PURPOSE: Chronic idiopathic thrombocytopenic purpura (CITP) is an autoimmune disease caused by autoantibodies reacting to certain antigens, and platelet glycoprotein (GP) IIb/IIIa and GP Ib/IX complexes are thought to be some of those antigens. However, the clinical significance of anti-GP autoantibodies in CITP patients is unknown. In this study, we investigated the clinical correlation between the presence of circulating autoantibodies against GP IIb/IIIa and GP Ib/IX, and disease activity. MEHTODS: From December 1997 to June 1998, 20 CITP patients were enrolled in this study. Autoantibodies against GP IIb/IIIa and GP Ib/IX in patient's sera during treatment were detected by immunoblotting, and their platelet counts at the initial evaluation and 6 month follow-up were compared according to the presence or the absence of antibodies. RESULTS: Autoantibodies to GP antigens were found in 40% (8/20) of the patients. Seven patients were positive for GP IIb/IIIa; 4 for GP Ib/IX and 3 for both. GP autoantibody-positive patients had lower mean platelet counts than GP autoantibody-negative patients at initial evaluation (133,000/microliter vs 172,000/microliter, P>0.05) and at 6 month follow-up (154,000/microliter vs 192,000/microliter, P>0.05). Detection of GP autoantibodies related more with active disease than with remission at initial evaluation (45.5%(5/11) vs 33.3%(3/9), P>0.05) and at 6 month follow-up (50.0%(5/10) vs 30.0% (3/10), P>0.05). There was no detection of GP-specific antibodies in 3 splenectomized patients. CONCLUSION: It is hard to conclude on our data alone that the presence of GP autoantibodies correlates with disease status in CITP, although it seems to associate with lower platelet counts.
Antibodies ; Autoantibodies* ; Autoimmune Diseases ; Blood Platelets* ; Follow-Up Studies ; Glycoproteins ; Humans ; Immunoblotting ; Platelet Count ; Purpura, Thrombocytopenic, Idiopathic*

PURPOSE: Chronic idiopathic thrombocytopenic purpura (CITP) is an autoimmune disease caused by autoantibodies reacting to certain antigens, and platelet glycoprotein (GP) IIb/IIIa and GP Ib/IX complexes are thought to be some of those antigens. However, the clinical significance of anti-GP autoantibodies in CITP patients is unknown. In this study, we investigated the clinical correlation between the presence of circulating autoantibodies against GP IIb/IIIa and GP Ib/IX, and disease activity. MEHTODS: From December 1997 to June 1998, 20 CITP patients were enrolled in this study. Autoantibodies against GP IIb/IIIa and GP Ib/IX in patient's sera during treatment were detected by immunoblotting, and their platelet counts at the initial evaluation and 6 month follow-up were compared according to the presence or the absence of antibodies. RESULTS: Autoantibodies to GP antigens were found in 40% (8/20) of the patients. Seven patients were positive for GP IIb/IIIa; 4 for GP Ib/IX and 3 for both. GP autoantibody-positive patients had lower mean platelet counts than GP autoantibody-negative patients at initial evaluation (133,000/microliter vs 172,000/microliter, P>0.05) and at 6 month follow-up (154,000/microliter vs 192,000/microliter, P>0.05). Detection of GP autoantibodies related more with active disease than with remission at initial evaluation (45.5%(5/11) vs 33.3%(3/9), P>0.05) and at 6 month follow-up (50.0%(5/10) vs 30.0% (3/10), P>0.05). There was no detection of GP-specific antibodies in 3 splenectomized patients. CONCLUSION: It is hard to conclude on our data alone that the presence of GP autoantibodies correlates with disease status in CITP, although it seems to associate with lower platelet counts.
Antibodies ; Autoantibodies* ; Autoimmune Diseases ; Blood Platelets* ; Follow-Up Studies ; Glycoproteins ; Humans ; Immunoblotting ; Platelet Count ; Purpura, Thrombocytopenic, Idiopathic*

The clinical cases presented here involve skeletal Class III malocclusion cases treated with maxillary protraction in a relaticely short period of time with good results. When used on young patients, satisfactory results were obtained in a short period of time, but even for those with less growth potential remainig, skeletal enhancement was still evident. However, data on the criteria of diagnosis or relapse following maxillary protraction is limited despite the number of studies on the subiect. The present study could not incude the observations on retention and relapse, and further studies in the future may include such observations.
Diagnosis ; Humans ; Malocclusion ; Orthopedics ; Recurrence

