OBJECTIVE: To evaluate the diagnostic value of computed tomography-myelography (CTM) compared to that of magnetic resonance imaging (MRI) in patients with lumbar radiculopathy. METHODS: The study included 91 patients presenting with radicular leg pain caused by herniated nucleus pulposus or lateral recess stenosis in the lumbar spine. The degree of nerve root compression on MRI and CTM was classified into four grades. The results of each imaging modality as assessed by two different observers were compared. Visual analog scale score for pain and electromyography result were the clinical parameters used to evaluate the relationships between clinical features and nerve root compression grades on both MRI and CTM. These relationships were quantified by calculating the receiver-operating characteristic curves, and the degree of relationship was compared between MRI and CTM. RESULTS: McNemar's test revealed that the two diagnostic modalities did not show diagnostic concurrence (p<0.0001). Electromyography results did not correlate with grades on either MRI or CTM. The visual analog pain scale score results were correlated better with changes of the grades on CTM than those on MRI (p=0.0007). CONCLUSION: The present study demonstrates that CTM could better define the pathology of degenerative lumbar spine diseases with radiculopathy than MRI. CTM can be considered as a useful confirmative diagnostic tool when the exact cause of radicular pain in a patient with lumbar radiculopathy cannot be identified by using MRI. However, the invasiveness and potential complications of CTM are still considered to be pending questions to settle.
Constriction, Pathologic ; Electromyography ; Humans ; Leg ; Magnetic Resonance Imaging* ; Myelography ; Pain Measurement ; Pathology ; Radiculopathy* ; Spine ; Visual Analog Scale

Since the launch of cervical total disc replacement (CTDR) in the early 2000s, many clinical studies have reported better outcomes of CTDR compared to those of anterior cervical discectomy and fusion. However, CTDR is still a new and innovative procedure with limited indications for clinical application in spinal surgery, particularly, for young patients presenting with soft disc herniation with radiculopathy and/or myelopathy. In addition, some controversial issues related to the assessment of clinical outcomes of CTDR remain unresolved. These issues, including surgical outcomes, adjacent segment degeneration (ASD), heterotopic ossification (HO), wear debris and tissue reaction, and multilevel total disc replacement (TDR) and hybrid surgeries are a common concern of spine surgeons and need to be resolved. Among them, the effect of CTDR on patient outcomes and ASD is theoretically and clinically important; however, this issue remains disputable. Additionally, HO, wear debris, multilevel TDR, and hybrid surgery tend to favor CTDR in terms of their effects on outcomes, but the potential of these factors for jeopardizing patients' safety postoperatively and/or to exert harmful effects on surgical outcomes in longer-term follow-up cannot be ignored. Consequently, it is too early to determine the therapeutic efficacy and cost-effectiveness of CTDR and will require considerable time and studies to provide appropriate answers regarding the same. For these reasons, CTDR requires longer-term follow-up data.
Cervical Vertebrae ; Diskectomy ; Female ; Follow-Up Studies ; Humans ; Intervertebral Disc Degeneration ; Ossification, Heterotopic ; Prognosis ; Radiculopathy ; Spinal Cord Diseases ; Spine ; Surgeons ; Total Disc Replacement

OBJECTIVE: The authors introduce a technique of direct repair of pars defects in symptomatic lumbar spondylolysis using pedicle screws and universal hooks. METHODS: From March 2001 to September 2001, six patients with symptomatic lumbar spondylolysis and positive pars injection test underwent this procedure. Patients with lumbar instability and discogenic pain were excluded. After posterior midline incision, clearing of fibrous, cartilaginous and sclerotic tissues in and around the defects of pars was done until healthy bone was exposed. Strips of cancellous bone were taken from adjacent laminae and packed into the defects of pars. After insertion of the pedicle screws, universal hooks were placed in the lower margin of the lamina of the involved vertebra. With gentle compression between the head of screw and universal hook, the nut was fixed. Same procedures were done on the contralateral side. RESULTS: Postoperatively, all six patients experienced clinical improvement and there was no complication related with operation. CONCLUSION: This new technique is considered useful for direct repair of the defects in symptomatic lumbar spondylolysis without significant injury in the normal structures.
Head ; Humans ; Nuts ; Spine ; Spondylolysis*

