1.Clinical usefulness of morphine skin prick test in diagnosis of allergic diseases.
Inseon S CHOI ; Seog Chea PARK ; Kwang Won KANG
Journal of Asthma, Allergy and Clinical Immunology 1999;19(3):476-483
BACKGROUND: Few studies have demonstrated an enhanced skin responsiveness to opiates in atopic subjects. OBJECTIVE: To determine whether the skin response to morphine is increased in atopics and to assess the clinical usefulness of morphine skin prick test in diagnosis of allergic diseases. METHOD: Allergy skin prick tests were performed using 55 common allergens, histamine, and morphine in 158 patients with allergic diseases. RESULTS: Wheal and flare sizes for morphine (1mg/mL) were significantly related to and smaller than those for histamine (1mg/mL). Although the proportion of subjects with allergic rhinitis and the level of serum total IgE were not different between responders (wheal >- 2mm) and nonresponders to morphine, the positive response rate to allergens was significantly lower in nonresponders. The flare sizes for morphine were significantly higher in positive allergen test group (A/H ratio >- 0.5). Among positive allergen test group, the subjects with atopy score >- 5 showed a larger flare size for morphine than those with atopy score < 5 while the sizes for histamine were not different. CONCLUSION: Morphine skin prick test is helpful for detecting false negative responses to allergens, and morphine skin test responses are increased in highly atopic patients probably due to enhanced mast cell releasability.
Allergens
;
Diagnosis*
;
Histamine
;
Humans
;
Hypersensitivity
;
Immunoglobulin E
;
Mast Cells
;
Morphine*
;
Rhinitis
;
Skin Tests
;
Skin*
2.Ichthyosis Hystrix: A Case Report Treated with Etretinate.
Won hyoung KANG ; Kwang Hoon LEE ; Hong Sang CHIN
Korean Journal of Dermatology 1984;22(1):97-106
Ichthyosis hystrix is characterized by extensive bilateral systemic involvement of thick hyperkeratotic verrucous papules forming confluent plaques or linear arrangement and is currently classified into a systematized epidermal nevi, which was once conaidered as an extreme variant of congenital ichthyosiform erythroderma. Here is presented a case with typical clinical features and characteristic histopathologic findings of epidermolytic hyperkeratosis. Our patient exhibited no skeletal or CNS abnormalities reported to be associated with this condition. Marked improvement was obtained with oral administration of etretinate.
Acitretin*
;
Administration, Oral
;
Eating
;
Etretinate*
;
Flushing
;
Humans
;
Hyperkeratosis, Epidermolytic
;
Hypertrophy
;
Ichthyosiform Erythroderma, Congenital
;
Ichthyosis*
;
Mandible
;
Nevus
;
Porcupines*
;
Sclerosis
;
Sweat
;
Sweating
;
Sweating, Gustatory*
;
Young Adult
3.Systemic Lupus Erythematosus Showing Vesiculobullous Eruptions: Report of Two Cases.
Young Jin KOH ; Kwang Hoon LEE ; Won Hyoung KANG
Korean Journal of Dermatology 1986;24(6):853-858
l6-year-old male and 48-year-old female with systemic lupus erythematosus (SLE) and renal disease presented with vesiculobullous eruptions during severe attack of the disease. They showed hypocomplementernia, and high ANA titers. Histopathologic findings revealed subepidermal blister and leukocytoclastic vasculitis, Direct immunofluorescence demonstratedlinear deposits of IgG, IgA and lgM at the dermoepidermal junction. The vesiculobullous eruption of SLE may be an important marker reflecting disease activity and prognosis.
Blister
;
Female
;
Fluorescent Antibody Technique, Direct
;
Humans
;
Immunoglobulin A
;
Immunoglobulin G
;
Lupus Erythematosus, Systemic*
;
Male
;
Middle Aged
;
Prognosis
;
Vasculitis
4.Tuberculosis Cutis Orificialis.
Seung Eon BAEK ; Won Hyoung KANG ; Kwang Hoon LEE
Korean Journal of Dermatology 1985;23(5):667-671
We report herein a case of tuberculosis cutis orificialis in a 50-year-old man. He suffered from well demarcated, 2x5cm sized, slightly tender, pus discharging, perianal ulcer with bluish edges for 3 months. The biopsy specimen from the ulcer revealed tuberculoid structure with Langhans giant cells in the deep dermis and a few acid-fast bacilli. AFB cultures from the sputum, pus, and tissue were successful. Intradermal test with PPD showed positive result. Chest roentgenographic findings disclosed advanced pulmonary tuberculosis. Almost complete healing of the perianal ulcers occurred following 2 months of therapy using antituberculosis drugs.
Biopsy
;
Dermis
;
Giant Cells, Langhans
;
Humans
;
Intradermal Tests
;
Middle Aged
;
Sputum
;
Suppuration
;
Thorax
;
Tuberculosis*
;
Tuberculosis, Pulmonary
;
Ulcer
5.DNCB Therapy in a Large Condyloma Acuminatum Resembling Buschke-Loewenstein Tumor.
