From Oct. 1985 to Mar. 1987, 141 cases of intraocuiar lenses were implanted, and 121 cases had been followed up for more than 2 months. The results were as follows: 1. Surgical technique is planned extracapsular cataract extraction(ECCE) in 81 eyes, Kelman phacoemulsification(KPE) in 21 eyes, Irrigation and Aspiration in 12 eyes, secondary implant in 4 eyes. 2. Post operative visual acuity of 0.5 or better was achieved in 112 eyes(92.5%) and or better in 75 eyes(61.9%). Average of visual acuity was 0.90 +/- 0.25 in toto, 0.88 +/- 0.24 in planned ECCE, 0.96 +/- 0.22 in KPE, 0.92 +/- 0.24 in others. There was not significant carrelation between planned EOCE and KPE(p<0.005). 3. The mean spherical equivalent of post operative corrective spectacle lens power was -0.59 +/- 1.13 in toto, -0.57 +/- 0.92 in planned ECCE. -0.85 +/- 1.13 in KPE. 4. Post operative repractive state was myopic in 98 eyes(80%), emetropic in 10 eyes(8%) and hyperopic in 9 eyes(7%).
Cataract ; Lens Implantation, Intraocular* ; Lenses, Intraocular* ; Visual Acuity

No abstract available.

Tuberculosis, once thought to be the most common cause of uveal is now thought to be a relatively rare cause of ocular disease. This is because of a decreased incidence of tuberculosis as well as a lessened emphasis on its diagnosis. Tuberculosis of uveal tract has long been a controversial subject in ophthalmology. Several factors have been implicated including the marked pleomorphism of the lesions, owing to variations in the virulence of the invading organisms, host resistance, and the presence or absence of host immunity. Solitary choroidal tuberculoma is rare and characterized as gradually growing until it resembles a tumor projecting as a round white or yellowish globular mass into the cavity of the eye. It may progress continuously and so finally, in the absence of treatment, the sclera is involved and perforation results which is followed by phthisis bulbi or pyogenic infection and panophthalmitis. We have experienced a 19-year old female who had a solitary choroidal tumor like lesion, which about 17 months later resulted in scleral perforation, in the posterior pole of the left eye. We performed enucleation of the left eyeball under the clinical diagnosis of the maligant melanoma associated with scleral perforation and obtained the histopathological diagnosis of ocular tuberculosis.
Choroid ; Diagnosis ; Female ; Humans ; Incidence ; Melanoma ; Ophthalmology ; Panophthalmitis ; Sclera ; Tuberculoma ; Tuberculosis ; Tuberculosis, Ocular ; Virulence ; Young Adult

No abstract available.
Carcinoma, Renal Cell* ; Caveolin 1*

No abstract available.
Child* ; Humans ; Infant*

There had been total 20 patients with early onset(4 months~2 years) primary nephrotic syndrome in the Department of Pediatrics, Seoul National University Children's Hospital, during the period from March 1987 to February 1993. We analysed clinical courses, response to treatment, pathological findings and prognosis of the patients And the results were as follows; 1) The initial responders to steroid treatment were 10(50%), of whom 3 became late nonresponders. Of the 10 initial nonresponders, 8 revealed continuing nonresponsiveness. 2) Incidence of hypertension was significantly higher in the intial nonresponders than in the initial responders. 3) Renal biopsies were performed in 9 initial nonresponders and 2 late nonresponders. And the results were 6 with minimal change lesion, 4 with focal segmental glomerulosclerosis and 1 with mesangiocapillary glomerulonephritis. 4) Six continuing or late nonresponders received methylprednisolone pulse therapy or cyclophosphamide. And partial remission was induced in 4 of them. 5) The overall 3 year maintenance rate of normal renal function was 81%(100% in the initial responders and 64% in the initial nonresponders). In conclusion, the initial steroid responsiveness and prognosis were poorer in patients with early onset nephrotic syndrome than in patients with usual childhood nephrotic syndrome.
Biopsy ; Cyclophosphamide ; Glomerulonephritis, Membranoproliferative ; Glomerulosclerosis, Focal Segmental ; Humans ; Hypertension ; Incidence ; Methylprednisolone ; Nephrotic Syndrome* ; Pediatrics ; Prognosis ; Seoul

