1.Translocation of p53 Protein in Melanocytes and Malignant Melanoma Cells After UVB Irradiation.
Kyoung Hee CHOI ; Hye Jin KIM ; Yong CHOI ; Kyu Han KIM ; Kyoung Chan PARK
Annals of Dermatology 2001;13(3):133-138
BACKGROUND: UVB is responsible for most of the carcinogenic effects of sun exposure. OBJECTIVE: Aim of this study was to investigate the regulation and intracellular redistribution of p53 protein after UVB irradiation. METHODS: Cultured normal human melanocytes and G361 melanoma cells were used for west-ern blotting and confocal microscopic examination for determining expression and distribution of p53. RESULTS: UVB irradiation increased p53 expression in cultured normal human melanocytes and G361 malignant melanoma cells according to increasing doses of UVB. Furthermore, p53 moved from cytosol to nucleus after UVB irradiation. CONCLUSIONS: UVB irradiation induced overexpression and redistribution of p53 in cultured normal human melanocytes and G361 malignant melanoma cells.
Cytosol
;
Humans
;
Melanocytes*
;
Melanoma*
;
Solar System
2.Sebaceous Carcinoma and Basal Cell Epithelioma Developed in Organoid Nevus.
Kyoung Ae JANG ; Seh Jin AHN ; Jee Ho CHOI ; Jai Kyoung KOH
Annals of Dermatology 1999;11(1):59-61
In about 20 to 30 percent of cases with organoid nevus (nevus sebaceus), benign and/or ma-al lignant tumors of the epidermis and adnexae may develop. We describe a 71-year-old woman with sebaceous carcinoma and basal cell epithelioma developed in organoid nevus.
Aged
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Carcinoma, Basal Cell*
;
Epidermis
;
Female
;
Humans
;
Nevus*
;
Organoids*
3.Purpura Fulminans.
Kyoung Ae JANG ; Gwang Jin KOH ; Jee Ho CHOI ; Kyung Jeh SUNG ; Kee Chan MOON ; Jai Kyoung KOH
Annals of Dermatology 1999;11(2):75-77
Purpura fulminans may be seen in three different clinical settings: (1) in the neonatal period from protein C and S deficiencies, (2) during severe bacterial infections such as “sepsis-associated” purpura fulminans, and (3) during the convalescence of an otherwise benign “preparatory” infectious disease most commonly involving the skin. We report a case of a 20-month-old male child with purpura fulminans as a presenting sign of disseminated intravascular coagulopathy (DIC). He had suffered from fever of unknown origin for a month. Although purpura fulminans is not a common disorder to dermatologists, the awareness of this disorder may be the clue to diagnose and treat underlying diseases.
Bacterial Infections
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Child
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Communicable Diseases
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Convalescence
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Fever of Unknown Origin
;
Humans
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Infant
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Male
;
Protein C
;
Purpura Fulminans*
;
Purpura*
;
Skin
4.Intravascular Fasciitis: A Case Report of an Intraoral Location.
Kyoung Ae JANG ; Seh Jin AHN ; Jee Ho CHOI ; Kyung Jeh SUNG ; Kee Chan MOON ; Jai Kyoung KOH
Korean Journal of Dermatology 1998;36(6):1109-1112
Intravascular fasciitis (IVF), a rare distinct variant of nodular fasciitis, possesses the same clinical and histologcal features of nodular fasciitis, but in addition, involves predominantly small to medium- sized veins and/or arteries intraluminally, intramurally and extramurally. Only 3 cases of intraoral IVF have been reported in the English literature. Herein we report a case of IVF developing on the inner lower lip and it was successfully treated with simple excision.
Arteries
;
Fasciitis*
;
Lip
;
Veins
5.A Case of Skin Metastasis from Mucoepidermoid Carcinoma of Parotid Gland Mimicking Radiodermatitis.
Kyoung Jin KIM ; Sung Eun CHANG ; Jee Ho CHOI ; Kyung Jeh SUNG ; Kee Chan MOON ; Jai Kyoung KOH
Annals of Dermatology 2001;13(3):171-174
Cutaneous metastasis from parotid gland carcinoma is very rare and there have been no re-ports in Korean literatures. Furthermore, it can often manifest as inflammatory type of skin metastasis and mimic a radiodermatitis. We report a case of a 31-year-old Korean man with cutaneous metastasis originated from parotid gland mucoepidermoid carcoinoma which mimicked clinically a radiodermatitis.
