1.A clinical study of segmental tibial fracture.
Chang Uk CHOI ; Jae Uk KWON ; Man Sik YANG ; Kwang Kon KO ; Seung Ryeol YOON
The Journal of the Korean Orthopaedic Association 1992;27(1):148-157
No abstract available.
Tibial Fractures*
2.Clinical Evaluation of Cementless Total Hip Arthroplasty in Avascular Necrosis of the Femoral Head in Adult
Chang Uk CHOI ; Soo Kyoon RAH ; Hee Soo CHOI ; Jae Wook KWON ; Young Ho KIM ; Kon Kwang KO
The Journal of the Korean Orthopaedic Association 1990;25(1):211-221
Recently, Prosthetic replacement of hip was recognized as a reliable technique for the treatment of avascular necrosis of femoral head in adult. There were many reports about post-operative evaluation of functional difference between hemiarthroplasty and total hip arthroplasty and which revealed that the revision rate for the total hip arthroplasty was less compared with the femoral endoprosthesis. Also, controversy was existed between the porous coating system and bone cement fixation. In order to evaluate the functional difference among each prosthetic replacement, authors reviewed the result of 10 cases of cementless unipolar endoprosthesis (abbreviated as UE), 10 cases of cementless bipolar endoprosthesis (abbreviated as BE), and 25 cases of cementless total hip replacement arthroplasy (abbreviated as THRA), performed at Department of Orthopaedic Surgery, Soon Chun Hyang University Hospital, during the period from September, 1985 to August, 1988. The following results were obtained: 1. The incidence was higher in 6th decade in UE, THRA groups, 4th decade in BE group. 2. The average follow up of UE, BE, and THRA groups were 30.7, 15.2, and 16.9 months, respectively. 3. By radiological classification of Marcus et al., the average stages of UE, BE, and THRA were 4.9, 4.0, and 5.3respectively. 4. According to Harris hip rating system, post-op. Harris scores were increased as much as 33.1, 37.2, and 43.4 in UE, BE, and THRA groups respectivelycompared with pre-op. score. 5. In this study, the last follow up results of hip function in BE, and THRA groups were better than that evaluated at 6 months after surgery in most cases. 6. External rotation, which was one of needed motion in cross leg sitting position, was significantly influenced by the degree of excision of joint capsule, the type of replacement prosthesis, the regimen of post-op. starting exercise, and a history of previous surgical treatment. 7. Because serious complications were not developed at recent follow up, the UE, BE, and THRA groups showed insignificant difference in functional difference in prosthetic replacement.
Adult
;
Arthroplasty, Replacement
;
Arthroplasty, Replacement, Hip
;
Classification
;
Follow-Up Studies
;
Head
;
Hemiarthroplasty
;
Hip
;
Humans
;
Incidence
;
Joint Capsule
;
Leg
;
Necrosis
;
Prostheses and Implants
3.Effects of Cigarette Smoking on Auditory Event-Related Potential P300.
Chang Mann CHUN ; Bung Kwang KIM ; Chang Uk LEE ; Sang Ick HAN ; In Ho PAIK
Journal of Korean Neuropsychiatric Association 1997;36(6):1099-1105
OBJECTIVES: The authors studied the effects of cigarette smoking on the cognitive function with topographic mapping of auditory event-related potential P300. METHODS: The subjects, 24 smokers and 14 nonsmokers, were assessed in the latencies and amplitudes of topographic auditory event-related potential P300 determined by Global Field Power Measurement. RESULTS: 1) There were significant differences of P300 latencies between smokers and controls artier smoking(ANOVAL F=10.45, P=0.0026). 2) There were no significant differences of P300 amplitude but a trend was present between smokers and nonsmokers after smoking(ANOVAL F=3.77, P=0.06). 3) There were no significant differences of difference between amplitude in maximal point and amplitude in minimal point but a trend was present between smokers and nonsmokers artier smoking(ANOVAL F=3.68, P=0.063). 4) There were no significant differences of maximal point in X-axis and in Y-axis, minimal point in X-axis and in Y-axis of P300 between smokers and nonsmokers artier smoking. CONCLUSIONS: These results support that auditory event-related potential P300 change by cigarrete smoking is indicative of enhanced cognitive function.
Evoked Potentials*
;
Smoke
;
Smoking*
;
Tobacco Products*
4.Osteogenic differentiation of bone marrow derived stem cells in gelatin-hydroxyapatite nanocomposite.
