1.Acute Pulmonary Hypertension Associated with Protamine Neutralization of Systemic Heparinization during Open Heart Surgery.
Korean Journal of Anesthesiology 1996;31(2):269-274
Protamine sulfate, a strong polycationic polypeptide, combined with acidic heparin to form a neutral salt, eliminates the anticoagulating properties of heparin. Heparin reversal with protamine after cardiopulmonary bypass may complicate with adverse hemodynamic effects including systemic hypotension, decreased cardiac output, changes in systemic and pulmonary vascular resistances, anaphylaxis and noncardiogenic pulmonary edema. We recently observed a case of severe pulmonary vasoconstriction with right ventricular failure after protamine administration in 37-year-old woman with mitral stenosis who underwent mitral valvuloplasty. After uneventful termination of cardiopulmonary bypass, administration of protamine was associated with sudden elevation of pulmonary arterial pressure with profound right ventricular distension and systemic hypotension by which heparin-protamine reaction is suspected. After intravenous epinephrine infusion and cardiac massage, these changes were reversed. Although the mechanism of this protamine-heparin induced response is unclear, complement activation and thromboxane release may play a role in the development of pulmonary vasoconstriction.
Adult
;
Anaphylaxis
;
Arterial Pressure
;
Cardiac Output
;
Cardiopulmonary Bypass
;
Complement Activation
;
Epinephrine
;
Female
;
Heart Massage
;
Heart*
;
Hemodynamics
;
Heparin*
;
Humans
;
Hypertension, Pulmonary*
;
Hypotension
;
Mitral Valve Stenosis
;
Protamines
;
Pulmonary Edema
;
Thoracic Surgery*
;
Vasoconstriction
2.The Effect of Thiopental on Jugular Venous Oxygen Saturation during Rewarming in Cardiopulmonary Bypass.
Kyu Sam HWANG ; In Cheol CHOI ; Myung Won CHO
Korean Journal of Anesthesiology 1996;31(4):484-493
BACKGROUND: We examined the ability of thiopental known to have protective effect on brain to prevent brain damage resulting from cerebral ischemia due to global imbalance in cerebral metabolic rate for oxygen and cerebral blood flow during rewarming period in cardiopulmonary bypass. METHODS: Jugular venous oxygen saturation(SjO2) was used as a reflection of cerebral oxygen balance. Thiopental 20 mg/kg(thiopental 10 mg/kg bolus and 10 mg/kg continuous infusion) was received during rewarming from hypothermic cardiopulmonary bypass of 27~30.5degrees C to 36degrees C and SjO2 compared with control group. RESULTS: In 8 patients of the 25 control group(32%) and 7 patients of the 24 thiopental group(29.2%), SjO2 were < or =50% with no difference between groups. Artery-jugular vein oxygen content differences (C(a-j)O2) and O2 extraction ratios increased significantly in SjO2 < or =50% patients suggesting increased oxygen consumption. Awake time prolonged significantly with thiopental. CONCLUSIONS: Thiopental(20 mg/kg) administration during rewarming in cardiopulmonary bypass for cerebral protection is not recommended.
Anesthetics
;
Brain
;
Brain Ischemia
;
Cardiopulmonary Bypass*
;
Heart
;
Humans
;
Oxygen Consumption
;
Oxygen*
;
Rewarming*
;
Thiopental*
;
Veins
3.The Effect of Selective Muscarinic Receptor Antagonists on Antiallodynic Action in a Rat Model of Neuropathic Pain.
Jai Hyun HWANG ; Heung Rak SHIM ; Kyu Sam HWANG
Korean Journal of Anesthesiology 1998;34(6):1104-1112
BACKGROUND: Peripheral nerve injury may produce a syndrome consisting of spontaneous pain, allodynia and hyperpathia. In previous study, we examined the antiallodynic action produced by intrathecal (i.t.) cholinesterase inhibitors (ChEi) in a neuropathic pain rat model and the reversal of antiallodynic state by i.t. atropine, muscarinic antagonist, but not by nicotinic antagonist mecamylamine. The purpose of this study was to determine the selective antagonistic action of four subtypes of muscarinic receptor on antiallodynic state by i.t. ChEi in a rat model of neuropathic pain. METHODS: Sprague Dawley rats were prepared with tight ligation of left L5/L6 spinal nerves with 6-0 black silk and chronic lumbar intrathecal catheters. After obtaining the baseline hindpaw withdrawal scores, edrophonium (100 microgram) or neostigmine (10 microgram) was administered intrathecally. Tactile allodynia was measured using von Frey filaments and allodynic threshold was calculated by the up-down method. Allodynic changes were tested at 15, 30, 45, 60, 90, 120 and 180 minutes. To examine the reversal of antiallodynia and to compare the antagonizing action of antiallodynic state produced by i.t. administration of ChEi, non-selective muscarinic receptor antagonists atropine (10 microgram), M1 antagonist pirenzepine (3 microgram), M2 antagonist methoctramine (3 microgram), M3 antagonist 4-DAMP (3 microgram) and M4 antagonist tropicamide (3 microgram) were injected intrathecally respectively 5 minutes prior to the injection of edrophonium or neostigmine. RESULTS: Antiallodynia produced by i.t. edrophonium was reversed by pretreatment with i.t. methoctramine, 4-DAMP, tropicamide and pirenzepine (P<0.05). On the contrary, antiallodynic state made by i.t. neostigmine was not antagonized by methoctramine, 4-DAMP and tropicamide. M1 antagonist pirenzepine had a moderate, statistically significant (P<0.05) effect on reversal of increased allodynic threshold while atropine showed a complete antagonism. CONCLUSION: These experiments suggest that antialllodynic action of cholinesterase inhibitors is likely due to mediation of spinal muscarinic system and M1 receptor subtype is more likely involved in this mechanism.
