33 cases of renal calculus received opene surgery for pyelonephrolithotomy (the operative procedres described by L.Q. Cat and N.B. Trieu - 1971, Resnick. M.I.1981) in Urology Department of hospital Viet Duc and hospital No 103. Renal function was determined with serum, blood ure nitrogen (BUN), creatinine and creatinine clearance. Creatinine clearance was calculated up on equations of Cockroft and Gault (1976). Author compared renal function preoperatively and postoperatively (5 -7 days). There was no significant difference in serum ure nitrogen (BUN), creatinin (n= 33) between preoperative and post operative (p>0.05). There was significant in creatinine clearance postoperation (p < 0.05).
Kidney Calculi ; Kidney Failure, Chronic ; surgery ; therapeutics

A study on 606 patients (male: 298, female: 308) with ages of 22-94 in Hue central hospital during 2001-2002 has shown that patients living in rural area (62,87%), anxiety- depressive disorder (8,3%) of witch anxiety-depressive disorder in young (8,9%), and anxiety depressive disorder in elderly (8%) mild depression (24%), moderate depression (16%), severe depression (60%) in tending suicide (4%), the clinical features comprised tired (94%), libido (92%), dizziness (60%), short breath (76%) and in feriority complex (86%).
Cardiovascular Diseases ; diagnosis

A study on 52 hypertensive patients in Hue central hospital; with ages of 40-80 (male: 63,46%) has shown that the most frequent clinical symptoms was headache (88,46%), followed by unstable (75%), and slow (48,08%). There was some symptoms occurred in men more than women such as anxiety complex. The mental disorders accompanying with the hypertension comprised obsess (38,46%), depression (26,92%), personality disorder (23,08%), the obsess was increased when having cardiac lesions
Mental Disorders ; hypertensive factor ; diagnosis

Clinical epidemiology and promoters of depressive-anxiety disorder was investigated on 200 patients at the HuÕ Central Hospital between December 2000 and May 2001. Results: Overall, the incidence of depressive-anxiety disorder is 15.5%, more common in older patients. Most is mild and moderate depression. The frequency of symptoms, as sadness, emptiness, fatigue, difficulty in attention, decrease in sexual activities, dizziness and etc is varied. The relationship between symptoms of depressive-anxiety disorder and number of physical problems in the same patient is insignificant; however, this disorder is more common in patients with cardio-vascular and gastrointestinal conditions. Unfavorable psychosocial and family factors can promote the development of depressive-anxiety disorder.
depression ; Patients ; Internal Medicine ; diagnosis

An investigation of 150 health staffs in Hue city (male: 49) has shown that there were 46 health staffs experienced alcohol abuse of which male: (36) and female (10) although they know the harmful effects of alcohol. The common out comes of alcohol abuse were protest of their families and society, impairment of family economy and accidents for them and others. The mental effects comprised tired, sleeping disorder and tremble.
Alcoholism ; Medical Staff ; diagnosis ; epidemiology

Background: Chlorophytum laxum R. Br. (Anthericaceae) are medicinal plants used by people to restore and improve the health of women after birth to boost energy quickly. Objectives: To anounce the results of acute toxicity and cytotoxic effect of Chlorophytum laxum R. Br. (Anthericaceae). Subjects and method: Using an acute toxicity test on Chlorophytum laxum R. Br. (Anthericaceae) collected at Thua Thien Hue province on September, 2005. The data was analysed by bio statistic based on the data analysis of Microsoft Excel. Results:At the dose of 120g/kg body weigh we have not found the oral LD\xac 50 so of the aqueous extract of Chlorophytum laxum R. Br. in mice. Methyl caffeate and 1,2Di-O-(9Z, 12Z- octadecatrienoyl) -3-O-beta-D-galactopyranosylglycerol were isolated from the methanol extract of the roots from Chlorophytum laxum R. Br. have antitumor activity in lung, liver cancer cells and pericardioma. Conclusion: This is the first scientifically published article on the biological effects of Chlorophytum laxum R. Br plant roots, particularly the cytotoxic effects on common cancer cell such as liver cancer, lung cancer from the isolated compounds in pure.
Acute toxicity ; cytotoxic effect of Chlorophytum laxum

Background: The hollow-fiber infection model (HFIM) is a valuable tool for evaluating pharmacokinetics/pharmacodynamics relationships and determining the optimal antibiotic dose in monotherapy or combination therapy, but the application for personalized precision medicine in tuberculosis treatment remains limited. This study aimed to evaluate the efficacy of adjusted antibiotic doses for a tuberculosis patient using HFIM. Methods: Model-based Bayesian forecasting was utilized to assess the proposed reduction of the isoniazid dose from 300 mg daily to 150 mg daily in a patient with an ultra-slowacetylation phenotype. The efficacy of the adjusted 150-mg dose was evaluated in a timeto-kill assay performed using the bacterial isolate Mycobacterium tuberculosis (Mtb) H37Ra in a HFIM that mimicked the individual pharmacokinetic profile of the patient. Results: The isoniazid concentration observed in the HFIM adequately reflected the target drug exposures simulated by the model. After 7 days of repeated dose administration, isoniazid killed 4 log 10 Mtb CFU/mL in the treatment arm, while the control arm without isoniazid increased 1.6 log 10 CFU/mL. Conclusion Our results provide an example of the utility of the HFIM for predicting the efficacy of specific recommended doses of anti-tuberculosis drugs in real clinical setting.

Background: and Purpose Intracranial arterial stenosis (ICAS)-related stroke occurs due to three primary mechanisms with distinct infarct patterns: (1) borderzone infarcts (BZI) due to impaired distal perfusion, (2) territorial infarcts due to distal plaque/thrombus embolization, and (3) plaque progression occluding perforators. The objective of the systematic review is to determine whether BZI secondary to ICAS is associated with a higher risk of recurrent stroke or neurological deterioration. Methods: As part of this registered systematic review (CRD42021265230), a comprehensive search was performed to identify relevant papers and conference abstracts (with ≥20 patients) reporting initial infarct patterns and recurrence rates in patients with symptomatic ICAS. Subgroup analyses were performed for studies including any BZI versus isolated BZI and those excluding posterior circulation stroke. The study outcome included neurological deterioration or recurrent stroke during follow-up. For all outcome events, corresponding risk ratios (RRs) and 95% confidence intervals (95% CI) were calculated. Results: A literature search yielded 4,478 records with 32 selected during the title/abstract triage for full text; 11 met inclusion criteria and 8 studies were included in the analysis (n=1,219 patients; 341 with BZI). The meta-analysis demonstrated that the RR of outcome in the BZI group compared to the no BZI group was 2.10 (95% CI 1.52–2.90). Limiting the analysis to studies including any BZI, the RR was 2.10 (95% CI 1.38–3.18). For isolated BZI, RR was 2.59 (95% CI 1.24–5.41). RR was 2.96 (95% CI 1.71–5.12) for studies only including anterior circulation stroke patients. Conclusion This systematic review and meta-analysis suggests that the presence of BZI secondary to ICAS may be an imaging biomarker that predicts neurological deterioration and/or stroke recurrence.