No abstract available.
Animals ; Ischemia* ; Peripheral Nerves* ; Rats*

With the recent development of tumor prosthesis, limb salvage technique has attributed to the preservation of the limb function in patients with malignant bone tumors around the knee without substantial difference of local recurrence and the survival rate. From Feb., 1991 to Sep., 1992, 9 patients were treated with limb salvage operation with total knee arthroplasty due to the malignant bone tumor around the knee at Dept. of Orthopedic Surgery, Kyungpook National University Hospital. We applied the above procedure mainly to young adult whose tumor was expected to be excised wide marginally without damaging major neurovascular structures. We evaluated the functional status of all 9 patients(4 osteosarcoma, 2 chodrosarcoma, 2 malignant fibrohistiocytoma, 1 malignant giant cell tumor) to estimate the efficacy of limb salvage operation with tumor prosthesis total knee arthroplasty. Mean follow up period was 10 months. Primary tumor site was 4 in distal femur, 5 in proximal tibia and stage was 4 IIa, 5 IIb. Range of the motion of knee is maximum 0°
Arthroplasty ; Arthroplasty, Replacement, Knee ; Artificial Limbs ; Extremities ; Femur ; Follow-Up Studies ; Giant Cells ; Gyeongsangbuk-do ; Humans ; Knee ; Limb Salvage ; Methods ; Orthopedics ; Osteosarcoma ; Prostheses and Implants ; Recurrence ; Survival Rate ; Tibia ; Young Adult

No abstract available.
Female ; Humans ; Pregnancy ; Pregnancy Trimester, Second*

PURPOSE: The criteria for Suspected hereditary nonpolyposis colorectal cancer(Suspected HNPCC) has been devised by the Korean Hereditary Tumor Registry for families who do not fulfill Amsterdam criteria, but hereditary background is strongly suggested. This study was performed to define the clinical characteristics of 'Suspected HNPCC'. METHODS: The 'Suspected HNPCC' criteria include the followings: a) vertical transmission of colorectal cancer or at least two siblings affected with colorectal cancer in a family and b) development of multiple colorectal tumors (including adenoma) or at least one colorectal cancer case diagnosed before the age of 50 years or development of extracolonic cancers (endometrium, urinary tract, small intestine, stomach, hepatobiliary system, ovary) in family members. We analysed the clinical characteristics of 93 patients from 39 Suspected HNPCC families and compared these characteristics with 176 HNPCC familes and with 1,204 non-hereditary colorectal cancer patients. RESULTS: The mean age of Suspected HNPCC patients at the time of diagnosis (49.0 years) was significantly lower than that of non-hereditary colorectal cancer patients (56.1 years), but higher than that of the HNPCC patients (44.5 years). Tumors were more frequently located in the right colon (34%) in Suspected HNPCC compared to non-hereditary colorectal cancer (23%). Dukes' A and B cancers were more frequent in the Suspected HNPCC as compared to non-hereditary colorectal cancer (55% vs. 48%, p<0.05), but tumor differentiation was not statistically different between the two groups. Among the Suspected HNPCC, 24.0% of the patients had synchronous adenomatous polyps and 20.0% had synchronous colorectal cancers and 15.6% had metachronous polyps or cancers. These findings were similar to HNPCC, but significantly higher than non-hereditary colorectal cancers (p<0.05). In Suspected HNPCC families, 42 patients had extracolonic malignancies with the stomach cancer being the most common (n=22). CONCLUSION: These data indicate that the clinical characteristics of Suspected HNPCC are similar to those of HNPCC and may suggest that the management principles of the HNPCC should also be applied to the Suspected HNPCC.
Adenomatous Polyps ; Colon ; Colorectal Neoplasms ; Diagnosis ; Humans ; Intestine, Small ; Korea* ; Polyps ; Siblings ; Stomach ; Stomach Neoplasms ; Urinary Tract

