The most common ocular finding of the idiopathic thrombocytopenic purpura(ITP) is superficial retinal hemorrhages in both eyes. But the descriptions of new vessel on the optic disc(NVD) associated with ITP are scarcely found in literatures. A 17-year-old girl who managed for ITP complained of visual distrubance of the right eye and floaters of the left eye. On fundoscopy the right eye was failed to examine due to thick vitreous hemorrhage and the left eye showed NVD and preretinal hemorrhage. After panretinal photocoagulation of the left eye, NVD was regressed.

OBJECTIVES: lschemic acute renal failure(ARF) is characterized by an abrupt and sustained decline in GFR within minutes to days after renal ischemia and not immediately reversed on restoration of renal blood flow. The typical delay of a few days to a few weeks suggests reversible parenchymal damage awaiting cell regeneration for functional recovery. Many potentially cell damaging factors, such as ATP depletion, plasma membrane phospholipid degradatian and superoxide-induced membrane damage, play a central part in ischemic injury. More recently, much attention has been focused on the role of calcium, especially ischemic cell injury and the possible therapeutic role of calcium channel blockers emerged from studies conducted several years ago. In the past, it was thought that activation of renin-angiotensin system plays a role in the pathogenesis of ARF. Now the role of angiotensin in human renal ischemia also appears to be controversial. The following study was done in order to investigate the effect of a calcium channel blocker, nifedipine, on gene expression of renin during acute ischemic renal injury. METHODS: The Sprague-Dawley rats were divided into 4 groups, group I(n=3) as the control, group II (n=3) as the sham operation group, group III(n=15) as the ischemic renal injury group without nifedipine pretreatment, and group IV(n=15) as the ischemic renal injury model by right nephrectomy and left renal artery clamping for 40 minutes with systemic nifedipine pretreatment(10mg/kg), 1n ischemic renal injury model(group III and IV), rats were further divided into three subgroups according to reperfusion time of 1,24,72 hours. The non-ischemic right kidney removed at the time of initial procedure served as paired control. Total renal RNA was extracted by Chomczynskis method and electrophoresis was done in a 1% agarose gel containing 2,2M formaldehyde. Northern was performed at 42degrees C with isotope labeled renin probe for 18 hours, Autoradiographs were obtained and quantitated by a densitometer measured at 530nm. RESULTS: 1) The expression of renin gene was markedly decreased after renal ischemia and slowly recovered to one half of the control level after 72 hours of reperfusion. 2) Renin gene expression pattern of ischemic renal injury with prior nifedipine treatment was similar to the ischemic group without nifedipine pretreatment. CONCLUSION: These findings suggest that the renin gene expression was markedly decreased after renal ischemia and slowly recovered. Systemic nifedipine pretreatment does not have a significant effect on gene expression pattern of renin in ischemic renal injury.
Adenosine Triphosphate ; Angiotensins ; Animals ; Calcium Channel Blockers ; Calcium Channels* ; Calcium* ; Cell Membrane ; Constriction ; Electrophoresis ; Formaldehyde ; Gene Expression* ; Humans ; Ischemia ; Kidney ; Membranes ; Nephrectomy ; Nifedipine ; Rats ; Rats, Sprague-Dawley ; Regeneration ; Renal Artery ; Renal Circulation ; Renin* ; Renin-Angiotensin System ; Reperfusion ; RNA ; Sepharose

We describe a case of xanthoma on the corneoscleral limbus in a 21-year-old man. It was characterized by a localized, round, elevated, yellowish mass on the right superonasal limbus with 6mm in size. There was no correlation with systemic or metabolic diseases such as hyperlipidemia and the microscopic examination revealed scanty fibrous element.
Humans ; Hyperlipidemias ; Metabolic Diseases ; Xanthomatosis* ; Young Adult

We describe a case of xanthoma on the corneoscleral limbus in a 21-year-old man. It was characterized by a localized, round, elevated, yellowish mass on the right superonasal limbus with 6mm in size. There was no correlation with systemic or metabolic diseases such as hyperlipidemia and the microscopic examination revealed scanty fibrous element.
Humans ; Hyperlipidemias ; Metabolic Diseases ; Xanthomatosis* ; Young Adult

No abstract available.
Acute Kidney Injury* ; Lymphoma*

The authors present a case of tuberculuos periostitis of the orbit which is extremely rare in nowadays. An 18-year-old man who had pulmonary and hepatic tuberculosis complained pain and erythematous swelling of periorbital region. Skull X-ray films showed multiple punched-out lesions on cranial vault. CT scan of the orbit revealed a homogenous mass on lateral orbital wall. The lesion was extended into the intracranial cavity with bony destruction and thickening of dura matter. The cold abscess of lower lid was drained by skin incision and Acid-fast bacilli was isolated from direct smear and culture.
Abscess ; Adolescent ; Humans ; Orbit* ; Periostitis* ; Skin ; Skull ; Tomography, X-Ray Computed ; Tuberculosis, Hepatic ; X-Ray Film

