1.Distraction Arthroplasty of the Elbow
Han Koo LEE ; Moon Sang CHUNG ; Chong Suh LEE ; Kyoung Won PARK ; Kye Hyoung LEE
The Journal of the Korean Orthopaedic Association 1989;24(2):483-488
So many modalities have been suggested for the treatment of servere pain and ankylosis of the elbow with destruction of the articular surfaces. Among them, two major methods which have been widely used are resection arthroplasty and prosthetic replacement arthroplasty. However prosthetic replacement arthroplasty has some problems. Its indications are limited in the elderly inactive subjects. And there have been many kinds of complications including loosening and infection. Also, resection arthroplasty in now rarely indicated due to severe instability. From July 1980 to July 1987, we tried distraction arthroplasty in 8 cases of elbow with severe destruction of its articular surfaces, mainly in the young active persons. The average follow-up period was 45 months. The effect of distraction arthroplasty on relief of pain was not remarkable. The average increase in ROM, including that of one reankylosed elbow, was 51 ±22 degrees in flexion-extension and 48 ±23 degrees in pronstion-supinstion. No deep wound infection and instability which was main complication of resection arthroplasty were observed with our method of distraction arthroplasty. On the basis of functional results, the the results were excellent in 4, good in 1, fair in 2 and poor in 1 cases. In conclusion, distraction arthroplasty of the elbow can be one of the of effective methods reconstruction for the young active patients with the destruction of the elbow, if they are intelligent and motivated.
Aged
;
Ankylosis
;
Arthroplasty
;
Arthroplasty, Replacement
;
Elbow
;
Follow-Up Studies
;
Humans
;
Methods
;
Wound Infection
2.Species and antimicrobial susceptibility of enteropathogenic bacteria isolated in 1986-1991.
Kwang Soo PARK ; Kye Won LEE ; Dong Il WON ; Kyung Won LEE ; Woon Seob JUNG ; Oh Hun KWON
Korean Journal of Infectious Diseases 1993;25(3):221-229
No abstract available.
Bacteria*
3.The study on extracardiac anomalies associated with congenital heart diseases.
Kye Hwan SEOL ; Kang Won LEE ; Chang Sung SON ; Joo Woo LEE ; Young Chang TOCKGO
Journal of the Korean Pediatric Society 1992;35(1):26-33
No abstract available.
Heart Diseases*
;
Heart*
4.A Case of Vascular Leak Syndrome During Induction Chemotherapy of Acute Lymphoblastic Leukemia (T Cell Type) .
Kye Wool KANG ; Hwang Min KIM ; Won Kyu CHOI ; Baek Keun LIM ; Chang Hun LEE
Journal of the Korean Pediatric Society 2001;44(9):1041-1046
Vascular leak syndrome(VLS) is characterized by endothelial damage, which causes extravasation of plasma proteins and fluid from capillaries into the extravascular space. It has been suggested that the increased vascular permeability is the result of an IL-2-induced suppression of endothelin-1 secretion by endothelial cells, an IL-2-induced activation of the complement cascade or TNF-alpha release from IL-2-activated T-cells. A 13-year-old male patient visited our hospital with abdominal pain. He was diagnosed with acute lymphoblastic leukemia(T cell type) by bone marrow study on his 2 nd day in hospital. On the 3 rd day of induction chemotherapy(prednisone, L-asparaginase, vincristine, intrathecal methotrexate), pulmonary edema and pleural effusion, ascites and generalized edema developed and lasted for 53 days without responding to supportive care. The laboratoy finding was that TNF-alpha was increased without evidence of infection and hypoalbuminemia was noted. It was suggested that the patient's clinical feature was induced by VLS.
Abdominal Pain
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Adolescent
;
Ascites
;
Blood Proteins
;
Bone Marrow
;
Capillaries
;
Capillary Permeability
;
Complement System Proteins
;
Edema
;
Endothelial Cells
;
Endothelin-1
;
Humans
;
Hypoalbuminemia
;
Induction Chemotherapy*
;
Male
;
Pleural Effusion
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
;
Pulmonary Edema
;
T-Lymphocytes
;
Tumor Necrosis Factor-alpha
;
Vincristine
5.An autopssy case of infant of diabetic mother with d-transposition of great arteries and hypertrophic cardiomyopathy.
Kye Hwan SEOL ; Eui Kyeung JUNG ; Chang Sung SON ; Joo Won LEE ; Soon Kyum KIM
Journal of the Korean Pediatric Society 1992;35(4):545-550
No abstract available.
Arteries*
;
Cardiomyopathy, Hypertrophic*
;
Humans
;
Infant*
;
Mothers*
6.Pulsed doppler echocardiographic analysis of pulmonary venous flow in congenital heart diseases with left-to-right shunt.
Kye Hwan SEOL ; Chang Sung SON ; Joo Won LEE ; Soon Kyum KIM ; Young Chang TOCKGO
Journal of the Korean Pediatric Society 1991;34(7):934-939
No abstract available.
Echocardiography*
;
Echocardiography, Doppler, Pulsed
;
Heart Diseases*
;
Heart*
7.The Proteasome Inhibitor MG132 Sensitizes Lung Cancer Cells to TRAIL-induced Apoptosis by Inhibiting NF-kappaB Activation.