Ultrasound studies of sixty five patients with thyroid mass histologically proven at KyungPook NationalUniversity Hospital from June 1983 to May were retrospectively analized. No specific sonographic characteristicsof thyroid mass lesions was found on the basis of histological diagnosis. Authors consider that ultrasound studymight be mere useful for detection and localization of a lesion, and guide to needle aspiration, monitoring thesize of a mass following therapy as well.
Diagnosis ; Gyeongsangbuk-do ; Humans ; Needles ; Retrospective Studies ; Thyroid Gland ; Ultrasonography

The surgical options for ulcerative colitis have developed rapidly in recent years, with emphasis on improving the quality of life by preservation of voluntary defecation and continence while eradicating the disease. In this paper, we have retrospectively analyzed 29 patients with pathologically proven ulcerative colitis who underwent surgical treatment at the Department of Surgery, Seoul National University Hospital between 1980 and 1996. We sought to correlate the changing patterns of the surgical management with their outcomes. The mean age at the time of definitive surgical procedures was 36.7(+/-11.9), and median duration of follow-up was 26 months. The final surgical procedures performed in these patients were ileal J pouch-anal anastomosis (14), total proctocolectomy with either end (7) or continent ileostomy (4), total colectomy with ileorectal anastomosis (1) or Hartmann procedure (2), and partial colectomy (1). Since 1993, we have been performing ileal pouch-anal anastomosis(IPAA), which was performed in all patients except two (one with toxic colitis and the other with disseminated colon cancer). In two patients who underwent partial colectomy and were available for follow-up, there was recurrence of symptoms related to ulcerative colitis. All 11 patients who received total proctocolectomy with either end or continent ileostomy experienced at least one postoperative complication, and 5 required reoperations for management of these complications. Tn particular, 3 out of 7 patients who received total proctocolectomy with continent ileosotmy required removal of the pouch due to pouch related complications. There were two postoperative deaths due to septic complications. On the other hand, while 8 out of 14 patients who received IPAA experienced postoperative complications, all were resolved with conservative management and none required reoperation. The function of ileal J pouch was assessed in 13 Patients at a median duration of 10 months (range : 3~27 months) after restoration of pouch continuity. The mean stool frequency per 24h was 7.6(+/-2.1) and mean nocturnal stool frequency was 1.6(+/-1.5). None of the patients had major incontinence while 7 had occasional spotting of mucous. The remaining 6 patients had normal continence. Only one patient needed antidiarrheal medication and 5 followed a strict diet. Confirmed pouchitis occurred in only one patient. All of the patients who received IPAA were satisfied with their bowel status and the operation. Our results confirm that IPAA is an acceptable surgical option for the management of ulcerative colitis.
Colectomy ; Colitis ; Colitis, Ulcerative* ; Colon ; Colonic Pouches ; Defecation ; Diet ; Female ; Follow-Up Studies ; Hand ; Humans ; Ileostomy ; Metrorrhagia ; Postoperative Complications ; Pouchitis ; Quality of Life ; Recurrence ; Reoperation ; Retrospective Studies ; Seoul ; Ulcer*

Local excision for rectal cancer can yield comparable results to traditional radical operations in selected group of patients. We have retrospectively analyzed 32 cases of rectal cancer patients treated by transanal local excision for curative intent at the Department of Surgery, Seoul National University Hospital between 1990 to 1996. These 32 cases represent 4.1% of total rectal cancer patients treated during the same period. Mean age of the patients were 57.0+/-11.8 years. Median tumor size was 2 cm(mean : 2.4+/-1.1 cm), and the median distance from the anal verge to the lower margin of the tumors was 5 cm(mean : 5.1+/-1.7 cm). Deepest layer invaded by cancer was as follows: mucosa, 31.3%; submucosa, 56.3%; muscularis propria, 9.4%; subserosa, 3.1%. Sixty-nine percent of the patients had well differentiated tumors and 31% had moderately differentiated tumors, while none of the cancers were poorly differentiated. No patient received any adjuvant therapy. After a median follow-up of 21 (range: 1~83) months, no local recurrence occurred in any of the patients. Our results indicate that transanal local excision can be performed with favorable outcome in selected group of rectal cancer patients.
Follow-Up Studies ; Humans ; Mucous Membrane ; Rectal Neoplasms* ; Recurrence ; Retrospective Studies ; Seoul

