1.Clinical analysis of cesarean section.
Chul Won JHANG ; Kyong Ran JU ; Seong Ho CHOO ; Bong Soo OH
Korean Journal of Obstetrics and Gynecology 1992;35(6):827-834
No abstract available.
Cesarean Section*
;
Female
;
Pregnancy
2.A clinical analysis of 27 patients with candidemia.
Hyoung Shik SHIN ; Kyong Ran PECK ; Hyun Ju PAE ; Mun Hyun JUNG ; Myoung Don OH ; Kang Won CHOE
Korean Journal of Infectious Diseases 1991;23(4):257-263
No abstract available.
Candidemia*
;
Humans
3.Bone Marrow Necrosis in CD7 positive Acute Myeloid Leukemia.
Wan Da SEO ; Young Mo KANG ; Han Ik BAE ; Jung Ran KIM ; Kyoung Yim HA
Korean Journal of Medicine 1998;54(3):441-445
Bone marrow necrosis is infrequently diagnosed during life, and its presence often signifies a poor prognosis. It has been associated with a variety of disease, including acute and chronic leukemia, carcinoma, malignant lymph oma, infection and sickle cell disease. About 5-26% of acute myeloid leukemia has been reported to express lymphoid differentiation markers, of which CD7 is ex pressed very early during T-cell ontogeny. A 46-year-old male complaining severe bone pain had pancytopenia, leukoerythroblastosis and bone marrow necrosis. Peripheral blood immature cells expressed CD7 as well as myeloid markers such as CD13 and CD33 on immunophenotypic studies. We report a case of CD7 positive acute myeloid leu kemia associated with bone marrow necrosis, confirmed by bone marrow biopsy and immunophenotypic study.
Anemia, Sickle Cell
;
Antigens, Differentiation
;
Biopsy
;
Bone Marrow*
;
Humans
;
Leukemia
;
Leukemia, Myeloid, Acute*
;
Male
;
Middle Aged
;
Necrosis*
;
Pancytopenia
;
Prognosis
;
T-Lymphocytes
4.A Case of EDTA Dependent Platelet Phagocytosis by Neutrophils in Mycosis Fungoides.
Gyoung Yim HA ; Moon Yeon KIM ; Jung Ran KIM ; Moo Ku SUH ; So Young KWEON ; Han Ik CHO
Korean Journal of Clinical Pathology 1998;18(1):46-50
In vitro ethylene-diamine-tetra-acetic acid (EDTA) dependent satellitism and phagocytosis of platelets by neutrophils have been considered to be rare phenomena. It is associated with pseudothrombocytopenia, abnormal histogram of platelets and pseudoleukocytosis on complete blood cell count (CBC) by automated blood cell counter, but these findings are not found in heparinized or sodium citrated blood. It has no clinical significance such as bleeding tendency or abnormal platelet function. EDTA dependent platelet satellitosis and phagocytosis must be differentiated from true thrombocytopenia. We report a case of EDTA dependent platelet phagocytosis by neutrophils in a 68 year-old male patient who was diagnosed as mycosis fungoides. His EDTA blood smear showed frequent phagocytosis of platelets by neutrophils and occasional platelet satellitism. The bood cell counts were within normal limits without pseudothrombocytopenia. Phagocytized platelets were confirmed by immunohistochemistry using GpIIb/IIIa antibody and transmission electron micrographs.
Aged
;
Blood Cell Count
;
Blood Platelets*
;
Cell Count
;
Edetic Acid*
;
Hemorrhage
;
Heparin
;
Humans
;
Immunohistochemistry
;
Male
;
Mycosis Fungoides*
;
Neutrophils*
;
Phagocytosis*
;
Sodium
;
Thrombocytopenia
5.Clinical Manifestations of Posttransplantation Lymphoproliferative Disorder (PTLD) after Liver Transplantation.
