1.The Effects of Handgrip and Cold Pressor Test on Mitral Flow in Patients with Left Ventricular Hypertrophy.
Hark RIM ; Shin Ho LEE ; Soo Yeol AHN ; Jin Kyoo KIM ; In Kwon JUNG ; Jae Woo LEE
Korean Circulation Journal 1991;21(6):1182-1189
BACKGROUND: Handgrip and cold pressor test may increase the afterload of the heart. And in left ventricular hypertrophy, it is known that mitral flow pattern is affected by decreased left ventricular compliance. We investigated the effects of handgrip and cold pressor test on mitral flow pattern in patients with left ventricular hypertrophy. METHODS: Handgrip and cold pressor test were performed in 12 subjects with left ventricular hypertrophy and in 14 healthy normal subjects. In supine position, blood pressure, heart rate and Doppler echocardiographic parameters(early peak flow velocity : E, atrial peak flow velocity : A) were obtained at rest, 1 and 3 minutes after the onset of tests respectively. RESULTS: In both groups, handgrip and cold pressor test increased blood pressure slightly without a statistical significance. In left ventricular hypertrophy group, there were significant increments in heart rates at 1 minute of handgrip (78+/-12min-1, p<0.001) and cold pressor test(77+/-7min-1, p<0.05) as compared to that at rest (73+/-12min-1). Mitral flow velocities did not show significant change after the tests in control group. A waves after 1 minute of handgrip(85.2+/-18.4cm/sec, p<0.05) and cold pressor test (87.3+/-17.8cm/sec, p<0.001) showed significant increases as compared to that at rest (79.1+/-14.9cm/sec) in left ventricular hypertrophy group whereas E waves did not. CONCLUSION: Although handgrip and cold pressor tests did not affect the mitral flow significantly in control group, each test raised A waves in left ventricular hypertrophy group. These results suggest that increased A waves may be due to a rise in afterload and decreased left ventricular compliance caused by handgrip and cold pressor test in left ventricular hypertrophy group.
Blood Pressure
;
Compliance
;
Echocardiography
;
Heart
;
Heart Rate
;
Humans
;
Hypertrophy, Left Ventricular*
;
Supine Position
2.Transcatheter arterial chemoembolization of hepatocellular carcinoma with portal vein invasion.
Young Rahn LEE ; Ki Yeol LEE ; Seong Beom CHO ; In Ho CHA ; Kyoo Byung CHUNG
Journal of the Korean Radiological Society 1993;29(4):698-703
Transcatheter arterial chemoembolization(TACE) is an imperative method for the managment of inoperable hepatocellular carcinoma(HCC). It is well known that primary HCC frequently invades the portal venous system and forms a tumor thrombus obstructing the portal blood flow which makes unfavorable prognosis of patiebt. We retrospetively reviewed 58 patients who reveived TACE(minimum 3 times) of HCC invading into portal venous system. Group 1(n=29) which showed peripheral portal vein invasion had better clinical and laboratory response. Group 2(n=17) which showed first order portal branch invasion had similar response to Group 3(n=12), which had main portal invasion. Group 1 showed no difference in survival time between TAC and TACE, but, in Group 2 and 3, emboliation with chemotherapy made longer survival than chemotherapy only. Clinical level of AFP was meaningful in Group 1 and 2 as decreasing value. Our results provides that careful selection of TACE and case by case Coil/Gelfoam embolization can improve the mean survival and clinical response when HCC evidently invades portal venous system.
Carcinoma, Hepatocellular*
;
Drug Therapy
;
Humans
;
Methods
;
Portal Vein*
;
Prognosis
;
Thrombosis
3.Transcatheter arterial chemoembolization of hepatocellular carcinoma with portal vein invasion.
Young Rahn LEE ; Ki Yeol LEE ; Seong Beom CHO ; In Ho CHA ; Kyoo Byung CHUNG
Journal of the Korean Radiological Society 1993;29(4):698-703
Transcatheter arterial chemoembolization(TACE) is an imperative method for the managment of inoperable hepatocellular carcinoma(HCC). It is well known that primary HCC frequently invades the portal venous system and forms a tumor thrombus obstructing the portal blood flow which makes unfavorable prognosis of patiebt. We retrospetively reviewed 58 patients who reveived TACE(minimum 3 times) of HCC invading into portal venous system. Group 1(n=29) which showed peripheral portal vein invasion had better clinical and laboratory response. Group 2(n=17) which showed first order portal branch invasion had similar response to Group 3(n=12), which had main portal invasion. Group 1 showed no difference in survival time between TAC and TACE, but, in Group 2 and 3, emboliation with chemotherapy made longer survival than chemotherapy only. Clinical level of AFP was meaningful in Group 1 and 2 as decreasing value. Our results provides that careful selection of TACE and case by case Coil/Gelfoam embolization can improve the mean survival and clinical response when HCC evidently invades portal venous system.
