No abstract available.
Teratoma*

PURPOSE: Nitric oxide(NO) is a highly reactive messenger molecule that is synthesized by nitric oxide synthase(NOS) in a number of tissues including the brain. Our aim was to examine the possible role of NO on pentylenetetrazole(PTZ)-induced seizure in rats as a proconvulsant or an anticonvulsant. METHODS: Male Sprague-Dawley rats weighing 200-300g were used. PTZ(40mg/kg) was used to induce seizure. In order to examine the role of NO in seizures, the neuronal nitric oxide synthase (nNOS) was blocked by a specific inhibitor, 50mg/kg 7-nitroindazole(7-NI), and a non-specific inhibitor, 50mg/kg L-nitroarginine(L-NA). Both 7-NI and L-NA were administered 30 min before the administration of PTZ. We evaluated the onset time of the first myoclonic jerk and the nature of seizures, such as the types and severity of the seizures in each group. Western blot and RT-PCR were used to examine the expression of nNOS mRNA and proteins in the hippocampus of each group. RESULTS: The onset time of the first rnyoclonic jerk was markedly delayed in the 7-NI and L-NA pretreated groups in comparison to the PTZ group. In addition, 7-NI and L-NA markedly sup- pressed the severity of PTZ-induced seizure. The expression of nNOS mRNA was higher in the PTZ and 7-NI pretreated groups than in the control group. The expression of nNOS protein was more suppressed in the 7-NI and L-NA pretreated groups than in the PTZ group. CONCLUSION: The expression of nNOS protein appears to increase in PTZ-induced seizures. Both specific and non-specific NOS inhibitors produce a reduction in seizure activity and nNOS protein expression. These results suggest that nNOS may be in a close relationship with seizures, and NO may play an important role as a proconvulsant in the PTZ-induced seizure in rats.
Animals ; Blotting, Western ; Brain ; Hippocampus ; Humans ; Male ; Myoclonus ; Nitric Oxide Synthase Type I ; Nitric Oxide* ; Pentylenetetrazole* ; Rats ; Rats, Sprague-Dawley ; RNA, Messenger ; Seizures*

PURPOSE: Metastatic carcinoma of the eye is a common sequela of widespread dissemination of malignancy. Metastasis to the iris is less frequent than that of the cilliary body and choroid. We report a case of iris metastasis in a patient with non-small cell lung cancer. METHODS: 57-Year-Old man was seen in the department of ophthalmology because of blurred vision in his right eye for seven days. The patient had a metastasis of non-small cell lung cancer in the brain. Trabeculectomy and iridectomy were performed due to secondary glaucoma. RESULTS: The case was diagnosed as iris metastasis of non-small cell lung cancer by the clinical and histopathologic findings.
Brain ; Carcinoma, Non-Small-Cell Lung* ; Choroid ; Glaucoma ; Humans ; Iridectomy ; Iris* ; Middle Aged ; Neoplasm Metastasis* ; Ophthalmology ; Trabeculectomy

A 69-year old man presented with severe epigastric pain for 1 day. He had early gastric cancer at the antrum and underwent a distal subtotal gastrectomy and Billorth II gastrojejunostomy one month later without any post-operative complications. Radiologic examination revealed a large amount of retroperitoneal free air formation. Because of unremitting pain and unstable vital sign, exploratory laparotomy was followed. During the operation, a perforated duodenal diverticulum at the posterior wall of the 2nd portion of the duodenum was identified. He underwent diverticulectomy and primary closure. He was discharged on the 18th post operative day and has been followed up without any evidence of comlpication for several months.
Aged ; Diverticulum* ; Duodenum ; Gastrectomy* ; Gastric Bypass* ; Humans ; Laparotomy ; Stomach Neoplasms ; Vital Signs

