1.Two Cases of Malignant Melanoma Diagnosed by MRI.
Kyoung Ho AHN ; Ki Bong KIM ; Choun Ki JOO
Journal of the Korean Ophthalmological Society 1991;32(9):825-831
A 10 month-old female visited our out-patient clinic, whose chief complaint was an enlargement of right eyeball since 5 month ago. Her physical examination disclosed Cafe-au-lait spots on abdomen and back and a tumor-like mass was seen on right vitreous cavity by slit lamp biomicroscopy, indirect ophthalmoscopy, and orbit CT. The working diagnosis was either neurofibromatosis or retinoblastoma, but choroidal hemangioma was also another possibility tomographically. However, MRI suggested the possibility of choroidal malignant melanoma unexpectedly. Subsequently the eye was enucleated and the tumor was confirmed to be a choroidal malignant melanoma. We report this interesting case and the other case of choroidal malignant melanoma diagnosed by MRI in 57 year-old male.
Female
;
Humans
;
Hemangioma
2.Sebaceous Carcinoma and Basal Cell Epithelioma Developed in Organoid Nevus.
Kyoung Ae JANG ; Seh Jin AHN ; Jee Ho CHOI ; Jai Kyoung KOH
Annals of Dermatology 1999;11(1):59-61
In about 20 to 30 percent of cases with organoid nevus (nevus sebaceus), benign and/or ma-al lignant tumors of the epidermis and adnexae may develop. We describe a 71-year-old woman with sebaceous carcinoma and basal cell epithelioma developed in organoid nevus.
Aged
;
Carcinoma, Basal Cell*
;
Epidermis
;
Female
;
Humans
;
Nevus*
;
Organoids*
3.Expression pattern of Hepatitis B Viral Core Antigen (HBcAg) and Surface Antigen (HBsAg) in Liver of the Inactive HBsAg Carriers.
Hee Jeong AHN ; Kyoung Ho KIM ; Young Nyun PARK ; Ho Guen KIM ; Chan Il PARK
Korean Journal of Pathology 1990;24(2):120-127
To understand better the complex natural course of HBV infection, the expression patterns of HBcAg and HBsAg in the liver of 51 inactive serum HBsAg carriers (24 CPH and 27 NPD) were studied by immunohistochemical methods. The inactive serum HBsAg carriers were devided into 3 groups by the following expression patterns of serum HBeAg/anti-HBe status and tissue HBcAg and HBsAg. Pattern A (18 cases) : HBeAg+, cHBcAg+ (94.4%), mHBsAg+ (61.1%), pATTERN B (14 cases) : anti-HBe+, nHBcAg+, cHBsAg+, Pattern C (19 cases) : anti-HBe+, HBcAg-, cHBsAg+ (89.5%). There were no significant differences between CPH and NPD, lthough the core free pattern was more common in the latter. The cHBcAg was expressed in 17 of 18 (94.4%) HBeAg seropositive cases but only one of 33 cases with serum anti-HBe, suggesting that the cHBcAg is intimately related to HBeAg. Since the inactive HBsAg carriers also expressed cHBcAg and/or mHBsAg, the necro-inflammatory activity of HBV infected liver is assumed to depend on the host immune response rather than their presence alone
4.Comparisons of Early MRI Patterns with Arthroscopic Findings of Possible Acute ACL Tears.
Kyoung Ho YOON ; Jin Hwan AHN ; Seung Ho KIM ; Kye Young HAN ; Kwon Ick HA
The Journal of the Korean Orthopaedic Association 1998;33(1):68-74
Early MRI and arthroscopic findings were compared to evaluate the efficacy of the former for patients, who upon physical examination, were diagnosed with possihle acute ACL tears. MRI, taken between 1-21 days after injury, had to reveal complete ACL tears and arthroscopic surgery should have taken place 3-12 weeks after the injury for patients of this prospective study. Fifty such cases were initially catagorized according to five MRI patterns. Types I to V were separated by the following ACL tear characteristics: Enlarged and diffusely increased in signal, horizontally oriented, non-visualized, discontinuous and vertically oriented. The cases were then divided into two groups of arthroscopic findings; Group A included cases of complete ACL tearing and group B included those with intact or minimally torn ACLs. Of MRI types I through V, there were 31, 9, 5, 4, and I cases of each respectively. 37 cases resulted in complete ACL tears (21 type I, 6 type II, 5 type III, 4 type IV and 1 type V) and 13 cases were catagorized into group B, 10 of which had pattern type I and 3 of which had pattern type II. As result, types III, IV and V had a 100% Positive Predictive Value (PPV) whereas types I and II together had a 67% PPV vaiue. Division of the cases into the five pattern types in early MRI proved valuble for possible cases of acute ACL tears. MRI pattern types III, IV and V were correlated with definite complete ACL tears. However, caution must be taken for types I and II, the majority of the cases, for which there exists a significant possibility for misdiagnosis and consequently unnecessary arthroscopic surgery.
Arthroscopy
;
Diagnostic Errors
;
Humans
;
Knee
;
Magnetic Resonance Imaging*
;
Physical Examination
;
Prospective Studies
5.The Hypereosinophilic Syndrome.
