1.Mucinous Adenocarcinoma Arising at the Anastomotic Site after Operation for Hirschsprung's Disease: Case Report .
Journal of the Korean Radiological Society 2004;50(1):55-57
To our knowledge, rectal cancer arising at the anastomotic site after surgery for Hirschsprung's disease has not been reported. We report a case of mucinous adenocarcinoma arising at the anastomotic site after Soave operation 26 years ago.
Adenocarcinoma, Mucinous*
;
Hirschsprung Disease*
;
Mucins*
;
Rectal Neoplasms
2.The effects of chromium exposure on sister chromatid exchange and concentration of 8-hydroxydeoxyguanosine.
Sang Hwan HAN ; Soo Hun CHO ; Heon KIM ; Soo Min PARK ; Mina HA ; Young Soo JOO ; Ho Jang KWON ; Yong Dae KWON ; Myung Hee KWON
Korean Journal of Preventive Medicine 1995;28(2):511-525
To elucidate some DNA adducts as a biological marker for workers of chromate pigment, the effects of chromium exposure on the formation of 8-hydroxydeoxyguanosine(8-OH-dG) and sister chromatid exchanges(SCEs) frequency in 38 workers of a pigment plant in Bucheon which utilized lead chromates, were examined. The chromium contents of venous blood and urine were measured as working environmental exposure level. The concentrations of 8-OH-dG in DNA isolated from lymphocytes were determined with high performance liquid chromatography and electrochemical detector and denoted as a molar ratio of 8-OH-dG to deoxyguanosine(dG). The SCEs frequency were analyzed in DNA isolated from lymphocytes. A significant correlation was found between creatinine adjusted urine chromium concentration and the molar ratio of 8-OH-dG to dG(r=0.47, p<0.01). After adjusting the current smoking habit, the correlation coefficient was increased(r=0.62, p<0.05). However, there was no significant correlation between the SCE frequency and chromium exposure. This significant results between molar ratio of 8-OH-dG to dG and chromium exposure are in good agreement with in vitro studies that support the importance of DNA adduct formation for the carcinogenic effect of chromium.
Biomarkers
;
Chromates
;
Chromatids
;
Chromatography, Liquid
;
Chromium*
;
Creatinine
;
DNA
;
DNA Adducts
;
Environmental Exposure
;
Gyeonggi-do
;
Humans
;
Lymphocytes
;
Molar
;
Plants
;
Siblings*
;
Sister Chromatid Exchange*
;
Smoke
;
Smoking
3.The Analysis of Methylenetetrahydrofolate Reductase Mutation in Recurrent Spontaneous Abortion Associated with Hyperhomocysteinemia.
Yoong Sung NAM ; Jong Soon CHOI ; Kwon Soo HA ; Zee Won LEE ; Do Yeon OH
Korean Journal of Fertility and Sterility 1999;26(3):441-446
OBJECTIVE : To analyze the methylenetetrahydrofolate reductase (MTHFR) mutation in recurrent spontaneous abortion associated with hyperhomocysteinemia. MATERIAL AND METHOD: The blood Sample of habitual aborter with high fasting homocysteine level was tested by PCR-RFLP method. RESULTS: The patient was found to be a homozygosity for MTHFR gene mutation that was confirmed by the finding which is consistent with the mutation at the nucleotide 677 C to T, Corresponding to Ala to Val. CONCLUSIONS: Hyperhomocysteinemia due to MTHFR mutation is a cause of recurrent spontaneous abortion. Therefore, the MTHFR mutation should be examined in the workup of recurrent spontaneous abortion showing hyperhomocysteinemia.
Abortion, Spontaneous*
;
Fasting
;
Female
;
Homocysteine
;
Humans
;
Hyperhomocysteinemia*
;
Methylenetetrahydrofolate Reductase (NADPH2)*
;
Pregnancy
4.Development And Evaluation Of Korean Diagnosis Related Groups: Medical Service Utilization Of Inpatients.
Young Soo SHIN ; Young Seong LEE ; Ha Young PARK ; Yong Kwon YEOM
Korean Journal of Preventive Medicine 1993;26(2):293-309
With expanded and extended coverage of the national medical insurance and fast growing health care expenditures, appropriateness of health service utilization and quality of care are concerns of both health care providers and insurers as well as patients. An accurate patient classification system is a basic tool for effective health care policies and efficient health services management. A classification system applicable to Korean medical information-Korean Diagnosis Related Groups (K-DRGs)-was developed based on the U. S. Refined DRGs, and the performance of the developed system was assessed in this study. In the process of the development, first the Korean coding systems for diagnoses and procedures were converted to the systems used in the definition of the U. S. Refined DRGs using the mapping tables formulated by physician panels. Then physician panels reviewed the group definition, and identified medical practice patterns different in two countries. The definition was modified for the difference in K-DRGs. The process resulted in 1,199 groups in the system. Several groups in Refined DRGs could not be differentiated in K-DRGs due to insufficient medical information, and several groups could not be defined due to procedures which were not practiced in Korea. However, the classification structure of Refined DRGs was retained in K-DRGs. The developed system was evaluated for its performance in explaining variations in resource use as measured by charges and length of stay(LOS), for both all and non-extreme discharges. The data base used in this evaluation included 373,322 discharges which was a random sample of discharges reviewed ad payed by the medical insurance during the five-month period from September 1990. The proportion of variance in resource use which was reduced by classifying patients into K-DRGs-r-square-was comparable to the performance of the U. S. Refined DRGs: .39 for charges and .25 for LOS for all discharges, and .53 for charges and .31 for LOS for non-extreme discharges. Another measure analyzed to assess the performance was the coefficient of variation of charges within individual K-DRGs. A total of 966 K-DRGs (87.7%) showed a coefficient below 100%, and the highest coefficient among K-DRGs with more than 30 discharges was 159%.
