1.Three cases of acute lobar nephronia in children.
Moon Sun YANG ; Yun Ho CHOI ; Yong CHOI ; Kwang Wook KO ; In Won KIM ; Kyung Mo YEON ; Whang CHOI
Korean Journal of Nephrology 1991;10(2):234-239
2.Valproate Adjuvant Cognitive Behavioral Therapy in Panic Disorder Patients With Comorbid Bipolar Disorder: Case Series and Review of the Literature
Psychiatry Investigation 2022;19(8):614-625
Anxiety disorders are the most common comorbid psychiatric disorders in patients with bipolar disorder. Managing anxiety symptoms in comorbid conditions is challenging and has received little research interest. The findings from preclinical research on fear conditioning, an animal model of anxiety disorder, have suggested that memory reconsolidation updating (exposure-based therapy) combined with valproate might facilitate the amelioration of fear memories. Here, three cases of successful amelioration of agoraphobia and panic symptoms through valproate adjuvant therapy for cognitive behavioral therapy in patients who failed to respond to two to three consecutive standard pharmacotherapy trials over several years are described. To the best of the author’s knowledge, this is the first attempt to combine CBT with valproate in patients with panic disorder, agoraphobia, and comorbid bipolar disorder. Additionally, the background preclinical research on this combination therapy based on the reconsolidation-updating mechanism, the inhibition of histone deacetylase 2, and critical period reopening, off-label use of valproate in panic disorder, plasticity-augmented psychotherapy, and how to combine valproate with CBT is discussed.
3.Assessing frailty using comprehensive geriatric assessment in older patients with hematologic malignancy
Blood Research 2022;57(S1):S1-S5
The incidence of hematologic malignancy increases with age; thus, the number of older patients who require intensive chemotherapy is expected to increase with the aging population. In Korea, 61.8%, 59.3%, 47.0%, and 46.7% of newly diagnosed cases of multiple myeloma, myelodysplastic syndrome, myeloproliferative disorder, and non-Hodgkin lymphoma, respectively, occurred in patients aged >65 years in 2018. Health status among older patients, defined by frailty, age-related syndrome of physiological decline and increased vulnerability, is associated with adverse health outcomes. Health status is highly heterogeneous among older patients, and treatment outcomes vary according to frailty and physiologic age rather than chronologic age. Comprehensive geriatric assessment (CGA) is a multidimensional and multidisciplinary diagnostic and treatment process that identifies multiple domains, including functional status, cognition, comorbidities, medications, socioeconomic status, and nutritional status, to develop a coordinated plan to improve treatment-related outcomes and quality of life. Frailty can be assessed with CGA findings, and CGA is considered the “gold standard of care” for frail, older patients. Through CGA, unidentified problems can be assessed, and pre-emptive and non-oncologic interventions can be delivered. CGA is an objective and reliable tool for predicting further treatment-related complications and identifying patients for whom intensive chemotherapy with curative intent is appropriate. CGA should be considered a routine practice before starting treatment planning in older patients diagnosed with hematologic malignancies who require intensive chemotherapy. Further study is needed to allocate individualized treatment plans or multidisciplinary geriatric interventions according to CGA results.
5.Renovascular Hypertension in Childhood.
Jae Won SONG ; Soo Heun LIM ; Yong CHOI ; Kwang Wook KO ; Chang Yee HONG ; Kyung Mo YEON
Journal of the Korean Pediatric Society 1986;29(4):33-38
No abstract available.
Hypertension, Renovascular*
6.Urinary Red Blood Cell Morphology in Hematuria.
Hong Jin LEE ; Chang Yeon LEE ; Hae Il CHEONG ; Yong CHOI ; Kwang Wook KO ; Myung Hee PARK
Journal of the Korean Pediatric Society 1988;31(11):1460-1467
No abstract available.
Erythrocytes*
;
Hematuria*
7.The relationship between spontaneous diuresis and changes of pulmonary function in infants with respiratory distress syndrome.
