Heterotropic ossifications have been known to occur around joints in many pathological conditions of the nervous system mostly in paraplegia and is affects most of the hip joint. Recently, 4 cases of heterotropic ossification in 18 cases of traumatic paraplegia have been reviewed at the orthopedic department of Kyungpook National University Hospital from April 1965 to July 1968 and the results obtained were as follows: 1. All cases were found in male of 3rd to 4th decade. 2. Heterotropic ossification affectected around the hip joint in 3 cases and in the other one case around the medial femoral condyle of knee joint. 3. Three cases affecting around hip joint expressed pressure sores on ipsilateral great trochanteric area, but the other one case affecting around medial femoral condyle had not any pressure sore. 4. In all cases, the heterotropic ossification was noted on X-ray film within 4 to 6 months after paraplegia.
Femur ; Gyeongsangbuk-do ; Hip Joint ; Humans ; Joints ; Knee Joint ; Male ; Nervous System ; Orthopedics ; Paraplegia ; Pressure Ulcer ; X-Ray Film

Simple congenital lymphedema is a congenital form of chronic lymphedema of unknown etiology which affects a part or all of the one extremity, especially the lower extremities, at or immediately after birth. A clinical classification of lymphedema was offered by Allen and Ghormley in 1935, based on a study of 300 cases of lymphedema of which 12 cases are simple congenital lymphedema. They classified the cases of lymphedema into two divisions: noninflammatory and inflammatory, with a tabulation of primary and secondary causes. One caes I reporting is classified as being of congenital origin and naturally comes under the noninflammatory group. On May 1960, a 3 year old girl entered to the Department of Orthopaedic Surgery, Kyungpook National University Hospital because of lymphedema of right leg. Since at birth, there were no history of skin infection, cellulitis and lymphangitis etc. Gross appearance of the skin of the affecte leg revealed leather like consistency and thickening. One week of preoperative preparation of the patient was sustained absolute bed rest with elevation of affected limb to ease drainage of lymphatic fluid. The two staged operation of Homans procedure were performed under general anesthesia, first to medical half and second to remaining lateral half of the affected leg. The end result was relatively good in decreasing the circumfence of affected leg but it was not quite acceptable in its cosmetic effect. The literature on primary lymphedema is reviewed.
Anesthesia, General ; Bed Rest ; Cellulitis ; Classification ; Drainage ; Extremities ; Female ; Gyeongsangbuk-do ; Humans ; Leg ; Lower Extremity ; Lymphangitis ; Lymphedema ; Parturition ; Skin

No abstract available.
Mesenteric Artery, Superior*

This report offers descriptive data about the drugs utilized in outpatient department (OPD) of Yeungnam University Hospital (YUH) in the period of March to August in 1985. The data in this report were produced by the computerized totalization of the number of mentions of individual drugs included in the prescriptions. The 100 drug entries that were most frequently recorded are listed in rank order. The listing is arbiturarily restricted to the drugs that were prescribed as single preparations, the drugs of basis of compound preparations and the drugs of adjuvant or corrective of compound preparations that have significant therapeutic effects either by generic names. And in addition, the listing also involves the compound preparations used in relatively large frequency, and the individual components of which have the unique pharmacological actions each other by proprietary names. And all routes of administrations were allowed. The 10 drugs most frequently named are diazepam, aluminum compounds, acetaminophen, isoniazid, metoclopramide, polaramine®, carboxymethylcystein, ephedrine, codeine and caroverine in order. The 521, 855 drug mentions listed as above are described by the chief therapeutic usage that each is intended to apply generally. The drugs which account the largest proportion of total mentions were those acting on the central nervous system (20.57%), including tranquillizers and sedative hypnotics (11.71%), analgesic antipyretics (5.55%), antidepressants (2.15%) etc. Gastrointestinal drugs and smooth muscle preparations (18.64%) included antacids and antiulcer drugs (9.24%), antiemetics (3.57%), spasmolytics (3.14%) and others. Respiratory drugs (16.11%) included expectorants and cough preparations (10.99%) and bronchodilators (5.12%). Chemotherapeutic agents (15.12%) included the antiTbc drugs (7.09%) most frequently, and the penicillins (3.33%) accounted the largest proportion among the antibiotics. Cardiovascular drugs (5.64%) included cardiac drugs and coronary vasodilator (4.12%) and antihypertensives and vasodilators (1.06%). And antiinflammatory drugs (4.33%), vitamins of single preparations (3.76%), hormones and their antagonists (3.29%), common cold preparations (3.12%), diuretics (2.81%), drugs supporting liver function (2.02%), drugs affecting autonomic nervous system (1.89%) including antiglaucomas, atropine and cerebral vasodilators, antihistamine drug (1.02%) and disinfectants (0.74%) were following in order. The data in the report were compared to those reported by H. Koch, et al. in United States (US), 1981 as “Drugs Most Frequently Used in Office Practice : National Ambulatory Medical Case Survey, 1981.” Cardiovascular drugs prescribed in YUH were much less in proportion than in US (10.56%), but gastrointestinal drugs accounted the larger proportion than in US (3.72%). Expectorants and preparations in YUH also accounted the larger proportion than in US (2.74%). In conclusion, in the period of March to August, 1985, OPD of YUH prescribed the CNS drugs including diazepam most frequently, and gastrointestinal, respiratory and chemotherapeutic drugs in next orders. It is supposed that the eating habits of Koreans and a unique atmospheric condition in Taegu as a basin were some important factors that affected the proportions of drugs acting on gastrointestinal and respiratory tracts.
Acetaminophen ; Aluminum Compounds ; Antacids ; Anti-Bacterial Agents ; Antidepressive Agents ; Antiemetics ; Antihypertensive Agents ; Antipyretics ; Atropine ; Autonomic Nervous System ; Bronchodilator Agents ; Cardiovascular Agents ; Central Nervous System ; Codeine ; Common Cold ; Cough ; Daegu ; Diazepam ; Disinfectants ; Diuretics ; Eating ; Ephedrine ; Expectorants ; Gastrointestinal Agents ; Humans ; Hypnotics and Sedatives ; Isoniazid ; Liver ; Metoclopramide ; Muscle, Smooth ; Outpatients ; Parasympatholytics ; Penicillins ; Prescriptions ; Respiratory System ; Therapeutic Uses ; United States ; Vasodilator Agents ; Vitamins

