1.A Case of Subconjuntival Sparganosis.
Dong Kwang CHOI ; Joon Sang LEE ; Kyong Hwan JOO
Journal of the Korean Ophthalmological Society 1979;20(1):89-93
The subconjuctival sparganosis is rare tissue helminthiasis which develops frequently in. orbital, abdominal, urethral, ureteral and vertebral cases. Authors reported a case of sparganosis which complained conjuntival hyperemia, chemosis, subconjuntival mass in the right eye for 10 months. The patient was a 37 years old male who had a history of having eaten raw snake in the So-Re Gun. Gyeonggi Do for the purpose of tonics 3 years ago. In the winter of 1977, he had experienced edematous changes in the right cheek intermittently. A few months later, he noticed the apperence of the congestion and a mass on the right eye. On surgical exploration, one larvae (5.8 cm in length and 5 m min width) was extracted from the right upper temporal subconjunctiva. It was actively motile in the bottle filled with saline, so this larvae was consulted to parasitology department of Korea University from our clinic under the impression of subconjunctival sparganosis. The sources of infection of some formely reported sparganosis in Korea were discussed. It is most probable that human sparganosis is acquired by consuming of raw snakes and frogs in this country.
Adult
;
Cheek
;
Estrogens, Conjugated (USP)
;
Gyeonggi-do
;
Helminthiasis
;
Humans
;
Hyperemia
;
Korea
;
Larva
;
Male
;
Orbit
;
Parasitology
;
Snakes
;
Sparganosis*
;
Ureter
2.Comparison of Endoscopic Variceal Ligation versus Combined Ligation and Sclerotherapy for Bleeding Esophageal Varices.
Kyong Han SHIN ; June Sung LEE ; Jung Hwan YOON ; Chul Joo HAN ; Hyo Suk LEE ; Chung Yong KIM
The Korean Journal of Hepatology 1998;4(2):143-150
BACKGROUND/AIMS: Combined esophageal variceal ligation and sclerotherapy has been hypothesized to be more effective for the control of bleeding esophageal varices than ligation alone. The present study was to compare the combined therapy with ligation alone in terms of variceal eradication, rebleeding, complication and survival rates in patients with bleeding esophageal varices. METHODS: Thirty-eight patients with bleeding esophageal varices were randomly assigned to receive ligation alone in 20 patients or the combined therapy in 18 patients. The clinical and endoscopic characteristics of patients in the ligation group were similar to those of patients in the combination group. In the combination group, 1-3 mL of ethanolamine was injected proximal to each ligated site. Treatments were repeated every 2- to 3-month until varices were eradicated. RESULTS: No significant differences were found between the ligation and combination groups in variceal eradication rates (70% vs. 72%), numbers of endoscopic sessions required to achieve eradication (3.5+/-0.33 vs. 3.3+/-0.31), rebleeding rates (30% vs. 28%) or 2-yr cumulative survival rates (95% vs. 75%). There were significantly more complications in the combination group (25% vs. 89%, p=0.001). CONCLUSION: Ligation alone is recommended rather than the combined ligation and sclerotherapy because of its lower complication rates.
Esophageal and Gastric Varices*
;
Ethanolamine
;
Hemorrhage*
;
Humans
;
Ligation*
;
Sclerotherapy*
;
Survival Rate
;
Varicose Veins
3.Comparison of Endoscopic Variceal Ligation versus Combined Ligation and Sclerotherapy for Bleeding Esophageal Varices.
Kyong Han SHIN ; June Sung LEE ; Jung Hwan YOON ; Chul Joo HAN ; Hyo Suk LEE ; Chung Yong KIM
The Korean Journal of Hepatology 1998;4(2):143-150
BACKGROUND/AIMS: Combined esophageal variceal ligation and sclerotherapy has been hypothesized to be more effective for the control of bleeding esophageal varices than ligation alone. The present study was to compare the combined therapy with ligation alone in terms of variceal eradication, rebleeding, complication and survival rates in patients with bleeding esophageal varices. METHODS: Thirty-eight patients with bleeding esophageal varices were randomly assigned to receive ligation alone in 20 patients or the combined therapy in 18 patients. The clinical and endoscopic characteristics of patients in the ligation group were similar to those of patients in the combination group. In the combination group, 1-3 mL of ethanolamine was injected proximal to each ligated site. Treatments were repeated every 2- to 3-month until varices were eradicated. RESULTS: No significant differences were found between the ligation and combination groups in variceal eradication rates (70% vs. 72%), numbers of endoscopic sessions required to achieve eradication (3.5+/-0.33 vs. 3.3+/-0.31), rebleeding rates (30% vs. 28%) or 2-yr cumulative survival rates (95% vs. 75%). There were significantly more complications in the combination group (25% vs. 89%, p=0.001). CONCLUSION: Ligation alone is recommended rather than the combined ligation and sclerotherapy because of its lower complication rates.