Hyun Kyun KI ; Kyong Mok SOHN ; Yu Mi WI ; Ji Young RHEE ; Chi Sook MOON ; Won Sup OH ; Kyong Ran PECK ; Jae Hoon SONG ; Sung Ju KIM ; Jae Won CHO ; Suk Ku LEE ; Young Hye KOH
Infection and Chemotherapy 2006;38(3):131-139
BACKGROUND: Post-transplantation lymphoproliferative disorder (PTLD) after liver transplantation is a rare but potentially fatal disease. Clinical manifestations and prevalence of PTLD after liver transplantation in Korea have not been investigated thoroughly. MATERIALS AND METHODS: A retrospective chart review was done for 284 liver transplant recipients at Samsung Medical Center, Seoul, Korea during the period from 1996 to 2003. RESULTS: The incidence of PTLD after liver transplantation was 3.9% (11/284). PTLDs were more prevalent in children (9/55, 16.4%) than in adults (2/237, 0.9%; P<0.01). Among the PTLD patients, four cases were male (36.3%) and seven were female (63.7%). Median time from the transplantation to PTLD diagnosis was 9 months. The type of PTLD was as follows:early lesion (6 cases, 54.5%), polymorphic PTLD (3 cases, 27.3%), and B cell lymphoma (2 cases, 18.2%). PTLDs were more prevalent in the patients with cyclosporine use (OR 13.28, 95% CI:1.29-136.31, P=0.03), acute rejection (OR 5.63, 95% CI:1.03-30.62, P=0.04), and negative serology for EBV VCA IgG (OR 19.15, 95% CI:1.99-183.98, P=0.01) by multivariate logistic regression. Three patients (27.3%) died of B cell lymphoma (2 cases) and polymorphic PTLD (1 case). The remaining patients were improved with reduction of immunosuppression and treatment with acyclovir. CONCLUSION: The incidence of PTLD was high in children. The risk factors of PTLD were negative serology for EBV VCA IgG, history of acute rejection, and cyclosporine use. Considering the poor prognosis of PTLD, effective strategies for prevention and early diagnosis for early treatment should be emphasized.
Acyclovir
;
Adult
;
Child
;
Cyclosporine
;
Diagnosis
;
Early Diagnosis
;
Female
;
Herpesvirus 4, Human
;
Humans
;
Immunoglobulin G
;
Immunosuppression
;
Incidence
;
Korea
;
Liver Transplantation*
;
Liver*
;
Logistic Models
;
Lymphoma, B-Cell
;
Lymphoproliferative Disorders*
;
Male
;
Prevalence
;
Prognosis
;
Retrospective Studies
;
Risk Factors
;
Seoul
;
Transplantation
6.Clinical Manifestations of Posttransplantation Lymphoproliferative Disorder (PTLD) after Liver Transplantation.
Hyun Kyun KI ; Kyong Mok SOHN ; Yu Mi WI ; Ji Young RHEE ; Chi Sook MOON ; Won Sup OH ; Kyong Ran PECK ; Jae Hoon SONG ; Sung Ju KIM ; Jae Won CHO ; Suk Ku LEE ; Young Hye KOH
Infection and Chemotherapy 2006;38(3):131-139
BACKGROUND: Post-transplantation lymphoproliferative disorder (PTLD) after liver transplantation is a rare but potentially fatal disease. Clinical manifestations and prevalence of PTLD after liver transplantation in Korea have not been investigated thoroughly. MATERIALS AND METHODS: A retrospective chart review was done for 284 liver transplant recipients at Samsung Medical Center, Seoul, Korea during the period from 1996 to 2003. RESULTS: The incidence of PTLD after liver transplantation was 3.9% (11/284). PTLDs were more prevalent in children (9/55, 16.4%) than in adults (2/237, 0.9%; P<0.01). Among the PTLD patients, four cases were male (36.3%) and seven were female (63.7%). Median time from the transplantation to PTLD diagnosis was 9 months. The type of PTLD was as follows:early lesion (6 cases, 54.5%), polymorphic PTLD (3 cases, 27.3%), and B cell lymphoma (2 cases, 18.2%). PTLDs were more prevalent in the patients with cyclosporine use (OR 13.28, 95% CI:1.29-136.31, P=0.03), acute rejection (OR 5.63, 95% CI:1.03-30.62, P=0.04), and negative serology for EBV VCA IgG (OR 19.15, 95% CI:1.99-183.98, P=0.01) by multivariate logistic regression. Three patients (27.3%) died of B cell lymphoma (2 cases) and polymorphic PTLD (1 case). The remaining patients were improved with reduction of immunosuppression and treatment with acyclovir. CONCLUSION: The incidence of PTLD was high in children. The risk factors of PTLD were negative serology for EBV VCA IgG, history of acute rejection, and cyclosporine use. Considering the poor prognosis of PTLD, effective strategies for prevention and early diagnosis for early treatment should be emphasized.