OBJECTIVE: This retrospective study was performed to evaluate the clinical and radiological results of anterior lumbar interbody fusion (ALIF) using two different stand-alone cages in the treatment of lumbar intervertebral foraminal stenosis (IFS). METHODS: A total of 28 patients who underwent ALIF at L5-S1 using stand-alone cage were studied [Stabilis(R) (Stryker, Kalamazoo, MI, USA); 13, SynFix-LR(R) (Synthes Bettlach, Switzerland); 15]. Mean follow-up period was 27.3 +/- 4.9 months. Visual analogue pain scale (VAS) and Oswestry disability index (ODI) were assessed. Radiologically, the change of disc height, intervertebral foraminal (IVF) height and width at the operated segment were measured, and fusion status was defined. RESULTS: Final mean VAS (back and leg) and ODI scores were significantly decreased from preoperative values (5.6 +/- 2.3 --> 2.3 +/- 2.2, 6.3 +/- 3.2 --> 1.6 +/- 1.6, and 53.7 +/- 18.6 --> 28.3 +/- 13.1, respectively), which were not different between the two devices groups. In Stabilis(R) group, postoperative immediately increased disc and IVF heights (10.09 +/- 4.15 mm --> 14.99 +/- 1.73 mm, 13.00 +/- 2.44 mm --> 16.28 +/- 2.23 mm, respectively) were gradually decreased, and finally returned to preoperative value (11.29 +/- 1.67 mm, 13.59 +/- 2.01 mm, respectively). In SynFix-LR(R) group, immediately increased disc and IVF heights (9.60 +/- 2.82 mm --> 15.61 +/- 0.62 mm, 14.01 +/- 2.53 mm --> 21.27 +/- 1.93 mm, respectively) were maintained until the last follow up (13.72 +/- 1.21 mm, 17.87 +/- 2.02 mm, respectively). The changes of IVF width of each group was minimal pre- and postoperatively. Solid arthrodesis was observed in 11 patients in Stabilis group (11/13, 84.6%) and 13 in SynFix-LR(R) group (13/15, 86.7%). CONCLUSION: ALIF using stand-alone cage could assure good clinical results in the treatment of symptomatic lumbar IFS in the mid-term follow up. A degree of subsidence at the operated segment was different depending on the device type, which was higher in Stabilis(R) group.
Arthrodesis ; Constriction, Pathologic ; Follow-Up Studies ; Humans ; Pain Measurement ; Retrospective Studies

OBJECTIVE: Treatments of osteoporotic bursting vertebral body fracture(OBF) of thoracic and lumbar spines have been limited to conservative managements especially in the elderly patients. The authors correct kyphosis and stabilize the spine by the posterior approach with intraoperative polymethylmethacrylate(PMMA) vertebroplasty. METHODS: From March 1999 to June 2000, eight patients with OBF underwent posterior approach with intraoperative vertebroplasty. The patients included 7 women and 1 man aged 54-82 year. Average T-score on bone marrow density was -3.02. In the case of old fracture with sclerosis in the posterior wall, after laminectomy, the retropulsed posterior wall of the fractured spine was reduced with L-shaped micro-bone impactor through the lateral epidural spaces, in prone position. About 6cc of PMMA was injected into the fractured vertebral body via transpedicular route, and then, small amount of PMMA was also injected into each entry point of the screws. All patients underwent one above and one below short segment fixation followed by correction of kyphotic deformity. RESULTS: The preoperative clinical symptoms improved gradually in all patients. During postoperative follow-up for more than 7 months, there was no recurrence of the preoperative clinical symptoms, aggravation of kyphosis or instrumentation failure. CONCLUSIONS: It is suggested that posterior approach with short segment fixation and intraoperative PMMA vertebroplasty could be a new surgical modality for osteoporotic bursting fracture of the thoracic and lumbar spines especially in the aged.
Aged ; Bone Marrow ; Congenital Abnormalities ; Epidural Space ; Female ; Follow-Up Studies ; Humans ; Kyphosis ; Laminectomy ; Osteoporosis ; Polymethyl Methacrylate ; Prone Position ; Recurrence ; Sclerosis ; Spine* ; Vertebroplasty*

