1.The Effect of the Administration of Nitroglycerin and Atropine on the Pattern of Left Ventricular Diastolic Filling as Assessed by Doppler Echocardiography in Normal Human Subjects.
Kyeong A OH ; Jong Cheol PARK ; Nam Jin YOO ; Soo Yeon WON ; Jin Won JEONG ; Yang Kyu PARK ; Ock Kyu PARK
Korean Circulation Journal 1994;24(3):412-425
BACKGROUND: The diastolic transmitral flow velocity pattern has been commonly used to assess left ventricular(LV) diastolic function. The effects of multiple factors(such as, LV preload, afterload and heart rate, etc.) make difficulties in accurate interpretation. METHODS: In order to investigate the diastolic transmitral filling patterns according to the changes of the proload or heart rate, we studied 27 normal subjects with pulsed Doppler echocardiography after the administration of nitroglycerin(0.6mg/tab.) sublingually or atropine(0.5mg/amp.) intravenously. RESULTS: 1) After nitroglycerin administration, the folowings were obtained. ; The systolic blood pressure and LV diastolic filling time(DFT) decreased by 10.1% and 15.3%, respectively(p<0.001), compared with baseline data. The ratio of peak early to late diastolic transmitral flow velocities (E/A) and time-velocity integrals(TVIE/TVIA) decreased by 10.3% and 14.8%, respectively(p<0.01). The early diastolic filling time(Time E) was unchanged. Therefore, we suggest that time E is helpful, compared with the increments of the preload or the diastolic dysfunction. 2) After atropin administration, the heart rate, peak late diastolic transmitral flow velocity(PA) and percent atrial contribution(%AC) significantly increased by 43.6%, 25.1% and 41.4%, respectively(p<0.001). The E/A, TVIE/TVIA and DFT significantly decreased by 42.9%, 38.9% and 43.0%, respectively(p<0.001) compared to the data before drug administration. 3) The heart rate correlated negatively to the E/A, TVIE/TVIA and DFT. It was correlated positively to %AC(r=+0.63; p<0.001). The normalized E/A ratio by DFT(E/A/DFT) didn't correlate. Therefore, E/A/DFT is helpful on the exclusion of the influences of heart rate by the administration of the atropine. CONCLUSION: The decrement of preload or the increment of heart rate changes the diastolic transmitral flow velocity patterns. Therefore, when the diastolic function is assessed by interpretation of the Doppler transmitral flow velocity pattern with pulsed Doppler echocardiogram, the potential influences of preload and heart rate must be taken into account.
Atropine*
;
Blood Pressure
;
Echocardiography
;
Echocardiography, Doppler*
;
Echocardiography, Doppler, Pulsed
;
Heart Rate
;
Humans*
;
Nitroglycerin*
;
Time
2.A Case of Hypogonadotrophic Hypogonadism due to Intrasellar Arachnoid Cyst.
Hyun Hee JO ; Kyeong A YEO ; Jin Hong KIM ; Ki Cheol KIL ; Hyoung Ju CHOI ; Sun Won YOO
Korean Journal of Obstetrics and Gynecology 2000;43(7):1290-1293
Primary amenorrhea due to intrasella arachnoid cyst is a very rare disease and require careful and frequent evaluation because may produce intracranial hemorrhage, elevated intracranial pressure and rapid expansion. Surgical intervention is needed only when visual disturbance, hypopituitarism or enlarging lesion is shown. Thus, we present a case of primary amenorrhea due to intrasella arachnoid cyst which was resected through the transsphenoidal approach.
Amenorrhea
;
Arachnoid*
;
Female
;
Hypogonadism*
;
Hypopituitarism
;
Intracranial Hemorrhages
;
Intracranial Hypertension
;
Rare Diseases
3.A Cases of Tuberculous Pericarditis Associated with Pseudoaneurysm of the Left Ventricle
Nam Jin YOO ; Jong Cheol PARK ; Kyeong A OH ; Kyeong Nyeon KIM ; Jin Won JEONG ; Yang Kyu PARK ; Ock Kyu PARK
Journal of the Korean Society of Echocardiography 1994;2(1):104-108
The incidence of left ventricular pseudoaneurysm is not known, but it appears to be quite rare. We experienced a case of apical pseudoaneurysm of left ventricle in a 73-year-old female who presented with progressive orthopnea. On the 2nd hospital day, cardiac tamponade developed. A small pseudoaneurysm of left ventricle with narrow neck associated with massive pericardial effusion was demonstrated by transthoracic echocardiography. Emergency coronary angiogram showed normal. Emergency operation was performed on the suspicion of rupture of the pseudoaneurysm. Microscopic examination of the wall of the aneurysm revealed fibrous tissue adhered to the granulomatous inflammatory pericardium.
