The most common ocular finding of the idiopathic thrombocytopenic purpura(ITP) is superficial retinal hemorrhages in both eyes. But the descriptions of new vessel on the optic disc(NVD) associated with ITP are scarcely found in literatures. A 17-year-old girl who managed for ITP complained of visual distrubance of the right eye and floaters of the left eye. On fundoscopy the right eye was failed to examine due to thick vitreous hemorrhage and the left eye showed NVD and preretinal hemorrhage. After panretinal photocoagulation of the left eye, NVD was regressed.

OBJECTIVES: lschemic acute renal failure(ARF) is characterized by an abrupt and sustained decline in GFR within minutes to days after renal ischemia and not immediately reversed on restoration of renal blood flow. The typical delay of a few days to a few weeks suggests reversible parenchymal damage awaiting cell regeneration for functional recovery. Many potentially cell damaging factors, such as ATP depletion, plasma membrane phospholipid degradatian and superoxide-induced membrane damage, play a central part in ischemic injury. More recently, much attention has been focused on the role of calcium, especially ischemic cell injury and the possible therapeutic role of calcium channel blockers emerged from studies conducted several years ago. In the past, it was thought that activation of renin-angiotensin system plays a role in the pathogenesis of ARF. Now the role of angiotensin in human renal ischemia also appears to be controversial. The following study was done in order to investigate the effect of a calcium channel blocker, nifedipine, on gene expression of renin during acute ischemic renal injury. METHODS: The Sprague-Dawley rats were divided into 4 groups, group I(n=3) as the control, group II (n=3) as the sham operation group, group III(n=15) as the ischemic renal injury group without nifedipine pretreatment, and group IV(n=15) as the ischemic renal injury model by right nephrectomy and left renal artery clamping for 40 minutes with systemic nifedipine pretreatment(10mg/kg), 1n ischemic renal injury model(group III and IV), rats were further divided into three subgroups according to reperfusion time of 1,24,72 hours. The non-ischemic right kidney removed at the time of initial procedure served as paired control. Total renal RNA was extracted by Chomczynskis method and electrophoresis was done in a 1% agarose gel containing 2,2M formaldehyde. Northern was performed at 42degrees C with isotope labeled renin probe for 18 hours, Autoradiographs were obtained and quantitated by a densitometer measured at 530nm. RESULTS: 1) The expression of renin gene was markedly decreased after renal ischemia and slowly recovered to one half of the control level after 72 hours of reperfusion. 2) Renin gene expression pattern of ischemic renal injury with prior nifedipine treatment was similar to the ischemic group without nifedipine pretreatment. CONCLUSION: These findings suggest that the renin gene expression was markedly decreased after renal ischemia and slowly recovered. Systemic nifedipine pretreatment does not have a significant effect on gene expression pattern of renin in ischemic renal injury.
Adenosine Triphosphate ; Angiotensins ; Animals ; Calcium Channel Blockers ; Calcium Channels* ; Calcium* ; Cell Membrane ; Constriction ; Electrophoresis ; Formaldehyde ; Gene Expression* ; Humans ; Ischemia ; Kidney ; Membranes ; Nephrectomy ; Nifedipine ; Rats ; Rats, Sprague-Dawley ; Regeneration ; Renal Artery ; Renal Circulation ; Renin* ; Renin-Angiotensin System ; Reperfusion ; RNA ; Sepharose

We describe a case of xanthoma on the corneoscleral limbus in a 21-year-old man. It was characterized by a localized, round, elevated, yellowish mass on the right superonasal limbus with 6mm in size. There was no correlation with systemic or metabolic diseases such as hyperlipidemia and the microscopic examination revealed scanty fibrous element.
Humans ; Hyperlipidemias ; Metabolic Diseases ; Xanthomatosis* ; Young Adult

We describe a case of xanthoma on the corneoscleral limbus in a 21-year-old man. It was characterized by a localized, round, elevated, yellowish mass on the right superonasal limbus with 6mm in size. There was no correlation with systemic or metabolic diseases such as hyperlipidemia and the microscopic examination revealed scanty fibrous element.
Humans ; Hyperlipidemias ; Metabolic Diseases ; Xanthomatosis* ; Young Adult

The author has measured refractive error and corneal curvature in 500 eyes of 250 patients who visited the Department of Ophthalmology, Ewha Womans University Hospital, with decreased visual acuity as chief complaint, for 6 months from Sep. 1, 1984 through Feb. 28, 1985, and found the following conclusions: First, as for the means of each corneal horizontal curvature and vertical curvature, the mean of horizontal curvature was 7.7876 +/- 0.9791mm; that of vertical curvature was 7.7217 +/- 0.8527mm in right cornera, while the mean of horizontal curvature was 7.8628 +/- 0.7295mm; that of vertical curvature was 7.5986 +/- 1.2349mm in the left cornea. Second, as for the comparison of corneal curvature by sex, it was highly significant(p<0.05) that the means of each corneal horizontal curvature and vertical curvature were always larger in the case of male than that of female. Third, as for the comparison by each age group(age groups under 25 years, from 25 through 44 years, and from 45 years up respectively), there were no significant differences(0 0.05) in respective means of each corneal horizontal curvature and vertical curvature among age groups. Fourth, as the result of this study on correlation between corneal curvature and refractive error, its correlation is 0.32% to 4.66%, showing no significant correlation between them.
Cornea ; Female ; Humans ; Male ; Ophthalmology ; Refractive Errors* ; Visual Acuity