Carcinoma, Hepatocellular*
;
Drug Therapy
;
Humans
;
Methods
;
Portal Vein*
;
Prognosis
;
Thrombosis
4.Primary pulmonary histiocytosis X: a case report.
Ki Yeol LEE ; Eun Young KANG ; Kyoo Byung CHUNG ; Yang Seok CHAE ; Hark Jei KIM
Journal of the Korean Radiological Society 1992;28(1):101-103
Pulmonary histiocytosis X is a rare granulomatous disorder of unknown etiology that alters the interstitium of the lung. When confined to the lung, it is known as primary pulmonary histiocytosis X or eosinophilic granuloma of the lung. The chest radiograph shows characteristic nodular, reticular, and cystic abnormalities, which are most apparent in the upper and middle lung zones, but spare the costophrenic angles, The CT demonstrates innumerable small cysts with thin walls, and fine nodules. Recently we experienced pathologically proven primary pulmonary histiocystosis X in 35 years old male patients who had recurrent pneumothorax.
Eosinophilic Granuloma
;
Histiocytosis, Langerhans-Cell*
;
Humans
;
Lung
;
Male
;
Pneumothorax
;
Radiography, Thoracic
5.Triple Phase Spiral CT of The Liver: Degree of Liver Parenchymal Enhancement.
Ki Yeol LEE ; In Ho CHA ; Cheol Min PARK ; Kyoo Byung CHUNG
Journal of the Korean Radiological Society 1996;35(4):531-536
PURPOSE: To determine the degree and effect of contrast enhancement of the hepatic parenchyma according to different injection rates, amounts and types of contrast materials. MATERIALS AND METHODS: A total of 270 patients were divided into nine groups. Each group received different volumes(120, 130, or 140ml) and was scannedwith different injection rates of 2, 3 or 4 ml/sec. Three kinds of contrast materials(Ultravist 370, Iopamiro 370, Optiray 320) were used. Hepatic enhancement was measured by comparing quantitative regions of interest(ROI) beforeand after bolus injection of contrast material which were evaluated on arterial, portal and delayed phase duringdouble spiral scanning. RESULTS: There was no significant statistical difference in contrast enhancement between the three kinds of contrast materials. In noncirrhotic patients, hepatic enhancement was greatest on portal phase and was greater at a rate of 4ml/sec than 2ml/sec or 3ml/sec on arterial phase. At the same injection rate, thevolume of contrast material was an important factor on portal and delayed phase. In the cirrhotic patients, Child's C showed more delayed peak enhancement than did Child's A. CONCLUSION: The important factors in contrast enhancement were injection rate on arterial phase and volume on portal and delayed phase. The optimal choice mustbe made after considering intrinsic variables ; in addition, our results are helpful for determining enhancement protocol during double spiral CT scanning.
Contrast Media
;
Humans
;
Iopamidol
;
Liver*
;
Tomography, Spiral Computed*
6.Improved Algorithms for the Identification of Yeast Proteins and Significant Transcription Factor and Motif Analysis.
Seung Won LEE ; Seong Eui HONG ; Kyoo Yeol LEE ; Do Il CHOI ; Hae Young CHUNG ; Cheol Goo HUR
Genomics & Informatics 2006;4(2):87-93
With the rapid development of MS technologiesy, the demands for a more sophisticated MS interpretation algorithm haves grown as well. We have developed a new protein fingerprinting method using a binomial distribution, (fBIND). With the fBIND, we improved the performance accuracy of protein fingerprinting up to the maximum 49% (more than MOWSE) and 2% than(at a previous binomial distribution approach studied by of Wool et al.) as compared to the established algorithms. Moreover, we also suggest a the statistical approach to define the significance of transcription factors and motifs in the identified proteins based on the Gene Ontology (GO).
Binomial Distribution
;
Fungal Proteins*
;
Gene Ontology
;
Peptide Mapping
;
Transcription Factors*
;
Wool
;
Yeasts*
7.Transient Inhomogeneous Contrast Enhancement of the Spleen on Arterial Phase of Spiral CT.