Aged
;
Aneurysm
;
Aneurysm, False
;
Cardiac Tamponade
;
Echocardiography
;
Emergencies
;
Female
;
Heart Ventricles
;
Humans
;
Incidence
;
Neck
;
Pericardial Effusion
;
Pericarditis, Tuberculous
;
Pericardium
;
Rupture
4.A Case of Infectious Mononucleosis Complicated by Myopericarditis.
Nam Jin YOO ; Jong Cheol PARK ; Kyeong A OH ; Jei Hyeong KIM ; Sei Hun YANG ; Seung Ha LEE ; Jin Won JEONG ; Yang Kyu PARK ; Ock Kyu PARK
Korean Circulation Journal 1995;25(1):110-113
Myopericarditis is an uncommon manifestation, but can be reaely a lethal complication of infectious mononucleosis. We experienced a case of infectious mononucleosis complicated by myopericarditis in which the clinical pictur was confused as acute myocarddial infarction. A 25-year-old male who presented with syncope and chest pain. The diagnosis of infectious mononucleosis was comfirmed by both a positive heterophil antibody test and a high titer of Epstein-Barr virus antibody. He was found to have completely normal findings at cardiac catheterization, including coronary arteriography. Pathologic specimen from right ventricular endomyocardial biopsy demonstrated extensive lymphocytic and eosinophilic infiltration of the myocardium.
Adult
;
Angiography
;
Biopsy
;
Cardiac Catheterization
;
Cardiac Catheters
;
Chest Pain
;
Diagnosis
;
Eosinophils
;
Herpesvirus 4, Human
;
Humans
;
Infarction
;
Infectious Mononucleosis*
;
Male
;
Myocardium
;
Syncope
5.Cholesterol embolism associated with acute renal failure after coronary angiography.
Hyeong Ho KIM ; Mi Kyeong KIM ; Jae Hyuk JUNG ; Doo Ryeon JUNG ; Won Seok YANG ; Jong Koo LEE ; Chang Gi HONG ; Eun Sil YOO
Korean Journal of Nephrology 1993;12(3):464-469
No abstract available.
Acute Kidney Injury*
;
Cholesterol*
;
Coronary Angiography*
;
Embolism, Cholesterol*
6.ST Segment Elevation in Lead V1on Treadmill Exercise Test in the Patients with Angina : A Predictor of Coronary Artery Disease and It's Location.
Jeong Cheol PARK ; Min Suck KIM ; Sung Shik SON ; Jae Bum SO ; Kyeong A OH ; Nam Jin YOO ; Jin Won JEONG ; Yang Kyu PARK ; Ock Kyu PARK
Korean Circulation Journal 1995;25(6):1140-1146
OBJECTIVES: To assess the relationship between ST segment elevation during exercise testing and coronary artery disease. METHODS: Treadmill exercise electrocardiography and coronary angiography were performed in 137 patients with angina with no Q waves. The J point elevation of > 0.03mV(0.3mm) measured from baseline, the elevation of ST segment at 80msec. from J point(ST80) measured larger in lead V1than in aV1, or both the elevation of ST segment at J point and at ST80 developed earlier than or concomitantly with ST depression were considered as abnormal responses. RESULTS: 1) There was no clinical significance of ST elevation in lead aV1. 2) Exercise-induced ST elevation in lead V1occurred in 29 of 137 patients with angina. 3) Abnormal St elevation in V1was detected in 26 of 86 patients with coronary artery disease, for a specificity of 98%. The patients with left anterior descending coronary artery or left main coronary artery stenosis were observed in 3 of 5(60%) patients with single-vessel disease, in 7 of 9(79%) with two-vessel disease, and in 9 of 10(90%) with three-vessel disease. 4) The standard ST depression yielded a specificity of 55% in the patients with isolated or predominant ST depression in inferior leads(II. III, and aVF) and of 81% in the patients with isolated or predominat ST depressin in precordial leads(p<0.001). 5) Abnormal exercise-induced ST elevation in V1was detected in 13 of 39(33%) patients with isolated or predominat ST depression in inferior leads and yielded a specificity of 94% for coronary artery disease. CONCLUSION: Abnormal ST segment elevation in V1may increase the specificity in isolated or predominat ST segment depression in inferior leads and may predict left anterior descending or left main coronary artery disease.
