1.Coxiella Burnetii Infection in Patiets with Various Diseases.
Journal of the Korean Pediatric Society 1994;37(3):356-367
Coxiella burnetii(C. burneii)was first recognized as the agent of Q fever in 1937. Q fever is an acute self-limited febrile illness. However, it manifests with several clinical symptoms depending upon the organs that are involved. The association of C. burnetii with human neoplasia has been rarely reported. We prospectively studied the 55 patients with fever of unknown origin, pneumonia, hepatosplenomegaly, lymphadenopathy, leukemia, lymphoma, and immunodeficiency and 14 persons who contacted the Q fever patients. The patient's sera were tested for antibodies specific for C. burnetii, using indirct fluorescent antibody techniques (IFA). 1) We serologically confirmed 23 C. burnetii infection. The 23 children with Q fever ranged in age from 0 to 15 years, with mean age of 4 years 11 months. Seventeen were boys and 6 were girls. 2) Characteristic symptoms and signs were fever (9/12 cases), rash (8/14 cases), hepatosplenomegaly (8/8 cases)and lymphadenopathy (14/27 cases). Five cases among 14 asymptomatic cases who contacted Q fever patients showed positive IFA test. One suffered from irregular uterine contraction, 4 weeks after contact with a Q fever patient. 3) There were no history of exposure to domestic animal carriers or contaminated dust, or drinking raw milk except one family. Three attending doctors and her father infected by a patient with Q fever. These suggested the person to person transmission of Q fever in a family and house staffs infected by a patient of Q fever. 4) Q fever (9 cases), acute lymphoblastic leukemia (2 cases), acute myelomonocytic leukemia (1 case), hairy cell leukemia (1case), Kawasaki disease (4 cases) and congenital dyserythropoietic anemia (1 case) showed positive IFA test. 5) Of 9 cases who suffered from lnly Q fever, 7 cases were confirmed hairy cell formation in their peripheral blood. One case was diagnosed as hairy cell leukemia after bone marrow study. Of 7 cases who showed hairy cells, all had hepatomegaly, 6 cases had lymphedenopathy and 5 cases showed splenomegaly. All except 1 case who was not followed cured after treatment. 6) We treated Q fever patients with rifampin and/or ciprofloxacin, and/or tetracyclin (over 8 year-old of age)for 2-4 weeks. One 25 month-old patient with hairy cell leukemia was treated with rifampin, ciprofloxacin and tetracyclin for 4 weeks, and rifampin for 8 months. A pregnant patient was administered with rifampin, and treated with rifampin and ciprofloxacin after delivery. We gave rifampin in one nweborn baby. In conclusion, we suggest that Q fever should be considered in the differential diagnosis of patients with FUO, hepatosplenomegaly and/or immunodeficiency.
Anemia, Dyserythropoietic, Congenital
;
Animals, Domestic
;
Antibodies
;
Bone Marrow
;
Child
;
Child, Preschool
;
Ciprofloxacin
;
Coxiella burnetii*
;
Coxiella*
;
Diagnosis, Differential
;
Drinking
;
Dust
;
Exanthema
;
Fathers
;
Female
;
Fever
;
Fever of Unknown Origin
;
Fluorescent Antibody Technique
;
Hepatomegaly
;
Humans
;
Internship and Residency
;
Leukemia
;
Leukemia, Hairy Cell
;
Leukemia, Myelomonocytic, Acute
;
Lymphatic Diseases
;
Lymphoma
;
Milk
;
Mucocutaneous Lymph Node Syndrome
;
Pneumonia
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma
;
Prospective Studies
;
Q Fever*
;
Rifampin
;
Splenomegaly
;
Uterine Contraction
2.A study on the length of the human umbilical cord.
Min Hee KIM ; Young Hyuk LEE ; Kyo Sun KIM
Journal of the Korean Pediatric Society 1991;34(12):1641-1646
No abstract available.
Apgar Score
;
Humans*
;
Umbilical Cord*
3.Hepatorenal Syndrome.
Kyo Sun KIM ; Young Mo SOHN ; Jung Soo KIM
Journal of the Korean Pediatric Society 1981;24(3):257-270
No abstract available.
Hepatorenal Syndrome*
4.Arterio-venous malformation in the chest wall: a case report.
Yun Young CHOI ; Kyo Nam KIM ; Heung Suk SEO
Journal of the Korean Radiological Society 1991;27(6):796-798
No abstract available.
