1.A Case of Acute Myocardial Infarction In Man Treated with Chemotherapy containing Doxorubicin for Non-Hodgkin Lymphoma..
Kyung Ho KIM ; Woo Jung PARK ; Taek Man NAM ; Duck Hyoung YOON ; Pil Seog HEO ; Young Choel DOO ; Kyu Rook HAN ; Dong Jin OH ; Kyu Hyeung YOO ; Jong Yoon LIM ; Kwang Hak LEE ; Young LEE
Korean Circulation Journal 2001;31(5):507-511
Anthracyclines have been widely used in cancer therapy because of their efficacy in the treatment of various solid tumors and hem -atologic malignancy. Cumulative dose-related cardiotoxicity was a well-known toxicity of anthracyclines. Particularly, at total doses of more than 550 mg/m2, therapy with anthracyclines could produce irreversible cardiac injury. Anthracycline-induced cardiac toxicity was usually manifested by congestive heart failure or arrhythmia. In co- ntrast, acute myocardial infarction is a rare event of anthracycline-induced heart diseases. A 31-year-old man with non-Hodgkin lymphoma(NHL) and single cardiac risk factor, including smoking, was presented with chest pain after receiving 2nd CEOP-BLAM chemo-therapy. An electrocardiogram revealed ST segment elevation in inferior leads consistent with acute myocardial infarction. An echocardiogram revealed an ejection fraction of 60% and severe hypokinesia in inferior and anteroseptal wall. Three days later, coronary angiography revealed 50% of luminal stenosis of right coronary artery(RCA) and near total occlusion with large thrombi in m-RCA. After balloon angioplasty and stent insertion, the patient was transferred to coronary care unit and continuous intravenous heparin infusion was started. On the 10th days, the patient was discharged in good condition. Six months later, follow-up coronary angiography showed no significant lesion in right coronary artery. In a young man with NHL, we report an acute myocardial infarction after 2nd course of CEOP-BLAM chemotherapy with a review of relevant literatures.
Adult
;
Angioplasty, Balloon
;
Anthracyclines
;
Arrhythmias, Cardiac
;
Chest Pain
;
Constriction, Pathologic
;
Coronary Angiography
;
Coronary Care Units
;
Coronary Vessels
;
Doxorubicin*
;
Drug Therapy*
;
Electrocardiography
;
Follow-Up Studies
;
Heart Diseases
;
Heart Failure
;
Heparin
;
Humans
;
Hypokinesia
;
Lymphoma, Non-Hodgkin*
;
Myocardial Infarction*
;
Phenobarbital
;
Risk Factors
;
Smoke
;
Smoking
;
Stents
2.A Case of Acute Myocardial Infarction In Man Treated with Chemotherapy containing Doxorubicin for Non-Hodgkin Lymphoma..
Kyung Ho KIM ; Woo Jung PARK ; Taek Man NAM ; Duck Hyoung YOON ; Pil Seog HEO ; Young Choel DOO ; Kyu Rook HAN ; Dong Jin OH ; Kyu Hyeung YOO ; Jong Yoon LIM ; Kwang Hak LEE ; Young LEE
Korean Circulation Journal 2001;31(5):507-511
Anthracyclines have been widely used in cancer therapy because of their efficacy in the treatment of various solid tumors and hem -atologic malignancy. Cumulative dose-related cardiotoxicity was a well-known toxicity of anthracyclines. Particularly, at total doses of more than 550 mg/m2, therapy with anthracyclines could produce irreversible cardiac injury. Anthracycline-induced cardiac toxicity was usually manifested by congestive heart failure or arrhythmia. In co- ntrast, acute myocardial infarction is a rare event of anthracycline-induced heart diseases. A 31-year-old man with non-Hodgkin lymphoma(NHL) and single cardiac risk factor, including smoking, was presented with chest pain after receiving 2nd CEOP-BLAM chemo-therapy. An electrocardiogram revealed ST segment elevation in inferior leads consistent with acute myocardial infarction. An echocardiogram revealed an ejection fraction of 60% and severe hypokinesia in inferior and anteroseptal wall. Three days later, coronary angiography revealed 50% of luminal stenosis of right coronary artery(RCA) and near total occlusion with large thrombi in m-RCA. After balloon angioplasty and stent insertion, the patient was transferred to coronary care unit and continuous intravenous heparin infusion was started. On the 10th days, the patient was discharged in good condition. Six months later, follow-up coronary angiography showed no significant lesion in right coronary artery. In a young man with NHL, we report an acute myocardial infarction after 2nd course of CEOP-BLAM chemotherapy with a review of relevant literatures.