A clinical study on therapeutic effects and toxicity of Netilmicin(Neticin(R)) in urinary tract infection was performed in 47 patients with various degrees of impairment of renal function and the following results were obtained. 1. Among 45 patients with various urinary tract infection, Netilmicin brought total elimination of the bacteria in 38 patients, persistent infection(one Serratia, one Pseudomonas fluoresce.) in 2 patients superinfection with a resistant strain of Psuedomonas fluoresces and a Netilmicin-sensitive
Anti-Bacterial Agents ; Bacteria ; Colon ; Creatinine ; Cystitis ; Cystostomy ; Humans ; Kidney ; Netilmicin* ; Preexisting Condition Coverage ; Pseudomonas ; Serratia ; Superinfection ; Urinary Tract Infections* ; Urinary Tract*

New bactericidal agent, Cefazolin was administered intramuscularly or intravenously in 1-3 divided doses of 1-3 grams daily in 30 cases of genitourinary tract infection and following results were obtained. 1) Among 12 cases of pyelonephritis, excellent effect was obtained, in 8 cases 2 cases were good and no improvement was noted in 2 cases. 2) Among 6 cases of acute cystitis. excellent in 4 cases and good in 2 cases was noted. 3) Among 4 cases of benign prostatic hypertrophy, excellent result in 1 case, good it 1 case and to improvement in Z cases was noted. 4) Among 3 cases of chronic non-gonococcal urethritis, 2 cases were good and no improvement in l case was noted. 5) Among 2 cases of gonorrhea, no improvement in l case and recurrence in 1 case was noted. 6) No improvement noted in 2 cases of chronic prostatitis and 1 case of prostatic abscess. No serious side effects were observed except slight dizziness in one case.
Abscess ; Cefazolin* ; Cystitis ; Dizziness ; Gonorrhea ; Prostatic Hyperplasia ; Prostatitis ; Pyelonephritis ; Recurrence ; Urethritis ; Urinary Tract Infections* ; Urinary Tract*

PURPOSE: Thyroid disease is the most common form of endocrinologic disease. Despite recent advances in diagnosis, controversy still remains concerning the surgical management of thyroid disease. The aim of this study was to analyze the clinical distribution and the inclination of surgical treatment for thyroid disease. METHODS: The medical records from 1,743 patients who had undergone thyroid resections for thyroid diseases between January 1989 and December 1998 at Kwangju Christian Hospital were reviewed retrospectively. RESULTS: Of the 1,743 patients with thyroid diseases, 1,285 had benign diseases and 458 had carcinomas, resulting in a 26.3% prevalence of malignancy. Female patients were predominate, being 6.89 times the number of males. The peak incidence of age was the 4th decade for patients with benign diseases (29.4%) and the 5th decade for those with malignant diseases (26.0%). Both benign (39.4%) and malignant diseases (42.1%) were more prevalent on the right lobe. The incidence of carcinomas was 28.9% in solitary nodules and 29.3% in multinodular goiters. In the histopathologic study, the most common type was a papillary carcinoma (84.5%) in malignancies and an adenomatous goiter (48.8%) in benign diseases. The most commonly performed surgical procedures were a total thyroidectomy (75.4%) for malignancies and a lobectomy for benign diseases (63.3%). Postoperative complications were 3.1% in patients with benign diseases and 29.7% in those with malignancies. Regional recurrence or distant metastases appeared in 5.5% of the patients during the 10 years following treatment. CONCLUSION: The treatments of choice were a thyroid lobectomy for patients with benign diseases and a total thyroidectomy for those with malignant diseases. However, the decision to perform a surgical resection should be based on the age and the general condition of patient.
Carcinoma, Papillary ; Diagnosis ; Female ; Goiter ; Gwangju ; Hospital Distribution Systems ; Humans ; Incidence ; Male ; Medical Records ; Neoplasm Metastasis ; Postoperative Complications ; Prevalence ; Recurrence ; Retrospective Studies ; Thyroid Diseases* ; Thyroid Gland* ; Thyroidectomy