Acyclovir
;
Adult
;
Child
;
Cyclosporine
;
Diagnosis
;
Early Diagnosis
;
Female
;
Herpesvirus 4, Human
;
Humans
;
Immunoglobulin G
;
Immunosuppression
;
Incidence
;
Korea
;
Liver Transplantation*
;
Liver*
;
Logistic Models
;
Lymphoma, B-Cell
;
Lymphoproliferative Disorders*
;
Male
;
Prevalence
;
Prognosis
;
Retrospective Studies
;
Risk Factors
;
Seoul
;
Transplantation
7.A Case of Henoch-Schonlein Purpura with Portal Vein and Mesenteric Vein Thrombosis.
Kyung Ran CHO ; Myung Ju AHN ; Jun Goo KANG ; Taeck Won HONG ; Tae Yeob KIM ; Yoon Kyong SUNG ; Jung Hye CHOI ; Young Yiul LEE ; In Soon KIM ; Il Young CHOI ; Sang Cheol BAE ; Sung Jun KWON ; Chan Kum PARK
Korean Journal of Hematology 2002;37(3):212-217
Henoch-Schonlein purpura is an immunologically mediated systemic leukocytoclastic vasculitis of small vessels that is characterized by symmetric nontraumatic, nonthrombocytopenic, painless palpable purpura on the lower extremities and buttock, arthralgias on usually the knees and ankles, gastrointestinal symptoms and glomerulonephritis. Although the jejunum and ileum are most frequently affected, any portion of gastrointestinal tracts may be involved. Generally, gastrointestinal manifestations of Henoch-Schonlein purpura are the edematous wall of involved bowel, submucosal hemorrhage and erosion. We experienced a 56-year-old man with Henoch-Schonlein purpura who initially presented acute abdominal pain with portal vein and superior mesenteric vein thrombosis.
Abdominal Pain
;
Ankle
;
Arthralgia
;
Buttocks
;
Gastrointestinal Tract
;
Glomerulonephritis
;
Hemorrhage
;
Humans
;
Ileum
;
Jejunum
;
Knee
;
Lower Extremity
;
Mesenteric Veins*
;
Middle Aged
;
Portal Vein*
;
Purpura
;
Purpura, Schoenlein-Henoch*
;
Thrombosis*
;
Vasculitis
;
Venous Thrombosis
8.Epidemiology and Clinical outcomes of Invasive Pulmonary Aspergillosis: A Nationwide Multicenter Study in Korea.
