The most common ocular finding of the idiopathic thrombocytopenic purpura(ITP) is superficial retinal hemorrhages in both eyes. But the descriptions of new vessel on the optic disc(NVD) associated with ITP are scarcely found in literatures. A 17-year-old girl who managed for ITP complained of visual distrubance of the right eye and floaters of the left eye. On fundoscopy the right eye was failed to examine due to thick vitreous hemorrhage and the left eye showed NVD and preretinal hemorrhage. After panretinal photocoagulation of the left eye, NVD was regressed.

OBJECTIVES: lschemic acute renal failure(ARF) is characterized by an abrupt and sustained decline in GFR within minutes to days after renal ischemia and not immediately reversed on restoration of renal blood flow. The typical delay of a few days to a few weeks suggests reversible parenchymal damage awaiting cell regeneration for functional recovery. Many potentially cell damaging factors, such as ATP depletion, plasma membrane phospholipid degradatian and superoxide-induced membrane damage, play a central part in ischemic injury. More recently, much attention has been focused on the role of calcium, especially ischemic cell injury and the possible therapeutic role of calcium channel blockers emerged from studies conducted several years ago. In the past, it was thought that activation of renin-angiotensin system plays a role in the pathogenesis of ARF. Now the role of angiotensin in human renal ischemia also appears to be controversial. The following study was done in order to investigate the effect of a calcium channel blocker, nifedipine, on gene expression of renin during acute ischemic renal injury. METHODS: The Sprague-Dawley rats were divided into 4 groups, group I(n=3) as the control, group II (n=3) as the sham operation group, group III(n=15) as the ischemic renal injury group without nifedipine pretreatment, and group IV(n=15) as the ischemic renal injury model by right nephrectomy and left renal artery clamping for 40 minutes with systemic nifedipine pretreatment(10mg/kg), 1n ischemic renal injury model(group III and IV), rats were further divided into three subgroups according to reperfusion time of 1,24,72 hours. The non-ischemic right kidney removed at the time of initial procedure served as paired control. Total renal RNA was extracted by Chomczynskis method and electrophoresis was done in a 1% agarose gel containing 2,2M formaldehyde. Northern was performed at 42degrees C with isotope labeled renin probe for 18 hours, Autoradiographs were obtained and quantitated by a densitometer measured at 530nm. RESULTS: 1) The expression of renin gene was markedly decreased after renal ischemia and slowly recovered to one half of the control level after 72 hours of reperfusion. 2) Renin gene expression pattern of ischemic renal injury with prior nifedipine treatment was similar to the ischemic group without nifedipine pretreatment. CONCLUSION: These findings suggest that the renin gene expression was markedly decreased after renal ischemia and slowly recovered. Systemic nifedipine pretreatment does not have a significant effect on gene expression pattern of renin in ischemic renal injury.
Adenosine Triphosphate ; Angiotensins ; Animals ; Calcium Channel Blockers ; Calcium Channels* ; Calcium* ; Cell Membrane ; Constriction ; Electrophoresis ; Formaldehyde ; Gene Expression* ; Humans ; Ischemia ; Kidney ; Membranes ; Nephrectomy ; Nifedipine ; Rats ; Rats, Sprague-Dawley ; Regeneration ; Renal Artery ; Renal Circulation ; Renin* ; Renin-Angiotensin System ; Reperfusion ; RNA ; Sepharose

We describe a case of xanthoma on the corneoscleral limbus in a 21-year-old man. It was characterized by a localized, round, elevated, yellowish mass on the right superonasal limbus with 6mm in size. There was no correlation with systemic or metabolic diseases such as hyperlipidemia and the microscopic examination revealed scanty fibrous element.
Humans ; Hyperlipidemias ; Metabolic Diseases ; Xanthomatosis* ; Young Adult

We describe a case of xanthoma on the corneoscleral limbus in a 21-year-old man. It was characterized by a localized, round, elevated, yellowish mass on the right superonasal limbus with 6mm in size. There was no correlation with systemic or metabolic diseases such as hyperlipidemia and the microscopic examination revealed scanty fibrous element.
Humans ; Hyperlipidemias ; Metabolic Diseases ; Xanthomatosis* ; Young Adult