Thoracic Wall*
;
Thorax*
5.Acute hepatitis in a 10 month old girl with Rubeola.
Youn Ha KANG ; Young Min AHN ; Kyo Sun KIM
Journal of the Korean Pediatric Society 1985;28(2):174-176
No abstract available.
Female*
;
Hepatitis*
;
Humans
;
Infant*
;
Measles*
6.Expression of the nm23 and E-cadherin Proteins in Breast Carcinoma.
Jean a KIM ; Won Il KIM ; Sang In SHIM ; Chang Suck KANG ; Kyo Young LEE ; Young Shin KIM
Korean Journal of Pathology 1998;32(1):29-34
Expression of the nm23 and E-cadherin proteins has been studied in a number of tumors. Reduced expression of the nm23 and E-cadherin proteins seems to be associated with metastasis or disease progression in some tumors, including breast carcinoma. To assess the role of nm23 and E-cadherin in tumor differentiation and metastasis of breast carcinoma, immunohistochemical staining for the nm23 and E-cadherin proteins was performed in paraffin embedded tumor samples from 86 breast carcinomas. The results were as follows: 1) Expression of the nm23 protein in breast carcinoma was strong positive in 32 cases (37.2%), weak positive in 26 cases (30.2%), and negative in 28 cases (32.6%) of the cases. Expression of the nm23 protein in breast carcinoma decreased according to histological grade and lymph node metastasis, but was not statistically significant. 2) Expression of the E-cadherin protein in breast carcinoma was strong positive in 50 cases (58.1%), weak positive in 24 cases (27.9%), and negative in 12 cases (14%) of the cases. Expression of the E-cadherin protein in breast carcinoma decreased according to histological grade and lymph node metastasis, but was not statistically significant. 3) There was a statistically significant correlation between the expression of the nm23 protein and the E-cadherin protein in breast carcinoma (p<0.05). These results suggest that the expression of the nm23 and E-cadherin proteins is related to tumor differentiation, and may also be an useful prognostic factor in breast carcinoma.
Breast Neoplasms*
;
Breast*
;
Cadherins*
;
Disease Progression
;
Lymph Nodes
;
Neoplasm Metastasis
;
Paraffin
7.Congenital Intracranial Teratoma with Extension into Oral Cavity: An autopsy case.
Young Sill KIM ; Kyo Young LEE ; Chang Suck KANG ; Sang In SHIM ; Sun Moo KIM
Korean Journal of Pathology 1990;24(3):326-330
Intracranial teratomas which were first described by Maier in 1861 are uncommon. Those presenting at birth are very rare and in our knowledge no case has been reported in Korea. In November, 1988, we experience a case of congenital intracrainal teratoma which replaced almost all cerebral tissue, filled out the oral cavity, and was protruded from the mouth. A female fetus was artificially delivered by a 25-year-old primigravida at 22 weeks of gestation, because of marked hydramnios and fetal hydrocephalus which were detected by prenatal ultrasonography. Microscopically, tissues from all three germ layers, including a lot of neuroepithelim and primitive mesenchymal tissue, were shown. A brief review of the literature was done.
Female
;
Humans
8.Henoch-Scholein Purpura Presenting with Acute Abdominal Pain Preceding Skin Rash: Review of 23 Cases .
Ju Young CHANG ; Yong Joo KIM ; Kyo Sun KIM ; Hee Ju KIM ; Jeong Kee SEO
Journal of the Korean Pediatric Society 2003;46(6):576-584
PURPOSE: For the early diagnosis of Henoch-Schonlein purpura(HSP) presenting with acute abdominal pain preceding skin rash. METHODS: The clinical, endoscopic and radiological records of 23 cases of HSP, presenting with gastrointestinal symptoms preceding skin rash were reviewed. RESULTS: The intervals from the onset of abdominal pain to the development of the skin rash were one day to 30 days(median five days), most of them were within two weeks. The presenting abdominal symptoms were abdominal pain(23 cases), vomiting(16 cases), hematochezia or melena(eight cases) and hematemesis(three cases). The abnormal endoscopic findings include coalescing erythematous lesions, areas of submucosal hemorrhage and superficial erosions and ulcers. The upper gastro intestinal endoscopy showed the abnormalities in 21 of 23 cases, which were observed in the duodenum(21 cases), the stomach(12 cases) and the esophagus(one case). Duodenitis with hemorrhage and/or erosions in the descending duodenum was the sole endoscopic abnormality in two cases and was the most marked finding in three cases. Sigmoidoscopy showed the abnormalities in six of eight cases. The abdominal ultrasonogram showed abnormalities in 12 of 17 cases, which included small bowel wall thickening(eight cases) and intramural hemorrhage(three cases). Recurrences after three months of symptom free intervals developed in four cases; three of them had persistent nephritis beyond one year. CONCLUSION: The erosive hemorrhagic duodenitis in the descending duodenum in the upper endoscopy and the small bowel wall thickening in the abdominal ultrasonogram can be useful findings in the diagnosis of HSP presenting with acute abdomen.
