No abstract available.
Hepatitis B virus* ; Hepatitis B* ; Hepatitis* ; Korea*

No abstract available.
Malocclusion*

The pharmacotherapy of schizophrenia exhibit wide inter-individual variabilities in clinical efficacy and adverse effects. Recently. human genetic diversity has been known as one of the essential factors to the variation in human drug response. This suggests that drug therapy should be tailored to the genetic characteristics of the individual. Pharmacogenetics is the field of investigation that attempts to elucidate genetic basis of an individual's responses to pharmacotherapy, considering drug effects divided into two categories as pharmacokinetics and pharmacodynamics. The emerging field of pharmacogenomics. which focuses on genetic determinants of drug response at the level of the entire human genome, is important for development and prescription of safer and more effective individually tailored drugs and will aid in understanding how genetics influence drug response. In schizophrenia, pharmacogenetic studies have shown the role of genetic variants of the cytochrome P450 enzymes such as CYP2D6, CYP2C19, and CYP2A1 in the metabolism of antipsychotic drugs. At the level of drug targets, variants of the dopamine D_(2), D_(3) and D_(4), and 5-HT_(2A) and 5-HT(2C) receptors have been examined. The pharmacogenetic studies in schizophrenia presently shows controversial findings which may be related to the multiple involvement of genes with relatively small effects and to the lack of standardized phenotypes. For further development in the pharmacogenomics of schizophrenia, there would be required the extensive outcome measures and definitious, and the powerful new tools of genomics, proteomics and so on.
Antipsychotic Agents ; Cytochrome P-450 CYP2D6 ; Cytochrome P-450 Enzyme System ; Dopamine ; Drug Therapy ; Genetic Variation ; Genetics ; Genome, Human ; Genomics ; Humans ; Metabolism ; Outcome Assessment (Health Care) ; Pharmacogenetics* ; Pharmacokinetics ; Phenotype ; Prescriptions ; Proteomics ; Receptor, Serotonin, 5-HT2C ; Receptors, Dopamine ; Schizophrenia*

No abstract available.
Animals ; Femoral Artery ; Rats

No abstract available.
Animals ; Calcitonin* ; Nasal Mucosa* ; Rats* ; Substance P*

The systolic time intervals, hemodynamics, and indices of myocardial contractility were measured in 158 normal Koreans with average age of 34(14~69) years by non-invasive technique, i.e. simultaneous recording of ECG, PCG, and carotid and femoral pulse tracing with paper speed 100mm/sec. by cardiograph. 1. Normal values of systolic time intervals were as follows(M+/-SD): QS1was 61.5+/-10.8, ICT 41.9+/-12.0, PEP 10.+/-14, LVET 281+/-24, and QS2 385+/-26 msec. 2. Regression equations of systolic time intervals to pulse rate were as follows: QS1; 0.04 x PR + 60.0 (r=+0.038, p>0.05), ICT; -0.2 x PR + 59.6 (r=-0.234, p<0.01), PEP; -0.2 x PR + 117 (r=-0.162, pp<0.05), LVET; -1.5 x PR + 389 (r=-0.725, pp<0.001), QS2; -1.7 x PR + 507 (r=-0.745, pp<0.001). 3. Each phase of systolic time intervals was affected by various factors: ICT and PEP by pulse rate, diastolic pressure and stroke volume, LVET by pulse rate and stroke volume, QS1by diastolic pressure, and QS2by pulse rate. Multiple linear regression analysis results in the following formulas for prediction of the systolic time intervals from the pulse rate, diastolic pressure and stroke volume: ICT; -0.299PR+0.230Pd-0.139Vs+28.1(r=0.38), PEP; -0.272PR+0.356Pd-0119Vs+104.8 (r=0.39), LVET; -1.475PR+0.167Vs+376.6 (r=0.74). 4. Systolic time intervals were not influenced by height, weight or body surface, but LVET and QS2were prolonged significantly in female group. 5. Normal values of hemodynamics calculated by Wezler's formula were as follows: stroke volume was 68.1+/-21.7ml, stroke index 50.2+/-14.9ml/m2, cardiac output 4.9+/-1.71/min., cardiac index 3.6+/-1.3 1min/m2, peripheral resistance 1696+/-507 dyne sec. cm(-5), and volume elasticity coefficient 1916+/-422 dyne cm(-5). 6. Normal values of non-invasive indices of myocardial contractility were as follows: ICT was 42+/-21 msec. PEP 10.+/-14 msec., 1/PEP2 9.87x10-5+/-2.79x10-5msec., 1/ICT28.56x10-3+/-1.65+/-10-3msec-2., Pd/ICT 1.96+/-0.92 mmHg/msec., Pd/PEP 0.723+/-0.125 mmHg/msec., PEP/LVEE 0.37+/-0.06, LVET/PEP 2.77+/-0.47, and LVET/ICT 7.45+/-3.19. 7. Each index of myocardial contractility was affected by various factors: ICT, PEP, 1/PEP2, PEP/LVET, LVET/PEP and LVET/ICT by pulse rate, diastolic pressure and stroke volume, 1/ICT2by pulse rate, and Pd/ICT and PD/PEP by pulse rate and diastolic pressure. 8. Correlation coefficients between PEP/LVET and other indices were relatively high in PEP, 1/PEP2and LVET/PEP, and relatively low in ICT, 1/ICT2Pd/ICT, Pd/PEP and LVET/ICT.
Blood Pressure ; Cardiac Output ; Elasticity ; Electrocardiography ; Female ; Heart Rate ; Hemodynamics* ; Humans ; Linear Models ; Reference Values ; Stroke ; Stroke Volume ; Systole* ; Vascular Resistance

