1.Variations in the size of the ischemic myocardium due to differences in the normal file.
Jae Tae LEE ; Kyu Bo LEE ; Jaekyeong HEO ; S Iskan ABDULMASSHI
Korean Journal of Nuclear Medicine 1992;26(1):49-57
No abstract available.
Myocardium*
2.The Findings of MRI and Transcranial Doppler Sonography in Three Cases of Moyamoya Disease.
Kwang S LEE ; Dong W YANG ; Sung W CHUNG ; Jung H NA ; Yeong I KIM ; Beum S KIM ; Kyu H CHOI
Journal of the Korean Neurological Association 1994;12(1):120-125
The confirmatory diagnosis of Moyamoya disease has been obtained by invasive angiographic examination. We report the results of MRI and transcranial doppler sonography of three cases ol Moyamoya disease, which ws disgnosed by clinical and angiography. We think that the diagnosis of Moyamoya disease can be made by noninvasive MRI and transcranial doppler sonography without conventional invasive angiography.
Angiography
;
Diagnosis
;
Magnetic Resonance Imaging*
;
Moyamoya Disease*
;
Ultrasonography, Doppler, Transcranial*
3.Comparison of Drug-eluting Coronary Stents, Bare Coronary Stents and Self-expanding Stents in Angioplasty of Middle Cerebral Artery Stenoses.
Jong Hyeog LEE ; Sung Min JO ; Kwang Deog JO ; Moon Kyu KIM ; Sang Youl LEE ; Seung Hoon YOU
Journal of Cerebrovascular and Endovascular Neurosurgery 2013;15(2):85-95
OBJECTIVE: The purpose of this study is to investigate the results of treatment using stent-angioplasty for symptomatic middle cerebral arterial (MCA) stenosis and comparison of in-stent restenosis between drug-eluting stents (DES), bare metal coronary stents (BMS) and self-expanding stents (SES). MATERIALS AND METHODS: From Jan. 2007 to June. 2012, 34 patients (mean age +/- standard deviation: 62.9 +/- 13.6 years) with MCA stenosis were treated. Inclusion criteria were acute infarction or transient ischemic attacks (TIAs) and angiographically proven symptom related severe stenosis. Stents used for treatment were DES (n = 8), BMS (n = 13) and SES (n = 13). National Institutes of Health Stroke Scale (NIHSS) at admission was 2.5 +/- 3.1 and mean stenosis rate was 79.0 +/- 8.2%. Assessment of clinical and angiographic results was performed retrospectively. RESULTS: Among 34 patients, periprocedural complications occurred in four cases (11.8%), however, only two cases (6.0%) were symptomatic. All patients were followed clinically (mean follow-up period; 40.7 +/- 17.7 months) and 31 were followed angiographically (91.2%. 13.4 +/- 8.5 months). There was no occurrence of repeat stroke in all patients; however, mild TIAs related to restenosis occurred in three of 34 patients (8.8%). The mean NIHSS after stent-angioplasty was 1.7 +/- 2.9 and 0.8 +/- 1.1 at discharge. The modified Rankin score (mRS) at discharge was 0.5 +/- 0.9 and 0.3 +/- 0.8 at the last clinical follow-up. In-stent restenosis over 50% occurred in five of 31 angiographically followed cases (16.1%), however, all of these events occurred only in patients who were treated with BMS or SES. Restenosis rate was 0.0% in the DES group and 20.8% in the other group (p = 0.562); it did not differ between BMS and SES (2/11 18.2%, 3/13 23.1%, p = 1.000). CONCLUSION: Stent-angioplasty appears to be effective for symptomatic MCA stenosis. As for restenosis, in our study, DES was presumed to be more effective than BMS and SES; meanwhile, the results did not differ between the BMS and SES groups.
Angioplasty
;
Constriction, Pathologic
;
Drug-Eluting Stents
;
Follow-Up Studies
;
Humans
;
Infarction
;
Ischemic Attack, Transient
;
Middle Cerebral Artery
;
National Institutes of Health (U.S.)
;
Stents
;
Stroke
4.Pathologic Examination of the Collagen Change by Interferon Gamma in the Obstructed Bladder of the Rat.
Kwang Myung KIM ; Jung Y JUNG ; Jong M YOON ; Kyung Chul LEE ; Kyu S LEE
Journal of the Korean Continence Society 1997;1(1):33-33
No abstract available.
Animals
;
Collagen*
;
Interferons*
;
Rats*
;
Urinary Bladder*
5.CKbeta8-1 alters expression of cyclin E in colony forming units-granulocyte macrophage (CFU-GM) lineage from human cord blood CD34 + cells.