Abdomen, Acute
;
Abdominal Pain*
;
Diagnosis
;
Duodenitis
;
Duodenum
;
Early Diagnosis
;
Endoscopy
;
Exanthema*
;
Gastrointestinal Hemorrhage
;
Hemorrhage
;
Nephritis
;
Purpura*
;
Recurrence
;
Sigmoidoscopy
;
Skin*
;
Ulcer
;
Ultrasonography
9.The Use of Flexible Intramedullary Nails in Fracture of the Tibial Shaft
Jang Sung LEE ; Kyo Woong KIM ; Byung Guk KIM ; Seung Ki JEONG ; Sang Young KIM
The Journal of the Korean Orthopaedic Association 1990;25(1):70-77
Forty five cases of adult tibial shaft fractures were treated with flexible intramedullary nails under image intensifier at the department of orthopaedic surgery, Capital Armed Forces General Hospital during between April 1986 to July 1988. The results were summarized as follows: 1. 45 cases were all male, the average age was 24.3 years and the most common cause of fractures was sports injury(20 cases) and the second most common cause was traffic accident(18 cases). 2. 11 cases out of 45 cases were open fracture and 34 cases were closed fracture. Eight cases of open fraeture were grade I and three cases were grade II. Twenty eight cases were comminuted fracture. The most common level of the fracture was middle third of the tibial shaft. 3. Average interval from injury to Ender nailing was 13.5 days and the mean duration of permission to full weight bearing was 9.2 weeks. 4. Out of 2 cases of delayed union, the average time of clinical bone union was 9.7 weeks and that of roentgenological bone union was 14 weeks. 5. 11 cases of complication were noted among the 45 cases of tibial shaft fracture which were treated by PGP nailing such as angulation, rotation, ankle joint stiffness, delayed union, shortening, and soft tissue infection. 6. PGP nailing is considered to be a valuable method in treating tibial shaft fracture because of their relative ease of nailing, allowing early weight bearing and decreased complication.
Adult
;
Ankle Joint
;
Arm
;
Fractures, Closed
;
Fractures, Comminuted
;
Fractures, Open
;
Hospitals, General
;
Humans
;
Male
;
Methods
;
Soft Tissue Infections
;
Sports
;
Tibial Fractures
;
Weight-Bearing
10.Paneth Cell-rich Carcinoma of the Stomach: A case report .
Ah Won LEE ; Young Shin KIM ; Kyo Young LEE ; Chang Suk KANG ; Sang In SHIM
Korean Journal of Pathology 1998;32(8):613-615
Paneth cell-rich carcinoma is essentially an adenocarcinoma with a predominance of Paneth cells. A 60-year-old male patient was admitted with a history of abdominal distension for several months. Endoscopic examination revealed a large ulceroinfiltrative tumor involving most of the areas of the stomach. The biopsy of the lesion confirmed poorly differentiated adenocarcinoma and total gastrectomy was followed. The submitted total stomach contained a diffuse infiltrative Borrmann type IV mass with ulceration, 8.0 3.5 cm, at the body along the lesser curvature. Microscopically, it was composed of Paneth cell differentiated cancer cells and poorly differentiated tubular adenocarcinoma cells. The Paneth cell differentiation was characterized by cytoplasmic coarse eosinophilic granules, which were PAS-positive and positive reaction for lysozyme. Electron microscopic examination showed numerous, spherical, electron-dense, homogeneous granules corresponding to those in Paneth cells as well as mucin granules in the signet-ring cells, and various intermediate forms in some cancer cells, which might be immature in the Paneth cell lineage.
Adenocarcinoma
;
Biopsy
;
Cell Differentiation
;
Cell Lineage
;
Cytoplasm
;
Eosinophils
;
Gastrectomy
;
Humans
;
Male
;
Middle Aged
;
Mucins
;
Muramidase
;
Paneth Cells
;
Stomach*
;
Ulcer