Pertutaueous transluminal angioplasty is the treatment of choice for renovascular hypertension in cases due to the renal vascular occlusion which is not severe enough to pass dilatation catheter. The advantages of percutaneous transluminal angioplasty are the use of local anesthesia, its noninvasiveness without surgical risk, feasibility of repetition and shorter hospital days compared with surgical methods. We are presenting a case of renovascular hypertension due to atherosclerosis cured by percutaneous transluminal angioplasty with the review of literatures.
Anesthesia, Local ; Angioplasty* ; Atherosclerosis ; Catheters ; Dilatation ; Hypertension, Renovascular*

PURPOSE: To evaluate the correlation between foveal thickness, as measured with optical coherence tomographic evaluation, and the visual acuity in patients who suffered from unilateral resolved central serous chorioretinopathy. METHODS: Twenty-eight consecutive patients who were diagnosed with unilateral resolved central serous chorioretinopathy were studied. High-resolution optical coherence tomography was performed on all of the patients. The foveal thickness of the involved eye was normalized by dividing its thickness with that of the uninvolved eye. The best-corrected visual acuity of the involved eye was normalized as well. The subjects were divided into two groups according to the minimum value of the normalized foveal thickness in the 22 healthy subjects. RESULTS: The mean foveal thickness was 128.68+/-22.06 micrometer in the involved eyes and 148.18+/-13.88 micrometer in the uninvolved eyes. There was a statistically significant correlation between the normalized foveal thickness and the normalized visual acuity. There were statistically significant differences in the normalized visual acuity and the duration of the symptoms between the group with foveal thickness above the minimum value and the group with foveal thickness below the minimum value. CONCLUSIONS: There was a statistically significant correlation between foveal thickness and visual acuity. The patient group with a foveal thickness value above the minimum value of the normalized foveal thickness showed a statistically significant improvement in visual acuity and a shorter duration of symptoms. It seems that the foveal thickness is associated with visual acuity and the duration of symptoms.
Central Serous Chorioretinopathy* ; Humans ; Tomography, Optical Coherence ; Visual Acuity*

OBJECTIVE: To obtain the mean value of physical parameters of those over 65- years of age. METHODS: Physical parameters including body weight, height, chest circumference, length of upper limb and lower limb, hand power, and range of motion of cervical, thoracic, lumbosacral spines and other major joints were measured in two hundred fourteen elderly subjects. RESULTS: Subjects were divided into three groups according to age (group 1, 65~74 years; group 2, 75~84 years; group 3, above 85 years) and sex (male; female). Descriptive statistical analysis of data provided the following results. 1) Mean measurement in order of group 1-men, group 2-men, group 3-men followed by women of each group: Body weight (kg) - 60.2, 59.6, 54.9, 56.8, 51.6, 47.2; Standing height (cm) - 156.7, 160.8, 156.6, 151.2, 146.9, 142.2; Sitting height (cm) - 99.8, 100.8, 103.1, 100.9, 104.9, 97.0; Chest circumference (cm) - 91.5, 93.5, 91.4, 92.1, 89.5, 86.4; Upper limb length (cm) - 72.3, 72.5, 71.3, 67.1, 66.9, 65.4; Lower limb length (cm) - 82.3, 82.1, 81.4, 77.3, 76.1, 74.6. 2) The hand power of grasping, tip pinch, lateral pinch, palmar pinch showed a decreasing trend in older age group in both sexes. 3) The range of motion of cervical, thoracic, and lumbosacral spine in group 1 had limitation of about 50% compared to normal range. 4) Of the major joints, limitation of motion or deformity was most common in the shoulder and knee joints. CONCLUSION: These data and knowledge of physical parameters of the elderly can aid in design of living environment and assistive devices for elderly.
Aged* ; Body Weight ; Congenital Abnormalities ; Female ; Hand ; Hand Strength ; Humans ; Joints ; Knee Joint ; Lower Extremity ; Range of Motion, Articular ; Reference Values ; Self-Help Devices ; Shoulder ; Spine ; Thorax ; Upper Extremity