Sung Han KIM ; Song Mi MOON ; Sang Hoon HAN ; Jin Won CHUNG ; Soo youn MOON ; Mi Suk LEE ; Eun Ju CHOO ; Young Hwa CHOI ; Shin Woo KIM ; In Gyu BAE ; Hyun Hee KWON ; Kyong Ran PECK ; Yang Soo KIM
Infection and Chemotherapy 2012;44(4):282-288
BACKGROUND: Invasive pulmonary aspergillosis (IPA) is an important cause of morbidity and mortality in immunocompromised patients. However, few data on clinical characteristics and outcomes of IPA in Korea have been reported. We conducted a nationwide multicenter study in Korea for evaluation of the epidemiology and clinical outcomes of invasive pulmonary aspergillosis. MATERIALS AND METHODS: A retrospective cohort study was conducted in 10 hospitals in Korea. We reviewed all adult patients who met the revised EORTC/MSG definitions between 2008 and 2010. RESULTS: A total of 334 cases, which included proven (26, 8%), probable (159, 48%), or possible (149, 44%) IPA, were identified. Patients with proven or probable IPA were evaluated, and, of these 185 IPA patients, 105 (57%) had neutropenia, 30 (16%) underwent hematopoietic stem cell transplantation, 25 (14%) underwent solid organ transplantation, and 32 (17%) without neutropenia and transplantation received immunosuppressive agents or corticosteroid. Aspergillus spp. were isolated from 42 patients (23%), and positive fungal culture rates from sterile fluid, sputum, and bronchoalveolar lavage fluid (BAL) were 67% (6/9), 21% (32/150), and 20% (9/44), respectively. Results of assays for sensitivity of serum and BAL galactomannan were 84% (155/184) and 89% (25/28), respectively. Amphotericin-B deoxycholate and itraconazole were most commonly administered as a primary therapy in 107 (58%) and 34 (19%) patients, respectively. Of 133 patients (73%) who received salvage therapy after primary antifungal therapy for a median period of six days (IQR 3-12), 82 (62%) patients were treated with voriconazole. Of 185 patients, 82 (44%) died within three months after diagnosis of IPA. CT findings, including small airway lesions and micronodules, ground glass opacities, and pleural effusion and persistent positive galactomannan status showed an independent association with worse outcome, while proven diagnosis of IPA showed an independent association with better outcome. CONCLUSIONS: Microbiologic confirmation of IPA was low in Korea; therefore, many Korean physicians were dependent on the galactomannan assay for microbiologic diagnosis. Primary therapy with Amphotericin-B deoxycholate followed by salvage therapy with voriconazole was the most common antifungal strategy for treatment of patients with IPA in Korea. Overall mortality and IPA-related mortality were comparable with data from Western clinical trials.
Adult
;
Aspergillus
;
Bronchoalveolar Lavage Fluid
;
Cohort Studies
;
Deoxycholic Acid
;
Glass
;
Hematopoietic Stem Cell Transplantation
;
Humans
;
Immunocompromised Host
;
Immunosuppressive Agents
;
Invasive Pulmonary Aspergillosis
;
Itraconazole
;
Korea
;
Mannans
;
Neutropenia
;
Organ Transplantation
;
Pleural Effusion
;
Pyrimidines
;
Retrospective Studies
;
Salvage Therapy
;
Sputum
;
Transplants
;
Triazoles
9.PIK3CA Mutation is Associated with Poor Response to HER2-Targeted Therapy in Breast Cancer Patients
Ju Won KIM ; Ah Reum LIM ; Ji Young YOU ; Jung Hyun LEE ; Sung Eun SONG ; Nam Kwon LEE ; Seung Pil JUNG ; Kyu Ran CHO ; Cheol Yong KIM ; Kyong Hwa PARK
Cancer Research and Treatment 2023;55(2):531-541
Purpose:
Mutations in the PIK3CA gene occur frequently in breast cancer patients. Activating PIK3CA mutations confer resistance to human epidermal growth factor receptor 2 (HER2)-targeted treatments. In this study, we investigated whether PIK3CA mutations were correlated with treatment response or duration in patients with HER2-positive (HER2+) breast cancer.
