Primary tubal carcinoma is a rare carcinoma of the female genital tract, comparising with only 0.3% to 1% of female genital tract malignancies. Its histologic appearance and clinical behavior resemble that of primary ovarian carcinoma, thus the evaluation and treatment are also essentially the same. Presenting symptoms are variable, so pre-operative diagnosis is rare. A postmenopausal women presented with pelvic mass and vaginal discharge. It was initially diagnosed as ovarian tumor but primary carcinoma of the fallopian tube was confirmed postoperatively on the basis of the pathologic examination of resected specimen. So, we reported a case with a brief review of the concerned literature.
Diagnosis ; Fallopian Tubes* ; Female ; Humans ; Vaginal Discharge

BACKGROUND: Nitric oxide synthase (NOS) has been suggested to have a role in renal injury of aging rats. METHODS: Renal function and histology were compared between 12 month-and 7-9 week-old rats. Proliferating activity and cell death were evaluated by PCNA index and apoptosis. Three isoforms of NOS (eNOS, iNOS, and nNOS) were stained by immunohistochemistry. RESULTS: Serum creatinine level was increased in old rats (1.0 mg/dL vs 0.5 mg/dL, p=0.000). 24 h proteinuria and urinary NO were comparable between the two groups. The percentage of global and segmental glomerulosclerosis increased in old rats. PCNA index decreased in the glomeruli (0.1 vs 0.6/glomerulus, p=0.005) and the tubulointerstitium (10.2 vs 19.2/mm2, p=0.019) of old rats compared to that of young rats. However, no difference was observed in the number of TUNEL positive cells. eNOS was not stained in young and old rat kidney, whereas iNOS was stained in the interstitial inflammatory cells of old rats (0.3 vs 0.0 of young rats/mm2, p=0.188). Macula densa nNOS staining significantly decreased in old rats compared to young rats (5.6 vs 9.5/mm2, p=0.009). CONCLUSIONS: Proliferating activity is more affected than cell death with aging. Decreased nNOS expression without alteration of eNOS and iNOS expressions may implicate nNOS as a marker of renal injury in the early stage of aging.
Aging* ; Animals ; Apoptosis ; Cell Death ; Creatinine ; Immunohistochemistry ; In Situ Nick-End Labeling ; Kidney* ; Nitric Oxide Synthase* ; Nitric Oxide* ; Proliferating Cell Nuclear Antigen ; Protein Isoforms ; Proteinuria ; Rats*

No abstract available.
Bacteria*

We describe here a case of minimal deviation endometrioid adenocarcinoma (MDEA) of the uterine cervix that was initially suspected according to the abnormal cytologic findings in a 39-year-old woman. The Papanicolaou (pap) smear showed many neoplastic glandular cells in monolayered sheets, rosettes, and clusters with palisading and feathering borders. The tumor cells had oval, hyperchromatic nuclei, with chromatin clumping and small nucleoli. Histologic examination disclosed endometrial-type glands with a bland, isolated, mainly rounded appearance and these glands were widely scattered deep into the cervical stroma with only scant stromal reaction. An association of MDEA with tubo-endometrioid metaplasia or cervical endometriosis has been suggested by identifying the tubo-endometrioid glands in the vicinity of the MDEA.
Female ; Humans ; Adenocarcinoma

No abstract available.
DNA Topoisomerases* ; DNA*

BACKGROUND: IgA nephropathy after renal transplantation (post-transplant IgAN) may recapitulate the IgAN of native kidneys, however, little has been reported about the histologic characteristics. The aim of this study is to apply glomerular morphometry using an image analyser to examine the histologic characteristics of post-transplant IgAN. METHODS: The outer margin of the glomerulus (Bowman's area, BA) and glomerular tuft area (GA) were traced manually. The measured area were automatically calculated by KS300 image analysis system (Kontron, Munchen, Germany). The mesangial area (MA) was calculated with a summing each manually traced mesangial area. The total number of glomerular (GC) and mesangial cells (MC) were counted. Eight cases of renal section obtained by nephrectomy due to renal cell carcinoma (normal control: N-CTRL) and nineteen cases of renal section obtained from post-transplantation patients without IgAN (transplantation control: Tx-CTRL) served as controls. RESULTS: A total of 35 biopsies were finally selected for measurement. BA and GA of post-transplant IgAN were 1.6 and 1.4 times larger than the N-CTRL, respectively, and were not significantly different from Tx-CTRL. MA was 1.4 times significantly larger than that of the Tx-CTRL. As compared to that of the N-CTRL, it was 1.2 times larger, but this difference was not statistically significant. The GC and MC of post-transplant IgAN and the Tx-CTRL were significantly lower than the N-CTRL. There were no significant correlations between glomerular hypertrophy and duration after renal transplantation, mesangial changes, segmental sclerosis, or degree of renal cortical interstitial fibrosis in post-transplant IgAN. CONCLUSIONS: Prominent glomerular hypertrophy and mesangial expansion suggest a hyperfiltration injury in post-transplant IgAN and a possible way to glomerulosclerosis.
Biopsy ; Carcinoma, Renal Cell ; Fibrosis ; Glomerulonephritis ; Glomerulonephritis, IGA* ; Humans ; Hypertrophy ; Immunoglobulin A* ; Kidney ; Kidney Transplantation ; Mesangial Cells ; Nephrectomy ; Sclerosis