Animals
;
Atropine
;
Catheters
;
Cholinesterase Inhibitors
;
Edrophonium
;
Hyperalgesia
;
Ligation
;
Mecamylamine
;
Models, Animal*
;
Negotiating
;
Neostigmine
;
Neuralgia*
;
Peripheral Nerve Injuries
;
Pirenzepine
;
Rats*
;
Rats, Sprague-Dawley
;
Receptors, Muscarinic*
;
Silk
;
Spinal Nerves
;
Tropicamide
4.Changes of Pulmonary Artery Pressure during Liver Transplantation.
Kyu Taek CHOI ; Jong Yeon PARK ; Kyu Sam HWANG ; Eun Ho LEE
Korean Journal of Anesthesiology 2001;40(3):340-347
BACKGROUND: Pulmonary hypertension (PH) associated with end stage liver disease is rare but the risk of hemodynamic deterioration during liver transplantation may be high. This study was done to characterize the pulmonary hemodynamics during liver transplantation and to seek the relationship between pulmonary artery pressure (PAP) and other hemodynamic variables. METHODS: One hundred patients undergoing liver transplantation were chosen and we divided patients into normal and PH groups (mean pulmonary artery pressure [MPAP] > 25 mmHg). Hemodynamic data was collected throughout the surgery. Studied variables between groups were analyzed with an unpaired t-test. The relationship between MPAP and other hemodynamic variables was analyzed with a linear regression test. Survival analysis was performed by cumulative survival analysis (Logrank test). RESULTS: Incidence of PH during liver transplantation was 34%, and true PH (pulmonary vascular resistance index [PVRI] > 150 dyne.sec/cm5/m2, MPAP > 25 mmHg) was 7%. MPAP, systemic vascular resistance index, cardiac index, right ventricular ejection fraction, maximum elastance, central venous pressure (CVP), pulmonary artery occlusion pressure (PAOP), and right ventricular end-diastolic volume index were significantly higher in the PH group. In the PH group, right ventricular function curve was abnormal. MPAP correlated significantly with PAOP, and CVP (P < 0.01). One year survival rate showed no significant difference between groups (Logrank test P = 0.49). CONCLUSIONS: Episodes of increased pulmonary artery pressure during liver transplantation was not infrequent. PAP was more dependent on preloads. In patients with high PAP, RV diastolic dysfunction was usually observed. Early mortality rate after liver transplantation was not associated with PH.
Central Venous Pressure
;
End Stage Liver Disease
;
Hemodynamics
;
Humans
;
Hydrogen-Ion Concentration
;
Hypertension, Pulmonary
;
Incidence
;
Linear Models
;
Liver Transplantation*
;
Liver*
;
Mortality
;
Pulmonary Artery*
;
Stroke Volume
;
Survival Rate
;
Vascular Resistance
;
Ventricular Function, Right
5.The Effect of Hyperventilation on Serum Potassium Concentration During Infusion of Mannitol.
