No abstract available.
Child* ; Dermatoglyphics* ; Down Syndrome* ; Humans ; Karyotype*

No abstract available.
Arthrogryposis* ; Humans ; Siblings*

In 1,146 term neonates without perinatal problems who were born in Kwangju Christian Hospital, blood TSH levels were measured by immunoradiometric assay. In 397 term neonates among them, blood T4 levels were measured by radioimmunoassay in same specimens. 1) In normal neonates aged 3~5 days, 6~10 days, 11~20 days and 21~28 days, the TSH levels were 8.88+/-5.21(mean+/-SD), 9.44+/-5.16, 9.69+/-4.98, 11.96+/-3.75 IU/ml and the T4 levels were 11.41+/-2.79, 11.37+/-2.82, 11.19+/-2.63, 10.51+/-2.99 g/dl respectively. 2) No significant sex difference in TSH level was found in each age group, and TSH level did not correlate with birth weight. In neonates delivered by Cesarean section, TSH levels were lower than those of the normally delivered. 3) T4 levels did not differ between both sexes, and between types of delivery in each age group, and nor did it correlate with birth wweight 4) If the recall rate should be set at 0.2% of the total, TSH levels above 26.9 IU/ml would be required to recall for serum sampling. TSH level above 2 SD was 19.7 IU/ml. Cutoff points of T4 levels at 1.5 SD and 2 SD were 5.8 and 7.2 g/dl respetively, and the lowest 10th percentile was 7.4 g/dl.
Birth Weight ; Cesarean Section ; Female ; Gwangju ; Humans ; Immunoradiometric Assay ; Infant, Newborn* ; Mass Screening* ; Parturition ; Pregnancy ; Radioimmunoassay ; Sex Characteristics

We observed 233 twins and 2 triplets cases among 16,774 newborns delivered at Kwangju Christian Hospital during 5 years from Jan, 1986 to Dec. 1990. The results obtained are as follows: 1) The overall incidence of win pregnancy was 1:72(1.4%)and that of triplets 1:z8387(0.01%). 2) The average male-female sex ratio of twins was 1.06:1 with male predominating and 86% were same sex pairs(male-male 43.8%, female-female 41.3%), only 14.0% being different. 3) The incidence of twin delivery tended to be more prevalent in primigravidas. 4) More than half of all cases(248/466)had birth weight less than 2,500 g, with 33% falling into the range of 2,001~2,500 g. No statistically significant differences of birth weight were noted between both sexes or among birth sequences. 5) At 5 minute after birth, Apgar score below 7 were found in 9.5% of the firtst born and in 11.6% of second born twins, with no significant difference noted. 6) The perinatal mortality rate of twins were 94.4/1,000 and the perinatal mortality rates of first and second twins were 77.2 and 111.6, resp., but not significantly different. The larger the difference of birth weight between co-twins, the shorter thee gestational age and the less the birth weight between co-twins, the shorter the gestation age and the less the birth weight of twins, the larger became the perinatal mortality. But, it was not related to the parities or maternal ages. 7) The overall principal causes of perinatal death were still birth (45.5%), respiratory distress syndrome(36.4%) and immaturity(11.4%) in descending order.
Apgar Score ; Birth Weight ; Gestational Age ; Gwangju ; Humans ; Incidence ; Infant, Newborn ; Male ; Maternal Age ; Parturition ; Perinatal Mortality ; Pregnancy ; Sex Ratio ; Triplets ; Twins*

No abstract available.
Barium* ; Intussusception*

No abstract available.
Humans ; Infant, Newborn* ; Pneumonia*

No abstract available.
Humans

No abstract available.
Goiter*

PURPOSE: To gather reference data for better genetic counseling, we have evaluated the outcomes of chromosomal analyses performed on the parents with chromosomal anomalous children and recurrent abortion in this hospital for the last 20 years. METHODS: Subjected to study were 108 parents (50 fathers & 58 mothers) who had children with Down syndrome, other chromosomal and congenital anomalies, and those who had experienced frequent miscarriages from March 1974 through August 1994. The Moorhead's method with G banding technique was used. RESULTS: 1) Of those 108 parents studied, 52 (48.1%) had Down babies, 27 (25.0%) had frequent miscarriages or stillbirths, 22 (20.4%) had children with congenital anomalies, and 7 (6.5%) had other chromosomal anomalies. 2) Abnormal karyotypes were detected in 9 (8.3%): 6 among 52 parents with Down babies (11.5%), 1 out of 7 parents whose children had other chromosomal abnormalities (14.2%), and 2 from 27 who had experienced miscarriages (7.4%). 3) Abnormal karyotypes of the parents who had Down babies were: balanced 14q21q translocations in 2 mothers and 1 father, balanced 21q21q translocation in a carrier mother who looked like Down's, and 14q+ in a normal-looking father. Among the parents having babies with anomalies other than Down's, one mother who gave births to 2 babies, one with balanced and the other with unbalanced translocation, was found to carry t(12;13) balanced translocation. Two women who had experienced frequent miscarriages were found to have balanced 14q21q translocation in one and XXq- in the other. 4) Abnormal karyotypes detected in 6 among those 52 parents with Down babies were: 3 out of 38 whose babies had 21-trisomy (7.9%), 2 among 8 parents having babies with 14q21q translocation (25%), and one from 6 parents whose babies had 21q21q translocation (16.7%). 5) Out of 375 Down children, 3 had Down sibling, with the overall recurrence rate of 0.8%, and 2 out of 6 parents of those 3 families were revealed to be balanced translocation carriers. CONCLUSIONS: The high incidence of carrying chromosomal anomaly among the parents having chromosomal anomalous children, but otherwise normal-looking, advocates it essential to have the parents analyzed for their chromosomal make-ups in order to provide better genetic counseling to those who gave birth to a baby with chromosomal abnormality or experienced frequent miscarriages.
Abnormal Karyotype ; Abortion, Habitual* ; Abortion, Spontaneous ; Child* ; Chromosome Aberrations ; Down Syndrome ; Fathers ; Female ; Genetic Counseling ; Humans ; Incidence ; Mothers ; Parents* ; Parturition ; Pregnancy ; Recurrence ; Siblings ; Stillbirth

No abstract available.
Humans ; Infant, Newborn* ; Membranes* ; Rupture*