OBJECTIVE: Soft tissue changes due to orthodontic treatment has large individual variation. Therefore continuous evaluation during treatment is required. Patients with fixed orthodontic appliances often wonder if their lip positions will change after the removal of brackets, but only a few studies exist on this topic. The objective of this study was to evaluate the changes of the lips and perioral soft tissue after bracket removal. METHODS: The sample used in this study was 19 males and 33 females. Cephalometric X-rays were taken at 3 stages - T1 (before debonding), T2 (just after debonding), T3 (1.5 months after debonding). RESULTS: The lower lip was retruded immediately after debonding (T2-T1), and 1.5 months after debonding (T3-T2). The mean amounts of retrusion from the vertical reference plane (sG perpendicular line) were about 0.38 mm for the upper lip and 0.88 mm for the lower lip. Immediately after debonding, lip retrusion of females was greater than that of males. During the post-debonding period, lower lip of males was retruded more than that of females. CONCLUSION: Lips are retruded after bracket removal, and there is no gender difference 1.5 months after debonding.
Female ; Humans ; Lip* ; Male ; Orthodontic Appliances

Fiber reinforced composite (FRC) has been widely used in operative and prosthetic fields of dentistry and its use is expanding into the orthodontic field. The purpose of this study was to examine the changes of flexural properties of FRC reinforced with silica glass fiber (FibreKor(R), Jeneric/Pentron Inc., Wallingford, U.S.A.) according to the duration of water absorption. Specimens were grouped according to their shape as round and rectangular cross sections, and were immersed in distilled water at room temperature (23 degrees C) for 0 hour, 1 hour, 1 week, 15 days, 1 month and 3 months. The number of specimens was 5 for each duration and bending test was done using a torque tester. The flexural stiffness after 24 hour water immersion was reduced to 59% for round specimens and 25% for rectangular specimens and after 3 months of water immersion it was reduced to 29% and 19% stiffness of the 0 hour-specimen respectively. Yield flexural moment after 24 hour water immersion was reduced to 45% for round specimens and 76% for rectangular specimens and after 3 months of water immersion it was reduced to 29% and 60% stiffness of the 0 hour-specimen respectively. Ultimate flexural moment after 24 hour water immersion was reduced to 36% for round specimens and 76% for rectangular specimens and after 3 months of water immersion it was reduced to 25% and 37% stiffness of 0 hour-specimen respectively. Those results suggested that the flexural stiffness of FibreKor(R) decreased greatly after initial water immersion. Consequently, further research for the maintenance of strength against water will be necessary.
Absorption* ; Dentistry ; Glass ; Immersion ; Silicon Dioxide ; Torque ; Water*

Periogen is a new caries activity test using real-time polymerase chain reaction. The aim of this study was to assess the validity of Periogen by evaluating the correlation with dmft, dmfts indices and comparing with Cariview and caries risk assessment tool (CAT).83 children under 6 participated in this study. Dmft, dmfts indices and CAT were collected through an examination of oral health status. Plaque samples for Periogen and Cariview were collected and manipulated according to the manufactures' instructions.The correlation coefficient of Periogen, Cariview and CAT with the dmfts index were 0.38, 0.56 and 0.66 in each (p < 0.01). The sensitivity of Periogen, Cariview and CAT were 43%, 76% and 95% and specificity were 80%, 72% and 74% respectively. Area under curve under the receiver operating characteristic curves in each method indicated 0.69, 0.81 and 0.85.CAT and Cariview were more effective in evaluation the risk of dental caries than Periogen so far. To be used Periogen clinically, more improvements for higher validity were needed.
Animals ; Area Under Curve ; Cats ; Child ; Dental Caries ; Humans ; Methods ; Oral Health ; Real-Time Polymerase Chain Reaction ; Risk Assessment ; ROC Curve ; Sensitivity and Specificity