To investigate the effect of diazepam on the contractility of the intestinal smooth muscle, longitudinal muscle strip isolated from rat ileum was prepared for myography in isolated organ bath. 1) Basal tone of ileal muscle was reduced by diazepam concentration-dependently. 2) Higher concentrations (30 and 100 microM) of diazepam inhibited (p<0.05, p<0.001) The carbachol-induced contraction in a concentration-dependent manner; but lower concentration of diazepam (10 microM) enhanced (p<0.05). 3) Histamine-induced contraction was inhibited by pretreatment with diazepam in a concentration-dependent manner. 4) Ca⁺⁺-induced tension recovery in calcium-free solution was inhibited in the presence of diazepam concentration-dependently. These results suggest diazepam reduces the contractility of the longitudinal muscle isolated from rat ileum via interference with influx of calcium into the muscle cells.
Animals ; Baths ; Calcium ; Carbachol* ; Diazepam* ; Ileum* ; Muscle Cells ; Muscle, Smooth ; Myography ; Rats*

No Abstract Available.
Humans ; Renal Dialysis*

Carbamazepine is a derivative of iminostilbene with carbamoyl group and related chemically to the tricyclic antidepressants. Carbamazepine has been introduced for treatment of trigeminal neuralgia. Recently it is used as an antiepileptic agent such as diphenylhydantoin. Antiepileptic drugs are known to affect experimentally induced cardiac arrhythmia and are now widely used clinically for treatment of ventricular tachyarrhythmias, particularly those produced by digitalis intoxication. Steiner et al. (1970) reported that carbamazepine was found to be very effective in converting ventricular tachycardia due to digitalis toxicity to normal sinus rhythm. Clinically bradycardia, complete heart block, ventricular standstill and Adams-stokes attack were reported in the course of carbamazepine treatment. The purpose of this study was to investigate the effects of carbamazepine on the ouabain-induced arrhythmia in vivo. The rabbits of either sex, weighing from 1.6 to 3.2 kg were anesthetized by urethane. After the trachea was cannulated, the rabbits were ventilated with room air using a respirator. Drugs were given into polyethylene cannula in the femoral vein. Blood pressure were recorded by physiograph via pressure tranducer connected with the cannula in the femoral artery. EKG were recorded by physiograph via electrode implanted in both fore leg and left hind leg. The results are summarized as follows 1. Arrhythmia was induced by continuous infusion of ouabain (65±8.8 µg/kg). 2. Single administration of ouabain (64 µg/kg) induced arrhythmia which was persisted for 7-8 min. 3. Ouabain induced arrhythmia was restored to normal sinus rhythm by administration of carbamazepine (the more dosage, the less frequent and the longer duration). 4. Severe bradycardia, A-V block, atrial fibrillation were seen on the EKG after injection of carbamzepine alone. By the above results, it may be concluded that carbamzepine inhibits the ouabain-induced arrhythmia by dose-dependent.
Anticonvulsants ; Antidepressive Agents, Tricyclic ; Arrhythmias, Cardiac* ; Atrial Fibrillation ; Blood Pressure ; Bradycardia ; Carbamazepine* ; Catheters ; Digitalis ; Electrocardiography ; Electrodes ; Femoral Artery ; Femoral Vein ; Heart Block ; Leg ; Ouabain ; Phenytoin ; Polyethylene ; Rabbits* ; Tachycardia ; Tachycardia, Ventricular ; Trachea ; Trigeminal Neuralgia ; Urethane ; Ventilators, Mechanical