Eui Kyu NOH ; Jae Sun RA ; Seong Ae LEE ; Byoung S KWON ; In Seob HAN
Experimental & Molecular Medicine 2005;37(6):619-623
A C6 beta-chemokine, CKbeta8-1, suppressed the colony formation of CD34 + cells of human cord blood (CB). Molecular mechanisms involved in CKbeta8-1-medicated suppression of colony formation of CD34 + cells are not known. To address this issue, the level of various G1/S cell cycle regulating proteins in CKbeta8-1-treated CD34 + cells were compared with those in untreated CD34 + cells. CKbeta8-1 did not significantly alter the expression of the G1/S cycle regulation proteins (cyclin D1, D3, and E), CDK inhibitor (p27and Rb), and other cell proliferation regulation protein (p53) in CB CD34 + cells. Here we describe an in vitro system in which CB CD34 + cells were committed to a multipotent progenitor lineage of colony forming units-granulocyte/macrophage (CFU-GM) by a simple combination of recombinant human (rh) GM-CSF and rhIL-3. In this culture system, we found that cyclin E protein appeared later and disappeared faster in the CKbeta8-1-treated cells than in the control cells during CFU-GM lineage development. These findings suggested that cyclin E may play a role in suppressing the colony formation of CFU-GM by CKbeta8-1.
Antigens, CD34/metabolism
;
Cell Cycle Proteins/metabolism
;
Cell Lineage
;
Cells, Cultured
;
Chemokines, CC/*pharmacology
;
Cyclin E/*metabolism
;
Fetal Blood/*cytology
;
G1 Phase/drug effects
;
Gene Expression Regulation/*drug effects
;
Granulocytes/cytology/*drug effects/metabolism
;
Growth Substances/pharmacology
;
Humans
;
Macrophages/cytology/*drug effects/metabolism
;
Research Support, Non-U.S. Gov't
;
Stem Cells/cytology/*drug effects/metabolism
6.A case of neuroacanthosis: an easy diagnosis.
Beom S JEON ; Te Gyu LEE ; Seong Hye CHOI ; Jae Kyu ROH ; Je G CHI
Journal of the Korean Neurological Association 1995;13(4):965-969
No abstract available.
Diagnosis*
7.A Clinical Study of Topical Minoxidil Therapy in Alopecia: Multicenter Trials.
Min Geol LEE ; Moon Soo YOON ; Jung Bock LEE ; Byung In RO ; Hyung Ok KIM ; Kyung Jae CHUNG ; Choong Rim HAW ; Kyu Suk LEE ; S N KIM ; S J SON ; J A KIM ; H J KIM ; H I KOOK ; H S SUNG ; Y P KIM ; C W IHM ; J K PARK ; K J KIM ; J H KIM
Korean Journal of Dermatology 1986;24(2):181-189
No abstract available.
Alopecia*
;
Minoxidil*
8.Genetic Identification of Spirometra decipiens Plerocercoids in Terrestrial Snakes from Korea and China.
Hyeong Kyu JEON ; Hansol PARK ; Dongmin LEE ; Seongjun CHOE ; Kyu Heon KIM ; Woon Mok SOHN ; Keeseon S. EOM
The Korean Journal of Parasitology 2016;54(2):181-185
Human sparganosis is a zoonotic disease caused by infection with larval forms (procercoid/plerocercoid) of Spirometra spp. The purpose of this study was to identify Spirometra spp. of infected snakes using a multiplex PCR assay and phylogenetic analysis of mitochondrial DNA sequence data from the spargana of terrestrial snakes obtained from Korea and China. A total of 283 snakes were obtained that included 4 species of Colubridae comprising Rhabdophis tigrinus tigrinus (n=150), Dinodon rufozonatum rufozonatum (n=64), Elaphe davidi (n=2), and Elaphe schrenkii (n=7), and 1 species of Viperidae, Agkistrodon saxatilis (n=60). The snakes were collected from the provinces of Chungbuk, Chungnam, and Gyeongbuk in Korea (n=161), and from China (n=122). The overall infection rate with spargana was 83% (235/283). The highest was recorded for D. rufozonatum rufozonatum (100%), followed by A. saxatilis (85%) and R. tigrinus tigrinus (80%), with a negative result for E. davidi (0%) and E. schrenkii (0%). The sequence identities between the spargana from snakes (n=50) and Spirometra erinaceieuropaei (KJ599680) or S. decipiens (KJ599679) control specimens were 90.8% and 99.2%, respectively. Pairwise genetic distances between spargana (n=50) and S. decipiens ranged from 0.0080 to 0.0107, while those between spargana and S. erinaceieuropaei ranged from 0.1070 to 0.1096. In this study, all of the 904 spargana analyzed were identified as S. decipiens either by a multiplex PCR assay (n=854) or mitochondrial cox1 sequence analysis (n=50).