Esophageal and Gastric Varices*
;
Ethanolamine
;
Hemorrhage*
;
Humans
;
Ligation*
;
Sclerotherapy*
;
Survival Rate
;
Varicose Veins
4.Two cases of ovarian pregnancy.
In Yul CHOI ; Kyong Hwa LEE ; Jung Ki HEO ; Tae Sik MOON ; Byong Chul YOON ; Hwan Joo CHOI
Korean Journal of Obstetrics and Gynecology 2001;44(5):982-985
Ovarian Pregnacy is a rare form of ectopic pregnacy. Its estimated overall incidence is highly variable, but improved diagnosis of acute hemoperitoneum of ovarian pregnancy may reveal a high incidence than reported earlier. Ovarian pregnancy occurs in the corpus luteum, and is usually accompanied with the rupture of the ovary and massive hemoperitoneum. It presents as a hemorragic ovary and frequently misdiagnosed as a ruptured corpus luteum. Risk facters to ovarian pregnacy include a history of pelvic inflammatory disease(PID), prior pelvic surgery, and use of an intrauterine contraceptive device(IUD). We have experienced two cases of ovarian pregnancy and reviewed it briefly.
Corpus Luteum
;
Diagnosis
;
Female
;
Hemoperitoneum
;
Incidence
;
Ovary
;
Pregnancy
;
Pregnancy, Ectopic*
;
Rupture
5.MCP-1 and RANTES Polymorphisms in Korean Diabetic End-Stage Renal Disease.
Kwon Wook JOO ; Young Hwan HWANG ; Jae Hyeon KIM ; Kook Hwan OH ; Hyunho KIM ; Hyoung Doo SHIN ; Woo Kyung CHUNG ; Jaeseok YANG ; Kyong Soo PARK ; Curie AHN
Journal of Korean Medical Science 2007;22(4):611-615
Macrophage infiltration has been observed in the renal biopsy specimens of diabetic nephropathy (DN), and hyperglycemic state stimulates the renal expression of RANTES (regulated upon activation, normal T-cell expressed and secreted) and MCP-1 (monocyte chemoattractant protein-1). Upregulation of RANTES and MCP-1 with infiltrating macrophages may play a crucial role in the development and progression of DN. Genetic polymorphisms of RANTES and its receptors were reported to be independent risk factors for DN. We genotyped single nucleotide polymorphism (SNPs) in the MCP-1 G-2518A, CCR2 G46295A, RANTES C-28G and G-403A in 177 diabetic end-stage renal disease (ESRD) patients and 184 patients without renal involvement (controls) in order to investigate the effects of these SNPs on DN in Korean patients with type 2 DM. There were no differences in the frequencies of SNPs and the distribution of haplotypes of RANTES promoter SNPs between two groups. In conclusion, there were no associations of MCP-1, CCR2 and RANTES promoter SNPs with diabetic ESRD in Korean population. Prospective studies with clearly-defined, homogenous cohorts are needed to confirm the effect of these genetic polymorphisms on DN.
Aged
;
Asian Continental Ancestry Group/*genetics
;
Chemokine CCL2/*genetics
;
Chemokine CCL5/*genetics
;
Chi-Square Distribution
;
Diabetes Mellitus, Type 2/complications
;
Female
;
Gene Frequency
;
Genotype
;
Haplotypes
;
Humans
;
Kidney Failure, Chronic/ethnology/etiology/*genetics
;
Korea
;
Male
;
Middle Aged
;
*Polymorphism, Single Nucleotide
;
Promoter Regions, Genetic
6.A case of peripheral polyneuropathy occurring in a small enterprise processing mobile phone cases.
Joo Youn SHIN ; Jong Han LEEM ; Yong Kyu KIM ; Shin Goo PARK ; Jee Na LEE ; Hwan Chul KIM ; Chang Hwan KIM ; Kyong Up CHO ; Mi JANG
Korean Journal of Occupational and Environmental Medicine 2005;17(2):138-143
OBJECTIVES: We report a case of n-hexane-induced occupational peripheral polyneuropathy. The patient had been cleaning mobile phone cases using n-hexane for 3 years without proper protection in the workplace. Method : Physical examinations, detailed history taking, laboratory studies and electrophysiological study were done. The n-hexane concentration in the ambient air of the workplace was analysed. RESULTS: The findings of the electrophysiological study revealed that the worker's neurologic symptoms were due to peripheral polyneuropathy. The average n-hexane concentration in the ambient air sampled at the workplace for 59 minutes was 1411.24ppm, from which the 8 hour time-weighted-average(TWA) was estimated as 882ppm. Because other alternative causes for peripheral polyneuropathy were ruled out by laboratory findings and detailed history taking, this TWA level strongly suggested that the disease was caused by n-hexane exposure. Conclusion : Although the neuro-toxicity of n-hexane is relatively well known, many problems have been identified in the management of this toxic material in terms of preventing toxic diseases in the workplace. We expect that this case will help in the planning of health management strategies for using n-hexane in the workplace.