Classification
;
Clinical Coding
;
Delivery of Health Care
;
Diagnosis*
;
Diagnosis-Related Groups*
;
Health Expenditures
;
Health Personnel
;
Health Services
;
Humans
;
Inpatients*
;
Insurance
;
Insurance Carriers
;
Korea
5.Improvement of titration methods for porcine rotavirus, its serum neutralizing antibody and of virus isolation from feces.
Hyock Jin KWON ; Seok Min YOON ; Rung Kong HA ; Sung Soo CHO ; Ji Byung YOON
Journal of the Korean Society of Virology 1991;21(2):113-117
No abstract available.
Antibodies, Neutralizing*
;
Feces*
;
Rotavirus*
6.The Study of the Effect on s-GOT, s-GPT after the Enflurane Auesthesia.
Gap Soo KWON ; In Sook YANG ; In Ho HA
Korean Journal of Anesthesiology 1984;17(4):255-262
In order to observe the effect on liver function after exposure to enlurane which has relatively minimal hepatotoxic effect, we evaluated the changes of the s-GOT & s-GPT levels caused by general anesthesia with enflurane. This study was undertaken to evaluate the effect of enflurane on liver function by comparing the preoperative and postoperative(1st day, 3rd day, 5th day, and 7th day) liver function(s-GOT & s-GPT) tests is il cases of the first general anesthesia with enflurane and 15 cases of a second general anesthesia with enflurane. The results were as folllows: 1) The 1st operative group. a. There are 5 cases (45%) of significant changes of s-GOT levels and no case of significant change in sGPT levels. b. In most of cases, the level of s-GOT & s-GPT have returned to normal values on the 7th postoperative day. 2) The 2nd operative group. a. The increase in the levels of s-GOT was found in 10 cases, and the s-GPT in 6 cases. b. Postoperatively, the simultaneous increase in the levels of s-GOT & s-GPT were found in 4 cases. c. On the 7th postoperative day, the levels of s-GOT & s-GPT was not normal in 3 cases, and not normal for s-GPT in 2 cases. The above results show that the higher of levels of s-GOT & s-GPT after the second general anesthesia with enflurane apparent compared to the levels after the first general anesthesia with enflurane. And it can be assumed that the extreme precaution is necessary in conduction the second general anesthesia with enflurane.
Alanine Transaminase
;
Anesthesia, General
;
Enflurane*
;
Liver
;
Reference Values
7.Clinical Studies of Risperidone in Korea.
Korean Journal of Psychopharmacology 2003;14(Suppl):128-139
There have been 91 papers on risperidone in Korea, which were composed of 21 reviews, 9 preclinical studies, 18 case reports, and 43 clinical trials, since this new antipsychotic was introduced. Case reports focused mainly on adverse effects of risperidone, and clinical trials on it's efficacy and safety. Review of Korean clinical trials revealed the paucity of well designed controlled studies which examined the effective dose and compared the efficacy of risperidone with those of other drugs. Future research should adopt more reliable and standardized methods. The efficacy of risperidone for various clinical populations needs to be elucidated. Researchers need to make an effort to implicate the clinical use of risperidone. Long-term outcome studies are expected.
Korea*
;
Outcome Assessment (Health Care)
;
Risperidone*
8.Induction of the c-fos in Rat Brain after Acute Carbon Monoxide Exposure.
Soo Hoon CHO ; Heon KIM ; Ho Jang KWON ; Mi Na HA
Korean Journal of Occupational and Environmental Medicine 1997;9(3):459-468
No abstract available.
Animals
;
Brain*
;
Carbon Monoxide*
;
Carbon*
;
Rats*
9.Percutaneous Release of Trigger Gingers
Kwon Ick HA ; Sung Ho HAHN ; In Young CHUNG ; Hee Joong KIM ; Hyun Soo PARK
The Journal of the Korean Orthopaedic Association 1989;24(1):94-96
A simple out-patient's procedure with the use of a simple 17 or 18G hypodermic needle for the percutaneous release of trigger finger is described. The authors are reporting the satisfactory result obtained by means of percutaneous release of tendon sheath without skin incision in 21 trigger fingers of 17 patients treated at the out-patient-basis.
Fingers
;
Ginger
;
Humans
;
Needles
;
Skin
;
Tendons
10.New compression dressing on the management of the otohematoma.
Young Ha KWON ; Ju Byoung SEONG ; Hyoung Keun CHA ; Back Am CHANG ; Soo Man PARK
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(5):1062-1064
No abstract available.
Bandages*