Adult
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Carcinoma, Mucoepidermoid*
;
Humans
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Neoplasm Metastasis*
;
Parotid Gland*
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Radiodermatitis*
;
Skin*
6.The Hypereosinophilic Syndrome.
Kyoung Ae JANG ; Se Jin AHN ; Jee Ho CHOI ; Kyung Jeh SUNG ; Kee Chan MOON ; Jai Kyoung KOH
Annals of Dermatology 2000;12(1):18-25
BACKGROUND: The hypereosinophilic syndrome(HES) represents a leukoproliferative process likely caused by a number of disorders, all of which are marked by sustained over-production of eosinophils. OBJECTIVES: The purposes of this study were aimed at evaluating the clinical and histopathological characteristics of HES. METHODS: The medical records and hist opathological slides of patients with HES who had skin biopsies performed in our department were reviewed. Criteria for the diagnosis of HES include (1) peripheral blood eosinophilia with eosinophil counts greater than 1,500/L for at least 6 months; (2) no evidence of parasitic, allergic, or other known causes of eosinophilia; and (3) presumptive signs and symptoms of multiple organ involvement. RESULTS: Four male and three female patients were included. HES developed in adulthood or old age (mean, 43.4 years). Because only the patients with cutaneous involvement were included, all the patients showed skin lesions. Heart, liver, stomach, nervous system, lymph nodes, and lung were involved organs in decreasing order of frequency. At the onset of HES, 40 to 80% of white blood cells were eosinophils in peripheral blood. White blood cell count and serum IgE level were elevated in all the tested patients. In six patients (85.7%), the level of serum erythrocyte sedimentation rate was elevated. Persistent hypereosinophilia (>1,500/L) was present for longer than 6 months in all patients. Stool examination and skin test for parasitic infestation all gave negative results. All the patients were not taking any medication. Histopathological examinations revealed perivascular mixed inflammatory cell infiltration; predominantly eosinophils in the stomach, liver, and nerve as well as in the skin. Interestingly, two patients who were presented with skin lesions showed the findings of eosinophilic vasculitis. In these patients, the skin lesions were consisted of Raynaud's phenomenon, digital gangrene, and several erythematous plaques. The most common cutaneous manifestations were papules and nodules on the extremities. The main treatment modality was systemic steroid. Except for one patient presented with central nervous system involvement of HES, all the patients were in a well-controlled state. In one patient with the typical clinical and hematologic features of HES, Hodgkin's disease followed. After the complete remission of Hodgkin's disease with chemotherapy, HES subsided. CONCLUSIONS: HES is a heterogenous collection of disorders marked by hypereosinophilia and organ damage. Most common cutaneous manifestations were papules and nodules on the extremities. Raynaud's phenomenon and digital gangrene can be the primary manifestation of HES in which cases cutaneous lesions showed eosinophilic vasculitis. Five patients (71%) responded well to systemic steroids. HES may be a herald of malignancy such as Hodgkin's disease. Further investigation will be mandatory ro elucidate the etiology and pathogenesis of HES.
Biopsy
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Blood Sedimentation
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Central Nervous System
;
Diagnosis
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Drug Therapy
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Eosinophilia
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Eosinophils
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Extremities
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Female
;
Gangrene
;
Heart
;
Hodgkin Disease
;
Humans
;
Hypereosinophilic Syndrome*
;
Immunoglobulin E
;
Leukocyte Count
;
Leukocytes
;
Liver
;
Lung
;
Lymph Nodes
;
Male
;
Medical Records
;
Nervous System
;
Skin
;
Skin Tests
;
Steroids
;
Stomach
;
Vasculitis
7.A Case of Acrodermatitis Continua of Hallopeau.
Hae Woong LEE ; Kyoung Jin KIM ; Mi Woo LEE ; Jee Ho CHOI ; Kee Chan MOON ; Jai Kyoung KOH
Annals of Dermatology 2004;16(3):141-143
No abstract available.
Acrodermatitis*
8.Laugier-Hunziker Syndrome.
Kyoung Ae JANG ; Seh Jin AHN ; Jeo Ho CHOI ; Kyung Jeh SUNG ; Kee Chan MOON ; Jai Kyoung KOH
Korean Journal of Dermatology 1999;37(1):108-110
Laugier-Hunziker syndrone is a rare, pigmentary disorder of the lips, oral mucosa, and nails. The absence of intestinal polyposis differentiated it from Peutz-Jeghers syndrome. We describe a 16-year-old boy with multiple, brownish, lenticular macules on the lips, oral mucosa, perianal area and anal mucosa, and on the digits of his fingers and toes, in wham intestinal polyposis was not detectable.