Coronary Angiography
;
Coronary Artery Disease*
;
Coronary Stenosis
;
Coronary Vessels*
;
Depression
;
Electrocardiography
;
Exercise Test*
;
Hexamethonium
;
Humans
;
Sensitivity and Specificity
7.Knowledge and Performance of Infection Control Guidelines.
Kyung Mi KIM ; Kyeong Sook CHA ; Ji Young LEE ; So Yeon YOO ; Ok Ja CHOI ; Sung Hun WIE ; Wan Shik SHIN ; Moon Won KANG
Korean Journal of Nosocomial Infection Control 2004;9(2):139-150
BACKGROUND: This study was purposed to identify the knowledge and performance level of the infection control guidelines and to improve their performance level of infection control for those nurses who care patients directly. METHODS: This study was based on the survey questionnaires about infection control guidelines with the total 626 nurses in Seoul and Kyunggi areas for the period between May 26, 2003 and July 14, 2003. RESULTS: The average knowledge level of infection control was 0.84 +/-0.07 (score range 0-1) and the average performance level of the infection control was 4.44+/-10.27 (score range 0-5). The correlation between knowledge and performance of the infection control showed positive correlation (r=.39; P<.001). The knowledge and performance level of the 'Prevention of the central catheter infection' were higher than other infection control guidelines. The performance levels of the 'Prevention of the surgical site infection' were lower than other infection control guidelines. The correlation between knowledge and performance of the 'Prevention of the nosocomial pneumonia' (r=.389; P<.001). 'Prevention of the urinary tract infection' (r=.325; P<.001), 'Prevention of the central catheter infection (r=.290; P<.001) and 'Intravascular infection control' (r=.446; P<.001) showed positive correlation. CONCLUSION: The study demonstrated that the nurses' knowledge and performance of infection control guidelines showed positive correlation. So the education on the infection control is required indispensably and it would contribute to reduce the hospital infection rate by performing the right treatment on the infection control with the basis of accurate knowledge.
Catheters
;
Cross Infection
;
Education
;
Gyeonggi-do
;
Humans
;
Infection Control*
;
Seoul
;
Urinary Tract
;
Surveys and Questionnaires
8.Diagnostic Significance of Pseudonormalization during Treadmill Exercise Test in Ischemic Heart Disease.
Moo Yong RHEE ; Rak Kyeong CHOI ; In Soo KIM ; Chang Won LEE ; Duk Whan JANG ; Hong Soon LEE ; Soo Woong YOO ; Hak Choong LEE
Korean Circulation Journal 1995;25(1):5-10
BACKGROUND: The interpretation of electrocardiographic change in treadmill exercise test is difficult when the test is performed in patients with abnormal resting electrocardiography. In patients with primary nagative T wave, normalization of primary negative T wave(pseudonormalization)is not uncommon finding during treadmill exercise test. The mechanism of pseudonormalization is uncertain and the interpretation is difficult. Thus this study was performed to evaluate the diagnostic significance of pseudonormalization during treadmill exercise test. METHODS: 200 cases who showed primary negative T wave at rest were included in this study. The results were classified as positive, borderline positive, borderline negative, negative, non-diagnostic and pseudonormalization. RESULTS: Pseudonormalization during treadmill exercise test was oberved in 78(39%) of the 200 cases who had primary negative T wave at rest. Coronary angiography and left ventriculography were performed in 13(mean age 56+/-7 year, male vs. female 1:2.25) of 78 cases who showed pseudonormalization during exercise. They had no history of acute myocardial infarction and no abnormalities such as abnormal Q wave, left ventricular hypertrophy,bundle branch block,right ventricular hypertrophy and QRS widening above 0.1ms in resting electrocardiography. There were significant stenosis in only 3 cases; 2 cases in left anterior descending coronary artery and 1 case in right coronary artery. CONCLUSION: In treadmill exercise tests, pseudonormalization appears as non-specific finding for the diagnosis of ischemic heart disease becuase it is observed in either patients with or without coronary artery stenosis.
