu YOUN ; Seung Keun OH
Journal of the Korean Surgical Society 2003;65(3):254-258
Retroperitoneal fibrosis is a rare fibrosing reactive process, which is characterized by diffuse or localized fibroblastic proliferation and chronic lymphoplasmacytic infiltration in the retroperitoneum causing compression or obstruction of the ureters, aorta, or other vascular structures. The majority of cases are idiopathic. A 35-year old woman was transferred for further evaluation and the management of a mass in the left adrenal area. She suffered from vague abdominal pain, which was dull, non-colicky and poorly localized. She had no obstruction of the ureters or vascular structures. The preoperative diagnosis was a tumor of the left adrenal gland. A solitary retroperitoneal mass was excised, which was proven to be localized idiopathic retroperitoneal fibrosis. She was discharged on the 9th post operative day without any complications.
Abdominal Pain
;
Adrenal Glands
;
Aorta
;
Diagnosis
;
Female
;
Fibroblasts
;
Humans
;
Retroperitoneal Fibrosis*
;
Ureter
5.A case of Primary Transitional Cell Carcinoma of Ureteral Stump Following nephreetomy for renal tuberculosis.
Won Jae YANG ; Woong Kyu HAN ; Ju Eui HONG ; Tae Woong NOH ; Hong Hwan SHIN ; Seong Kyoo CHOI ; Seung Chul YANG
Korean Journal of Urology 2000;41(4):584-586
No abstract available.
Carcinoma, Transitional Cell*
;
Tuberculosis, Renal*
;
Ureter*
6.Novel anal sphincter saving procedure with partial excision of levator-ani muscle in rectal cancer invading ipsilateral pelvic floor.
Gyoung Tae NOH ; Jeonghee HAN ; Chinock CHEONG ; Yoon Dae HAN ; Nam Kyu KIM
Annals of Surgical Treatment and Research 2017;93(4):195-202
PURPOSE: Tumors at the level of the anorectal junction had required total levator-ani muscle excision to achieve an adequate resection margin. However, in the cases of tumor invading ipsilateral levator-ani muscle and intact external sphincter, en bloc resection of rectum with levator-ani muscle including tumor would be possible. This hemilevator excision (HLE) technique enables preserving the anal sphincter function while obtaining oncologic clearance and avoiding permanent colostomy in those patients. This study aimed to evaluate the surgical outcomes and feasibility of HLE. METHODS: Data on 13 consecutive patients who underwent HLE for pathologically proven low rectal cancer were retrospectively collected. All 13 patients presented low rectal cancer at the anorectal ring level that was suspected to invade or abut to the ipsilateral side of the levator-ani muscle. RESULTS: A secure resection margin was achieved in all cases, and anastomotic leakage occurred in 2 patients. During follow-up, 3 patients experienced tumor recurrence (2 systemic and 1 local). Among 6 patients who underwent diverting ileostomy closure after the index operation, 2 complained of fecal incontinence. The other 4 patients without fecal incontinence showed <10 times of bowel movement per day. Accessing their incontinence scale, mean Wexner score was 9.4. CONCLUSION: HLE is a novel sphincter-preserving technique that can be a treatment option for low rectal cancer invading ipsilateral levator-ani muscle, which has been an indication for abdominoperineal resection (APR) or extralevator APR. However, the long-term oncologic and functional outcomes of this procedure still need to be assessed to confirm its validity.
Anal Canal*
;
Anastomotic Leak
;
Colostomy
;
Fecal Incontinence
;
Follow-Up Studies
;
Humans
;
Ileostomy
;
Pelvic Floor*
;
Rectal Neoplasms*
;
Rectum
;
Recurrence
;
Retrospective Studies
7.Clinical Analysis of Malignant Pheochromocytoma.