Taik Kun KIM ; Hyo Jun KANG ; Ki Yeol LEE ; Cheol Min PARK ; Kyoo Byung CHUNG
Journal of the Korean Radiological Society 1997;36(2):265-270
PURPOSE: To assess the relationship between splenic transient inhomogeneous contrast enhancement(CE) on the arterial phase of spiral CT, and splenic volume, and to classify the CE pattern in liver cirrhosis. MATERIALS AND METHODS: We measured the splenic volume of 120 patients, 60 showed inhomogeneous splenic CE on arterial phase,and 60 showed homogeneous splenic CE. CT scans with intrinsic splenic pathology were excluded. Sixteen patients with clinically confirmed liver cirrhosis were included. Splenic volumes of the inhomogeneous and homogeneous CE group were compared. The inhomogeneous group was divided into three grades according to areas of non-enhanced portion (grade I, focal geographic ; grade II, multifocal patchy, grade III, extensive serpentine inhomogeneous CE) , and these were correlated with splenic volume. RESULTS: Among the 60 inhomogeneous CE scans, 23 cases(38.3%) showed splenomegaly (spleen volume>220cm3); in contrast, this applied to only 8 cases (13.3%) of the 60 homogeneous CE scans. Mean splenic volume in the inhomogeneous CE group (226.74+/-129.78cm3) was greater than in the homogeneous CE group (184.56+/-77.44cm3) (p<0.033). A larger splenic volume and extensive inhomogeneous CE(grade III) were noted, and most liver cirrhosis patients(14/16) were grade III. Three such patients who had shown inhomogeneous splenic CE on arterial phase showed inhomogeneous CE even on portal phase. CONCLUSION: Inhomogeneous splenic CE on arterial phase was more common in cases of an enlarged spleen, and more extensive in liver cirrhosis. These findings suggest hemodynamic change of the spleen may be a contributory factor.
Hemodynamics
;
Humans
;
Liver Cirrhosis
;
Pathology
;
Spleen*
;
Splenomegaly
;
Tomography, Spiral Computed*
;
Tomography, X-Ray Computed
8.CT Features of Malignant Hepatic Tumors: the Significance of Capsular Retraction.
Bo Kyoung SEO ; Ji Yong RHEE ; Hae Young SEOL ; Ki Yeol LEE ; Cheol Min PARK ; Kyoo Byung CHUNG
Journal of the Korean Radiological Society 1998;38(2):267-271
PURPOSE: To evaluate the prevalence of capsular retraction in malignant hepatic tumors and the factorsinvolved. MATERIALS AND METHODS: Between January 1994 and December 1996, we retrospectively reviewed the CT scansof 152 patients with pathologically-proven, peripherally-located, malignant hepatic tumors. We evaluated size,site, portal and hepatic venous obstruction, bile duct dilatation, and liver atrophy in 18 cases involvingcapsular retraction. RESULTS: The overall prevalence of capsular retraction among malignant hepatic tumors was18/152(12%) ; the prevalence was 9/129(7%) in hepatocellular carcinoma, 6/14(43%) in cholangiocarcinoma and3/9(33%) in metastatic cancer ; among cases of cholangiocarcinoma and metastatic cancer, the prevalence washigh(p <0.05). Portal venous obstruction was seen in six patients with hepatocellular carcinoma (a high incidence ;p=0.041) and one with cholangiocarcinoma. Hepatic venous obstruction was demonstrated in one patient withhepatocellular carcinoma and one with cholangiocarcinoma. Among cholangiocarcinoma patients, bile duct obstructionwas seen in four and liver atrophy in three, but among metastatic cancer cases there were no similar findings. CONCLUSION: The main factors causing capsular retraction were portal venous obstruction in hepatocellularcarcinoma and bile duct obstruction and liver atrophy in cholangiocarcinoma.