Cellular Phone*
;
Humans
;
Neurologic Manifestations
;
Physical Examination
;
Polyneuropathies*
7.Clinical characteristics and prognostic factors for survival in hemophagocytic lymphohistiocytosis.
Khi Joo KIM ; Ki Hwan KIM ; Taek Jin LEE ; Jin Kyong CHUN ; Chuhl Joo LYU ; Dong Soo KIM
Korean Journal of Pediatrics 2008;51(3):299-306
PURPOSE: Hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disorder characterized by fever, splenomegaly, pancytopenia, and hemophagocytosis in the bone marrow and other tissues. In this study, we investigated the clinical manifestations and prognostic factors in patients with HLH. METHODS: We retrospectively analyzed the data from 29 patients who were diagnosed whit HLH in the Severance Children's Hospital from Jan. 1996 to Feb. 2007. RESULTS: The median age at diagnosis was 3.8 years (range 0.1-12.2). The ratio of male to female patients was 1.1:1. The 5-year overall survival rate was 55.2% with a median follow-up duration of 32 months. In a multivariate analysis, the duration of fever before admission (survival vs. non-survival, 6.5 days vs. 14 days, P=0.010), the interval from the day of fever onset to the day of initiation of etoposide (survival vs. non-survival, 10 days vs. 35 days, P=0.002) and the presence of neurologic symptoms (survival vs. non-survival, 1 case vs. 7 cases, P=0.010) were independent, poor prognostic factors of HLH. EBV infection, gender, and the level of serum ferritin had no relations to the poor prognosis of the disease. CONCLUSION: This study showed that the presence of neurologic symptoms and a longer duration of fever were related to a poor prognosis. Therefore, if a patient develops neurologic symptoms and the duration of fever is prolonged, a prompt diagnostic approach and aggressive treatment for HLH are necessary.
Bone Marrow
;
Epstein-Barr Virus Infections
;
Etoposide
;
Female
;
Ferritins
;
Fever
;
Follow-Up Studies
;
Humans
;
Lymphohistiocytosis, Hemophagocytic
;
Male
;
Multivariate Analysis
;
Neurologic Manifestations
;
Pancytopenia
;
Prognosis
;
Retrospective Studies
;
Splenomegaly
;
Survival Rate
8.Serially Passaged Normal Human Nasal Epithelial Cells: Morphology and Mucous Secretory Differentiation.
Hwan Jung ROH ; Eui Kyung GOH ; Soo Geun WANG ; Kyong Myong CHON ; Joo Heon YOON ; Yoo Sun KIM
Journal of Rhinology 1999;6(2):107-112
BACKGROUND AND OBJECTIVES: The purpose of this study was to develop a subculturing technique that allows the formation of large amounts of normal human nasal epithelial (NHNE) cells without compromising the cells' ability to differentiate into secretory and ciliated cells. MATERIALS AND METHODS: Freshly isolated nasal epithelial cells, collected from normal inferior turbinates, were subcultured repeatedly in a serum-free medium on plastic culture dishes. The subcultured cells were tested for growth curve and electromicroscopic characteristics in air-liquid interface (ALI) cultures and for mucous secretory differentiation. RESULTS: The cultures grew rapidly during the first three passages, demonstrating a 20- to 40-fold expansion with each subculture. Ciliogenesis usually started on day 12 and the cultured cells formed cellular sheets exhibiting microvilli in the apical membrane, intracytoplasmic secretory granules, electron lucent, scant endoplasmic reticulum and complex tight junctions on the basolateral side. Passage-1 (P-1) and passage-2 (P-2) cells maintained their potential to differentiate into mucin-secretory and ciliated epithelial cells, and this potential was confirmed by immunocytochemistry with H6C5 and transmission electron microscopy. Although the number of NHNE cells on day 16 of culture decreased as the passage progressed from P-1 to P-3, the relative number of secretory cells did not significantly change. CONCLUSION: In conclusion, P-2 NHNE cell cultures retain the features of normal epithelium and are suitable for conducting many studies on upper airway cell biology.
Cell Culture Techniques
;
Cells, Cultured
;
Endoplasmic Reticulum
;
Epithelial Cells*
;
Epithelium
;
Humans*
;
Immunohistochemistry
;
Membranes
;
Microscopy, Electron, Transmission
;
Microvilli
;
Mucins
;
Plastics
;
Secretory Vesicles
;
Tight Junctions
;
Turbinates
9.A Case of Eosinophilic Granulomatosis with Polyangiitis Presenting with Subarachnoid Hemorrhage and Mononeuritis Multiplex.