Adolescent
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Fingers
;
Humans
;
Intestinal Polyposis
;
Lip
;
Male
;
Mouth Mucosa
;
Mucous Membrane
;
Peutz-Jeghers Syndrome
;
Toes
9.Knowledge of human papillomavirus infection and acceptability of vaccination among adult women in Korea.
Kyoung A CHOI ; Jung Hye KIM ; Kyoung Soon LEE ; Jin Kyoung OH ; Shan Ni LIU ; Hai Rim SHIN
Korean Journal of Obstetrics and Gynecology 2008;51(6):617-623
OBJECTIVE: The HPV vaccination target adolescents, and may be influenced by opinion of parents and other family member. For implementation of HPV vaccine, we measured knowledge of HPV infection and acceptability of vaccination among adults in Korea. METHODS: From August 2006 to November 2007, we provided a written questionnaire to females (above 19 years- olds) who visited Il-sin Christian hospital for prenatal care or gynecological examination. The questionnaire was built using elements of The Health Belief Model. We measured (1) awareness of HPV (2) perceived susceptibility (3) perceived seriousness (4) perceived benefit of vaccination (5) perceived barriers (6) cues to action. RESULTS: Total 975 females answered the questionnaire, and the mean age was 40 years. Only 23.8% knew the fact cervical cancer is related to HPV infection. 78.3% of respondents were willing to accept HPV vaccination after they understood HPV vaccination can prevent cervical cancer. Financial burden and possible side effect were barriers to vaccination. CONCLUSIONS: Despite of low awareness of HPV infection, most (78.3%) adults favored having HPV vaccination. But the vaccine was more likely to be accepted if it is recommended by a physician and reasonably priced.
Adolescent
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Adult
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Cues
;
Surveys and Questionnaires
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Female
;
Gynecological Examination
;
Humans
;
Korea
;
Papillomavirus Infections
;
Parents
;
Prenatal Care
;
Uterine Cervical Neoplasms
;
Vaccination
10.A Clinical Observation in 14 Children with SLE.
Jin Nyoung PARK ; Jai Kyoung CHOI ; Ha Baik LEE ; Hahng LEE
Journal of the Korean Pediatric Society 1994;37(4):510-519
To elucidate the clinical characteristics of childhood onset systemic lupus erythematosus (SLE), we carried out a retrospective reivew on medical records of fourteen patients who were diagnosed as SLE on the base of "the 1982 revised criteria for the SLE"(by american Rheumatism Association) at the Department of pediatrics, Hanyang University Hospital from January 1980 through August 1992. The results were summerized as follows: 1) Eleven girls and three boys were recruited in our study, The eight of them were early teens at the time of SLE diagnosis. 2) The frequencies of their clinical manifestations on admission were persistent facial rashes, edema, hepatosplenomegaly, renal abnormalities were proteinuria and hematuria. 3) Immunologic abnormalities were noted as follows: Positive ANA 100%. positive LE cell 64%, elevated anti DS-DNA antibody 64%, and decreased only C3 level 28%, decreased both C3 & C4 64% of the patients. 4) Serum anti-DS DNA(>10units) titer was increased in clinical exacerbated three patients and decreased in four resolved. 5) The high ANA titers( >1;80)obtained in eleven and/or homogenous pattern shown in seven strongly suggested SLE. 6) Renal biopsies of the four patients revealed lupus nephritis and three of the four patients had lupus band in their biopsied skin. 7) Three of 14 patients were recoverd spontaneously with supportive care. Other 11 patients were treated: 7 with prednisolone only, 4 combined prednisolone and other agents. After treatment five were clinically improved. But 4 patients were frequently exacerbated over 2 years, and 2 patients were died of their complications. In conclusion, serum anti-DS DNA level and ANA may be useful for the screening of SLE and for predicting clinical course and prognosis of SLE.
Adolescent
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Biopsy
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Child*
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Diagnosis
;
DNA
;
Edema
;
Exanthema
;
Female
;
Hematuria
;
Humans
;
Lupus Erythematosus, Systemic
;
Lupus Nephritis
;
Mass Screening
;
Medical Records
;
Neutrophils
;
Pediatrics
;
Prednisolone
;
Prognosis
;
Proteinuria
;
Retrospective Studies
;
Rheumatic Diseases
;
Skin