Ocular ischemic syndrome, characterized by rubeosis iridis, anterior uveitis, retinal arterial narrowing, retinal hemorrhage, cherry red spot, and neovascularization of the disc and/ or retina, is due to anterior and posterior segment ischemia caused by carotid artery obstruction. A 67-year-old man presented a typical ocular ishemic syndrome. The patient complained marked visual disturbance of the both eyes and headache for 15 days. On slit-lamp examination, there were no abnormal findings of the cornea, iris, and lens. Funduscopic finding revealed bilateral edema of the optic disc, marked attenuation of the arteriole with focal constriction, and dilatation of the veins. Fluorescein angiography showed prolonged arm-to-retinal circulation and retinal arteriovenous transit time, multiple microaneurysms, and staining retinal vessels of the both eyes. About 1+1/2 months later, iritis, rubeosis iridis, and cataract of both eyes were noticed. In carotid angiogram the left internal carotid artery was completely occluded, and the right internal carotid artery was incompletely occluded. About 7 months later, he died of CVA.
Aged ; Arterioles ; Carotid Arteries ; Carotid Artery, Internal ; Cataract ; Constriction ; Cornea ; Dilatation ; Edema ; Fluorescein Angiography ; Headache ; Humans ; Iris ; Iritis ; Ischemia ; Prunus ; Retina ; Retinal Hemorrhage ; Retinal Vessels ; Retinaldehyde ; Uveitis, Anterior ; Veins

Amyloid may involve the conjunctiva without deposits of the skin of the eyelid in primary localized amyloidosis, but extremely rare in primary systemic amyloidosis. We describe the clinicopathologic features of a case of primary systemic amyloidosis which invloved the conjunctiva and larynx. A 58-years-old woman presented a conjuctival mass of the left eye. Slit lamp microscopy showed a pinkish, flat elevated mass on the bulbar conjunctiva, fornix, and upper tarsal conjunctiva. There was no history of antecedent ocular or systemic diseases. She had undergone total laryngectomy for laryngeal amyloidosis. Microscopically, a pale amorphous eosinophilic material was deposited in the subcojunctival tissue. The deposit showed metachromasia with crystal violet, and dichroism and birefringence in polarized light following Congo red staining. Electron microscopically amyloid was comprised of linear add non-branching fibrils, which were about 11nm in width.
Amyloid ; Amyloidosis* ; Birefringence ; Congo Red ; Conjunctiva* ; Eosinophils ; Eyelids ; Female ; Gentian Violet ; Humans ; Laryngectomy ; Larynx ; Microscopy ; Skin

For an accurate diagnosis we analyzed 15 cases of clinically suspected idiopathic inflammatory pseudotumor(pseudotumor). The patients were 11 men and 4 women(mean age, 45.9 years). They were followed up for an average of 22 months. The final diagnosis was drawn collectively with clinical symptoms and signs, orbital computed tomography(CT), pathologic finding, and response to corticosteroids. In most instances the pathologic reading was reactive lymphoid hyperplasia(RLH). The final diagnosis was not constantly correlated with the pathologic reading; 5 were pseudotumor,6 RLH, and 4 undetermined. It could be concluded that the pseudotumor in the case which presented acute in flammatory symptoms and sings, involved the entire orbit in CT scan, or was cured by corticosteroid therapy. In the cases of no significant inflammatory sings it was difficult to differentiate pseudotumor from RLH with CT scan, pathologic finding, or response to corticosteroids. Although CT-guided fine needle biopsy often provides an insufficient specimen for pathologic diagnosis, it seems a useful diagnostic method, which is a simple and noninvasive technoque. At least the other orbital tumors or granulomatous lesions could be excluded by CT-guided fine needle biopsy.
Adrenal Cortex Hormones ; Biopsy, Fine-Needle ; Diagnosis* ; Granuloma, Plasma Cell* ; Humans ; Male ; Orbit* ; Pseudolymphoma ; Tomography, X-Ray Computed

