1.A Case of Apocrine Hidrocystoma.
Sung Dae KWON ; Young Chul KYE ; Soo Nam KIM
Annals of Dermatology 1999;11(3):179-181
Apocrine hidrocystoma is an uncommon benign tumor derived from the secretory segment of apocrine sweat glands and another name for it is apocrine cystadenoma. A 48-year-old female patient had a solitary, translucent red-brownish cystic nodule, 10 × 6 × 7mm in size, on the periorbital area of her left eye. The lesion had enlarged very slowly for 25 years. We excised the lesion and identified it as apocrine hidrocystoma. This is a case of apocrine hidrocystoma with typical clinical and histopathological findings.
Cystadenoma
;
Female
;
Hidrocystoma*
;
Humans
;
Middle Aged
;
Sweat Glands
2.Resurfacing of Pitted Facial Acne Scars with a Pulsed Erbium: YAG laser.
Sung Dae KWON ; Soo Nam KIM ; Young Chul KYE
Annals of Dermatology 1999;11(1):5-8
BACKGROUND: Laser resurfacing has beneficial effects for the treatment of several skin conditions. Recently, the pulsed erbium:YAG laser has been shown to be a highly effective treatment for several kinds of pitted facial scars. OBJECTIVE: The purpose of this study was to assess the efficacy and safety of pulsed erbium:YAG laser skin resurfacing at the setting of low or high energy for pitted acne scars. METHODS: 65 patients with pitted acne scars were included in this study. All patients had skin types III or IV. All patients were instructed to use tretinoin cream 0.05% nightly for 2-4 weeks prior to the laser treatment. The pulsed erbium:YAG laser with a 2 mm handpiece at the setting of 500 mJ/pulse, 3.5-5 W in 45 patients and 1,000 mJ/pulse, 7-10 W in 20 patients was used. Two weeks after laser treatment, topical application of hydroquinone 4%, tretinoin 0.05%, and hydrocortisone 1% cream was recommended for 2-4 weeks. Facial photographs were obtained at baseline and 2 week intervals postoperatively. The results of treatment were evaluated for the changes of skin texture and color at 1 month, 3 months, and 6 months. RESULTS: In 45 cases treated with 500 mJ/pulse energy, pitted acne scars were improved about 46.7 % on average and no erythema and postinflammatory hyperpigmentation was observed after 6 months. In 20 cases treated with 1,000 mJ/pulse energy, pitted acne scars were improved about 64% on average and erythema in two patients and postinflammatory hyperpigmentation in one patient were observed after 6 months. CONCLUSION: The results of laser treatment for pitted facial acne scars at the setting of high energy are better than those of laser treatment at the setting of low energy.
Acne Vulgaris*
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Cicatrix*
;
Erbium*
;
Erythema
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Humans
;
Hydrocortisone
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Hyperpigmentation
;
Lasers, Solid-State*
;
Skin
;
Tretinoin
3.Synchronous Onset of Symmetrically Associated Extragenital Lichen Sclerosus and Vitiligo on both Breasts and the Vulva.
In Hyuk KWON ; Heesang KYE ; Soo Hong SEO ; Hyo Hyun AHN ; Young Chul KYE ; Jae Eun CHOI
Annals of Dermatology 2015;27(4):456-457
No abstract available.
Breast*
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Lichen Sclerosus et Atrophicus*
;
Lichens*
;
Vitiligo*
;
Vulva*
4.An Associated Case of Common Blue Nevus with Satellite Lesions and Ectopic Mongolian Spot.
In Hyuk KWON ; Heesang KYE ; Dai Hyun KIM ; Jae Eun CHOI ; Soo Hong SEO ; Hyo Hyun AHN ; Young Chul KYE ; Hwa Jung RYU
Korean Journal of Dermatology 2014;52(6):438-439
No abstract available.
Mongolian Spot*
;
Nevus, Blue*
5.Adult Multiple Myofibromas on an Atrophic Patch on the Thigh.
Heesang KYE ; In Hyuk KWON ; Soo Hong SEO ; Hyo Hyun AHN ; Young Chul KYE ; Jae Eun CHOI
Annals of Dermatology 2015;27(5):622-623
No abstract available.
Adult*
;
Humans
;
Myofibroma*
;
Thigh*
6.Adult Multiple Myofibromas on an Atrophic Patch on the Thigh.
Heesang KYE ; In Hyuk KWON ; Soo Hong SEO ; Hyo Hyun AHN ; Young Chul KYE ; Jae Eun CHOI
Annals of Dermatology 2015;27(5):622-623
No abstract available.
Adult*
;
Humans
;
Myofibroma*
;
Thigh*
7.Cutaneous Metastatic Rectal Adenocarcinoma in Zosteriform Distribution.
In Hyuk KWON ; Heesang KYE ; Soo Hong SEO ; Hyo Hyun AHN ; Young Chul KYE ; Jae Eun CHOI
Annals of Dermatology 2016;28(3):393-395
No abstract available.
Adenocarcinoma*
8.Clinicohistopathologic Findings in Keratoacanthoma and its Immunohi-stochemical Study of Ki-67, p53, bcl-2 and Involucrin Protein Expression.