Adult
;
Angioplasty, Balloon
;
Anthracyclines
;
Arrhythmias, Cardiac
;
Chest Pain
;
Constriction, Pathologic
;
Coronary Angiography
;
Coronary Care Units
;
Coronary Vessels
;
Doxorubicin*
;
Drug Therapy*
;
Electrocardiography
;
Follow-Up Studies
;
Heart Diseases
;
Heart Failure
;
Heparin
;
Humans
;
Hypokinesia
;
Lymphoma, Non-Hodgkin*
;
Myocardial Infarction*
;
Phenobarbital
;
Risk Factors
;
Smoke
;
Smoking
;
Stents
3.The Clinical Characteristics of Hyperthyroidism Combined with Ocular Myasthenia Gravis: Report of Six cases.
Ji Young SEO ; Doo Man KIM ; Hyeon Kyu KIM ; Cheol Soo CHOI ; Sung Hee IHM ; Jae Myung YOO ; Moon Gi CHOI ; Hyung Jun YOO ; Sung Woo PARK ; Hyeung Cheul KIM ; Hong Ki SONG ; Deuk Hwan KIM
Journal of Korean Society of Endocrinology 2000;15(4-5):606-613
Myasthenia gravis is an autoimmune disease characterized by impaired neuromuscular transmission due to circulating antiacetylcholine receptor autoantibodies. The relation between myasthenia gravis and thyroid disease remains unclarified. The association is thought to be uncommon and approximately 0.2% of myasthenia gravis has been reported in patients with autoimmune thyroid disease. Clinical expression of myasthenia gravis varies, ranging from a mild localized disease such as ocular myasthenia gravis (OMG) to a severe generalized disease. A higher frequency of thyroid antibodies has been observed in OMG compared to generalized myasthenia gravis, but the exact mechanisms of this increased association between OMG and thyroid autoimmunity has not been confirmed. The "see-saw" relationship between hyperthyroidism and myasthenia gravis is presented by some authors, while others reported that the optimal maintenance of euthyroid status was essential in treatment. Today many authors agree to the latter and we think that the adequate control of hyperthyroidism is more important. We have experienced six cases of hyperthyroidism combined with OMG and it was somewhat difficult to diagnose myasthenia gravis when the patient have Graves' ophthalmopathy.
Antibodies
;
Autoantibodies
;
Autoimmune Diseases
;
Autoimmunity
;
Humans
;
Hyperthyroidism*
;
Myasthenia Gravis*
;
Thyroid Diseases
;
Thyroid Gland
4.Urine Cotinine and Environmental Tobacco Exposure in Korean Adolescents.
Hae Reung LEE ; Hyeon Keun KIM ; Jang Suk YOO ; Kyu Nam KIM ; Seon Yeong LEE ; Sun Mi YOO ; Hyo Bin KIM ; Bong Seong KIM ; Soo Jong HONG ; Ja Hyeung KIM ; So Yeon LEE ; Moon Woo SEONG ; Do Hoon LEE
Korean Journal of Family Medicine 2009;30(1):31-38
BACKGROUND: The aim of this study was to elucidate the relationship of environmental tobacco smoke (ETS) exposure and the urine cotinine concentrations in Korean adolescents. METHODS: The study population was 1st grade high school adolescents (n = 1467, girls 22.2%) recruited from four high schools, two from Seoul, one from Kangleung and one from Woolsan. We obtained information on active smoking and ETS exposure through self-reported questionnaire and urine cotinine concentrations. RESULTS: The prevalence of active smoking was 6.9% in boys and 0.9% in girls. Median urine cotinine concentrations were 19.5 microgram/L (range, 0-2341 microgram/L) among smokers, and 0 microgram/L (range, 0-1359 microgram/L) among nonsmokers. The positive rate of urine cotinine among nonsmokers exposed to ETS was 2.9%. Boys were exposed to ETS in the order of frequency in PC room (79.6%), home (39.4%), school (11.5%), and public places (5.9%); girls were exposed in the order of frequency in home (40.9%), PC room (33.2%), public places (28.0%), and school (15.2%). The frequency and duration of ETS exposure were significantly larger and longer in boys than in girls. Boys contacted friends who smoked more than girls did (32.6% vs. 17.1%). Parents; smoking status was similar both in boys and girls. Any information on ETS exposure did not differ according to the detectable urine cotinine among nonsmoking adolescents. CONCLUSION: Low positive rate of urine cotinine and no association of urine cotinine with various ETS exposure history reflect that urine cotinine may not be a good marker for ETS exposure in Korean adolescents.
Adolescent
;
Cotinine
;
Friends
;
Humans
;
Prevalence
;
Smoke
;
Smoking
;
Tobacco
;
Surveys and Questionnaires
5.Serum high sensitivity C-reactive protein is associated with carotid intima-media thickness, but not with microvascular complications in type 2 diabetes.