Seung Eon BAEK ; Kwang Hoon LEE ; Won Hyoung KANG
Korean Journal of Dermatology 1985;23(6):805-809
We report herein a 53-year-old male patient with a large condyloma acuminaturn of 16 months duration on his penis. Clinically, an approximat;ely 3.5 X 2.0 Cm sized, asyrnptomatic, verrucous-surfaced, papilloma was present on his prepuce and glans. Elistological examination disclosed hyperkeratosis, marked acanthosis, papillomatosis, vacuolated upper malphigian cells, dilated capillaries, and mononuclear infiltrntes in the upper dermis. Trial of DNCB immunotherapy showed a dramatic effect on tumor regression.
Capillaries
;
Dermis
;
Dinitrochlorobenzene*
;
Humans
;
Immunotherapy
;
Male
;
Middle Aged
;
Papilloma
;
Penis
6.Colloid Milium : Electron Microscopic Findings.
Soo Il CHUN ; Won Hyoung KANG ; Kyu Kwang WHANG
Korean Journal of Dermatology 1986;24(2):314-319
Ultrastructural study was taken in a 48 year old male farmer with colloid milium. Electrcn microscopically, colloid was mainly composed of protofilaments, amorphous substance and degenerating collagens surrounded by halos. Colloidal filaments were curved and branched at their ends. Fibroblasts near the colloid island contained amorphous materials and protofilaments idnitical to that of colloid materials, Thus we suggest that. colloid milium may be produced by the abnormal fibroblasts or may be derived from actiinically damaged collagen fibers.
Collagen
;
Colloids*
;
Fibroblasts
;
Humans
;
Male
;
Middle Aged
8.A clinical analysis on urinary lithiasis.
Chang Hoon PARK ; Won Tak KANG ; Sung Kwang PARK ; Sung Kyew KANG
Korean Journal of Nephrology 1991;10(1):44-48
No abstract available.
Urolithiasis*
9.Revitalization of Idiopathic Osteonecrosis of the Femoral Head by Vascular Pedicled Iliac Bone Grafting
Sung Won SOHN ; Ho Kyu LEE ; Chearl Hyoung KANG ; Kwang Soon SONG ; Chang Soo KANG
The Journal of the Korean Orthopaedic Association 1990;25(5):1444-1452
Osteonecrosis of the femoral head seems to be due to circulatory disturbance of the femoral head, usually idiopathic in origin, but also associated with chronic alcoholism, gout, prolonged treatment with corticosteroids, sickle cell disease, Caisson's disease and surface and degenerative changes in the hip joint. Aims of this procedure are to decompress the femoral head hence allowing better circulation, to revitalize the dead head by insertion of vascularized pedicle bone and to give a mechanical support preventing further collapse of the femoral head. Authors reviewed 19 cases of the vessel pedicled iliac bone graft performed for the idiopathic osteonecrosis of femoral head from January, 1984 to April, 1988 with follow-up periods from 23 months to 66 months, average 37.5 months. The purpose of this follow-up note is to report the long term follow-up result and to show the critical points of this technique.
Adrenal Cortex Hormones
;
Alcoholism
;
Anemia, Sickle Cell
;
Bone Transplantation
;
Follow-Up Studies
;
Gout
;
Head
;
Hip Joint
;
Osteonecrosis
;
Transplants
10.Total Hip Replacement Using High Hip Center in Osteoarthritis Secondary to Hip Dysplasia(Preliminary study)
Byung Woo MIN ; Chang Soo KANG ; Kwang Soon SONG ; Chearl Hyoung KANG ; Gi Won PARK
The Journal of the Korean Orthopaedic Association 1995;30(6):1610-1617
Total hip replacement for adults with severe acetabular dysplasia presents a difficult problem because deficient bone stock and soft tissue contractures usually prevent sitting at the normal anatomic level. The rationales of high hip center are due to high failure rate of bulk structural weight bearing graft, good short-term result of hemispherical cementless acetabular component in revision surgery, high hip center but not lateral which does not adversely affect the biomechanics of the hip, and intimate apposition with viable host bone. We represented the short-term results of 21 total hip replacements with proximal placement of the acetabular cup than the anatomical position that is normally used. The mean duration of follow up was 18 months(range, 12-58 months) and the mean age of the patient was fifty-one years(range, thirty to sixty-seven years). Most of these hips had a major deficiency or defect of the acetabular bone stock. They had an aver- age Harris hip score of 47 points preoperatively and 90 points postoperatively. Roentgenographic measurements showed that the mean change in the height of the center of the hip postoperatively was only +6.6 millimeters and the mean change of horizontal location of them was 10 millimeters medial to the preoperative position. Postoperative complications included calcar fracture(1 case), trochanteric bursitis(1 case), postop- erative dislocation(1 case) and one case of radiological loosening of the acetabular component. The center of the hip in THR is not a crucial parameter with regard to the long-term stability of acetabular component, so our recommendation is to place the acetabular component at a more proximal but not lateral position if strong bone stock is available. But future studies of high hip center need to address femoral component longevity.
Acetabulum
;
Adult
;
Arthroplasty, Replacement, Hip
;
Contracture
;
Femur
;
Follow-Up Studies
;
Hip Joint
;
Hip
;
Humans
;
Longevity
;
Osteoarthritis
;
Postoperative Complications
;
Transplants
;
Weight-Bearing