BACKGROUND: Defective adhesion and migration of melanocyte may be involved in pathogenesis of vitiligo. Tenascin, a glycoprotein of the extracellular matrix, has a role in cell adhesion and migration. It has been reported that abundant expression of tenascin in vitiligo lesion may inhibit melanocyte adhesion and migration. OBJECTIVE: To investigate the tenascin expression in vitiligo skin lesions and to compare with clinical findings. METHODS: We studied 9 patients with vitiligo. The expressions of tenascin were studied by immunahistochemieal techniques.
Cell Adhesion ; Extracellular Matrix ; Glycoproteins ; Humans ; Melanocytes ; Skin ; Tenascin* ; Vitiligo*

No abstract available.
Humans ; Immunoglobulin G* ; Immunoglobulins* ; Pneumonia*

Eleven cases of juvenile diabetes mellitus who were admitted Seoul National University Hospital from Jan., 1969 to Aug., 1978 were aha1yzed. The mean age of onset was 7 and female to male ratio was 8 to 3 with female preponderance. Four had family history of diabetes, although none had diabetic sibling. Polyuria and polydipsia were noted in all cases as initial symptoms, and symptoms of weight loss (6 cases), disturbances in consciousness (5), generalized weakness (5), anorexia (4) and enuresis (3) were noted in the order of frequency. Leucocytosis was noted in 5 cases, but only 2 among the 4 who had infection revealed leucocytosis, The mean blood glucose level was 320 mg% and serum osmolality was 293 mOsm/L. There was no significant difference in the level of blood sugar and serum osmolality according to the consciousness status. Eight episodes of ketoacidosis occured in 5 cases. Three episodes developed due to discontinuance of insulin and three episodes accompanied infection. The mean blood glucose level was 495 mg% and serum osmolality was 300 mOsm/L in ketoacidosis. The consciousness cleared in average 20 hours and ketonuria disappeared in average 26 hours after the administration of insulin (average 5 units/kg of body weight). At discharge, the average dose of insulin needed was 1.2 U/kg/d. Six patients were followed from 6 months to 6 years. Two developed pulmomary tuberculosis during the period of follow up.
Age of Onset ; Anorexia ; Blood Glucose ; Consciousness ; Diabetes Mellitus* ; Enuresis ; Female ; Follow-Up Studies ; Humans ; Insulin ; Ketosis ; Male ; Osmolar Concentration ; Polydipsia ; Polyuria ; Seoul ; Siblings ; Tuberculosis ; Weight Loss

OBJECTIVES AND METHODS: To directly examine the function of the endothelial cell(EC) and smooth muscle cell in umbilical arteries acquired from preeclampsia patients between June 1998 to November 1999, using a conventional tension measurement and bioassay experiment. RESULTS: Relaxation responses to EC-dependent relaxing agents including bradykinin and A23187 in human umbilical artery rings were significantly decreased in preeclampsia(p<0.01). Relaxation responses to EC-independent agents(SNP and SNAP) were also inhibited in umbilical artery rings acquired from preeclampsia patients(p<0.01). To test the change of endothelial cell function in preeclampsia without involvement of smooth muscle dysfunction, we used human umbilical artery and rabbit femoral artery as a donor and detector, respectively, in bioassay experiment. Relaxation responses to EC-dependent agents(A23187 and bradykinin) showed similar results to conventional tension measurement (p<0.01). Relaxation responses to 8-bromo-cGMP in human umbilical artery rings were also significantly decreased in preeclampsia(p<0.01). CONCLUSIONS: It can be concluded that increased vascular resistance in preeclampsia is not only due to the disturbance of endothelial function, but also to smooth muscle dysfunction.
Biological Assay ; Bradykinin ; Calcimycin ; Endothelial Cells ; Femoral Artery ; Humans ; Muscle, Smooth ; Myocytes, Smooth Muscle ; Pre-Eclampsia* ; Relaxation* ; Tissue Donors ; Umbilical Arteries* ; Vascular Resistance