Eun Seok KANG ; Hyeung Jin KIM ; Sihoon LEE ; Hae Jin KIM ; Yoo Mee KIM ; Kyu Yeon HUR ; Wan Sub SHIM ; Cheol Woo AHN ; Bong Soo CHA ; Sung Kil LIM ; Hyun Chul LEE
Korean Journal of Medicine 2003;65(4):443-450
BACKGROUND: High sensitivity C-reactive protein (hsCRP) is more sensitive than standard CRP assay in evaluating a risk of coronary heart diseases and other atherosclerotic events. By this time, there are several reports that type 2 diabetic subjects have higher level of hsCRP than non-diabetic subjects. However, there are few reports about factors which have influence upon the level of serum hsCRP in type 2 diabetic subjects. We had evaluated the association of serum hsCRP level with risk factors of cardiovascular diseases, carotid intima-media thickness (IMT) and microvascular complications in type 2 diabetic subjects. METHODS: 105 patients (59 men and 46 women) with type 2 diabetes were recruited, and subjects with severe cardiovascular diseases were excluded. All subjects were undergone carotid ultrasonography for evaluation of carotid IMT. Serum hsCRP concentrations were measured. For evaluation of microvascular complications, fundus photography, nerve conduction velocity test were performed, and 24-hour urine protein/albumin excretion amounts were measured. RESULTS: Serum hsCRP level was correlated with mean left IMT (r=0.366, p=0.003), maximal left IMT (r=0.370, p=0.002), mean right IMT (r=0.281, p=0.023) and maximal right IMT (r=0.370, p=0.002). Body mass index (r=0.377, p<0.001), waist circumference (r=0.342, p<0.001), waist-hip ratio (r=0.229, p=0.020), serum total cholesterol (r=0.202, p=0.024), serum triglyceride (r=0.292, p=0.022) and serum low density lipoprotein (r=0.133, p=0.044). There was no difference of serum hsCRP level between groups with or without retinopathy (1.26+/-0.83 vs 1.13+/-1.13 mg/L, p=0.704), neuropathy (1.30+/-1.27 vs 0.88+/-0.80 mg/L, p=0.203) or nephropathy (1.10+/-0.93 vs 1.06+/-1.06 mg/L, p=0.863). CONCLUSION: We conclude that serum hsCRP level is correlated with carotid IMT and the risk factors of cardiovascular diseases, and may be useful to predict accelerated atherosclerotic process in type 2 diabetic subjects. But, diabetic microvascular complications do not effect on the level of serum hsCRP.
Body Mass Index
;
C-Reactive Protein*
;
Cardiovascular Diseases
;
Carotid Intima-Media Thickness*
;
Cholesterol
;
Coronary Disease
;
Diabetes Mellitus, Type 2
;
Humans
;
Lipoproteins
;
Male
;
Neural Conduction
;
Photography
;
Risk Factors
;
Triglycerides
;
Ultrasonography
;
Waist Circumference
;
Waist-Hip Ratio
6.The Relation of Overweight to Asthma and Other Allergic Diseases in High School Students in Korea.
Ni Ell SHIN ; Sun Mi YOO ; Kyu Nam KIM ; Seon Yeong LEE ; Eun Ji LEE ; Hyo Bin KIM ; Bong Seong KIM ; Soo Jong HONG ; Ja Hyeung KIM ; So Yeon LEE
Korean Journal of Family Medicine 2009;30(4):269-276
BACKGROUND: The worldwide prevalence of obesity and allergic diseases has increased. We aimed to explore the relation of overweight to asthma, atopic dermatitis, allergic rhinitis and conjunctivitis in a sample of Korean adolescents. METHODS: We investigated the prevalence of symptoms of asthma and other allergic diseases by using a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. The survey was conducted among 1,499 high school students in 3 regions of Korea. RESULTS: The lifetime prevalence of wheezing (21.2% vs. 15.7%, P = 0.04), the 12 months-prevalence of wheezing (4.5% vs. 2.0%, P = 0.04), exercise induced wheezing (13.8% vs. 9.3%, P = 0.04), treatment of asthma (3.3% vs. 1.1%, P = 0.01) and the prevalence of symptoms of allergic rhinitis (11.0% vs. 5.1%, P = 0.001) were signifi cantly higher in overweight boys than normal weight boys, but not in girls. However, there were no signifi cant differences of the prevalence of symptoms and past history of atopic dermatitis and allergic conjunctivitis between overweight and normal weight groups. In boys, overweight increased the risk of the lifetime prevalence of wheezing (OR 1.54, 95% CI: 1.05-2.24) and 12 months-prevalence of exercise induced wheezing (OR 1.64, 95% CI: 1.05-2.55) after adjusting for confounding variables. CONCLUSION: Overweight could be a risk factor for the development of symptoms of asthma and allergic rhinitis in adolescent boys, whereas it was not a signifi cant risk factor for allergic diseases in girls.
Adolescent
;
Asthma
;
Confounding Factors (Epidemiology)
;
Conjunctivitis
;
Conjunctivitis, Allergic
;
Dermatitis, Atopic
;
Humans
;
Hypersensitivity
;
Korea
;
Obesity
;
Overweight
;
Prevalence
;
Respiratory Sounds
;
Rhinitis
;
Rhinitis, Allergic, Perennial
;
Risk Factors