Sung Dae KWON ; Young Chul KYE ; Soo Nam KIM
Korean Journal of Dermatology 2000;38(12):1630-1640
BACKGROUND: Keratoacanthoma(KA) is common, benign cutaneous tumor that is most likely derived from hair follicle cells, and most often occurs on sun-exposed sites in light-skinned persons of middle age or older. Some authors believed that keratoacanthoma is a variant of squamous cell carcinoma(SCC), which it often resembles clinically and histopathologically. So, the distinction between KA and SCC is still debatable and a matter of speculation. OBJECTIVE: The purpose of this study was to investigate the clinicohistopathologic findings of KA and its expression patterns, compared with SCC, of immunohistochemical staining using Ki-67, p53, bcl-2, and involucrin. METHODS: This clinicohistopathologic study included 20 cases that had confirmed to KA. We performed the immunohistochemical staining with Ki-67, p53, bcl-2 in 14 and with involucrin in 13 KAs. Ki-67, p53, bcl-2, and involucrin staining was also performed in 6 SCCs. RESULTS: All of KAs were solitary lesions. The male to female ratio was 1.2:1. The average age was 63.315.1 years and 11 of 20(55.5%) developed in sixth and seventh decades. The site of predilection were sun-exposed areas(85%) such as face, forearm, neck. Histologically, all of KAs were fully-developed lesions, and 17 of 20(85%) were dome or berry-shaped type II KAs. 17 of 20(85%) KAs showed exo-endophytic growth pattern. Common histologic findings in this study were horn-filled crater formation(80%), epidermal collarette(85%), epidermal proliferation in the perilesional area and the base of crater(100%), lateral extension tendency(80%), individual keratinization(75%), intraepithelial neutrophilic microabscess(65%), and eosinophilic glassy appearance in kertinocytic cytoplasm(95%). In immunohistochemical study using Ki-67, p53, bcl-2, and involucrin, there were no significant differences between KA and SCC except of the distribution pattern of Ki-67 positive cells in tumor. Ten of 14(71.4%) KAs revealed the marginal pattern, whereas no SCCs showed marginal pattern in Ki-67 staining. CONCLUSION: KA is a rapidly growing, cutaneous tumor that most often occurs on sun-exposed sites in sixth and seventh decades. Our results showed that KA is almost similar to SCC immunohistochemically, we suggest that KA is a type of SCC. And also, the characteristic distribution pattern of Ki-67 positve cells is helpful in making differentiation between KAs and SCCs.
Eosinophils
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Female
;
Forearm
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Hair Follicle
;
Humans
;
Keratoacanthoma*
;
Male
;
Middle Aged
;
Neck
;
Neutrophils
9.A Case of Recurrent Leiomyoma in Vesicovaginal Septum.
Yong Hee LEE ; Hyun Haing LEE ; Byung Sun BAE ; Myung Chul SHIN ; Wee Hyun LEE ; Kye Weon KWON
Korean Journal of Obstetrics and Gynecology 1998;41(11):2883-2885
Leiomyoma of vagina is relatively rare benign tumor. And majority of these lesions occur in labia major and anterior vaginal wall. The recurrence of this tumor is extremely rare and its cellular atypism, mitotic activity, tumor size and contour are known as important factors in its recutrence. A case of recutrent leiomyoma causing urinary frequency in vesicovaginal septum was reported with a brief review of literature.
Leiomyoma*
;
Recurrence
;
Vagina
10.Serum Hepcidin Level as an Early Marker of Hematopoietic Activity after Allogeneic Peripheral Blood Stem Cell Transplantation.
Jimyung KIM ; Kye Chul KWON ; Sun Hoe KOO
Journal of Laboratory Medicine and Quality Assurance 2013;35(1):1-7
BACKGROUND: Hepcidin plays a central role in the regulation of iron metabolism, and hepatic iron production is stimulated by iron load and inflammation. Recent animal studies have shown that hepcidin levels increase when hematopoiesis is blocked. We aimed to monitor pre- and post-stem cell transplantation hepcidin levels and evaluate its association with hematologic recovery. METHODS: The study group comprised 12 patients with hematologic malignancies (7 with AML, 4 with ALL, and 1 with refractory anemia with excess blasts-2) undergoing allogeneic peripheral blood stem cell transplantation (PBSCT). One day before and 3 days, 1 week, 2 weeks, 4 weeks, and 8 weeks after PBSCT, reticulocyte count and levels of Hb, ferritin, and C-reactive protein were monitored; serum hepcidin-25 was measured by ELISA. RESULTS: The median serum hepcidin-25 levels (ng/mL) were significantly higher until 1 week after PBSCT (103.6, 103.3, and 96.5) than those at 2, 4, and 8 weeks after PBSCT (63.9, 53.9, and 56.6, respectively). The reticulocyte count also significantly increased from 2 weeks after PBSCT. The hepcidin level showed an inverse correlation with reticulocyte count (r=-0.56, P<0.001) and a weak positive correlation with ferritin (r=0.27, P=0.02). At 2 weeks, patients with high hepcidin levels (> or =63.9) tended to demonstrate lower Hb recovery at 8 weeks than patients with low hepcidin levels did (P=0.15), but without any differences in the incidence of complications. CONCLUSIONS: These findings indicate that hepcidin production is associated with erythropoietic activity and that hepcidin level may be used as an early marker of hematopoietic recovery in PBSCT.
Anemia, Refractory
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Animals
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Antimicrobial Cationic Peptides
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C-Reactive Protein
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Cell Transplantation
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Ferritins
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Hematologic Neoplasms
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Hematopoiesis
;
Humans
;
Incidence
;
Inflammation
;
Iron
;
Organothiophosphorus Compounds
;
Peripheral Blood Stem Cell Transplantation
;
Reticulocyte Count
;
Stem Cell Transplantation
;
Transplants