1.Endoscopic Findings and Its Diagnostic Accuracy in Gastric Cancer Confirmed by Surgery.
Kyung Su KIM ; Hee Ug PARK ; Jang Rack CHOI ; Chul Soo SONG ; Ung Suk YANG ; Yoon HUH ; Han Kyu MOON
Korean Journal of Gastrointestinal Endoscopy 1990;10(1):59-64
In order to evaluate the accuracy of endoscopic findings in the diagnosis of gastric can the endoscopic findings of gastric lesion were compared with the macroscopic and pathologic findings of excised identical lesion. 105 operated gastric cancer paitients (advanced cancer 95 cases, early cancer 10 cases) who were diagnosed endoscopically at Pusan National University Hospital from January 1983 to August 1987 were studied. The results were as follows; 1) The accuracy of endoscopic findings were 94.7% in the advanced gastric cancer, and 45.5% in the early gastric cancer. 2) The accuracy of gross findings endoscopic and pathologic in advanced gastric cancer were 50.0% in Borrmann type I, 45.0% in Borrmann type II, 73.2% in Borrmann type III, and 66.7% in Borrmann tyye IV. 3) The accuracy of the endoscopy ia morphologic classification of advanced gastric cancer according to pathologic tumor location were 60.0% in C (upper 1/3), 43.9% in M(middle 1/3),76.3% in A (lower 1/3), 55.6% in the anterior wall, 50.0% in the posterior wall, 66.7% in the greater curavature, and 67.2% in the lesser curvature. 4) The accuracy of endoacopy in morphologic classification of gastric cancer to tumor size ware 54.5% in below 2 cm, 54.5% in from 2.1 cm to 4 cm, 65.4% in from 4.1 cm to 6.0 cm, 80% in from 6.1 cm to 8 cm, 75.0% in above 8.1 cm. 5) The accuracy of endoscopy in the morphologic classification according to the pathologic tumor stage in advanced gastric cancer were 55.6% in TNM stage I, 52.0% in TNM stage II, 65.4% in TNM stage III, and 73,7% in TNM stage IV.
Busan
;
Classification
;
Diagnosis
;
Endoscopy
;
Stomach Neoplasms*
2.Age-related Changes of Mac1-positive Cell Distribution in the Thymus, Spleen and Popliteal Lymph Node in C57BL/6 Mice.
Chang Wook LEE ; Won Kyu LEE ; Young Buhm HUH ; Hee Kyung AHN
Korean Journal of Physical Anthropology 1999;12(2):277-288
The following experiment was performed to clarify distributional change of the Mac1-positive cells at 1, 4, 8 ,12 and 40 weeks after birth. Thymuses, spleens and lymph nodes were removed and immunocytochemical staining using the specific Mac1 antibody was performed The results obtained from the present experiment were as follows : 1. Mac1-positive cell was absent at 1 week, they were increased by 4 weeks and decreased at 40 weeks in the thymus after birth. 2. There was no Mac1-positive cell in the marginal zone of the spleen at 4, 40 weeks, but they were shown at 8 weeks. 3. Mac1-positive cells were increased at 4 weeks in the subfollicular area of lymph nodes. There was no change of distribution in the lymph nodes. From the above results, we suggest that the age-related decrease of the immunity might be caused by decrease of Mac1-positive cells in the antigen-presenting area.
Animals
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Lymph Nodes*
;
Mice*
;
Parturition
;
Spleen*
;
Thymus Gland*
3.Aneurysms Presenting with Neural Compression:Response to Treatment with Guglielmi Detachable Coils Embolization.
Jin Young PARK ; Jung Yong AHN ; Ryoong HUH ; Hun Kyu CHOI ; Byung Hee LEE ; Moon Soo SHIN ; Bong Sub CHUNG
Journal of Korean Neurosurgical Society 2000;29(11):1491-1498
No abstract available.
Aneurysm*
4.Seizure-Related Change of NADPH-diaphorase and Calbindin D28k Positive Neurons in the Cerebral Cortex of Rats.