Malignant transformation of mature cystic teratoma is a rare complication. Most com-mon malignant transformation of mature cystic teratoma is squamous cell carcinoma, which represents about 75 to 80% followed by adenocarcinoma in 6 to 7%. It is generally consi-dered that prognosis is extremely poor in case of adenocarcinoma associated with cystic te-ratoma. In this paper, we describe an adenocarcinoma arising from a mature cystic teratoma of left ovary in 47 year old woman. Left ovary was measured 18x15x7cm, 1,295gm in size. Uterus and right ovary were normal appearance. Left ovarian cyst was adhered to omentum and peritoneum. But neither rupture of cyst nor ascites were found at laparotomy. A brief review of concerned literatures was presented.
Adenocarcinoma* ; Ascites ; Carcinoma, Squamous Cell ; Female ; Humans ; Laparotomy ; Middle Aged ; Omentum ; Ovarian Cysts ; Ovary* ; Peritoneum ; Prognosis ; Rupture ; Teratoma* ; Uterus

Primary squamous cell carcinoma of the thyroid gland (PSCCT) is a rare malignancy that presents with advanced disease and poor prognosis. It is difficult to diagnose PSCCT in its early stage because of its rarity and lack of typical imaging findings. We experienced an elderly woman with PSCCT confirmed by surgery. Although preoperative fine-needle aspiration revealed no malignancy, surgical resection was performed because the ultrasonogram showed diffuse microcalcifications, which suggested malignancy, and clinically, the mass grew rapidly to compress the trachea. Local tumor recurrence was noted at 3 months after surgery. Surgical resection or repeat biopsy should be considered if a cytologically benign thyroid mass shows imaging or clinical features of malignancy.
Aged ; Biopsy ; Biopsy, Fine-Needle ; Carcinoma, Squamous Cell* ; Female ; Humans ; Neoplasm Recurrence, Local ; Prognosis ; Recurrence* ; Thyroid Gland* ; Trachea ; Ultrasonography

We report an unbalanced translocation involving chromosome 2 and 7 due to a balanced reciprocal translocation 2;7 in the father. The female fetus had a partial trisomy of the long arm of chromosome 2 with a partial monosomy of distal 7q. Ultrasound at the first trimester had indicated normal fetal anatomy, including normal intracranial structures. Parental karyotypes showed a paternal balanced translocation: 46,XY,t(2;7)(q37.3;->q34). The unbalanced translocation in the fetus resulted in trisomy for 2q37.3 qter and monosomy for 7q34->qter. Postnatal examination showed that the female abortus had a cleft lip and palate, and mild dysmorphic features. The clinical phenotype was in agreement with previous descriptions and allowed us to propose a fetal phenotype for this chromosomal abnormality.
Abnormalities, Multiple/embryology ; Abnormalities, Multiple/genetics* ; Abortion, Habitual/genetics ; Abortion, Therapeutic ; Adult ; Chromosome Disorders/embryology ; Chromosome Disorders/genetics* ; Chromosomes, Human, Pair 2/ultrastructure* ; Chromosomes, Human, Pair 7/ultrastructure* ; Female ; Fetal Diseases/genetics ; Fetal Diseases/pathology ; Fetus/abnormalities* ; Human ; Male ; Monosomy* ; Phenotype ; Pregnancy ; Translocation (Genetics)* ; Trisomy*

The endometrial osseous metaplasia is one of a rare conditions which gynecologist experience clinically. Clinical presentation may include irregular menstration, abnormal uterine bleeding, discharge, dysmenorrhea, pelvic pain, and secondary infertility. However the etiology and treatment about this disease are unclear. Recently, ultrasound-guided management of ectopic bone in uterus was suggested more potentially safer based on reported multi-patients women, a large majority was successfully treated. We have experienced a case of endometrial osseous metaplasia diagnosed and treated by ultrasound-guided dilatation and curettage. Which is presented with a brief review of literatures.
Dilatation and Curettage* ; Dilatation* ; Dysmenorrhea ; Female ; Humans ; Infertility ; Metaplasia ; Pelvic Pain ; Uterine Hemorrhage ; Uterus