Tuberculosis and Respiratory Diseases 2008;65(6):476-486
BACKGROUND: TRAIL (TNF-related apoptosis inducing ligand) is a newly identified member of the TNF gene family which appears to have tumor-selective cytotoxicity due to the distinct decoy receptor system. TRAIL has direct access to caspase machinery and induces apoptosis regardless of p53 phenotype. Therefore, TRAIL has a therapeutic potential in lung cancer which frequently harbors p53 mutation in more than 50% of cases. However, it was shown that TRAIL also could activates NF-kappaB in some cell lines which might inhibit TRAIL-induced apoptosis. This study was designed to investigate whether TRAIL can activate NF-kappaB in lung cancer cell lines relatively resistant to TRAIL-induced apoptosis and inhibition of NF-kappaB activation using proteasome inhibitor MG132 which blocks I kappa B alpha degradation can sensitize lung cancer cells to TRAIL-induced apoptosis. METHODS: A549 (wt p53) and NCI-H1299 (null p53) lung cancer cells were used and cell viability test was done by MTT assay. Apoptosis was confirmed with Annexin V assay followed by FACS analysis. To study NF-kappaB-dependent transcriptional activation, a luciferase reporter gene assay was used after making A549 and NCI-H1299 cells stably transfected with IgGkappa-NF-kappaB luciferase construct. To investigate DNA binding of NF-kappaB activated by TRAIL, electromobility shift assay was used and supershift assay was done using anti-p65 antibody. Western blot was done for the study of I kappa B alpha degradation. RESULTS: A549 and NCI-H1299 cells were relatively resistant to TRAIL-induced apoptosis showing only 20~30% cell death even at the concentration 100 ng/ml, but MG132 (3microM) pre-treatment 1 hour prior to TRAIL addition greatly increased cell death more than 80%. Luciferase assay showed TRAIL-induced NF-kappaB transcriptional activity in both cell lines. Electromobility shift assay demonstrated DNA binding complex of NF-kappaB activated by TRAIL and supershift with p65 antibody. I kappa B alpha degradation was proven by western blot. MG132 completely blocked both TRAIL-induced NF-kappaB dependent luciferase activity and DNA binding of NF-kappaB. CONCLUSION: This results suggest that inhibition of NF-kappaB can be a potentially useful strategy to enhance TRAIL-induced tumor cell killing in lung cancer.
Annexin A5
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Apoptosis
;
Blotting, Western
;
Cell Death
;
Cell Line
;
Cell Survival
;
DNA
;
Genes, Reporter
;
Homicide
;
Humans
;
I-kappa B Proteins
;
Leupeptins
;
Luciferases
;
Lung
;
Lung Neoplasms
;
NF-kappa B
;
Phenotype
;
Proteasome Endopeptidase Complex
;
Proteasome Inhibitors
;
Transcriptional Activation
8.Comparative Analysis of Simultaneous and Staged Bilateral Total Knee Arthroplasty
Dae Kyung BAE ; Young Yong KIM ; Won Suck RHI ; Kye Lim LEE
The Journal of the Korean Orthopaedic Association 1988;23(2):403-410
Between January 1982 and September 1986, at the Department of Orthopaedic Surgery of Kyung Hee University Hospital, 82 total knee arthroplasties were performed in 57 patients. We studied 25 patients (50 Knees) who had been operated by bilateral total knee arthroplasties to compare one stage and two stage operations. The follow-up ranged from 10 months to 5 years and 7 months (average 1 year and 8 months). All operations were performed by one of the authors (D.K.B.), but the follow-up study and the entire medical record were independently evaluated by another authors. The clinical results of preoperative and postoperative assessments and rehabilitation processes are as follows; 1. Group I (10 patients) had both kness replaced by one stage simultaneous operation under same anesthesia, and Group II(15 patients) had replaced by two stage operation at the intervals of 2 weeks. 2. The periods required to do bilateral weight bearing were 10.3 days for Group I, 23.6 days for Group II. 3. Complications in one stage operation was no more than the in two stage operation. 4. The postoperative pain and ROM were not significantly different in both groups. 5. Using the hospital for special surgery rating system, we found the clinical results to be similar in both groups. 6. Comparing to two stage operation, the advantages of one stage operation were shorter operative and tourniquet time, lesser use of antibiotics, reduced medical cost and hospital stay. In conclusion, if patient conditions do not prevent prolonged anesthetic time and surgeons have good surgical techniques, we recommend one stage simultaneous operation in bilateral total knee replacement.
Anesthesia
;
Anti-Bacterial Agents
;
Arthroplasty
;
Arthroplasty, Replacement, Knee
;
Follow-Up Studies
;
Humans
;
Knee
;
Length of Stay
;
Medical Records
;
Pain, Postoperative
;
Rehabilitation
;
Surgeons
;
Tourniquets
;
Weight-Bearing
9.A Case of Molluscum Contagiosum Developed Symmetrically on Both Heels That Are Weight-bearing Area.
Dong Won LEE ; Dae Yeon KIM ; Hyo Hyun AHN ; Young Chul KYE ; Soo Hong SEO
Korean Journal of Dermatology 2018;56(8):517-518
No abstract available.
Heel*
;
Molluscum Contagiosum*
;
Weight-Bearing*
;
Zea mays
10.A Case of Primary Carcinoma of the Fallopian Tube.
Sun Young PARK ; Hae Hyeog LEE ; Tae Hee KIM ; Kye Hyun NAM ; Kwon Hae LEE ; Kye Won KWON
Korean Journal of Obstetrics and Gynecology 2004;47(8):1596-1600
Primary tubal carcinoma is a rare carcinoma of the female genital tract, comparising with only 0.3% to 1% of female genital tract malignancies. Its histologic appearance and clinical behavior resemble that of primary ovarian carcinoma, thus the evaluation and treatment are also essentially the same. Presenting symptoms are variable, so pre-operative diagnosis is rare. A postmenopausal women presented with pelvic mass and vaginal discharge. It was initially diagnosed as ovarian tumor but primary carcinoma of the fallopian tube was confirmed postoperatively on the basis of the pathologic examination of resected specimen. So, we reported a case with a brief review of the concerned literature.
Diagnosis
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Fallopian Tubes*
;
Female
;
Humans
;
Vaginal Discharge