BACKGROUND: Erythema induratum was first described by Bazin in association with tuberculosis. However, the tuberculous cause of this entity has been questioned by several authors and gradually, the concept of nontiiberculous nodular vasculitis has been accepted OBJECTIVE: The purpose of this study is to document the clinicopathologic features of erythema induratum. METHODS: We investigated clinical and histopathological findings of 31 patient with erythema induratum who showed positive tuberculin hypersensitivity reaction or had active associated tuberculosis. RESULTS: The ages of the 31 patients(M7: F24) ranged from 13 to 66 years(mean 37.1 years). All patients displayed recurrent crops of tender, painful, violaceous noudules or plaques. Most lesions were present on the legs, but they also occurred on the thighs, feet, buttocks, and forearms. The skin lesions evolved for several weeks and healed with scarring and residual pigmentation. Histological examination revealed lobular or septolobular panniculitis with varying cornbinations of granulomatous inflammaticn, primary vasculitis and necrosis in most biopsies. Twenty two patients were treated with isoniazid alone and the remaining 9 patients received combination anti tuberculous treatment. Relapses were encountered in 4 patients who received isoniazid alone or stopped the medicationrgainst medical advice. CONCLUSION: A diagncisis of erythema induratum should be rendered in the presence of relevant clinicopathologic features, strong positive Mantoux test reaction, and good therapeutic response to antituberculous treatme,it. A full course of combination antituberculous therapy is indicated to achieve a cure of the skin lesions of erythema induratum.
Biopsy ; Buttocks ; Cicatrix ; Erythema Induratum* ; Erythema* ; Foot ; Forearm ; Humans ; Hypersensitivity ; Isoniazid ; Leg ; Necrosis ; Panniculitis ; Pigmentation ; Recurrence ; Skin ; Thigh ; Tuberculin ; Tuberculosis ; Vasculitis

Although the rates of tuberculosis cases are continuing decline with advent of newer drugs, sporadic cases of urinary tuberculosis still occur. During last 5 years, we experienced 22 cases of reconstructive surgery and 18 cases of endourologic procedures for preservation of renal function. The following results were obtained: 1. Reconstructive surgeries including ureteroneocystostomy etc. were underwent in 22 cases and improvement were noted in 18 cases. 2. In 18 endourologic cases, there has been a substantial improvement in renal function, decrease in upper tract dilatation and relief of symptom. Average indwelling duration was 2.4 months and the mean number of dilatation per patient was 1.8 time. 3. Endopyelotomy and direct ureterotomy with ureteroscope are useful modalities in multiple ureteral stricture or upper ureter stricture. 4. It should be emphasized that percutaneous antegrade stent indwelling was more easier than retrograde technique especially in failure cases.
Constriction, Pathologic ; Dilatation ; Humans ; Stents ; Tuberculosis ; Tuberculosis, Renal* ; Ureter ; Ureteroscopes

BACKGROUND: In the skin, it is often difficult to differentiate lymphomas from reactive lymphoid lesions by light microscopic examination. OBJECTIVE: Our purpose was to determine whether immunologic data obtained from mutine-processed specimens could be used to further objective morphologic interpretations. METHODS: We conducted an immunohistochcmical staining in 44 cases of benign and malignant cutaneous lymphoproliferative lesions using nine antibodies, including anti-CD3, UCHL1, MT1, MT2, L26, MB2, BerH2, 123C3, and MIB1. RESULTS: 1. Immunophenotyping with anti-CD3, UCHL1, MT1, L26, and MB2 was useful for the diagnosis of T cell or B cell lymphoma. However, these antibodies showed a lack of specificity for neoplastic cells, 2. Antibody to CD56, 123C3 showed positivity in 4 cases of angiocentric lymphoma, but negativity in 8 cases showing angiocentric lymphoma-like pathology. 3. Antibody to CD30, BerH2 showed positivity in all 6 cases of CD30 positive large cell lymphoma, but negativity in 6 cases showing diffuse lymphoma-like pathology. 4. Antibody to Ki-67, MIB1 showed positivity in more than 30% of infiltrating cells in 6 cases of angiocentric lymphoma, 4 cases of diffuse B cell lymphoma, and in more than 60% of infiltrating cells in 6 cases of CD30 positive large cell lymphoma. CONCLUSION: These observations suggest that immunostaining may provide useful adjunctive information in distinguishing benign from malignant cutaneous lymphoproliferations in paraffin sections.
Antibodies ; Diagnosis ; Immunophenotyping ; Lymphoma ; Lymphoma, B-Cell ; Paraffin ; Pathology ; Pseudolymphoma* ; Sensitivity and Specificity ; Skin