Kyoung Ae JANG ; Se Jin AHN ; Jee Ho CHOI ; Kyung Jeh SUNG ; Kee Chan MOON ; Jai Kyoung KOH
Annals of Dermatology 2000;12(1):18-25
BACKGROUND: The hypereosinophilic syndrome(HES) represents a leukoproliferative process likely caused by a number of disorders, all of which are marked by sustained over-production of eosinophils. OBJECTIVES: The purposes of this study were aimed at evaluating the clinical and histopathological characteristics of HES. METHODS: The medical records and hist opathological slides of patients with HES who had skin biopsies performed in our department were reviewed. Criteria for the diagnosis of HES include (1) peripheral blood eosinophilia with eosinophil counts greater than 1,500/L for at least 6 months; (2) no evidence of parasitic, allergic, or other known causes of eosinophilia; and (3) presumptive signs and symptoms of multiple organ involvement. RESULTS: Four male and three female patients were included. HES developed in adulthood or old age (mean, 43.4 years). Because only the patients with cutaneous involvement were included, all the patients showed skin lesions. Heart, liver, stomach, nervous system, lymph nodes, and lung were involved organs in decreasing order of frequency. At the onset of HES, 40 to 80% of white blood cells were eosinophils in peripheral blood. White blood cell count and serum IgE level were elevated in all the tested patients. In six patients (85.7%), the level of serum erythrocyte sedimentation rate was elevated. Persistent hypereosinophilia (>1,500/L) was present for longer than 6 months in all patients. Stool examination and skin test for parasitic infestation all gave negative results. All the patients were not taking any medication. Histopathological examinations revealed perivascular mixed inflammatory cell infiltration; predominantly eosinophils in the stomach, liver, and nerve as well as in the skin. Interestingly, two patients who were presented with skin lesions showed the findings of eosinophilic vasculitis. In these patients, the skin lesions were consisted of Raynaud's phenomenon, digital gangrene, and several erythematous plaques. The most common cutaneous manifestations were papules and nodules on the extremities. The main treatment modality was systemic steroid. Except for one patient presented with central nervous system involvement of HES, all the patients were in a well-controlled state. In one patient with the typical clinical and hematologic features of HES, Hodgkin's disease followed. After the complete remission of Hodgkin's disease with chemotherapy, HES subsided. CONCLUSIONS: HES is a heterogenous collection of disorders marked by hypereosinophilia and organ damage. Most common cutaneous manifestations were papules and nodules on the extremities. Raynaud's phenomenon and digital gangrene can be the primary manifestation of HES in which cases cutaneous lesions showed eosinophilic vasculitis. Five patients (71%) responded well to systemic steroids. HES may be a herald of malignancy such as Hodgkin's disease. Further investigation will be mandatory ro elucidate the etiology and pathogenesis of HES.
Biopsy
;
Blood Sedimentation
;
Central Nervous System
;
Diagnosis
;
Drug Therapy
;
Eosinophilia
;
Eosinophils
;
Extremities
;
Female
;
Gangrene
;
Heart
;
Hodgkin Disease
;
Humans
;
Hypereosinophilic Syndrome*
;
Immunoglobulin E
;
Leukocyte Count
;
Leukocytes
;
Liver
;
Lung
;
Lymph Nodes
;
Male
;
Medical Records
;
Nervous System
;
Skin
;
Skin Tests
;
Steroids
;
Stomach
;
Vasculitis
6.Intravascular Fasciitis: A Case Report of an Intraoral Location.
Kyoung Ae JANG ; Seh Jin AHN ; Jee Ho CHOI ; Kyung Jeh SUNG ; Kee Chan MOON ; Jai Kyoung KOH
Korean Journal of Dermatology 1998;36(6):1109-1112
Intravascular fasciitis (IVF), a rare distinct variant of nodular fasciitis, possesses the same clinical and histologcal features of nodular fasciitis, but in addition, involves predominantly small to medium- sized veins and/or arteries intraluminally, intramurally and extramurally. Only 3 cases of intraoral IVF have been reported in the English literature. Herein we report a case of IVF developing on the inner lower lip and it was successfully treated with simple excision.
Arteries
;
Fasciitis*
;
Lip
;
Veins
7.Laugier-Hunziker Syndrome.
Kyoung Ae JANG ; Seh Jin AHN ; Jeo Ho CHOI ; Kyung Jeh SUNG ; Kee Chan MOON ; Jai Kyoung KOH
Korean Journal of Dermatology 1999;37(1):108-110
Laugier-Hunziker syndrone is a rare, pigmentary disorder of the lips, oral mucosa, and nails. The absence of intestinal polyposis differentiated it from Peutz-Jeghers syndrome. We describe a 16-year-old boy with multiple, brownish, lenticular macules on the lips, oral mucosa, perianal area and anal mucosa, and on the digits of his fingers and toes, in wham intestinal polyposis was not detectable.
Adolescent
;
Fingers
;
Humans
;
Intestinal Polyposis
;
Lip
;
Male
;
Mouth Mucosa
;
Mucous Membrane
;
Peutz-Jeghers Syndrome
;
Toes
9.Diagnosis of Xeroderma Pigmentosum by Measuring Unscheduled DNA Synthesis.
Kyu Han KIM ; Phil Soo AHN ; Jin Ho CHUNG ; Kyoung Chan PARK
Annals of Dermatology 1996;8(2):135-139
No abstract available.
Diagnosis*
;
DNA*
;
Ichthyosis*
;
Xeroderma Pigmentosum*
10.Clinical evaluation of lung cancer in patients younger than 40 years.
Jun Ho MOON ; Kyoung Tae CHA ; Yong HUR ; Wook Su AHN ; Byung Yul KIM ; Jung Ho LEE
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(11):861-865
No abstract available.
Humans
;
Lung Neoplasms*
;
Lung*