Seong Jae CHA ; Young Buhm HUH ; Won Kyu LEE ; Jung Hye KIM ; Jin Hwa YOO ; Hee Kyung AHN
Korean Journal of Anatomy 1999;32(6):821-829
Administration of kainate (KA) results in the induction of epileptiform activity and limbic motor seizures. Nitric oxide (NO) is a gaseous messenger that plays a role in neural transmission, long term potentiation, depression and cerebral blood flow. NO is formed by NO synthase (NOS) from arginine. NO mediates the increase in cerebral blood flow during seizure activity. However, the production site of NO has not been clearly defined. Recent report showed that constitutive NOS may be induced under certain conditions. Therefore, the present study was aimed to investigate the change of NOS and calbindin D28k in the rat cerebral cortex following seizure. Rats were injected with KA and killed at 6 hours, 1, 3, 6 and 12 days after seizure. Expressional change of nNOS and calbindin D28k was assessed by histochemistry, immunohistochemistry and RT-PCR in the rat brain. Induced NADPH-d positive neurons were observed in the cerebral cortex of 1, 3, 6 and 12 days after seizure and found in specific cortical areas, such as motor cortex, somatosensory cortex, auditory cortex, visual cortex, ectorhinal cortex and perirhinal cortex. The level of nNOS mRNA increased at 1, 3, 6 and 12 days after seizure compared with control group. Induced calbindin D28k positive neurons were observed in motor cortex and somatosensory cortex 1 and 3 days after seizure. The level of calbindin D28k mRNA in the cerebral cortex was slightly decreased at 1 day after seizure. Therefore, in this study, the induced NADPH-d, calbindin D28k positive neurons and upregulated NADPH-d positive neurons may influence the cerebral blood flow and neuronal activity in the cerebral cortex during post-seizure period.
Animals
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Arginine
;
Auditory Cortex
;
Brain
;
Calbindin 1*
;
Calbindins*
;
Cerebral Cortex*
;
Depression
;
Immunohistochemistry
;
Kainic Acid
;
Long-Term Potentiation
;
Motor Cortex
;
Neurons*
;
Nitric Oxide
;
Nitric Oxide Synthase
;
Rats*
;
RNA, Messenger
;
Seizures
;
Somatosensory Cortex
;
Synaptic Transmission
;
Visual Cortex
5.Clinical Trial to Evaluate the Safety and Efficacy of Scalp Med(R) in Treatment of Patients with Androgenetic Alopecia.
Bark Lynn LEW ; Woo Young SIM ; Chang Hun HUH ; Jang Kyu PARK
Korean Journal of Dermatology 2008;46(6):776-783
BACKGROUND: Androgenetic alopecia (AGA) is characterized by the structural miniaturization of androgen-sensitive hair follicles in susceptible individuals and is anatomically defined within a given pattern of the scalp. Oral finasteride and topical minoxidil are the only drugs whose effect and safety were demonstrated and approved by the FDA. However, the treatment result of these medications are not always satisfactory. Here, we report the result of a clinical trial of the new topical agent, Scalp med(R) to patients with AGA. OBJECTIVE: The goal of this study was to test Scalp med(R), the solution including minoxidil, retinol, polysorbate 80 and phytosterol in the treatment of AGA. METHODS: Included in this study were males between the ages of 20 and 60 years, in good health, with mild to moderate AGA. Efficacy was evaluated by terminal hair count per 1 cm2 and hair thickness. RESULTS: The results of this clinical trial showed a highly positive response to treatment. After 24 weeks of treatment, a significant improvement in hair count and hair thickness was demonstrated in all the patients. CONCLUSION: This clinical study establishes the effectiveness and safety of Scalp med(R) in the treatment of AGA.
Alopecia
;
Finasteride
;
Hair
;
Hair Follicle
;
Humans
;
Male
;
Miniaturization
;
Minoxidil
;
Polysorbates
;
Scalp
;
Vitamin A
6.Patient Selection for Early Surgery in Ruptured Intracranial Aneurysm : Based on 10-year Experience with 1026 Patients.
