1.N-cadherin Immunoreaction in the Interventricular Septum in Developing Rat Heart.
Bang Hun LEE ; Won Kyu KIM ; Ho Sam CHUNG
Korean Circulation Journal 2000;30(12):1555-1562
BACKGROUND AND OBJECTIVES: N-cadherin is known to be expressed in neuroectodermal tissue such as central nervous system and various mesodermal origin tissues such as kidney and heart. We investigated N-cadherin expression in the endocardial cushion in developing rat heart by immunohistochemical method. MATERIALS AND METHOD: Fetal rat hearts at the 11th, 13th, 15th, 17th, and 19th day of gestation and the 1st day neonatal rat heart were used. Hematoxylin and eosin stain was performed for normal cardiogenesis, and immunohistochemistry was performed for the expression of N-cadherin in interventricular septum(IVS) during cardiogenesis in rat. RESULTS: Ventricular wall and membranous part of the IVS showed positive reaction with anti-N-cadherin at the 11th day of gestation. Membranous part of IVS was begun to show tracely positive reaction at the 15th day of gestation, and thereafter the immunoreactivity was increased with maturation. At the 17th day of gestation mesenchymal cells in membranous muscular part of the IVS showed positive reaction. The similar immunoreactivity of membranous and muscular parts of IVS were shown at the 19th day of gestation. CONCLUSION: As the immunoreaction of mesenchymal cells in the membraneous part of IVS to anti-N-cadherin was increased with time, it is suggested that mesenchymal cells in membranous part of IVS were differentiated into the cardiomyocytes.
Animals
;
Cadherins*
;
Central Nervous System
;
Endocardial Cushions
;
Eosine Yellowish-(YS)
;
Heart*
;
Hematoxylin
;
Immunohistochemistry
;
Kidney
;
Mesoderm
;
Myocytes, Cardiac
;
Neural Plate
;
Pregnancy
;
Rats*
2.A Case of Lichen Planus.
Jong Sud PARK ; Sam Jo RIM ; Yung Kyu KIM
Korean Journal of Dermatology 1972;10(1):59-62
A case of Lichen planus in 41 year old with predisposing emotional factor is reported here and reviewed therapeutic experiences and reveiwed of literatures. This patient who has been suffering from pruritic, dull erythematous maculo-papular eruptions of trunk and extremites which was preoccupied with imagination as if she were exposed sequela to atomic bomb explosion in Japan, World War II, is presented.
Adult
;
Explosions
;
Fibrinogen
;
Humans
;
Imagination
;
Japan
;
Lichen Planus*
;
Lichens*
;
Nuclear Weapons
;
World War II
3.Two Cases of Xeroderma Pigmentosum in Brothers.
Sam Jo RIM ; Jong Sub PARK ; Yung Kyu KIM
Korean Journal of Dermatology 1971;9(3):81-84
Two cases of xeroderma pigmentosum in brothers without complicated by malignant changes were presented. The clinical and histopathological studies revealed characteristic features of the disease and literatures reviewed.
Humans
;
Ichthyosis*
;
Siblings*
;
Xeroderma Pigmentosum*
4.Two Cases of Xeroderma Pigmentosum in Brothers.
Sam Jo RIM ; Jong Sub PARK ; Yung Kyu KIM
Korean Journal of Dermatology 1971;9(3):81-84
Two cases of xeroderma pigmentosum in brothers without complicated by malignant changes were presented. The clinical and histopathological studies revealed characteristic features of the disease and literatures reviewed.
Humans
;
Ichthyosis*
;
Siblings*
;
Xeroderma Pigmentosum*
5.The Effects of Retinoic Acid on Development of the Knee Joint in Rat.
Won Kyu KIM ; Moon Koo LEE ; Ho Sam CHUNG
Korean Journal of Physical Anthropology 2000;13(1):39-54
No abstract available.
Animals
;
Knee Joint*
;
Knee*
;
Rats*
;
Tretinoin*
6.Peak Expiratory Flow in Normal Healthy Korean Subjects Measured by mini-Wright Peak Flow Meter.