Byeong Hyun KIM ; Jae Kag CHOI ; Yeon Kyun OH ; Kwang Soo OH ; Hyang Suk YOON ; Chong Duk KIM
Journal of the Korean Pediatric Society 1993;36(8):1094-1100
To evaluate the relationship between spontancous diuresis and improvement of pulmonary function in respiratory distress syndrome, 15 premature neonates requiring mechanical ventilation for RDS, who admitted in NICU of Wonkwang University Hospital from January 1990 to June 1992, were studied. The results were as follows (results are mean+/-SEM) 1) Mean birth weight of study infants was 1.82+/-0.08Kg, and mean gestational age was 32.80+/-0.54 weeks. 2) The onset of diuresis occured at a mean age of 29.1+/-2.48 hours with maximum diuresis at a mean age of 41.9+/-1.8 hours 3) Mean urine output increased from 2.25+/-0.43ml/Kg/hr at the stage of pre 12 hours-onset of diuresis (p<0.001), then decreased 3.5+/-0.2ml/Kg/hr at the stage of after maximum diuresis (p<0.05). 4) After maximum diuresis, inspired oxygen gradient, peak inflating pressure, peak end expiratory pressure, mean airway pressure, and respiratory rate were decreased significantly (p<0.05), and alveolar-arterial oxygen gradient was decreased more significantly (p<0,01). So, We conclude that the pulmonary function was rapidly improving after maximum diuresis and these changes reflect the general principle used in ventilatory management of infants with RDS.
Birth Weight
;
Diuresis*
;
Gestational Age
;
Humans
;
Infant*
;
Infant, Newborn
;
Oxygen
;
Respiration, Artificial
;
Respiratory Rate
8.The incidence of fetal chromosomal abnormalities in recurrent miscarriage couples with balanced translocation.
So Yeon PARK ; Kye Hyun KIM ; Bum Chae CHOI ; Inn Soo KANG ; Kwang Moon YANG ; Keun Jai YOO ; In Ok SONG
Korean Journal of Obstetrics and Gynecology 2000;43(7):1189-1193
OBJECTIVES: The most common chromosomal abnormality contributing to recurrent abortion is the balanced chromosomal translocation. However the exact incidence of fetal losses are still unknown. The objectives of this study were to evaluate the incidence of fetal chromosomal abnormalities and outcome of pregnancy in recurrent miscarriage couples with balanced translocation. DESIGN: A retrospective analysis of recurrent spontaneous abortion patients with balanced chromosomal translocation. MATERIALS AND METHODS: Cytogenetic analysis was performed in 56 couples with history of recurrent abortions from 1995 to 1999. The use of high resolution banding technique and fluorescent in situ hybridization (FISH) in the chromosomal analysis has made the precise evaluation of chromosome aberrations. RESULTS: Among 56 couples, 42 patients had reciprocal translocation and 14 had Robertsonian translocation. Chromosomal aberrations were more frequent in women (36 cases) than in men (20 cases). Prenatal cytogenetic analyses were carried out in 14 subsequent pregnancies for carrier couples with balanced translocation. The fetal karyotypes showed that 5 cases (35.7%) was normal, 8 (57.1%) were balanced translocation, and 1 (7.1%) was unbalanced translocations. And cytogenetic analyses were done on 15 subsequent chorionic villi samples of abortuses for carrier couples with balanced translocations. Fourteen of fifteen abortuses (93.3%) were abnormal karyotype. CONCLUSIONS: Although the incidence of chromosomal imbalance in the fetuses was relatively low in prenatal cytogenetic analysis, individuals with balanced translocations are predisposed to giving birth to malformed offsprings with chromosomal imbalance (partial trisomy or monosomy). Therefore we recommend preimplantation genetic diagnosis (PGD) for recurrent abortions with balanced translocation and preventing the birth of offspring with chromosomal abnormalities.
Abnormal Karyotype
;
Abortion, Habitual*
;
Abortion, Spontaneous
;
Chorionic Villi
;
Chromosome Aberrations*
;
Cytogenetic Analysis
;
Family Characteristics*
;
Female
;
Fetus
;
Humans
;
In Situ Hybridization, Fluorescence
;
Incidence*
;
Karyotype
;
Male
;
Parturition
;
Pregnancy
;
Preimplantation Diagnosis
;
Retrospective Studies
;
Translocation, Genetic
;
Trisomy
9.CNS Lesions in Tuberculous Meningitis.
Hee Young SHIN ; Jung Hwan CHOI ; Jeong Kee SEO ; Kyung Mo YEON ; Kwang Wook KO ; Hahn Woong CHOE
Journal of the Korean Pediatric Society 1983;26(3):213-219
No abstract available.
Tuberculosis, Meningeal*
10.The left parasternal movement in children with heart diseases.
Dae Ho CHOI ; Byung Hyun KIM ; Hyang Suk YOON ; Kwang Soo OH ; Yeon Gyun OH ; Jong Duck KIM
Journal of the Korean Pediatric Society 1992;35(7):942-948
No abstract available.
Child*
;
Heart Diseases*
;
Heart*
;
Humans
;
Physical Examination