Seung Eun CHOI ; Young Cheol KIM ; Tae Seon KIM ; Dong Young NOH ; Yeo Kyu YOUN ; Kuk Jin CHOE ; Seung Keun OH
Journal of the Korean Cancer Association 1999;31(6):1307-1314
PURPOSE: There are no specific clinical and histopathologic characteristics of malignant pheochromocytoma and the optimal treatment modality has not been established yet. We analyzed the clinical and histopathologic features of malignant pheochromocytoma and treatment results. MATERIALS AND METHODS: We reviewed the clinical records of 10 patients with malignant pheochromocytoma diagnosed at Seoul National University Hospital from March 1987 to June 1998. RESULTS: Nine of 10 (90%) patients had functional tumors. The biochemical laboratory findings showed elevated 24-hour urine VMA level in nine patients available. The median size of the tumors was 11x11 cm. Six of 10 (60%) patients were initially diagnosed as malignant tumors because of direct invasions to adjacent tissues or distant metastases. On the other hand, remaining 4 patients were initially diagnosed as benign, but the distant metastases developed metachronously after resection of the primary lesion. The median duration between the initial operation and the detection of metastases was 57 months (range: 47~72 months) in these patients. The liver was the most common site of metastases (60%). With regards to the histopathological features, most of the tumors (87.5%) showed capsulation, necrosis and hemorrhage. The findings of lymphatic invasion, angio-invasion, and mitosis were found in 62.5% of the cases. All but 2 patients were initially treated with radical operation for the primary lesions. The disease recurrences or metastases occurred in 7 out of 10 patients. Of these, 4 patients were treated with chemotherapy or interferon- a after recurrences. Overall, the median survival for all patients was 82 months (range: 37~143 months). Two patients is alive and only one patient is alive without recurrence. CONCLUSION: The careful follow-up for at least 5 years and the aggressive multi-disciplinary therapy may be needed for the diagnosis and the management of malignant pheochromocytoma.
Diagnosis
;
Drug Therapy
;
Follow-Up Studies
;
Hand
;
Hemorrhage
;
Humans
;
Liver
;
Mitosis
;
Necrosis
;
Neoplasm Metastasis
;
Pheochromocytoma*
;
Recurrence
;
Seoul
8.H rthle Cell Neoplasm of the Thyroid Gland.
Jeong Eon LEE ; Tae Seon KIM ; Young Cheol KIM ; Dong Young NOH ; Yeo Kyu YOUN ; Kuk Jin CHOE ; Seung Keun OH
Journal of the Korean Surgical Society 2000;58(5):629-634
PURPOSE: H rthle cell neoplasm of the thyroid gland is a rare disease. The reported cases in Korea are not so many; thus, there has been a lack of common therapeutic and prognostic guidance. METHODS: The cases of 15 patients with a H rthle cell neoplasm of the thyroid gland, hospitalized at Seoul National University Hospital from Nov. 1981 to Feb. 1998, were retrospectively reviewed. RESULTS: There were 4 males and 11 females. The ages varied from 23 to 69 years old (mean: 46.3 years old). Among them, 13 had neck masses with a mean size of 3.3 cm (1.2-6.0 cm), and the mean duration of the symptom was 4 years (5 months-8 years). Of the other two, one had laryngeal discomfort for 2 months, and the other one was diagnosed through a fine needle aspiration follow-up. One of the 15 patients had hyperthyroidism whereas the others had euthyroidism. The thyroid scans for 10 of them showed cold nodules. The operations consisted of a unilateral lobectomy in 2 cases, a unilateral lobectomy and isth mectomy in 11 cases, a unilateral lobectomy, isthmectomy and contralateral partial lobectomy in 1 case, and a total thyroidectomy and neck lymph node dissection in the 1 case that was combined with a papillary carcinoma. Thirteen patients (86.7%) had a H rthle cell adenoma, and two of them (13.3%) had a H rthle cell carcinoma. The mean duration of follow-up was 33 months (range 1 month-12 years), and no recurrence or death occurred during the follow-up period. CONCLUSIONS: The incidence of H rthle cell neoplasms is higher in women and the sex ratio is 1:2.8. The incidence of H rthle cell carcinomas among H rthle cell neoplasms is 13.3% (2/15). We found no specific clinical features for differentiating a H rthle cell adenoma from a H rthle cell carcinoma and no factors for adequate operative methods and prognosis due to the rarity of the condition and the short duration of the follow-up. Because of the low incidence of H rthle cell neoplasms and our limited experience, not only co-research of centers but also pathologic research is needed.