Young Sam KIM ; Ahn Ae RAN ; Se Kyu KIM ; Joon CHANG ; Chul Min AHN ; Jai Joon OH ; Sung Kyu KIM
Tuberculosis and Respiratory Diseases 2001;50(3):320-333
BACKGROUND: Peak expiratory flow (PEF) provides a simple, quantitative, and reproducible measure of the existence and severity of airflow obstructions. Peak flow meters are designed to monitor the condition asthma patients. There are many reports showing the normal predicted value of PEF in other countries. studies on healthy Korean adults have been performed in a relatively small sample number and a lower limit for the normal value was not reported. therefore, an attempt to provide normal predictive PEF value with a lower limit was made. METHOD: The PEF(Mini-Wright peak Flow Meter) measurements and spirometry were done in 233 men and 631 woman without history of respiratory disease. all subjects were non-smokers with no respiratory symptoms. the normal predictive value and its lower limit were developed by multiple regression analysis. The result was compared with regression equations in other reports. RESULTS: The regression equation for the normal PEF predictive value(L/min) is 25.117+4.587×Age(year)-0.064×Age2+2.931×Height(cm) in men in men(R2=0.25), and 146.942-0.011×Age2+1.795×Height(cm)+0.836×Weight (kg) in women(R2=0.21). The regression equation for the lower limit of this value (L/min) is 25.117+4.587×Age(year)-0.064×Age2+1.936×Height (cm) in men, and 146.942-0.011×Age2+1.232× Height (cm)+0.481×Weight (kg) in women. The residuals were normally distributed. The PEF in Korean males was similar to those reported in British and Japanese subjects. The PEF in Korean females was similar to that in British subjects, But higher than the PEF in Japanese subjects. The lower limit of normal value was 71% of normal predictive PEF value in men and 76% in women. CONCLUSION: The normal predictive PEF value and its lower limit was measured from 233 male and 631 female asymptomatic, lifelong non-smoking participants. The normal predictive value was different from those of other studies on Korean subjects. Therefore, further studies are required.
Adult
;
Asian Continental Ancestry Group
;
Asthma
;
Female
;
Humans
;
Male
;
Reference Values
;
Spirometry
7.Measurement of Malonate Concentration using Malonyl-CoA Synthetase and Its Relationship with Disease.
Seung Kyoo HAN ; Jeung Kyu KIM ; Seung Ryeoul PARK ; Chung Soon CHANG ; Yu Sam KIM
Journal of the Korean Pediatric Society 1995;38(9):1167-1175
No abstract available.
Ligases*
8.An Immunohistochemical study on distribution of natural killer(NK) cell in patients with cervical dysplasia and cervical cancer.
Kyu Wan LEE ; Hai Joong KIM ; Pyoung Sam KU ; Bom Woo YEOM
Korean Journal of Gynecologic Oncology and Colposcopy 1993;4(1):19-31
Natural Killer (NK) cells are a subpopulation of in vivo activated lymphocytes that display spontaneous cytotoxicity against a variety of targets as virus-infeeted, and transformed neoplastic cells, in major histocompatibility-unrestricted fashion. Depression of the NK aetivity in patients with advanced stages of various types of solid neopls,sms appears to be dependent upon the prcgressive growth and metastatic spread of the tumor. There are many reports that different distribution of subpopulations of lymphocytes in neopiastic tissue may influence the prognosis of the patients, In this study, we have performed immunohistochemieal study with Leu-7, MT1, LN2, and antilysozyrne antiserum on the tissue of uterine cervieal dysplasia and cancer to investigate the distribution of the NK cell, T cell, B cell, and macrophage. The results were as follows ; 1. The major subpopulation of lymphocytes infiltrating the lesion of intraepithelial neoplasia and squamous cell carcinama was T cell. 2. The number of infiltrated. lymphocytes was layer in the lesion of keratinzing type than in that of non keratinizing and small cell earcinorna of the uterine cervix. 3. NK cell was more frequently noted in the malignant lesion than the dysplastic lesion.
Cervix Uteri
;
Depression
;
Female
;
Humans
;
Killer Cells, Natural
;
Lymphocytes
;
Macrophages
;
Prognosis
;
Uterine Cervical Neoplasms*
9.A clinicopathologic review of the early gastric adenocarcinoma (231 cases).
Byeung Ahm LEE ; Woo Young KIM ; Yoon Kyu PARK ; Eul Sam CHUNG
Journal of the Korean Cancer Association 1992;24(1):130-139
No abstract available.
Adenocarcinoma*
10.Treatment of polymastia involving labia majora.
Shin Kyu LEE ; Ing Gon KIM ; Hee Youn CHOI ; Jai Mann LEW ; Sam Hyun JO
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1992;19(3):453-458
No abstract available.