In surgical treatments of degenerative lumbar disc disease, arthrodesis is well known to be a gold standard; however various disadvantages related to elimination of the segmental motion and the procedures of fusion surgery have become a matter of concern. To this end, total disc replacement (TDR) was recently highlighted as one of alternative surgical modalities and being used widely. However, although it has been almost 10 years since lumbar TDR was int- roduced and actively used in the clinic, its clinical usefulness is still in dispute. The authors review and put together the history, biomechanics, and currently available prostheses of lumbar TDR in the present study. Some of the recent preliminary, mid-term and long-term clinical results of lumbar TDR in degenerative lumbar spine diseases are also reviewed. Lastly, we look out over the future prospect of lumbar TDR.
Arthrodesis ; Biomechanics ; Dissent and Disputes ; Intervertebral Disc Degeneration ; Intervertebral Disc Displacement ; Prostheses and Implants ; Spine ; Total Disc Replacement

OBJECTIVE: Little is known about the comprehensive molecular and biological mechanism on the development of the degeneration of the intervertebral disc. Many kinds of matrix metalloproteinase(MMP) initiate the degradation of the extracellular matrix including several kinds of collagens and proteoglycans. We compared molecular and immunohistochemical features of degenerated intervertebral disc and normal counterparts in order to investigate the role of MMP-1, 2, 3, 9. METHODS: We have evaluated MMP-1, 2, 3, 9 expression in 30 surgically resected lumbar disc from degenerative disc disease patients and 5 normal control cases. RT-PCR(reverse transcriptase-polymerase chain reaction) and immunohistochemistry were performed. RESULTS: By RT-PCR, normal tissue samples showed merely scant expression of MMP-1, 2, 3, 9 mRNA, but degenerated disc samples revealed more pronounced expression. mRNA amplifications were detected in 60%, 63.3%, 70%, 53.3% cases. By immunohistochemistry, normal tissue samples showed minimal protein expression of MMP-1, 2, 3, 9, but degenerated disc samples revealed more pronounced expression. Protein expressions were detected in 73.3%, 63.3%, 76.7%, 63.3% cases. Both the mRNA amplification and protein overexpression rates were significantly higher in degenerated disc than in the normal tissue. Concordance between both the mRNA amplification and protein expressions of MMP-1, 3, 9 were not observed, but there is well correlation in MMP-2 expression. CONCLUSION: We concluded that the over-expressions of the MMP-1, 2, 3, 9 may contribute to the development of degeneration of the intervertebral disc.
Collagen ; Extracellular Matrix ; Humans ; Immunohistochemistry ; Intervertebral Disc ; Matrix Metalloproteinases* ; Proteoglycans ; RNA, Messenger