Agkistrodon
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China*
;
Chungcheongbuk-do
;
Chungcheongnam-do
;
Colubridae
;
DNA, Mitochondrial
;
Gyeongsangbuk-do
;
Humans
;
Korea*
;
Multiplex Polymerase Chain Reaction
;
Sequence Analysis
;
Snakes*
;
Sparganosis
;
Sparganum
;
Spirometra*
;
Viperidae
;
Zoonoses
9.Palpation Device for the Identification of Kidney and Bladder Cancer: A Pilot Study.
Jae Won LEE ; Enrique Ian S LORENZO ; Bummo AHN ; Cheol Kyu OH ; Hyung Joo KIM ; Woong Kyu HAN ; Jung KIM ; Koon Ho RHA
Yonsei Medical Journal 2011;52(5):768-772
PURPOSE: To determine the ability of a novel palpation device to differentiate between benign and malignant tissues of the kidney and bladder by measuring tissue elasticity. MATERIALS AND METHODS: A novel palpation device was developed, mainly composed of a micromotor, a linear position sensor, a force transducer, and a hemisphere tip and cylindrical body probe. Motion calibration as well as performance validation was done. The tissue elasticity of both benign and malignant tissues of the kidney and bladder was measured using this device. A single investigator performed the ex-vivo palpation experiment in twelve kidneys and four bladder specimens. Malignant tissues were made available from partial nephrectomy specimens and radical cystectomy specimens. Palpations for benign renal parenchyma tissue were carried out on nephroureterectomy specimens while non-involved areas in the radical cystectomy specimens were used for benign bladder samples. Elastic modulus (Young's modulus) of tissues was estimated using the Hertz-Sneddon equation from the experimental results. These were then compared using a t-test for independent samples. RESULTS: Renal cell carcinoma tissues appear to be softer than normal kidney tissues, whereas tissues from urothelial carcinoma of the bladder appear to be harder than normal bladder tissues. The results from renal cell carcinoma differed significantly from those of normal kidney tissues (p=0.002), as did urothelial carcinoma of the bladder from normal bladder tissues (p=0.003). CONCLUSION: Our novel palpation device can potentially differentiate between malignant and benign kidney and bladder tissues. Further studies are necessary to verify our results and define its true clinical utility.
Adult
;
Aged
;
Elastic Modulus
;
Elasticity Imaging Techniques/*instrumentation
;
Equipment Design
;
Female
;
Humans
;
Kidney/physiology
;
Kidney Neoplasms/*diagnosis/physiopathology
;
Male
;
Middle Aged
;
Palpation/*instrumentation
;
Phantoms, Imaging
;
Pilot Projects
;
Urinary Bladder/physiology
;
Urinary Bladder Neoplasms/*diagnosis/physiopathology
10.Mitochondrial Genome Sequences of Spirometra erinaceieuropaei and S. decipiens (Cestoidea: Diphyllobothriidae).
Keeseon S EOM ; Hansol PARK ; Dongmin LEE ; Seongjun CHOE ; Kyu Heon KIM ; Hyeong Kyu JEON
The Korean Journal of Parasitology 2015;53(4):455-463
The present study was performed to compare the mitochondrial genomes between 2 Spirometra tapeworms, Spirometra erinaceieuropaei and Spirometra decipiens (Cestoidea: Diphyllobothriidae), which larval stages are important etiological agents of sparganosis in humans. For each species, the full mitochondrial genome was amplified in 8 overlapping fragments using total genomic DNA purified from a single worm as the template. The mitochondrial genomes were 13,643 bp (S. erinaceieuropaei) and 13,641 bp (S. decipiens) in length and contained 36 genes; 12 protein-coding genes, 2 ribosomal RNA (rRNA, small and large subunits), and 22 transfer RNAs (tRNAs). The 12 protein-coding genes constituted 10,083 bp (S. erinaceieuropaei) and 10,086 bp (S. decipiens) of their respective mitochondrial genomes. The tRNA genes, ranging in length from 56 to 70 bp, were identified based on putative secondary structures such as the typical cloverleaf shape. A total of 23 intergenic sequences, varying from 1 to 204 bp in size, were interspersed in S. erinaceieuropaei (total, 504 bp) and S. decipiens (total, 496 bp) mtDNA. The 12 protein-coding genes of S. erinaceieuropaei and S. decipiens differed by 12.4%, whereas the overall difference in mtDNA sequence between S. erinaceieuropaei and S. decipiens was 12.9%. Thus, from the standpoint of the mitochondrial genome, S. decipiens represents a valid species that can be distinguished from S. erinaceieuropaei.
Animals
;
Base Sequence
;
Cestode Infections/parasitology
;
DNA, Mitochondrial/chemistry/genetics
;
*Genome, Helminth
;
*Genome, Mitochondrial
;
Humans
;
Molecular Sequence Data
;
Nucleic Acid Conformation
;
Open Reading Frames
;
Phylogeny
;
Spirometra/chemistry/classification/*genetics