BACKGROUND: Specified clinical observations regarding skin changes in viral hepatitis have not yet been accomplished in Korea, especially in view of serotypes. OBJECTIVE: This study was conducted to identify various cutaneous manifestations of viral hepatitis according to viral serotypes and the stages of the disease. METHODS: We performed a clinical observation of cutaneous manifestations in 450 patients who were diagnosed with viral hepatitis. RESULTS: 1. Cutaneous manifestations were found in 383(85.1%) patients. Patients with a longer duration seemed to have skin lesions more frequently. 2. The frequency of cutaneous manifestations was highest in HAV(94.4%) and HBV(84.9%) serotypes. The most common cutaneous manifestation was pruritus(32.4%) in all studied subjects. In HBV hepatitic patients, the most common cutaneous manifestation was pruritus(35.4%), in HCV hepatitic patients, vasculitic purpura(74.5%), in HAV hepatitic patients, urticaria(88.8%), in the hepatitic patients with the mixed form, spider angioma(30.2%) and vasculitic purpura(30.2%). 3. Urticarial lesions in non-HCV hepatitis were of the lymphocytic vasculitis type but HCV hepatitis was associated with neutrophilic vasculitis. The purpuric lesions with HCV hepatitis were of the neutrophilic vasculitis type while lymphocytic vasculitis was present in non-HCV hepatitis. 4. The most severe pruritus was present in HBV hepatitic patients. CONCLUSION: The cutaneous manifestations in viral hepatitis have different clinical features depending on the viral types.
Hepatitis* ; Humans ; Korea ; Neutrophils ; Pruritus ; Skin ; Spiders ; Vasculitis

We report s case of angiokeratoma of the vulva occuring in a 36-year-old woman. Numerous grayish dark purple papulovesicular lesions, ranging from 0.2 to 2.0mm in size, were observed on the right labium majus. All lesions were excised under local snesthesia after the diagnosis of angio keratoma was made histopathologically. No new lesions appeared during the follow-up period of one year.
Adult ; Angiokeratoma* ; Diagnosis ; Female ; Follow-Up Studies ; Humans ; Keratosis ; Research Report ; Vulva*

This presentation is a case of osteomalacia, the cause of which was a nutritional deficiency. The patient was a 42-year-old female who had pseudofractures of ribs, ulnae, pelvic raml, the right second metacarpai bone and both femoral necks. Following treatment by medication combined with internal fixation of the femoral necks, the result was good.
Adult ; Female ; Femur Neck ; Humans ; Malnutrition ; Osteomalacia ; Ribs ; Ulna

We report herein a case of cutaneous metastasis from carcinoma of the urinary bladder in a 73-year-old male. He visited our department with a 3 month history of erythematous to dark brown colored, hard, non-tender, non-movable subcutaneous nodules on the anterior chest and neck. Skin biopsy specimens from the chest and the neck lesions revealed variable sized polygonal cells with hyperchromatic nuclei, and these histopathological findings were compatible with the metastatic transitional cell carcinoma of the urinary bladder.
Aged ; Biopsy ; Carcinoma, Transitional Cell ; Humans ; Male ; Neck ; Neoplasm Metastasis* ; Skin ; Thorax ; Urinary Bladder*

We report a case of silicone granuloma of the breast in a 38-year-old female patient who had been injected with liquid silicone by an unauthorized practitioner for augmentation of her breast. On histopathological examination, we could observe numerous variable sized ovoid or round cavities that gave the section a ""Swiss cheese"" appearance in the dermis and subcutaneous fat. She was treated initially with oral antibiotics and corticosteroids with no significant improvement, and she was referred to the Plastic Surgery Department for surgical removal of the silicone granuloma.
Adrenal Cortex Hormones ; Adult ; Anti-Bacterial Agents ; Breast ; Dermis ; Female ; Granuloma* ; Humans ; Silicones* ; Subcutaneous Fat ; Surgery, Plastic

No abstract available.
Humans ; Hypoplastic Left Heart Syndrome* ; Survivors*

We report two cases of hyperkeratosis of the nipple and areola which occurred in 22-year-old woman and 13-year-old girl. The former was suffered from mild pruritic, verrucous thickening and brownish discoloration of both nipples and areolae for 5 years. The latter had asymptomatic, verrucous thickening and dark brownish hyper- pigmentation of the right nipple and areola for 3 years. Both showed mild to marked hyperkeratosis and papillomatosis with increased pigmentation in the basal cell layer histopathologically. In both cases, the lesions were not responsive to the topical medications including steroids and keratolytic agents. Therefore we recommended surgical excision because the patients are greatly disturbed by the appearance of the lesions.
Adolescent ; Female ; Humans ; Keratolytic Agents ; Nipples* ; Papilloma ; Pigmentation ; Steroids ; Young Adult

BACKGROUND: Although it is evident that androgens have an important role in pathogenesis of acne, the results of current studies on the relationship between serum androgens and acne are inconsistent. Additionally there has been sparse clinical datas about hormonal derangcment with regard to acne in Korea. OBJECTIVE: This study was conducted to elucidate hormonal abnormalities by detecting the quantitative difference between the acne patients and normal persons with respect to the levels of plasma free/total Testosterone(T), Dihydrotestosterone(DHT), Dehydroepiandrosterone-sulfate(DHEA-S) and Estradiol(E2) in acne patients. METHODS: In this study, we measured serum levels of free T, total T, DHT, DHEA-S and E2 in 25 women and in 15 men with acne and in 40 healthy control subjects. RESULTS: 1. The levels of free T and E2 in the male patient group were significantly higher than those in the control groups. In the female patient group the levels of DHT were more elevated than those in the control groups. 2. The levels of free T and E2 in all the male subgroups classified by Burke & Cunliffe were significantly elevated compared to those in the male control groups. The plasma levels of DHT in all the female clinical subgroups were significantly higher than those in the female control groups. However, we could not find any correlative relationship between hormonal parameters and the clinical severity in all the patient groups. 3. There was a positive relationship between free T levels and E2 levels in the male patient gfOUp. 4. The patients with menstrual cyclic irregularity had higher mean free T and acne grading scores when compared with those who had regular periods. Also they were younger than the patients with regular menstrual cyclicity. CONCLUSION: The levels of free T and E2 in male patients were higber than in normal control subjects. In the female patients the levels of DHT were higher than in the control subjects. However, there was no correlative relationship between hormonal parameters and the clinical severity of acne. Also the patients with irregular menstrual cyclicity had a higher free T and showed severe acne clinically.
Acne Vulgaris* ; Androgens ; Dihydrotestosterone* ; Estradiol* ; Female ; Humans ; Korea ; Male ; Periodicity ; Plasma* ; Testosterone*

No abstract available.
Pregnancy*

Angiosarcoma is a rare malignant vascular tumor of endothelial cell origin. Most lesions of cutaneous angiosarcoma occur over the face and scalp. We experienced a case of angiosarcoma of the scalp in a 63-year-old man. Multiple pea-sized erythematous papules and nodules developed on the forehead 6 months ago. Thereafter, the lesions have extended to make violaceous, compressible and hemorrhagic plaques. On histologic examination, there were irregular, often anastomosing vascular channels lined by the atypical endothelial cells in the dermis.
Dermis ; Endothelial Cells ; Forehead ; Hemangiosarcoma* ; Humans ; Middle Aged ; Scalp*