Constriction, Pathologic
;
Coronary Angiography
;
Coronary Stenosis
;
Coronary Vessels
;
Diagnosis
;
Electrocardiography
;
Exercise Test*
;
Female
;
Humans
;
Hypertrophy
;
Male
;
Myocardial Infarction
;
Myocardial Ischemia*
9.The effect of Vitamin D(3)addition on bone mineral density in postmenopausal hormone replacement.
Sun Won YOO ; Hyun Hee JO ; Kyeong A YEO ; Young Ok LEW ; Dong Jin KWON ; Gi Wook CHUNG ; Jang Heub KIM ; Jin Hong KIM
Korean Journal of Obstetrics and Gynecology 2000;43(6):992-997
OBJECTIVE: To determine the effect of the addition of Vit. D3 (1,25-Dihydroxychole calciferol D3) to the conventional postmenopausal hormone replacement therapy on bone mineral density(BMD) DESIGN: A 2-year retrospective , randomized study Setting : Department of Obstetrics and Gynecology of Catholic university hospital Patients : 388 postmenopausal women were recruited and divided into 5 groups according to treatment regimen; A: conjugated estrogens only treated group(n=146), B : conjugated estrogens and progesterone treated group(n=103), C : conjugated estrogens and Vit.D3 treated group (n=36), D : conjugated estrogens, progesterone and Vit.D3 treated group (n=41), E : control group (n=60). METHODS: The bone mineral density of the lumbar spines and femoral neck were determined by dual-energy X-ray absorptiometry(DEXA) every 2 years. STATISTICS: The difference between before and after treatment was determined by paired t-test. The comparison among the groups were determined by one way ANOVA test and student's t-test. RESULTS: The addition of progesterone to estrogen showed insignificant increase in the lumbar and femoral neck BMD. The addition of Vit. D3 compared with conventional hormone replacement therapy insignificantly influened bone density in women with initially normal BMD, but definitely increase in women with initially osteopenic and osteoporotic BMD of femoral neck rather than lumar spine(p<0.05). CONCLUSIONS: The use of Vit. D3 combined with postmenopausal estrogen replacement effects the increase of BMD in low bone density than normal bone density, especially femoral neck.
Bone Density*
;
Estrogen Replacement Therapy
;
Estrogens
;
Estrogens, Conjugated (USP)
;
Female
;
Femur Neck
;
Gynecology
;
Hormone Replacement Therapy
;
Humans
;
Obstetrics
;
Progesterone
;
Retrospective Studies
;
Spine
;
Vitamins*
10.Distribution of Phospholipase C Isozymes in Rat Retina: Immunohistochemical Study.
Ji Myong YOO ; Wan Sung CHOI ; Myeong Ok KIM ; Hea Won YOON ; Jong Moon PARK ; Joon Kyeong SONG
Journal of the Korean Ophthalmological Society 1992;33(12):1194-1199
In order to explore the existence and distribution of phospholipase (PLC) isozymes in the rat retina, immunohistochemical staining was applied using monoclonal antibodies against PLC isozymes (PLC beta; K92, PLC gamma; D7, F7, PLC delta; R32, S11). For immunohistochemical detection, avidin-biotin peroxidase complex (ABC) method was performed on frozed tissue sections of rat retina. Our study showed that PLC isozymes have particular distributional patterns in the retina. Namely, PLC beta is broadly distributed in the outer and inner segments of photoreceptor cell layer, nuclear layer and ganglion cell layer. PLC gamma is mainly appeared in the nerve fiber layer, ganglion cell layer and inner nuclear layer. PLC delta is confined only in the ganglion cell layer. These results clearly demonstrate the PLC isozymes may have their own role in the transduction of light pathway in the retina. However, further studies will be required to verify theirs precise role in the photoreception.
Animals
;
Antibodies, Monoclonal
;
Ganglion Cysts
;
Immunohistochemistry
;
Isoenzymes*
;
Nerve Fibers
;
Peroxidase
;
Phospholipase C beta
;
Phospholipases*
;
Photoreceptor Cells
;
Rats*
;
Retina*
;
Type C Phospholipases*