In order to find out health problems among inhabitants in slum areas in Kwanak-Ku, Seoul, a series of health survey was conducted upon 510 households by interview from March to December, 1976. The results obtained were as follows: 1. Employments of householders were unstable; Out of 508 householders, 164(32.3%) were unemployed and 184(36.2%) were daily or temporary employees. 2. Average number of households per house was 2.0 and average area of residential room per person was 4.0m2. 3. 476(93.3%) out of 510 households were supplied with tap water and rest of them made use of ground water as a source of drinking water. 4. Only 279(18.3%) out of 1527 live births were delivered at medical facilities, 496(32.7%) were at home attended by doctors or midwives and 358(25.1%) took prenatal care. The above findings were worse in urban slum area than in other urban area of relatively high economic level, but were better than in rural area of less medical facilities. 5. Initiation of treatment were delayed until their illnesses were advanced in most of the households, 472(92.5%) out 510. In the early stage of the illness, 131(25.6%) of the households sought physicians in their clinics or general hospitals and 250(40.9%) visited chemists, to buy drugs at first hand. Frequency of visits to physician increased to 52.8% as the disease aggravated in later stages. 6. Cost of medical expenditure per household amounted to 815 won, and was paid to, in the order of chemists, physicians, chinese herb stores, chinese herb doctors. 7. Concerning the health knowledge of the inhabitants, 273(53.9%) out of 506 respondents were aware of the infectivity of pulmonary tuberculosis, and 68(13.4%) of them checked regularly their chest findings by X-ray at least once every two years. 8. As for the family planning, although 448(87.3%) out of 510 respondents were in favor of it, 213(41.8%) of them were actually practicing contraception. 9. About 40.6% (125 respondents) of them obtained information and knowledge concerning contraception through personal contact with family planning workers. 10. Nutritional status of housewives was generally poor: 49(38.3%) out of 128 housewives were found to be anemic and average serum protein level was 7.5+/-0.82 g/dl.
Asian Continental Ancestry Group ; Contraception ; Surveys and Questionnaires ; Drinking Water ; Family Characteristics ; Family Planning Services ; Groundwater ; Hand ; Health Expenditures ; Health Surveys ; Hospitals, General ; Humans ; Live Birth ; Midwifery ; Nutritional Status ; Poverty Areas* ; Prenatal Care ; Seoul ; Thorax ; Tuberculosis, Pulmonary ; Water

No abstract available.
Animals ; Dogs* ; Guided Tissue Regeneration*

There are many reports of ventricular arrhythmias following the injection of epinephrine under general anesthesia with halothane or cyclopropane. Raventos reported that catecholamines given animals during chloroform, cyclopropane or halothane anesthesia have caused ventricular arrhythmias which sometimes developed into ventricular fibrillation. But there are a few reports of atrial arrhythmias in patients under general anesthesia with alone halothane. While it is known that hypercapnia can elicit arrhythmia during halothane anesthesia, Black and coworkers that hypercapnia of 60 to 140mmHg (average 92mmHg) is necessary for the occurrence of arrhythmias during halothane anesthesia. Hellewell and Potts reported 12 cases of arrhythmias under halothane anesthesia which were treated by propranolol, producing a return of sinus rhythm in an average time of 46 seconds. The authors reported one case with atrial arrhythmias induced by halothane anesthesia, which were arrested by the IV injection of 5mg of tolamolo, beta-receptor blocking agent. Thereafter arrhythmias did not reappear.
Anesthesia* ; Anesthesia, General ; Animals ; Arrhythmias, Cardiac* ; Catecholamines ; Chloroform ; Epinephrine ; Halothane* ; Humans ; Hypercapnia ; Propranolol ; Ventricular Fibrillation

No abstract available.
Staphylococcus aureus* ; Staphylococcus*