Becker's nevus is a cutaneous hamartoma characterized by unilateral hairy hyperpigmentation and can be associated with subjacent and distant soft tissue and bony abnormalities. Ipsilateral breast hypoplasia is a rare abnormality in Becker's nevus, suggesting that increased androgenic receptors or early postzygotic mutation may play a role in the pathogenesis of Becker's nevus. We report a case of Becker's nevus associated with ipsilateral breast hypoplasia in a 24-year-old female.
Breast ; Female ; Hamartoma ; Humans ; Hyperpigmentation ; Nevus* ; Young Adult

Endogenously or exogenously generated oxidative stress impair organs, especially brain. Also, the oxidative stress appears to be a negative factor on normal brain function, like memory and cognition. Our result showed that BF-7, extracted from Bombyx mori, effectively diminished oxidative stress, leading to the protection of neuron from reactive oxygen species donated by FeSO4 . Clinical experiments showed that BF-7 significantly improved memory and cognitive functions of normal adults in a dose-dependent manner. Thus, our results suggest that BF-7 play a role in the improvement of brain functions by removing oxidative stress, and provide therapeutic potential role of BF-7 to protect nervous system from oxidative damage.
Adult ; Apoptosis ; Bombyx ; Brain ; Cognition ; Humans ; Memory* ; Nervous System ; Neurons* ; Oxidative Stress* ; Reactive Oxygen Species

To investigate whether BF-7, extracted from Bombyx mori, improved learning and memory of ordinary people, Rey-Kim Memory Test was performed with placebo group (32 persons), 200 mg BF-7 treated group (33 persons) and 400 mg BF-7 treated group (34 persons). BF-7 enhanced significantly learning and memory function in a dose-dependent manner. To know how BF-7 plays such a positive role, we measured the concentration of acetylcholine in the brain from memory impairment animal model. Treatment of BF-7 significantly increased the concentration of acetylcholine. So, it is supposed that the protection of cholinergic neuron and/or keeping proper concentration of acetylcholine might be one of the mechanisms by which BF-7 improve brain function. So, our results suggest that the BF-7 is effective material for improving learning and memory ability.
Acetylcholine ; Bombyx ; Brain ; Cholinergic Neurons ; Humans ; Learning* ; Memory* ; Models, Animal

The aim of this project was to use 3D scanning data collected at incident scenes and various evidence to 1) develop surveying methods based on 3D data consisting of overall and detailed scene evidence, captured by long-range and micros-canner, which can be shared by personnel working in different fields such as forensic medicine, video analysis, physical analysis, traffic engineering, and fire investigation; 2) create digital storage for human skeletons and set the foundation for virtual anthropology; and 3) improve the credibility of 3D evidence by virtual remodeling and simulation of incident scenes and evidence to provide a basis for advanced and high-tech scientific investigation. Two complete skeletons of male and female were scanned using 3D micro-scanner. Each bone was successfully reproduced and assembled in virtual space. In addition, recreating evidence scheduled for invasive examination by creating RP (rapid prototype) was possible. These outcomes could play an important role in setting up the new field of virtual anthropology. Case-specific surveying methods were developed through analysis of 3D scanning data collected by long-range surface scanners at the scenes of vehicular accidents, falls, shootings, and violent crimes. A technique and recording method was also developed for detecting forged seals by micro-scanning the pressure exerted on the seal. Appraisal methods developed in this project could be utilized to secure 3D data of human skeletal remains and incident scenes, create a standard for application, and increase objectivity, reproducibility, and accuracy of scanning methods. We plan to develop case-specific 3D data analysis techniques to improve the credibility of analysis at the NFS and to establish a 3D data collection and analysis team.
Crime ; Data Collection ; Female ; Fires ; Forensic Medicine ; Forensic Sciences ; Humans ; Male ; Skeleton ; Statistics as Topic