A clinical observations of skin lesions was performed on 189 patients suffering from hepatitis who were admitted to the Department of Internal Medicine in Armed. Forces General Hospital. The result were as follows: 1) Cutaneous manifestations were found in 143 patients(75.7%). 2) Purpuric lesion was found in 62 patients(32. 8%), spider angioma in 57 patients(30%), palmar erythema in 40 patients(21.2%), melanosis in 37 patients(19. 6%) acne in 22 patients(11,6%), jaundice in 15 patients(7.9%) and striae distensae in 14 patients(7.4%). 3) Among rnelanosis, there were 14 patients with diffuse pigmentation, 3 patients with localized pigmentation, 14 patients with palmar crease pigmentation, 10 patients with accentuation of freckling and 11 patients with chloasma. 4)Common cutaneous manifestations in acute hepatitis were spider angioma (21. 4%), palmar erythema (21.4%) and purpuric lesion (17.9%), in chronic hepatitis, purpuric lesion(44.8%) spider angioma(37%) and melanosis(24.8%).
Acne Vulgaris ; Arm ; Erythema ; Hemangioma ; Hepatitis* ; Hepatitis, Chronic ; Hospitals, General ; Humans ; Internal Medicine ; Jaundice ; Melanosis ; Pigmentation ; Skin ; Spiders ; Striae Distensae

A clinical observation of self-inflicted lesions was made during physical examination for conscription in Choongcheongnamdo from May to July, 1980. The result were as follows: 1) The prevalence of self-inflicted lesions was 8. 1% (579/7148). 2) The number of persons with criminal history was 68(ll.7%). 3) The educational level of self-injured was lower than that of non self-injured. 4) Most frequently used tools for self-inflicted lesions were cigarette(72%), knife(19. 9%), rnatch(14.7%) and grass(12.8%) in decreasing order of frequency and only one tool was used in 438 cases(75.6%). 5) The favorite site of self injury were the left forearm(89. 5%), right forearm (19.3%) and left upper arm (5.9%) 6) The average age of first injury was 16. 5 years. 7) The complications of self injury were found in 8. 8% of self-injured and they were hypertrophic scar, keloid, pyoderma and depigmentation. Some degree of hyperpigrnentation and hypopigmentation was found in most of cases. Tattoo was accompanied in 20. 7% of self-injured.
Adolescent* ; Arm ; Cicatrix, Hypertrophic ; Criminals ; Forearm ; Humans ; Hypopigmentation ; Keloid ; Physical Examination ; Prevalence ; Pyoderma

BACKGROUND: Clinical features of atopic dermatitis(AD) have been well described according to age in the English literature. In Korea there have been some reports about clinical analyses of AD. However, there is no report about the clinical characteristics of adult AD. OBJECTIVE: We tried to characterize the clinical features of adult AD by comparing them with the childhood/infantile type. In addition we aimed to study the prognostic factors that may be related to the persistence of dermatitis into adult life. METHODS: Patients with AD were divided into the adult and childhood/infantile types according to the patient's age. Sixty three adult patients were compared with 107 childhood/infantile patients. Various clinical characteristics of AD were compared between these groups. RESULTS: Orbital darkening, foot eczema, and extensor involvement were more frequently observed in the childhood/infantile type, whereas flexural lichenification, especially in the antecubital fossa, prurigo papules in the extensor part of the extremities, cheilitis, forehead lichenification, Hertoghe's sign, nipple eczema, and anterior neck fold involvement were more frequent in the adult type. Light sensitivity was more prominent in the adult type. Later age at onset of AD was observed in adult patients. The incidence of respiratory atopy (asthma and allergic rhinitis) was higher in the adult group. CONCLUSION: In the adult type flexural involvement with lichenification became more prominent and prurigo papules were more frequently observed in the extensor part of the extremities. Later onset of AD and association with respiratory atopy were considered to be bad prognostic factors.
Adult* ; Age of Onset ; Cheilitis ; Dermatitis ; Dermatitis, Atopic* ; Eczema ; Extremities ; Foot ; Forehead ; Humans ; Incidence ; Korea ; Neck ; Nipples ; Orbit ; Photophobia ; Prurigo

Primary cystic neoplasia of the liver is rare. We report a cystadenoma with mesenchymal stroma (CMS) and a cystadenocarcinoma, and make a review of literature with particular reference to their histogenesis. The CMS has many similarities to the ovarian mucinous cystadenoma; occurring almost exlusively in female, being lined by mucus-secreting epithelial cells, and containing dense ovarian-like stroma. These features suggest that CMS may arise from the ectopic ovarian tissue within the liver. Cystadenocarcinoma may have its origin in CMS or cystadenoma without mesenchymal stroma of CMS. Cholangiocarcinoma arising from the congenital hepatic cysts can be differentiated only when it contains benign epithelia.
Female ; Humans ; Cysts