No abstract available.
Hamartoma*

BACKGROUND: A fully automated enzyme-immunoassay (EIA) analyzer, Enzymun System, ES-300 (Boehringer Mannheim, Germany) uses streptavidin technology and performs single test or panels of up to 12 tests per run. We evaluated the results of ES-300 for anti-HCV by comparing the results with microplate-EIA, radioimmunoassay (RIA), and confirmatory test. METHODS: Total 79 sera (51 positive, 24 negative, 4 indeterminate results confirmed by Lucky HCD Confirm) were analysed. ES-300 with Enzymun-Test(R) Anti-HCV (Boehringer Mannheim, Germany) and microplate-EIA (Green Cross Center Innotest HCV 3.0(R)) were used. Fifty one sera were examined additionally by 2nd-generation RIA method, NANBDINE 125C(General Biologicals Corp., R.O.C.). And all results were compared to the results of Lucky HCD Confirm. RESULTS: The overall concordance rate of ES-300 and Innotest(R) was 72/79 (91.1%). The results of Lucky HCD Confirm on seven discrepant samples were five negative and two indeterminate. The results of ES-300 and NANBDINE 125C showed concordance rate of 90.2%. The sensitivity and specificity of ES-300 with regard to Lucky HCD Confirm were 94.5%, and 87.5%, respectively, and that of Innotest(R) were 98.2% and 66.7%, respectively. Clear distinction of positive and negative results by signal/cut off ratio was available in both EIAs. The positive predictive values of ES-300 and Innotest(R) were 94.5%, and 87.1%, respectively. CONCLUSIONS: ES-300 showed relatively good results in sensitivity and positive predictive value with regard to confirmatory test. In EIA-positive persons, however, follow-up study would be necessary for reliable evaluation of HCV infection.
Humans ; Radioimmunoassay ; Sensitivity and Specificity ; Streptavidin

BACKGROUND: Transforming growth factor (TGF)- has a large variety of biological functions, including the modulation of inflammation and the immune system, and is presumed to play important roles in repairing wounds and reducing scarring. The objective of this study is to examine the effects of TGF-1 on healing wounds and reducing scarring. We have also analysed the ability of the hemagglutinating virus of Japan (HVJ) liposome mediated antisense oligodeoxynucleotides (ODNs) to specifically inhibit wound-induced expressions of TGF-1 proteins and mRNA in the rat skin. METHODS: Skin wounds were created on the backs of 80 anesthetized rats. The first group of wounds, as the controls, was unmanipulated. The second group of wounds, as positive controls or an excessive scarring model, was injected with TGF-1 subcutaneously. The third group of wounds was injected with anti-TGF-1 antibody subcutaneously. The fourth group of wounds was injected with HVJ liposome mediated antisense ODNs for TGF-1 subcutaneously. The wounds of all groups were bisected and analysed histologically 5, 10, 15, 30, and 50 days after the wounds were made. RESULTS: All control wounds (TGF-1 or no injection) healed with scarring, whereas the wounds treated with the antibody or antisense ODNs healed with less scar formation compared to the control group. The wounds treated with the antibody or antisense ODNs had fewer macrophages, less collagen and fibronectin contents than the other wounds. Northern blotting and in situ hybridization analysis showed that wound sites treated with HVJ liposome mediated antisense ODNs for TGF-1 exhibited decreased levels of TGF-1 mRNA after injury. CONCLUSIONS: These findings suggest an important new approach to controlling scarring in normal wound healing, complementing the practice of adding exogenous growth factors to chronic wounds in the attempt to inhibit collagen deposition.
Animals ; Blotting, Northern ; Cicatrix* ; Collagen ; Complement System Proteins ; Fibronectins ; Genetic Therapy* ; Immune System ; In Situ Hybridization ; Inflammation ; Intercellular Signaling Peptides and Proteins ; Liposomes ; Macrophages ; Oligodeoxyribonucleotides ; Oligoribonucleotides ; Rats ; RNA, Messenger ; Sendai virus ; Skin ; Transforming Growth Factor beta ; Transforming Growth Factors ; Wound Healing ; Wounds and Injuries