Atrophy
;
Bile Ducts
;
Carcinoma, Hepatocellular
;
Cholangiocarcinoma
;
Cholestasis
;
Dilatation
;
Humans
;
Incidence
;
Liver
;
Prevalence
;
Retrospective Studies
9.Causes and Clinical Outcomes of Revision Total Knee Arthroplasty
Dong Hyun LEE ; Seung Hun LEE ; Eun Kyoo SONG ; Jong Keun SEON ; Hong An LIM ; Hong Yeol YANG
The Journal of Korean Knee Society 2017;29(2):104-109
PURPOSE: The purpose of this study was to evaluate causes and clinical outcomes of revision total knee arthroplasty (TKA) with a minimum 2-year follow-up. MATERIALS AND METHODS: We performed a retrospective review on the records of 225 revision TKAs performed from 2003 to 2012 at a single institution. Finally, 206 cases were conducted. To evaluate clinical outcomes, we checked the range of motion (ROM), Knee Society (KS) score, Hospital for Special Surgery (HSS) score, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score preoperatively, 6 months postoperatively and yearly thereafter and complications after revision TKA. RESULTS: The causes of revision TKA were septic complications in 120 and aseptic complications in 86. The main aseptic complication was periprosthetic fracture in 36, followed by 25 loosening, 13 polyethylene wear and 9 instability. At the final follow-up, patients showed improvements in ROM and KS, HSS and WOMAC scores. Of the total, 7 patients underwent re-revision due to reinfection in 6 and periprosthetic fracture in 1. CONCLUSIONS: Due to development of implants and surgical techniques, mechanical complications such as aseptic loosening and instability that need a revision decreased whereas septic complications relatively increased. Therefore, we should be cautious for the occurrence of infection. Overall, revision TKA provided clinical improvement in knee function and patient satisfaction.
Arthroplasty
;
Arthroplasty, Replacement, Knee
;
Follow-Up Studies
;
Humans
;
Knee
;
Ontario
;
Osteoarthritis
;
Patient Satisfaction
;
Periprosthetic Fractures
;
Polyethylene
;
Range of Motion, Articular
;
Retrospective Studies
10.Exercise-Induced ST-Segment Depression in Patients after Successful Coronary Angioplasty.
Yung Cheoul DOO ; Byung Dong CHO ; Ho Yeol CHOI ; Jo Young CHOI ; Soon Hee KOH ; Kyoo Rok HAN ; Dong Jin OH ; Kyu Hyung RYU ; Chong Yun RIM ; Young Bahk KOH ; Young LEE
Korean Circulation Journal 1995;25(4):723-729
BACKGROUND: Exercise induced ST-segment depression in patients after coronary angioplasty is frequently observed but the mechanism responsible for exercise induced myocardial ischemia early after successful coronary angioplasty is poorly understoodd. The object of this study is to investigate potential determinants of this phenomenon by analizing the clinical, exercise testing, and angiographic characteristics in patients with exercise induced ST-segment depression. METHODS: The study group comprised 13 patients with exercise induced ST-segment depression(Positive group,M:12, mean age:59+/-9year) and 26 patients without exercise induced ST-segment depression(Negative group, M; 22, mean age; 55+/-13 year) after succeessful coronary angioplasty in single vessel disease. We compared preangioplasty clinical, angiographic, and hemodynamic variables in group with positive and negative results on exercise testing after successful PTCA. RESULTS: 1) Clinical characteristics: The initial diagnosis were acute myocardial infarction in 5, unstable angina in 8 patients at positive group, and 16 and 10 patients at negative group, respectively. There were no significant different in initial diagnosis, risk factor for coronary artery disease, and medication used before exercise test at between two groups. 2) Cornary angiography and PTCA: The maximal ballooning size were significantly smaller in positive group than negative group(2.7+/-0.5 vs 3.1+/-0.4mm, 2.9+/-0.4mm, vs 3.2+/-0.4mm, respectively(p<0.05) but there were no significantly different in ejection fraction, end-diastolic volume, end-systolic volume before PTCA. degree of stenosis of lesion before and after PTCA, total ballooning time, balloon pressure, lesion site and infarction relation of lesion at between two groups. 3) Exercise test: The mean time from angioplasty to the performance of exercise testing were 9.5+/-4.0 days in positive group and 6.1+/-4.5 days in negative group. The mean depression of ST-segment was 1.5+/-0.5mm and was predominantly noted in lateral leads(V4-6)(9/13:69%). There were no significantly different in total exercise time, rate-pressure product, and metabolic equivalents-exercise time at positive and negative group. But positive results at follow up exercise test were significantly higher in positive group(p<0.05). CONCLUSION: There were no definite determinating factors for exercise induced ST-segment depression early after successful coronary angioplasty by analizing the clinical, angiographic, and exercise testing variables. The pathophysiologic mechanism of this findding remain to be elucidated, especially for association of microvascular functional alternation.
Angina, Unstable
;
Angiography
;
Angioplasty*
;
Constriction, Pathologic
;
Coronary Artery Disease
;
Depression*
;
Diagnosis
;
Exercise Test
;
Follow-Up Studies
;
Hemodynamics
;
Humans
;
Infarction
;
Myocardial Infarction
;
Myocardial Ischemia
;
Risk Factors