Ganglioneuromas of retroperitoneal cavity which not originate from adrenal gland are very rare tumor, and usually recognized incidental to some other aliment or on a routine physical examination. Ganglioneuromas are generally considered to be the mature form of a triad of tumors arising from neural crest tissue which include malignant neuroblastoma and ganglioneuroblastoma. We report one case of retroperitoneal non-adrenal ganglioneuroma with review of literature.
Adrenal Glands ; Ganglioneuroblastoma ; Ganglioneuroma* ; Neural Crest ; Neuroblastoma ; Physical Examination

No abstract available.
Acute Kidney Injury* ; Nifedipine* ; Plasma* ; Renin*

For an accurate diagnosis we analyzed 15 cases of clinically suspected idiopathic inflammatory pseudotumor(pseudotumor). The patients were 11 men and 4 women(mean age, 45.9 years). They were followed up for an average of 22 months. The final diagnosis was drawn collectively with clinical symptoms and signs, orbital computed tomography(CT), pathologic finding, and response to corticosteroids. In most instances the pathologic reading was reactive lymphoid hyperplasia(RLH). The final diagnosis was not constantly correlated with the pathologic reading; 5 were pseudotumor,6 RLH, and 4 undetermined. It could be concluded that the pseudotumor in the case which presented acute in flammatory symptoms and sings, involved the entire orbit in CT scan, or was cured by corticosteroid therapy. In the cases of no significant inflammatory sings it was difficult to differentiate pseudotumor from RLH with CT scan, pathologic finding, or response to corticosteroids. Although CT-guided fine needle biopsy often provides an insufficient specimen for pathologic diagnosis, it seems a useful diagnostic method, which is a simple and noninvasive technoque. At least the other orbital tumors or granulomatous lesions could be excluded by CT-guided fine needle biopsy.
Adrenal Cortex Hormones ; Biopsy, Fine-Needle ; Diagnosis* ; Granuloma, Plasma Cell* ; Humans ; Male ; Orbit* ; Pseudolymphoma ; Tomography, X-Ray Computed

In general, occlusion of the retinal vein causes marked dlminished visual acuity and poor recovery in elderly persons. Author studied 59 cases of occlusion of retinal vein in the views of sexual and age distribution, laterality, early and later visual acuity, combined systemic and ocular diseases, complications, treatment, and especially findings of fundus fluorescein angiography. The results were as follows: 1. There was no statistical significance in the difference of sexual and age distribution, and laterality of affected eye. 2. The incidence of central retinal vein occlusion is 2.3 times of that of branch retinal vein occlusion. And 78% of all branch retinal vein occulusion affected in superotemporal branch, and remainders in inferotemporal branch. In one case the occlusion had occured at superotemporal and superonasal branch. 3. The early and later visual acuity was poor in central retinal vein occlusion, inferotemporal branch vein occlusion, and superotemporal branch vein occlusion in order. 4. The improvement of visual acuity more than one line in test chart was 52.5% on the average; central retinal vein occlusion(27.8%), inferotemporal branch vein occlusion (55.5%), and superotemporal branch vein occlusion(65.6%). 5. The combined systemic diseases were hypertension, arteriosclerosis, diabetes mellitus etc, and the occular diseases were open-angle glancama and iritis. 6. The causes of poor visual acuity were cystoid macular edema, vitreous hemorrhage, optic nerve damage, complicated neovascular glaucoma, and preexisting open-angle glaucoma. 7. The fundus fluorescein angiography showed delayed filling time, marked dilatation and engorgement of affected vein, dye leakage from affected vein or radial peripapillary capillaries, capillaries, capillary nonperfusion, microaneurysms, cystoid macular edema, collateral circulation, and retinal neovascularization.
Age Distribution ; Aged ; Arteriosclerosis ; Capillaries ; Collateral Circulation ; Diabetes Mellitus ; Dilatation ; Fluorescein Angiography ; Glaucoma, Neovascular ; Glaucoma, Open-Angle ; Humans ; Hypertension ; Incidence ; Iritis ; Macular Edema ; Optic Nerve ; Retinal Neovascularization ; Retinal Vein Occlusion ; Retinal Vein* ; Retinaldehyde* ; Veins ; Visual Acuity ; Vitreous Hemorrhage