Kuk Hee YANG ; Hyeon Seon PARK ; Yong Sam SHIN ; Jin Yang JOO ; Seung Kon HUH ; Kyu Chang LEE
Journal of Korean Neurosurgical Society 1996;25(11):2303-2309
The purpose of this study was to set the guidelines for selection of patients to do early surgery in ruptured intracranial aneurysm. We assessed 706 patients with single rupture and without large hematoma, who underwent aneurysm surgery from 1985 to 1995. The male and female ratio was 1:1.5. Among the 706 patients, early surgery was performed in 214 cases. The results of early surgery were good in 193 cases(90.2%), fair in 13 cases(6.0%), poor in 1 case(0.5%) and dead in 7 cases(3.3%). The rate of dead outcome in the early surgery group was higher compared to other timing groups. The Fisher group 1, 2 and 3 reveale good outcome in early surgery group;92.6%, 96.3%, 88.8% respectively. The incidence of delayed ischemic deficits(DID) of early surgery group was same as other groups. However, in Fisher group 3, the incidence of DID was significantly low, 32.5%, in early surgery group. It is suggested that the criteria of selection of early surgery in patients with ruptured intracranial aneurysm would include as follows:1) patients with good clinical grade, 2) poor grade patients with marked irritability, acute hydrocephalus, and poorly controlled hypertension, 3) none-complex aneurysm requiring less brain retraction, dissection and brief temporary clipping, 4) age under 60 or over 60 with good physical status, and 5) Fisher group 3 requiring cisternal larvage and anticipated triple-H therapy.
Aneurysm
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Brain
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Female
;
Hematoma
;
Humans
;
Hydrocephalus
;
Hypertension
;
Incidence
;
Intracranial Aneurysm*
;
Male
;
Patient Selection*
;
Rupture
7.Efficacy of Combined Gemcitabine/Cisplatin Chemotherapy for Locally Advanced or Metastatic Urothelial Cancer.
Kwan Sik BAE ; Kyu Il AHN ; Seung Hyun JEON ; Jung Sik HUH ; Sung Goo CHANG
Cancer Research and Treatment 2006;38(2):78-83
PURPOSE: We wanted to determine and report on the outcome of combined gemcitabine/cisplatin chemotherapy for patients suffering with locally advanced or metastatic urothelial cancer. MATERIALS AND METHODS: Between July 1999 and December 2004, 43 selected patients were enrolled in this study. Group 1 (the adjuvant chemotherapy group) had undergone radical surgery with removal of evident tumor from the following primary sites: bladder (n=8), renal pelvis (n=7) and ureter (n=3). Group 2 (the salvage chemotherapy group) had undergone palliative surgery with a remnant tumor at the following primary sites; bladder (n=23) and renal pelvis (n=2). All the patients were given gemcitabine/ciplatin and they evaluated for the therapeutic effect and toxicity. The patients were initially treated with gemcitabine 1000 mg/m2 intravenously for 30 minutes on days 1, 8 and 15 of a 28-day cycle, and cisplatin 70 mg/m2 was administered intravenously on day 1 using prehydration measures. RESULTS: Group 1: The median follow-up period was 16.5 months. The mean age was 63 years (males: 15 cases, females: 3 cases), and eleven patients (61%) remained alive. The estimated median relapse-free survival period and 2-year survival rate were 24 months and 63%, respectively. Group 2: the median follow-up period was 20 months, the mean patient age was 63.8 years (males: 22 cases, females: 3 cases), and nine patients (36%) remained alive. The overall response and 2-year survival rates were 36% and 43%, respectively. Toxicities: Grade 3 toxicities developed in 14 cycles during the total 232 cycles. Grade 4 toxicity did not occur. CONCLUSIONS: The results of this study confirm that adjuvant and salvage chemotherapy with using gemcitabine and cisplatin is tolerable and safe.
Chemotherapy, Adjuvant
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Cisplatin
;
Drug Therapy*
;
Female
;
Follow-Up Studies
;
Humans
;
Kidney Pelvis
;
Palliative Care
;
Survival Rate
;
Ureter
;
Urinary Bladder
;
Urologic Neoplasms
8.Correlation of Neuronal Nitric Oxide Synthase with Penile Erection in Diabetic Rats.
