1.Pathogenesis of Chronic Obstructive Pulmonary Disease: A Role for Apoptosis.
Tuberculosis and Respiratory Diseases 2001;50(3):281-292
No abstract available.
Apoptosis*
;
Pulmonary Disease, Chronic Obstructive*
2.A stepwise approach in the management of COPD patients.
Korean Journal of Medicine 2002;62(5):591-594
No abstract available.
Humans
;
Pulmonary Disease, Chronic Obstructive*
3.A Case of Impetigo Herpetiformis.
Sung Yeol LEE ; Young Chul KYE ; Young Woo CINN
Korean Journal of Dermatology 1988;26(5):724-728
We report herein a case of impetigo hepetiformis treated with etretinate. The patient was 30 year old female in the 7th month of her second pregnancy, who had suffered from generalized coalesced pustular eruption with slightly itching and hurning sensation with fever on whole body except face, both had and foot. The euption began as an erythemations patch which developed pustules along the mar gin. I'here was extensian by the develupment of fresh peripheral pustules and coaleence of these patches. Histopathological findings showed hyperkeratosis, subcorneal spongiform pustule, spon,iosis in the epidermis and vascular proliferation in the devmis, She was treated successfully with etretinate for 4 weeks.
Acitretin
;
Adult
;
Epidermis
;
Etretinate
;
Female
;
Fever
;
Foot
;
Humans
;
Impetigo*
;
Pregnancy
;
Pruritus
;
Sensation
4.A Case of Metastatic Cutaneous Squamous Cell Carcinoma Arising in Chronic Osteomyelitic Focus.
Sung Yeol LEE ; Young Chul KYE ; Young Woo CINN
Korean Journal of Dermatology 1988;26(3):442-446
No abstract available.
Carcinoma, Squamous Cell*
;
Osteomyelitis
5.The Changes of Breathing Pattern Observed During Maximal Exercise Testing in the Patients with Chronic Airflow Obstruction: the Correlation Between the Change of Inspiratory Duty Cycle and the Degree of Airflow Obstruction.
Kye Young LEE ; Young Koo JEE ; Keun Youl KIM
Tuberculosis and Respiratory Diseases 1997;44(3):574-582
BACKGROUND: Normal humans meet the increased ventilatory need during exercise initially by the increase of tidal volume (TV) and later by the increase of respiratory frequency (Rf). And the inspiratory duty cycle (Ti/Ttot) is also increased more than 50% for the compensation of the decrease of respiratory cycle provoked by the increase of respiratory frequency. The patients with chronic airflow obstruction show rapid and shallow breathing pattern during exorcise because of the degreased ventilatory capacity and the increased dead space ventilation. However, the studies about the change of inspiratory duty cycle are only a few and there is no literature about the relationship between the change of inspiratory duty cycle and the degree of airflow obstruction. METHODS: The subjects were the twelve patients with chronic airflow obstruction (CAO) and ten normal people. The incremental exercise test was done. The increase of work load was 10 Win CAO group and 25 Win normal control group. The analysis of the results was done by the comparison of the parameters such as minute ventilation (VE), TV, Rf, physiologic dead space (Vd/vt), and inspiratory duty cycle between the two groups. Each parameters were compared after transformation into % control duration base that means dividing the total exercise time into five fractons and % control duration data were obtained at rest, 20%, 40%, 60%, 80%, and max. Statistical analysis was done by repeated measure ANOVA using SAS program. RESULTS: The changes of VE and TV were significantly different between two groups while the change of Rf was not significant. The decrease of Vd/vt was significantly low in CAO group. Ti/Ttot was markedly increased from 38.4+3.0% at rest to 48.6+4.5% at max in normal control group while Ti/Ttot showed little change from 40.5+2.2% at rest to 42.6+3.5% at max. And the change of inspiratory duty cycle showed highly good correlation with the degree of airflow obstruction (FEVl%). (r=0.8151, p<0.05) CONCLUSIONS: The increase of Ti/Ttot during exercise observed in normal humans is absent in the patients with CAO and the change of Ti/TtDt is well correlated with the degree of airflow obstruction.
Compensation and Redress
;
Exercise Test*
;
Humans
;
Pulmonary Disease, Chronic Obstructive*
;
Respiration*
;
Tidal Volume
;
Ventilation
6.Measurement of Ventilatory Threshold in the Patients with Chronic Airway Obstruction.
Kye Young LEE ; Young Koo JEE ; Keun Yeol KIM
Tuberculosis and Respiratory Diseases 1997;44(2):309-320
BACKGROUND: There are many suggested methods for the indirect determination of anaerobic threshold(AT) using the changes of ventilatory parameters in respones to ventilatory load accompanying the increase of blood lactic acid level during exercise and the threshold derived from them is called ventilatory threshold( VT). They include ventilatory equivalent method(VEM), End-tidal PO2 method(PETO2), V-slope method(VSM), and respiratory quotient method(RQ). But in the patients with chronic airway ohstruction(CAO), the AT determined by ventilatory methods may not reflect true AT because the patients with GAO show inadequate ventilatory response to the increase of blood lactic acid level during excercise. METHODS: For the investigation of detection rate and reliability of above four VT determination methods in the patients with GAO, we performed the symptom-limited and maximal incremental exercise test in 17 patients with GAO and 12 normal controls. The incremental workload was 10 W/min in GAO group and 25 W/min in control group. The reliability of VT in each group was investigated by the calculation of Spearman correlation coefficient. RESULTS: The detection rates of VT were 100% by RQ, 91.7% by both VEM and POETO2, and 83.3% by VSM in normal control group, while 94.1% by RQ, 64.7% by VEM and PETO2, and 83.3% by VSM in GAO group. Good correlations were noted among VEM, PETO2, and VSM except RQ in normal control group. But there was no significant correlation except between VEM and PETO2 in GAO group. CONCLUSIONS: RQ is very sensitive but crude and VEM is near similar to PETO2. The clinical usefulness of VT determined by ventilatory method might be limited in patients with severe GAO.
Airway Obstruction*
;
Exercise Test
;
Humans
;
Lactic Acid
7.Induction of preneoplastic lesion in the large intestine of rats by oral administration of 2-amino-1-methyl-6-phenylimidazo4,5-bpyridine.
Yong Suk KIM ; Kwang Soo LEE ; Kye Young JUN
Journal of the Korean Society of Coloproctology 1993;9(2):125-130
No abstract available.
Administration, Oral*
;
Animals
;
Intestine, Large*
;
Rats*
8.Induction of preneoplastic lesion in the large intestine of rats by oral administration of 2-amino-1-methyl-6-phenylimidazo4,5-bpyridine.
Yong Suk KIM ; Kwang Soo LEE ; Kye Young JUN
Journal of the Korean Society of Coloproctology 1993;9(2):125-130
No abstract available.
Administration, Oral*
;
Animals
;
Intestine, Large*
;
Rats*
9.Electron microscopic study on fine needle aspiration cytology of metastatic malignant melanoma.
Dong Wha LEE ; So Young JIN ; Kye Hyun KWON
Korean Journal of Cytopathology 1992;3(2):82-89
No abstract available.
Biopsy, Fine-Needle*
;
Melanoma*
10.The Study for GER in Patients with Chronic Unexplained Cough Using Combined 24 Hour Esophageal pH and Motility Monitoring.
Young Koo JEE ; Yoon Seob KIM ; Chang Young LIM ; Kye Young LEE ; Kun Yeol KIM
Korean Journal of Medicine 1997;53(5):636-644
No abstract available.
Cough*
;
Humans
;
Hydrogen-Ion Concentration*