Materials and Methods:
We retrospectively reviewed the clinical information of patients with HER2+ breast cancer who received HER2-targeted therapy for early-stage or metastatic cancers. The pathologic complete response (pCR), progression-free survival (PFS), and overall survival were compared between patients with wild-type PIK3CA (PIK3CAw) and those with mutated PIK3CA (PIK3CAm). Next-generation sequencing was combined with examination of PFS associated with anti-HER2 monoclonal antibody (mAb) treatment.
Results:
Data from 90 patients with HER2+ breast cancer were analyzed. Overall, 34 (37.8%) patients had pathogenic PIK3CA mutations. The pCR rate of the PIK3CAm group was lower than that of the PIK3CAw group among patients who received neoadjuvant chemotherapy for early-stage cancer. In the metastatic setting, the PIK3CAm group showed a significantly shorter mean PFS (mPFS) with first-line anti-HER2 mAb. The mPFS of second-line T-DM1 was lower in the PIK3CAm group than that in the PIK3CAw group. Sequencing revealed differences in the mutational landscape between PIK3CAm and PIK3CAw tumors.
Conclusion
Patients with HER2+ breast cancer with activating PIK3CA mutations had lower pCR rates and shorter PFS with palliative HER2-targeted therapy than those with wild-type PIK3CA. Precise targeted-therapy is needed to improve survival of patients with HER2+/PIK3CAm breast cancer.
10.Mortality of Community-Acquired Pneumonia in Korea: Assessed with the Pneumonia Severity Index and the CURB-65 Score.
Hye In KIM ; Shin Woo KIM ; Hyun Ha CHANG ; Seung Ick CHA ; Jae Hee LEE ; Hyun Kyun KI ; Hae Suk CHEONG ; Kwang Ha YOO ; Seong Yeol RYU ; Ki Tae KWON ; Byung Kee LEE ; Eun Ju CHOO ; Do Jin KIM ; Cheol In KANG ; Doo Ryeon CHUNG ; Kyong Ran PECK ; Jae Hoon SONG ; Gee Young SUH ; Tae Sun SHIM ; Young Keun KIM ; Hyo Youl KIM ; Chi Sook MOON ; Hyun Kyung LEE ; Seong Yeon PARK ; Jin Young OH ; Sook In JUNG ; Kyung Hwa PARK ; Na Ra YUN ; Sung Ho YOON ; Kyung Mok SOHN ; Yeon Sook KIM ; Ki Suck JUNG
Journal of Korean Medical Science 2013;28(9):1276-1282
The pneumonia severity index (PSI) and CURB-65 are widely used tools for the prediction of community-acquired pneumonia (CAP). This study was conducted to evaluate validation of severity scoring system including the PSI and CURB-65 scores of Korean CAP patients. In the prospective CAP cohort (participated in by 14 hospitals in Korea from January 2009 to September 2011), 883 patients aged over 18 yr were studied. The 30-day mortalities of all patients were calculated with their PSI index classes and CURB scores. The overall mortality rate was 4.5% (40/883). The mortality rates per CURB-65 score were as follows: score 0, 2.3% (6/260); score 1, 4.0% (12/300); score 2, 6.0% (13/216); score 3, 5.7% (5/88); score 4, 23.5% (4/17); and score 5, 0% (0/2). Mortality rate with PSI risk class were as follows: I, 2.3% (4/174); II, 2.7% (5/182); III, 2.3% (5/213); IV, 4.5% (11/245); and V, 21.7% (15/69). The subgroup mortality rate of Korean CAP patients varies based on the severity scores and CURB-65 is more valid for the lower scores, and PSI, for the higher scores. Thus, these variations must be considered when using PSI and CURB-65 for CAP in Korean patients.
Adolescent
;
Adult
;
Aged
;
Aged, 80 and over
;
Asian Continental Ancestry Group
;
Cohort Studies
;
Community-Acquired Infections/*mortality
;
Female
;
Humans
;
Intensive Care Units
;
Male
;
Middle Aged
;
Pneumonia/*mortality
;
Prospective Studies
;
Republic of Korea
;
*Severity of Illness Index
;
Young Adult