The respiratory function is relevant to the craniofacial growth and orthodontic diagnosis. The size of the pharyngeal airway was measured in lateral cephalometric view in children visited Kyung Hee University Hospital from January 2015 to August 2017. A total of 74 healthy children (36 boys and 38 girls) aged 7 - 11 years (mean, 8.5 years) with a normodivergent facial pattern were divided into three groups according to anteroposterior jaw relation measuring A point-Nasion-B point (ANB) angle. Lateral cephalometric data were used to measure the airway dimensions. The dimensions of the middle airway were significantly lower, reducing the upper airway space, in large ANB angle group than in other children, suggesting that children with large ANB angle have narrower airway space than others.
Child ; Diagnosis ; Humans ; Jaw ; Malocclusion

The purpose of this study is to evaluate the effect of the spread of a new type of coronavirus infection (COVID-19) on the mental state in school-age children and parents focusing on the aspects of sleep disorders and depression. A questionnaire survey was conducted for 123 parents and 108 school-age children who visited Department of Pediatric Dentistry, Kyung Hee University Dental Hospital at Gangdong from April 2, 2020 through April 25, 2020, via the direct writing method. Participants were assessed with Pittsburgh Sleep Quality Index, Generalized Anxiety Disorder (GAD)-7, Center for Epidemiology Scale for Depression. Logistic regressions were used with a level of significance of 5%.
The prevalence of GAD, depression, and poor sleep in parents were 34.1%, 17.1% and 44.7%, respectively. The prevalence of GAD in children was 20.4%.
Logistic regression showed that stress from Emergency Alert Messages about COVID-19 was associated with GAD and depression in parents. In children, the degree of emotional change after COVID-19 was associated with GAD.
This study confirmed that there was a change in the psychological status of children and guardians due to the epidemic of coronavirus disease-2019, and it would be necessary to consider their psychological status during dental treatment.

Fiber reinforced composite (FRC) is usually used as a connector joining a few teeth into one unit in orthodontics. However, fracture often occurs during the two to three years of the orthodontic treatment period due to repeated occlusal loading or water sorption in the oral environment. We simulated the repair by overlapping and attaching portions of two FRC strips in the middle and performed a three-point bending test to investigate the changes of the repair strength among the different FRC groups. The specimens were grouped according to the overlapping lengths of the two FRC strips, which were 1, 2, 3 and 4 mm (group E1, E2, E3 and E4, respectively) and the control group consisted of unrepaired, intact FRC strips. Each group consisted of 6 specimens and were cured with a light emitting diode curing unit. Group E4 showed the highest maximum loads of 2.67 N, then the control group (2.39 N), group E3 (2.35 N), E2 (2.10 N), and E1 (1.75 N) in decreasing order. Group E4 also showed the highest stiffness, which was 2.32 N/mm, however, the stiffness of group E3 (2.06 N/mm) was higher than that of the control group (1.88 N/mm). According to the visual examination, the specimens tended to be bent rather than being fractured into two pieces with an increased length of overlapping portions. The above results suggest that a minimum overlapping length of 3 mm was necessary to obtain an adequate repair of a 10 mm length of FRC connector. In addition, the critical section adjacent to the joint area, where the thickness decreased abruptly, should be reinforced with flowable resin to minimize the bending tendency.
Joints ; Orthodontics ; Tooth ; Water

The aim of this study was to measure the shear bond strength (SBS) of different adhesive systems to calcium silicate-based materials (Biodentine and RetroMTA). Eighty cylindrical acrylic blocks, with a hole (5.0 mm diameter, 2.0 mm height) in each, were prepared. The holes were filled with Biodentine (BD) and RetroMTA (RMTA), and the specimens were divided into 2 groups. Each group was classified into 4 subgroups: Clearfil™ SE (CSE) ; AQ bond (AQ) ; All bond universal Self-etch (ABU-SE) ; and All bond universal Total-etch (ABU-TE). After the application of different adhesive systems, composite resin (Z350) was applied over BD and RMTA. The SBS was measured using a universal testing machine, and the data were compared using the Kruskal-Wallis test and the Mann-Whitney test. The highest and lowest values of SBS were observed for BD-ABU-SE and RMTA-AQ, respectively. No significant differences were found in the SBS between ABU-TE and ABU-SE and between ABU-TE and CSE to BD and RMTA. According to the data, BD showed a higher SBS than did RMTA when BD and RMTA are compared in the same adhesive agents. Further, among all groups, composite resin with ABU-SE showed better bond strength to BD and RMTA.
Adhesives ; Calcium