Ki Hak MOON ; Hee Chang JUNG ; Tong Choon PARK ; Yung Chang LEE ; Khun HUH ; Jong Min PARK ; Jun Kyu SUH
Korean Journal of Urology 1997;38(6):575-584
Diabetes mellitus (DM) is an important cause of organic impotence in man. The exact pathogenesis remains debatable although it has been focused on cavernosal neuropathy and/or endothelial dysfunction. This study was designed to investigate the effect of DM on penile erection, especially in association with nitric oxide synthase (NOS) in corpus cavernosum of diabetic rats. NOS studies of rat penis were performed in diabetic (DM was induced for 3, 6, 9, 12 weeks, respectively, by intraperitoneal administration of streptozotocin, 60mg/kg), in control and neurotomy group (3 weeks after bilateral cavernous nerve transection). The experiments consisted of nicotinamide dinucleotide phosphate (NADPH) diaphorase activity with spectrophotometric assay for NOS catalytic activity, NADPH diaphorase staining for the identification of NOS containing nerve fibers, and Western blotting analysis with anti-brain NOS antibody for the expression of neuronal NOS. Finally, these results were compared with erectile response to cavernous nerve stimulation in diabetic and in control rats. In assay of NADPH diaphorase activity, NOS activity decreased significantly in penis of diabetic rat as compared to that of controls. Between the diabetic groups, NOS activity was not seen significantly different, and in neurotomy groups it was similar to that of diabetic groups. On histochemical staining of penile tissues, the number of NADPH-positive nerve fibers in control group (a mean of 127+/-6 fibers recorded in 4 random fields on each corporal side) contrasted significantly with that of the bilateral cavernous nerve ablation group (a mean of 12+/-2). In diabetic group, the number of NOS-containing nerve fibers was gradually reduced along with duration of diabetes (from 92+/- 3 at 3 weeks to 28+/-3 at 12 weeks). In addition, analysis of blot density of neuronal NOS by Western blotting showed similar findings: 16% at 3 weeks and 8% at 12 weeks in diabetic group, 5% in neurotomy group and 27% in controls, based on the density of the rat cerebellum. Furthermore, erection response to cavernous nerve stimulation was also decreased in diabetic rats along with DM duration. The results, indicated that reduction of cavernous NOS, particularly, its neuronal form at the level of NO production plays an important role on the pathogenesis of erectile impotence in diabetic rats although the role of endothelial N0S in DM remains to be elucidated. Furthermore, cavernosal NADPH diaphorase staining and/or NOS activity may allow to characterize certain pathological condition, which comprise neurogenic impotence.
Animals
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Blotting, Western
;
Cerebellum
;
Diabetes Mellitus
;
Erectile Dysfunction
;
Male
;
NADPH Dehydrogenase
;
Nerve Fibers
;
Neurons*
;
Niacinamide
;
Nitric Oxide
;
Nitric Oxide Synthase
;
Nitric Oxide Synthase Type I*
;
Penile Erection*
;
Penis
;
Rats*
;
Streptozocin
9.Diagnosis of Constipation: a Systematic Review.
Seung Jae MYUNG ; Tae Hee LEE ; Kyu Chan HUH ; Suck Chei CHOI ; Chong Il SOHN
The Korean Journal of Gastroenterology 2010;55(5):316-324
To diagnose constipation accurately in self-reported constipated patients is very important not to miss organic disease and prevent therapeutic abuse. To investigate the etiology of functional constipation is also important to determine the therapeutic modality of constipation. In this systemic review, the clinical usefulness of symptom evaluation, diagnostic tests to rule out organic and systemic disease, and functional tests to discriminate underlying pathophysiology in the diagnosis of constipation were discussed. No specific symptoms or tests were available to predict organic versus functional constipation or differentiate slow transit constipation versus evacuation disorder. Therefore, collaborative studies are necessary to determine the pathophysiology of this disorder.
Blood Chemical Analysis
;
Colonoscopy
;
Constipation/*diagnosis/etiology
;
Defecography
;
Humans
;
Severity of Illness Index
;
Thyroid Function Tests
10.Diagnosis of Constipation: a Systematic Review.
Seung Jae MYUNG ; Tae Hee LEE ; Kyu Chan HUH ; Suck Chei CHOI ; Chong Il SOHN
The Korean Journal of Gastroenterology 2010;55(5):316-324
To diagnose constipation accurately in self-reported constipated patients is very important not to miss organic disease and prevent therapeutic abuse. To investigate the etiology of functional constipation is also important to determine the therapeutic modality of constipation. In this systemic review, the clinical usefulness of symptom evaluation, diagnostic tests to rule out organic and systemic disease, and functional tests to discriminate underlying pathophysiology in the diagnosis of constipation were discussed. No specific symptoms or tests were available to predict organic versus functional constipation or differentiate slow transit constipation versus evacuation disorder. Therefore, collaborative studies are necessary to determine the pathophysiology of this disorder.
Blood Chemical Analysis
;
Colonoscopy
;
Constipation/*diagnosis/etiology
;
Defecography
;
Humans
;
Severity of Illness Index
;
Thyroid Function Tests