Adenoma
;
Aged
;
Biopsy, Fine-Needle
;
Carcinoma, Papillary
;
Female
;
Follow-Up Studies
;
Humans
;
Hyperthyroidism
;
Incidence
;
Korea
;
Lymph Node Excision
;
Male
;
Neck
;
Prognosis
;
Rare Diseases
;
Recurrence
;
Retrospective Studies
;
Seoul
;
Sex Ratio
;
Thyroid Gland*
;
Thyroidectomy
9.Clinical Analysis of Phyllodes Tumor of the Breast .
Hee Joung KIM ; Tae Seon KIM ; Hee Joon KANG ; Hang Joung CHO ; In Ae PARK ; Dong Young NOH ; Yeo Kyu YOUN ; Seung Keun OH ; Kuk Jin CHOE
Journal of the Korean Surgical Society 2000;58(3):352-360
PURPOSE: Phyllodes tumor is a rare fibroepithelial tumor of the breast, first described by Johannes Muller in 1838. Much has been written about phyllodes tumor, but very few widely accepted conclusions about its clinical behavior, treatment modality, and prognosis have been reached. This study aims to analyze the clinical, radiological, and pathological characteristics of phyllodes tumor of the breast. METHODS: The medical records of 41 patients with phyllodes tumor who had been treated between February 1982 and August 1998 at the Department of Surgery, Seoul National University Hospital, were retrospectively reviewed for clinical, radiological and pathological findings, treatment modalities, and follow-up results. RESULTS: Of these 41 cases, there were 28 cases (68.3%) of benign tumors and 13 cases (31.7%) of malignanat tumors. All patients were females, and the mean ages of onset were 33.2 years for benign tumors and 40.8 years for malignant tumors. Most patients, 100% of benign and 92.3% of malignant, presented with a papable mass in the breast. The median duration of illness was 2 months for malignant tumors and 8 months for benign tumors. The tumor size was greater than 10 cm in diameter in 5 cases (38.5%) of malignant tumors and in 3 cases (10.7%) of benign tumors. Only 4 cases were preoperatively diagnosed as having a phyllodes tumor by using radiological and fine needle aspiration cytology. Out of the 10 malignant cases reviewed, 5 cases were confirmed as malignant, and 5 cases were confirmed as borderline phyllodes tumors. Cellularity was moderate or above in all 5 malignant and 5 borderline cases. Atypism above moderate degree was found in 4 of 5 (80%) malignant tumors, in 3 of 5 (60%) borderline tumors, and in 4 of 24 (16.7%) benign tumors. Mitotic counts in all 5 malignant cases were 5 or more per 10 high power field while those in the 5 borderline tumors were 2-5 mitoses per 10 high power field. The most commonly performed operative procedures were a simple mastectomy (50%) for malignant tumors and a simple excision (64.3%) for benign tumors. Post-operative adjuvant therapy was done for 4 cases; out of these, 1 case had been initially diagnosed as a malignant phyllodes tumor, but the diagnosis was changed to a benign phyllodes tumor upon review. Of the 27 follow-up cases, recurrences developed in 3 cases (16.7%) of benign tumors. CONCLUSION: From the above results, there were no specific clinical features for differentiating benign from malignant phyllodes tumor preoperatively; therefore, we cannot help depending on the pathologic findings. Pathologic reviews showed that among several criteria, atypism, cellularity, and mitotic count were the most definite pathologic characteristics in differentiating benign from malignant phyllodes tumor. But much more experience and long-term follow-up may be needed to define optimal treatments and to analyze the prognosis for phyllodes tumors of the breast.
Biopsy, Fine-Needle
;
Breast*
;
Diagnosis
;
Female
;
Follow-Up Studies
;
Humans
;
Mastectomy, Simple
;
Medical Records
;
Mitosis
;
Phyllodes Tumor*
;
Prognosis
;
Recurrence
;
Retrospective Studies
;
Seoul
;
Surgical Procedures, Operative
10.A Study on the Factors that Influence the Surgical Outcomes of Choledochal Cyst in Children.
Jong Kyu KIM ; Gyoung Tae NOH ; Seok Ki MIN ; Kum Ja CHOI
Journal of the Korean Association of Pediatric Surgeons 2012;18(1):1-11
No abstract available.
Child
;
Choledochal Cyst
;
Humans