We had experienced 2 cases of acute subdural hematoma due to vitaimin K(vit. K) deficiency. They were 44-and 42-day-old. After the adminstration of vit.K1, prolonged prothrombin time(PT) and activated partial thromboplastin time(APTT) were corrected, so the surgical treatment ws performed. We supposed the predisposing factors were breast feeding and unknown hepatic pathology. No complication remained to one infant but the other multiple cerebral infarctions. The etiology, pathogenesis, diagnosis, prevention are discussed. We insist on neonatal administration of vit. K1 for the prevention of bleeding tendency. If intracranial hemorrhage develops, we must keep in mind that the early neurosurgical intervention may be needed.
Breast Feeding ; Causality ; Cerebral Infarction ; Diagnosis ; Hematoma, Subdural, Acute* ; Hemorrhage ; Humans ; Infant* ; Intracranial Hemorrhages ; Partial Thromboplastin Time ; Pathology ; Prothrombin ; Prothrombin Time ; Thromboplastin ; Vitamin K Deficiency ; Vitamins*

No abstract available.
Dermatitis, Contact* ; Prurigo*

No abstract available.
Hemangioma* ; Injections, Intralesional* ; Propranolol ; Triamcinolone*

Author list should be corrected.

No abstract available.
Dapsone* ; Herpesvirus 4, Human* ; Hypersensitivity*

PURPOSE: Recently, there are many good reports on the arthroscopic management of tibial condylar fractures. But, it may be appropriate for selected tibial condylar fractures and also needs a skilled technique. So we report the results of the tibial condylar fractures treated by the arthroscopy and limited percutaneous fixation or the arthroscopic-assisted management with conventional internal fixation without arthrotomy. MATERIALS AND METHODS: From June 1996 to December 1997, we treated 22 cases of the tibial condy- lar fractures including relatively comminuted one and analysed the results of patients who have been observed at least 1 year with Porters knee evaluation criteria. RESULTS: In 18 out of 22 cases, the results were Acceptable on symptoms(excellent 3, good 15, fair 4), in 18, on function(excellent 10, good 8, fair 3), in 21, on appearance(excellent 12, good 9, fair 1) and in 20, on radiographic appearance(excellent 11, good 9, fair 2). Overall results were Acceptable in 18 cases(82%) and Unacceptable in 4 cases(18%). CONCLUSION: The arthroscopic-assisted management with conventional internal fixation without arthrotomy can be the recommendable treatment for the tibial condylar fractures, including relatively comminuted one, without complications.
Arthroscopy ; Humans ; Knee

A case of carbuncle of the left kidney is reported with a review of literature. The patient reported herewith was 19 years old student, who complained of fever, vomiting and the tenderness in the left flank. His urine specimen showed numerous pus cells and hematological studies revealed leucocytosis. On intravenous pyelography the left kidney appeared normal. However, dye excretion by the right idney was delayed and there was a compression deformity of the lower calyx and extravasation of the dye into the renal parenchyma of the lower pole. The history and clinical findings seemed consistent with a renal carbuncle. A nephrectomy was performed as the procedure of choice. The specimen revealed, on cut surface, a large necrotic area measuring 2.1 cm in diameter, which communicated with the lower calyx. Culture of the abscess disclosed colonies of staphylococcus.
Abscess ; Carbuncle* ; Congenital Abnormalities ; Fever ; Humans ; Kidney ; Nephrectomy ; Staphylococcus ; Suppuration ; Urography ; Vomiting ; Young Adult