Kyu Sam HWANG ; Joung Uk KIM ; Jong Ho CHOI ; So Young LEE ; Eun Ju LEE ; Sung Min HAN
Korean Journal of Anesthesiology 1997;33(5):876-882
BACKGROUND: Mannitol is widely used in neurosurgical patients and may induce an increase in serum potassium concentration according to doses and administration rates with unknown mechanism. The treatment of hyperkalemia is aimed at eliminating the causes and includes calcium, sodium bicarbonate, glucose with insulin, loop diuretics and hyperventilation. This study was undertaken to observe the effects of hyperventilation on the serum potassium concentration following infusion of mannitol (2.0 gm/kg). METHODS: We studied 30 patients who were operated brain aneurysm clipping surgery and were divided into 3 groups (n=10). In control group, mild hypocapnia was maintained (PaCO2, 32 2 mmHg) before and after mannitol infusion. In group I, moderate hypocapnia was maintained (PaCO2, 27 2 mmHg) before and after mannitol infusion. In group II, mild hypocapnia (PaCO2, 32 2 mmHg) was maintained before 30 minutes of mannitol infusion and moderate hypocapnia (PaCO2, 27 2 mHg) after mannitol infusion. We started infusion of 20% mannitol with a dosage of 2.0 gm/kg, 15~20 min after cranium was opened. RESULTS: The changes of serum potassium were as follows (Mean SD mEq/l) (just before and 15min, 30min, 60min after mannitol infusion): 3.79 0.48, 4.66 0.60, 4.44 0.48, 4.13 0.40 (Control group), 3.62 0.18, 3.63 0.42, 4.14 0.51, 3.95 0.33 (Group I), 3.76 0.20, 3.91 0.15, 4.11 0.30, 4.04 0.23 (Group II). After 15 minutes of mannitol infusion, the serum potassium levels of group I and II were lower than that of control group (p<0.05) and there was no significant difference between group I and II. CONCLUSIONS: These results suggest that hyperventilation may blunt the increase in serum potassium concentration following rapid infusion of high dose mannitol.
Calcium
;
Glucose
;
Humans
;
Hyperkalemia
;
Hyperventilation*
;
Hypocapnia
;
Insulin
;
Intracranial Aneurysm
;
Mannitol*
;
Potassium*
;
Skull
;
Sodium Bicarbonate
;
Sodium Potassium Chloride Symporter Inhibitors
6.The Effects of Pressor Response upon Intravenous Ephedrine Following Oral Clonidine Premedication in Anesthetized Patients.
Hee Jung JUN ; So Young LEE ; Kyu Sam HWANG
Korean Journal of Anesthesiology 1999;37(3):363-367
BACKGROUND: In some studies, 5 microgram/kg clonidine premedication was claimed to enhance the pressor effects of ephedrine in anesthetized patients. We studied hemodynamic responses to intravenous responses, themselves responses to intravenous ephedrine in patients who received clonidine 3 microgram/kg. METHODS: 40 ASA pysical status I or II patients were randomly assigned to either the clonidine group (n = 20), receiving oral clonidine 3 microgram/kg 90 min before general anesthesia, or the control group (n = 20), receiving no clonidine. Hemodynamic measurements were made at one-minute intervals for ten minutes after ephedrine 0.1 mg/kg was injected as a bolus. RESULTS: The magnitude of maximal systolic blood pressure increases in the clonidine group (13.2+/-9.3%) was no different in the control group (12.4+/-12.3%). There were no difference in the pressor effect and duration of response of ephedrine in both groups. CONCLUSIONS: The pressor effect of ephedrine is not enhanced in patients given 3 microgram/kg clonidine premedication during general anesthesia.
Anesthesia, General
;
Blood Pressure
;
Clonidine*
;
Ephedrine*
;
Hemodynamics
;
Humans
;
Premedication*
7.Anesthesia for Synchronous Liver-Kidney Transplantation.
In Young HUH ; In Sook CHO ; Kyu Sam HWANG ; Kyu Taek CHOI
Korean Journal of Anesthesiology 2002;42(3):414-421
Until recently liver transplantation has been considered a contraindication in patients with multi-organ failure. However, developements in surgery and anesthetic technique involving intraoperative extrarenal purification provide adequate conditions for performing synchronous liver-kidney transplantation (SLKT), and it is clear that double transplantation is the best therapeutic option in end stage liver and kidney disease. Liver transplantation involves a large blood loss and fluid replacement, as well as administration of large amounts of blood products. Patients with end stage liver and kidney disease have a reduced capacity to excrete free water, predisposing them to an accumulation of extravascular water. Precise monitoring and the intraoperative use of an extrarenal purification technique to maintain these patients within acceptable hydroelctrolyte and hemodynamic parameters is needed. We experienced two cases of SLKT and report on anesthetic management and problems.
Anesthesia*
;
Hemodynamics
;
Humans
;
Kidney
;
Kidney Diseases
;
Liver
;
Liver Transplantation
;
Transplantation
;
Water
8.Anesthetic Experience in Ex Situ Resection of The Liver: A case report.
Jong Yeon PARK ; In Gu JUN ; Kyu Sam HWANG ; Kyu Taek CHOI
Korean Journal of Anesthesiology 2004;46(1):127-130
Ex situ resection of the liver is an alternative surgical procedure for patients with conventionally unresectable hepatic tumors, and with contraindications to liver transplantation. We experienced a case of ex situ resection of the liver in a 40-year-old female patient suffering from sclerosing hepatocellular carcinoma. Preoperative liver function was normal. The duration of the anhepatic period was 2 hours and 55 minutes. No severe hemodynamic or pulmonary complications, and no significant metabolic or coagulatory disorders occurred. To obtain good results by ex situ resection of the liver, anesthesiologist should understand the physiology of the anhepatic period and guard against possible problems during the operation. (Korean J Anesthesiol 2004; 46: 127~130)
Adult
;
Carcinoma, Hepatocellular
;
Female
;
Hemodynamics
;
Hepatectomy
;
Humans
;
Liver Transplantation
;
Liver*
;
Physiology
;
Transplantation
9.Hemodynamic Response to a Rapid Fluid Challenge in End-Stage Liver Disease .