OBJECTIVES: The percutaneous vertebroplasty provides a good result in the treatment of osteoporotic vertebral compression fractures. But, the epidural leakage of polymethylmetacrylate(PMMA) after vertebroplasty may decrease the therapeutic effects because of the compression of thecal sac and/or nerve roots. The authors carried out a prospective study to evaluate the causative factors of epidural leakage of PMMA and to assess the influence on the outcome. METHODS: This study involved 347 vertebral levels of compression fractures in 159 patients. Among these, the epidural leakages were identified in 92 vertebral levels(26.5%) in 64 patients(40.3%) on post-operative CT scan. RESULTS: The incidence of epidural leakage of PMMA was significantly higher in the level above T7(p=0.001). The large amount of the injected PMMA and the use of an injector also increased the incidence(p=0.03 and p=0.045, respectively). The position of the needle tip in the vertebral body and the pattern of venous drainage did not influence. The immediate post-operative visual analogue scale(VAS) scores and facial scales(FS) were higher in the patients with epidural leakage(p=0.009). But there were no significant differences between the two groups after three months of operation(p=0.541). Conclusions: The incidence of epidural leakage of PMMA after percutaneous vertebroplasty appears to have relationship with the amount of PMMA and the levels injected. The epidural leakage of PMMA reduced the immediate therapeutic effects of vertebroplasty, but did not influence the late outcome. However, the epidural leakage should be avoided because of its potential neurological complications.
Drainage ; Fractures, Compression* ; Humans ; Incidence ; Needles ; Osteoporosis ; Polymethyl Methacrylate* ; Prospective Studies ; Tomography, X-Ray Computed ; Vertebroplasty*

OBJECTIVE: This retrospective study of 101 patients with symptomatic lumbar disc herniation (LDH) treated via percutaneous endoscopic surgery using the extreme lateral transforaminal approach (ELTFA) was performed to assess the clinical results and to determine the relationship between the location of the herniated disc fragment and surgical success. METHODS: The operated levels were distributed as one case of L2-3, ten cases of L3-4, 83 cases of L4-5 and seven cases of L5-6. The clinical outcomes were assessed using visual analogue pain (VAS), Oswestry disability index (ODI) and MacNab's criteria. All assessments were performed one day prior to the operation, as well as three days and one month after the operation. RESULTS: Mean preoperative back VAS (4.33+/-1.48) and leg VAS (6.29+/-2.72) were significantly decreased three days (1.43+/-1.48, 2.03+/-1.98, respectively) and one month (1.23+/-1.25, 1.89+/-1.72, respectively) postoperatively. Mean preoperative ODI score was improved from 45.86+/-20.44% to 18.92+/-12.98% after three days and to 16.34+/-9.86% one month after operation. Twenty-three patients showed a vertical migration of the herniated disc of greater than 4 mm. There was no statistically significant difference between the extents of improvement in VAS or ODI score or between the degrees of vertical migration. According to MacNab's criteria assessment, the overall surgical success rate, as measured by surgeries classified as "excellent" and "good," was 89.8%. Surgical complications included seven patients with transient leg paresthesia, one patient with transient motor weakness and one patient with postoperative discitis. CONCLUSION: This study demonstrates that percutaneous endoscopic surgery using ELTFA is an effective surgical endoscopic approach for selected LDH patients. This procedure is safe and could expand indications to vertically migrated discs.
Discitis ; Diskectomy ; Humans ; Intervertebral Disc Displacement ; Leg ; Paresthesia ; Retrospective Studies

OBJECTIVE: There is still debate about the diagnostic efficacy of digital infrared thermographic imaging(DITI), nevertheless, it has been used for the diagnosis of carpal tunnel syndrome(CTS). We performed comparative study between patient and control groups to investigate the diagnostic value of DITI in CTS. METHODS: We studied 27 patients with electrodiagnostically-proven CTS and 18 symptom-free volunteers as a control. We measured thermal difference on DITI in the corresponding regions of the hands and forearms. We statistically analyzed the thermal data using a t-test. RESULTS: The average thermal difference in the diagnosed patient group ranged from 0.0303 degrees C to 0.2856 degrees C, while that in control group ranged from 0.0611 degrees C to 0.2878 degrees C. In the CTS patient group, thermal difference between each 2nd finger was higher than that of other regions. However, there was no statistical significance between patient and control groups. CONCLUSION: We found that the diagnostic value of DITI in CTS was not sufficient. There should be a reconsideration of the usefulness of DITI in CTS.
Carpal Tunnel Syndrome* ; Diagnosis* ; Fingers ; Forearm ; Hand ; Humans ; Thermography* ; Volunteers