In general, occlusion of the retinal vein causes marked dlminished visual acuity and poor recovery in elderly persons. Author studied 59 cases of occlusion of retinal vein in the views of sexual and age distribution, laterality, early and later visual acuity, combined systemic and ocular diseases, complications, treatment, and especially findings of fundus fluorescein angiography. The results were as follows: 1. There was no statistical significance in the difference of sexual and age distribution, and laterality of affected eye. 2. The incidence of central retinal vein occlusion is 2.3 times of that of branch retinal vein occlusion. And 78% of all branch retinal vein occulusion affected in superotemporal branch, and remainders in inferotemporal branch. In one case the occlusion had occured at superotemporal and superonasal branch. 3. The early and later visual acuity was poor in central retinal vein occlusion, inferotemporal branch vein occlusion, and superotemporal branch vein occlusion in order. 4. The improvement of visual acuity more than one line in test chart was 52.5% on the average; central retinal vein occlusion(27.8%), inferotemporal branch vein occlusion (55.5%), and superotemporal branch vein occlusion(65.6%). 5. The combined systemic diseases were hypertension, arteriosclerosis, diabetes mellitus etc, and the occular diseases were open-angle glancama and iritis. 6. The causes of poor visual acuity were cystoid macular edema, vitreous hemorrhage, optic nerve damage, complicated neovascular glaucoma, and preexisting open-angle glaucoma. 7. The fundus fluorescein angiography showed delayed filling time, marked dilatation and engorgement of affected vein, dye leakage from affected vein or radial peripapillary capillaries, capillaries, capillary nonperfusion, microaneurysms, cystoid macular edema, collateral circulation, and retinal neovascularization.
Age Distribution ; Aged ; Arteriosclerosis ; Capillaries ; Collateral Circulation ; Diabetes Mellitus ; Dilatation ; Fluorescein Angiography ; Glaucoma, Neovascular ; Glaucoma, Open-Angle ; Humans ; Hypertension ; Incidence ; Iritis ; Macular Edema ; Optic Nerve ; Retinal Neovascularization ; Retinal Vein Occlusion ; Retinal Vein* ; Retinaldehyde* ; Veins ; Visual Acuity ; Vitreous Hemorrhage

No abstract available.
Acute Kidney Injury* ; Nifedipine* ; Plasma* ; Renin*

Dermatoglyphics has been studied in various diseases including mongolism, ruhella syndrome, congenital heart disease, selected neurologic diseases and other disorders. However, reports of derrnatoglyphic studies in patients with leprosy have not been evcountered a lot. Although Ieprasy is an infectious disease due to the hfycobacterium leprae, the hereditary susceptibility of the host to the organism is proposed as an additional predisposing factor. Thia concept has been proposed to reconcile the low incidence of lisease among large numbers of contacts. Most reports delving into the role of heredity in leprosy have been related ta epidemiological studies. Prasad and Mohamad suggest, on the basis of data related to rnultiple patient families, that the acquisition of leprosy may be determined genetically on the assumption of incomplete dominance of genes; on the other hand, Spickett suggested that if there is any genetic effect, it is but a component af the familial effect. This study of dennatoglyphics in 77 male leprosy patients was undcataken to determine if there might be significance in the analysis of dermal patterns af the hands as related to the hereditary susceptibility of individuals to the disease comparing with those of 234 healthy Korean soldiers. Results are as follows: 1. In the analysis of the total fingertip ridges, there is significant difference (P<0.01) between the leprosy (137.66+4.7) and the control group (152.93+9.50). 2. A aignificant statistical difference between the leprosy and the control group (14.73+2.79) does not exist with respect to the pattern intensity, however that af the borderline group of leprosy (12.00+5.09)is decreased (P<0.025). 3. In the incidence of simian lines, the leprosy group (5.20%) shows lower incidence rate than that of control group (8.98%). 4. As for the a-b ridge count, it is decreased significantly (P<0.05) in the left hand of leprosy group (34.71+0.87) than that of the eontrol group (37.11+0.52), Also there is significant difference(P<0. 05) in the right hands of tuberculoid type of leprosy (34.64+1.38). 5. With respect to the propoetional distance (mm.) between the distal flexion crease of the wrist to the base of the middle finger with the distance (mm.) of the same point of the wrist to the axial triradius, a significant statistical difference between the leprosy and the control group does not exist, but significantly longer distance (mm.) exists in the tuberculoid type of leprosy (P<0.05). 6. No significant fingertip pattern differences are noted between the leprosy and the control group.
Causality ; Communicable Diseases ; Dermatoglyphics* ; Down Syndrome ; Epidemiologic Studies ; Fingers ; Hand ; Heart Defects, Congenital ; Heredity ; Humans ; Incidence ; Korea* ; Leprosy* ; Male ; Military Personnel ; Wrist