BACKGROUND: UVB irradiation induces acute inflammation through expressions of IL-6, IL-8, and TNF-alpha, in keratinocytes. Curcumin, extracted from the rhizomes of Curcuma longa, has been described as having anti-inflammatory properties; however, it still unknown as to whether curcumin inhibits the UVB-induced expressions of IL-6, IL-8, and TNF-alpha in HaCaT cell lines. OBJECTIVE: In this study we investigated the effects of curcumin on the expression of IL-6, IL-8, and TNF-alpha in HaCaT cells, as well as the photoprotective effect of curcumin ointment in UVB-irradiated hair less mice. METHODS: HaCaT cells were irradiated with various doses of UVB (0, 100, 200, 300 mJ/cm2). Total RNA was extracted from the cells and gene expression was confirmed by RT-PCR, EMSA, and Western blot analysis. In addition we examined whether the ointment containing curcumin prevents the photo damaging events in hairless mice. RESULTS: UVB-irradiated HaCaT cells clearly showed an increased expression of IL-6, IL-8, and TNF-alpha in a UVB dose-dependent manner (0, 100, 200, 300 mJ/cm2). Interestingly, pretreatment of curcumin (40 uM) dramatically reduced the expressions of UVB-induced IL-6, IL-8, and TNF-alpha. In addition, activation of NF-kappaB and MAPKs (p38, JNK, ERK) by UVB were partially attenuated by pretreatment of curcumin in HaCaT cells. Furthermore, the application of ointment containing curcumin partially protected the erythema and skin atrophy in UVB-irradiated hairless nude mice. CONCLUSION: Collectively, these results indicate that curcumin may be applied as a promising anti-inflammatory natural agent through modulation of inflammatory cytokines such as IL-6, IL-8, and TNF-alpha.
Atrophy ; Blotting, Western ; Curcuma ; Curcumin ; Cytokines ; Erythema ; Gene Expression ; Hair ; Inflammation ; Interleukin-6 ; Interleukin-8 ; Keratinocytes ; NF-kappa B ; Rhizome ; RNA ; Skin ; Tumor Necrosis Factor-alpha

OBJECTIVE: The purpose of this study was to evaluate the clinical course of discordant fetal growth and perinatal outcome in relation to dichorionic and monochorionic twin for different degrees of birth weight difference. METHODS: Between Jan. 1992 and Dec, 1997, 154 twin pairs were born at Yonsei medical center and there were 36 pairs of twins which had 20% or more birth weight difference. The placental examination were performed routinely on all multiple births and 13 pairs of dichorionic twins and 23 pairs of monochorionic twins were consisted of the study population. These twin pairs were divided into three groups based on birth weight difference: 20-29%(as group A), 30-39%(as group B), and 40% or more(as group C). Gestational age, birth weight, gender and perinatal outcomes were observed for each twin pairs. RESULTS: The perinatal death in the monochorionic twin pairs showed 9(34.6%) as group A, 4(50%) as group B, and 5(41,7%) as group C and in the dichorionic twin paus 1(10.0%) as youp A, 0 as group B and 5(62.5%) as group C. Up to 40% of birth weight difference, dichorionic twin pairs showed good perinatal outcomes compared with monochorionic twin pairs but over 40% or more of birth weight diffaence, however there were no significant difference of perinatal outcomes by chorionicity. In the monochorionic twin pairs, the cause of perinatal death showed 3 cases of prematurity, 2 cases of congenital anomalies and 2 cases of IIOC and 2 cases of cord lesions in group A whenas in the group B and C 3 cases of prematurity and 6 cases of congenital anomalies. In the dichorionic twin pairs, different-sex twin pairs showed no perinatal death in all three groups but in same-sex twin pairs there were 6 perinatal deaths. CONCLUSION: More recent improved fetal ultrasonographic surveillance such as determination of chorionicity, identification of fetal sex and evaluation of fetal anomalies help to make a clinical decision in growth discordant twin up to 40% of weight difference each other.
Birth Weight ; Chorion ; Fetal Development* ; Gestational Age ; Humans ; Multiple Birth Offspring ; Pregnancy, Twin

We report a case of focal dermal hypoplasia associated with ichthyosis in an 18-year-old Korean female. The patient showed a yellowish atrophic patch on the left side of her abdomen, abnormal skin pigmentation, nail dystrophy and ichthyosis since birth.We could also find skeletal and dental deformities. The biopsy specimen obtained from the yellowish atrophic patch showed marked attenuation of collagen fibers and ectopic fatty tissue nearly reaching up to the upper dermis.
Abdomen ; Adipose Tissue ; Adolescent ; Biopsy ; Collagen ; Congenital Abnormalities ; Dermis ; Female ; Focal Dermal Hypoplasia* ; Humans ; Ichthyosis* ; Skin Pigmentation