Mucoepidermoid carcinoma occurs commonly in salivary gland, but rarely in lacrimal gland. In literature about ten or more cases of mucoepidermoid carcinoma of the lacrimal gland have been described. A 73-year-old woman had noted upper lid swelling and lacrimation of the left eye for 2 months. Computed tomographic scan demonstrated a large homogenous mass on superotemporal portion of the left orbit. The mass extended into the left temporal fossa, middle cranial fossa, and ethmoidal sinus with bone destruction. Histopathologically, the mass was proved to be a intermediate grade mucoepidermoid carcinoma of the lacrimal gland.
Aged ; Carcinoma, Mucoepidermoid* ; Cranial Fossa, Middle ; Female ; Humans ; Lacrimal Apparatus* ; Orbit ; Salivary Glands

No abstract available.
Acute Kidney Injury* ; Lymphoma*

In general, occlusion of the retinal vein causes marked dlminished visual acuity and poor recovery in elderly persons. Author studied 59 cases of occlusion of retinal vein in the views of sexual and age distribution, laterality, early and later visual acuity, combined systemic and ocular diseases, complications, treatment, and especially findings of fundus fluorescein angiography. The results were as follows: 1. There was no statistical significance in the difference of sexual and age distribution, and laterality of affected eye. 2. The incidence of central retinal vein occlusion is 2.3 times of that of branch retinal vein occlusion. And 78% of all branch retinal vein occulusion affected in superotemporal branch, and remainders in inferotemporal branch. In one case the occlusion had occured at superotemporal and superonasal branch. 3. The early and later visual acuity was poor in central retinal vein occlusion, inferotemporal branch vein occlusion, and superotemporal branch vein occlusion in order. 4. The improvement of visual acuity more than one line in test chart was 52.5% on the average; central retinal vein occlusion(27.8%), inferotemporal branch vein occlusion (55.5%), and superotemporal branch vein occlusion(65.6%). 5. The combined systemic diseases were hypertension, arteriosclerosis, diabetes mellitus etc, and the occular diseases were open-angle glancama and iritis. 6. The causes of poor visual acuity were cystoid macular edema, vitreous hemorrhage, optic nerve damage, complicated neovascular glaucoma, and preexisting open-angle glaucoma. 7. The fundus fluorescein angiography showed delayed filling time, marked dilatation and engorgement of affected vein, dye leakage from affected vein or radial peripapillary capillaries, capillaries, capillary nonperfusion, microaneurysms, cystoid macular edema, collateral circulation, and retinal neovascularization.
Age Distribution ; Aged ; Arteriosclerosis ; Capillaries ; Collateral Circulation ; Diabetes Mellitus ; Dilatation ; Fluorescein Angiography ; Glaucoma, Neovascular ; Glaucoma, Open-Angle ; Humans ; Hypertension ; Incidence ; Iritis ; Macular Edema ; Optic Nerve ; Retinal Neovascularization ; Retinal Vein Occlusion ; Retinal Vein* ; Retinaldehyde* ; Veins ; Visual Acuity ; Vitreous Hemorrhage

A 50-year-old man had orbital pain, diplopia, proptosis of left eye, hypesthesia on the left forehead and pain of left extremities of one month's duration. Four months prior to visit, he had undergone 131I-Lipiodol therapy for hepatocellular carcinoma of the liver. CT scan showed a homogenous, well-defined mass on superotemporal portion of the left orbit. The mass extended into anterior cranial fossa with bony destruction. Orbital CT-guided fine needle biopsy was performed. And pathologic findings confirmed metastatic hepatocellular carcinoma.
Biopsy, Fine-Needle ; Carcinoma, Hepatocellular* ; Cranial Fossa, Anterior ; Diplopia ; Exophthalmos ; Extremities ; Forehead ; Humans ; Hypesthesia ; Liver ; Middle Aged ; Orbit* ; Tomography, X-Ray Computed

Ocular ischemic syndrome, characterized by rubeosis iridis, anterior uveitis, retinal arterial narrowing, retinal hemorrhage, cherry red spot, and neovascularization of the disc and/ or retina, is due to anterior and posterior segment ischemia caused by carotid artery obstruction. A 67-year-old man presented a typical ocular ishemic syndrome. The patient complained marked visual disturbance of the both eyes and headache for 15 days. On slit-lamp examination, there were no abnormal findings of the cornea, iris, and lens. Funduscopic finding revealed bilateral edema of the optic disc, marked attenuation of the arteriole with focal constriction, and dilatation of the veins. Fluorescein angiography showed prolonged arm-to-retinal circulation and retinal arteriovenous transit time, multiple microaneurysms, and staining retinal vessels of the both eyes. About 1+1/2 months later, iritis, rubeosis iridis, and cataract of both eyes were noticed. In carotid angiogram the left internal carotid artery was completely occluded, and the right internal carotid artery was incompletely occluded. About 7 months later, he died of CVA.
Aged ; Arterioles ; Carotid Arteries ; Carotid Artery, Internal ; Cataract ; Constriction ; Cornea ; Dilatation ; Edema ; Fluorescein Angiography ; Headache ; Humans ; Iris ; Iritis ; Ischemia ; Prunus ; Retina ; Retinal Hemorrhage ; Retinal Vessels ; Retinaldehyde ; Uveitis, Anterior ; Veins