Jang Ho SONG ; Kyu Sam HWANG ; Heung Rak SHIM ; Mi Jeung GWAK ; Su Keoung LEE ; Kyu Taek CHOI
Korean Journal of Anesthesiology 2002;42(3):318-324
BACKGROUND: Patients with end-stage liver disease have a hyperdynamic circulatory state complicated by a high right ventricular end-diastolic volume index (RVEDVI) and a low ventricular performance. These changes often make if difficult to evaluate volume status and preload. In this study, we analyzed hemodynamic profiles after a rapid fluid challenge in the recipients of a liver transplant. METHODS: Hemodynamic responses were evaluated before and after 200 ml of a 5% albumin challenge in forty patients, recipients of a liver transplant with a Swan-Ganz right-heart ejection fraction oximetry thermodilution cathether. Patients were divided into two groups, group A (responders, n=12, >or= 10% increase in stroke volume index (SVI) after fluid challenge) and group B (non-responders, n = 28, decrease or < 10% increase in SVI after fluid challenge). We analyzed hemodynamic data obtained from the two groups before and after the fluid challenge. RESULTS: Group B had a lower baseline right ventricular ejection fraction (REF) (49.9+/-5.9% vs 42.8+/-5.7%), a higher RVEDVI (120.8+/-19.4 ml/m2 vs 143.6+/-26.3 ml/m2), and a higher right ventricular end-systolic volume index (RVESVI) (60.8+/-14.0 ml/m2 vs 82.8+/-20.5 ml/m2) than group A. In group B, the cardic index (CI) and right ventricular stroke work index (RVSWI) were not increased after the fluid challenge. There was a mild decrease in the mean arterial pressure (MAP) in group B after the fluid challenge. There was a moderate negative correlation between the fluid-induced change in SVI and the baseline RVEDVI in all patients (r =-0.40, P<0.05). CONCLUSIONS: Our study suggests that there is no improvement of hemodynamic profiles after a rapid fluid challenge in many patients with end-stage liver disease, especially those with a high RVEDVI.
Arterial Pressure
;
Hemodynamics*
;
Humans
;
Liver Diseases*
;
Liver*
;
Oximetry
;
Stroke
;
Stroke Volume
;
Thermodilution
;
Transplantation
10.Hemodynamic Changes during the Pringle Maneuver in Patients with Abnormal Liver Function.
Soon Eun PARK ; Kyu Taek CHOI ; Kyu Sam HWANG ; Mi Young AHN ; Kwang Min PARK
Korean Journal of Anesthesiology 1999;37(6):1020-1026
BACKGROUND: During the Pringle maneuver (PM), the increase of systemic vascular resistance (SVR) and the active constriction of the intrahepatic capacitance vessels could minimize arterial blood pressure change. Pressor reactivity to sympathetic agonists is impaired and blood volume buffering capability is less efficient in a cirrhotic liver. Accordingly, we evaluated the relations between hemodynamics during PM and preoperative liver function test (LFT) by serum aminotransferase and Indocyanine Green (ICG) clearance. METHODS: Twenty-seven patients undergoing hepatectomy with PM were classified into two groups according to the liver function state assigned by serum aminotransferases and ICG clearance test. Sequential changes of hemodynamics were measured with Doppler flowmeter during PM. Hemodynamic data were analyzed by using ANOVA for repeated measurement. Correlation between LFTs were sought using Pearson correlation and logistic regression. RESULTS: During the PM, cardiac output decreased significantly compared to the preclamping period in the abnormal LFT group. There were no significant changes in any other hemodynamic variables in the normal LFT group. When comparing the two groups during PM, mean arterial blood pressures and cardiac output were significantly lower in the abnormal LFT groups compared to the normal LFT groups (P< 0.05). CONCLUSIONS: These differences may suggest that cardiovascular responsiveness to reflex autonomic stimulation during the PM is significantly impaired in patients with abnormal LFT compared with normal LFT subjects.
Arterial Pressure
;
Blood Volume
;
Cardiac Output
;
Constriction
;
Flowmeters
;
Hemodynamics*
;
Hepatectomy
;
Humans
;
Indocyanine Green
;
Liver Function Tests
;
Liver*
;
Logistic Models
;
Reflex
;
Transaminases
;
Vascular Resistance