Se Hwan OH ; Won PARK ; Seong Ryul KWON ; Mie Jin LIM ; Ko Woon JOO ; Oh Hyun LEE ; Ha Young LEE ; Se Yang OH ; Kyong Hee JUNG
Journal of Rheumatic Diseases 2015;22(3):190-194
Eosinophilic granulomatosis with polyangiitis (EGPA), previously called Churg-Strauss syndrome, is an anti-neutrophil cytoplasmic antibody associated vasculitis, accompanied by asthma, hypereosinophilia, nonfixed pulmonary infiltrates, and sinusitis. Peripheral neuropathy is common in patients with EGPA; however, a few cases of EGPA with central nervous system (CNS) involvement have been reported. A 45-year-old female referred for right side weakness and posterior neck pain was diagnosed as EGPA with subarachnoid hemorrhage and mononeuritis multiplex. She was effectively treated with a high dose glucocorticoid, cyclophosphamide, and intravenous immunoglobulin. EGPA with CNS involvement is uncommon and causes significant morbidity and mortality. Therefore more rapid and accurate diagnostic evaluation may be required. EGPA should be considered in patients with neurological symptoms and hypereosinophilia.
Antibodies, Antineutrophil Cytoplasmic
;
Asthma
;
Central Nervous System
;
Churg-Strauss Syndrome
;
Cyclophosphamide
;
Eosinophils*
;
Female
;
Humans
;
Immunoglobulins
;
Middle Aged
;
Mononeuropathies*
;
Mortality
;
Neck Pain
;
Peripheral Nervous System Diseases
;
Sinusitis
;
Subarachnoid Hemorrhage*
;
Vasculitis
10.Pattern of Reinnervation in Denervated Rat Gastrocnemius Muscle by Various Procedures of Reinnervation.
Yong Jin KWON ; Jun Yonug KIM ; Young Il MOON ; Il Woo LEE ; Byung Joo LEE ; Hwan Jung ROH ; Eui Kyung GOH ; Kyong Myong CHON ; Soo Geun WANG ; So Min HWANG
Korean Journal of Otolaryngology - Head and Neck Surgery 2002;45(7):693-705
BACKGROUND AND OBJECTIVES: We tried to investigate the effectiveness of various methods of reinnervation including nerve-muscle pedicle transfer, nerve anastomosis, nerve implantation. MATERIALS AND METHOD: Forty Sprague-Dawley rats were used. Control group and experimental groups each consisted 5 rats, as follows: a denervated tibial nerve without reinnervation (control), a common peroneal nerve and 2X2 mm tibialis anterior muscle pedicle grafted to the denervated gastrocnemius muscle after the removal of epimysium (group I), a common peroneal nerve and 4X4 mm tibialis anterior muscle pedicle grafted to the denervated gastrocnemius muscle after the removal of epimysium (group II), a common peroneal nerve and 2X2 mm tibialis anterior muscle pedicle grafted to the denervated gastrocnemius muscle after removal of epimysium and part of muscle (group III), a common peroneal nerve and 4X4 mm tibialis anterior muscle pedicle grafted to the denervated gastrocnemius muscle after removal of epimysium and part of muscle (group IV), a common peroneal nerve and 2X2 mm tibialis anterior muscle pedicle inserted to the denervated gastrocnemius muscle (group V), a common peroneal nerve inserted to the denervated gastrocnemius muscle (group VI), and anastomesed common peroneal nerve to distal tibialis nerve (group VII). Electromyography, muscle contraction power study, histotological analysis and counting of motor end-plate were applied for estimating the reinnervation of denervated muscle. RESULTS: In motor nerve conduction studies, Group VII and III showed significantly higher amplitude of the compound muscle action potentials than other groups. In muscle contraction power studies, Group VII and III showed significantly powerful contraction. In histological analysis, group VII and III showed less muscle atrophy. The motor end-plate count was more in the groups VII, III, I, V, VI, II and IV in order. CONCLUSION: Nerve anastomosis and 2X2 mm nerve-muscle pedicle transfer showed more successful regeneration of denervated muscle than other reinnervation methods including nerve implantation.
Action Potentials
;
Animals
;
Electromyography
;
Motor Endplate
;
Muscle Contraction
;
Muscle, Skeletal*
;
Muscular Atrophy
;
Nerve Transfer
;
Neural Conduction
;
Peroneal Nerve
;
Rats*
;
Rats, Sprague-Dawley
;
Regeneration
;
Tibial Nerve
;
Transplants