BACKGROUND: Recently the sensitive measurement of radiation damage to DNA using flowcytometric analysis of nucleoid preparations was reported which allows an analysis of damage within the DNA of single cells. We applied flowcytometric analysis of the nucleoids for the detection of DNA damage by UVB. OBJECTIVE: The purpose of this study was to establish the method of detecting UVB-induced damage of DNA by flowcytometry and to elucidate the usefulness of this method to detect cell damage. METHODS: Human melanoma cells were cultured and were irradiated with various of UVB. Immediately after UVB irradiation nucleoid suspensions were prepared and flowcytometric analysis was done. RESULTS: The changes in fluorescence, forward scatter, and side scatter reflected damage of DNA induced by UVB quite well especially at lower UVB doses. CONCLUSION: Flowcytometric analysis of nucleoid will be a useful methosd to detect DNA damage by UVB.
DNA ; DNA Damage ; Fluorescence ; Humans ; Melanoma ; Methods ; Suspensions ; Ultraviolet Rays*

Parathyroid carcinoma is a relatively rare endocrine tumor, accounting for approximately 1 to 5% of patients with primary hyperparathyroidism. Patients with parathyroid carcinomas are often symptomatic, have markedly elevated calcium levels, and have a palpable cervical mass. They are equally distributed between the sexes and usually present 10 years before their benign counterparts. The diagnosis is suspected when the tumor is large, parathyroid hormone levels are high, and a palpable mass is present in the neck. Parathyroid carcinoma is often misdiagnosed preoperatively, suspected intraoperatively, and only confirmed postoperatively. We experienced a case of hyperfunctioning parathyroid carcinoma in a 36 year old man, which was confirmed microscopically. The tumor showed: 1) capsular and blood vessel invasion; 2) frequent mitotic figures in the parenchymal cells; 3) a trabecular pattern, and 4) intervening thick fibrous bands. Immunohistochemical stain of p53 may be one of the useful methods in identifying malignancy of parathyroid gland.

BACKGOUND: Because heterogeneity of the human tyrosinase gene has been reported, it is of vital significance to know the correct nucleotide sequence of tyrosinase in Koreans in order to study the molecular basis of oculocutaneous albinism. OBJECTIVE: This study was done to analyze the nucleotide sequence of tyrosinase gene in Koreans. METHODS: All exons were amplified from genomic DNAs and sequenced directly from three healthy Koreans. RESULTS: The nucleotide sequence of the tyrosinase gene in Koreans encode 511 amino acids with a molecular weight of 58,000. CONCLUSION: The nucleotide sequence of coding region is the same with that of pHTrl(Shibahara et al. Tohoku J Exp Med 156: 403-414, 1988). As we couldn't observe any polymorphisms in Koreans these results suggested the homogeneity of Korean people.
Albinism, Oculocutaneous ; Amino Acids ; Base Sequence ; Clinical Coding ; DNA ; Exons ; Humans* ; Molecular Weight ; Monophenol Monooxygenase* ; Population Characteristics ; Sequence Analysis*

We repart herein a case of psoriasifomi sarcoidosis. A histopathological examination reveaied sarcoidal ulomas throughout the dermis. There wa no systemic nvolvement, The skin lesions resolved aftier one month following treatment with low dose oral prednisolone. This is the first case of psoriasiform sarcoidosis in Korea.
Dermis ; Korea ; Prednisolone ; Sarcoidosis* ; Skin

BACKGROUND: Recently doubts have been raised regarding the diagnostic significance of some of the minor clinical features of atopic dermatitis (AD) proposed by Hanifin and Rajka. Some of them may be nonspecific and racial difference was suggested. OBJECTIVE: The purpose of this study is to evaluate the diagnostic significance of 14 minor clinical features out of Hanifin and Rajka's 23 minor features of AD in the Korean pediatric population. The significance of 5 more items was evaluated as additional minor features. METHODS: The difference in frequency of the total 19 features of AD was compared between 100 patients with AD and 76 controls. RESULTS: Fourteen of these were shown to be significantly more frequent in patients than in controls including our 5 additional clues such as scalp scaling, postauricular fissure, infraauricular fissure, forehead lichenification, and infragluteal eczema. CONCLUSION: Our study about the minor features may be a valuable guideline for the diagnosis of AD in the Korean pediatric population.
Dermatitis, Atopic* ; Diagnosis ; Eczema ; Forehead ; Humans ; Scalp

BACKGROUND: Recently doubts have been raised regarding the diagnostic significance of some of the minor clinical features of atopic dermatitis (AD) proposed by Hanifin and Rajka. Some of them may be nonspecific and racial difference was suggested. OBJECTIVE: The purpose of this study is to evaluate the diagnostic significance of 14 minor clinical features out of Hanifin and Rajka's 23 minor features of AD in the Korean pediatric population. The significance of 5 more items was evaluated as additional minor features. METHODS: The difference in frequency of the total 19 features of AD was compared between 100 patients with AD and 76 controls. RESULTS: Fourteen of these were shown to be significantly more frequent in patients than in controls including our 5 additional clues such as scalp scaling, postauricular fissure, infraauricular fissure, forehead lichenification, and infragluteal eczema. CONCLUSION: Our study about the minor features may be a valuable guideline for the diagnosis of AD in the Korean pediatric population.
Dermatitis, Atopic* ; Diagnosis ; Eczema ; Forehead ; Humans ; Scalp