Hyun Jun JEON ; Young Sup HWANG ; Uk Kyu KIM ; Dae Seok HWANG ; Kwang Ho LEE ; Myung Cheol CHANG
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2009;35(1):7-12
PURPOSE: Gelatin-hydroxyapatite nanocomposite is similar to inorganic nanostructure of bone. To make a scaffold with osteoinductivity, bone marrow derived stem cells from rabbit femur were impinged into the nanocomposite. This vitro study was to test osteogenic differentiation of the stem cells in the nanocomposite, which was made by authors. MATERIAL & METHODS: Gel-HA nanocomposite with 10g of HA, 3 g of Gel has been made by co-precipitation process. Bone marrow was obtained from femur of New Zealand White rabbits and osteogenic differentiation was induced by culturing of the BMSCs in an osteogenic medium. The BMSCs were seeded into the Gel-HA nanocomposite scaffold using a stirring seeding method. The scaffolds with the cells were examined by scanning electron microscopy (SEM), colorimetry assay, biochemical assay with alkaline phosphatase (ALP) diagnostic kit, osteocalcin ELISA kit. RESULTS: Gel-HA nanocomposite scaffolds were fabricated with relatively homogenous microscale pores (20-40 micrometer). The BMSCs were obtained from bone marrow of rabbit femurs and confirmed with flow cytometry, Alizarin red staining. Attachment and proliferation of BMSCs in Gel-HA nanocomposite scaffold could be identified by SEM, ALP activity and osteocalcin content of BMSCs. CONCLUSION: The Gel-HA nanocomposite scaffold with micropores could be fabricated and could support BMSCs seeding, osteogenic differentiation.
Alkaline Phosphatase
;
Anthraquinones
;
Bone Marrow
;
Colorimetry
;
Durapatite
;
Enzyme-Linked Immunosorbent Assay
;
Femur
;
Flow Cytometry
;
Microscopy, Electron, Scanning
;
Nanocomposites
;
Nanostructures
;
Osteocalcin
;
Rabbits
;
Seeds
;
Stem Cells
5.Osteogenic differentiation of bone marrow derived stem cells in gelatin-hydroxyapatite nanocomposite.
Hyun Jun JEON ; Young Sup HWANG ; Uk Kyu KIM ; Dae Seok HWANG ; Kwang Ho LEE ; Myung Cheol CHANG
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2009;35(1):7-12
PURPOSE: Gelatin-hydroxyapatite nanocomposite is similar to inorganic nanostructure of bone. To make a scaffold with osteoinductivity, bone marrow derived stem cells from rabbit femur were impinged into the nanocomposite. This vitro study was to test osteogenic differentiation of the stem cells in the nanocomposite, which was made by authors. MATERIAL & METHODS: Gel-HA nanocomposite with 10g of HA, 3 g of Gel has been made by co-precipitation process. Bone marrow was obtained from femur of New Zealand White rabbits and osteogenic differentiation was induced by culturing of the BMSCs in an osteogenic medium. The BMSCs were seeded into the Gel-HA nanocomposite scaffold using a stirring seeding method. The scaffolds with the cells were examined by scanning electron microscopy (SEM), colorimetry assay, biochemical assay with alkaline phosphatase (ALP) diagnostic kit, osteocalcin ELISA kit. RESULTS: Gel-HA nanocomposite scaffolds were fabricated with relatively homogenous microscale pores (20-40 micrometer). The BMSCs were obtained from bone marrow of rabbit femurs and confirmed with flow cytometry, Alizarin red staining. Attachment and proliferation of BMSCs in Gel-HA nanocomposite scaffold could be identified by SEM, ALP activity and osteocalcin content of BMSCs. CONCLUSION: The Gel-HA nanocomposite scaffold with micropores could be fabricated and could support BMSCs seeding, osteogenic differentiation.
Alkaline Phosphatase
;
Anthraquinones
;
Bone Marrow
;
Colorimetry
;
Durapatite
;
Enzyme-Linked Immunosorbent Assay
;
Femur
;
Flow Cytometry
;
Microscopy, Electron, Scanning
;
Nanocomposites
;
Nanostructures
;
Osteocalcin
;
Rabbits
;
Seeds
;
Stem Cells
6.Lactoferrin Sequestration and Its Contribution to Iron Deficiency Anemia in Helicobacter pylori Infected Gastric Mucosa.
Kwang Bin MOON ; Chang Kyu KANG ; Yon Ho CHOE ; Hye Seung HAN ; Sun Uk SONG
Korean Journal of Pediatric Gastroenterology and Nutrition 2002;5(1):11-18
PURPOSE: It is known that lactoferrin serves as a source of iron for H. pylori in gastric mucosa. This study was undertaken to investigate the relationship between lactoferrin and H. pylori infection coexistent with iron-deficiency anemia by determining the lactoferrin levels in gastric biopsy specimens, and by locating the major sites of lactoferrin expression, according to the presence or absence of iron-deficiency anemia. METHODS: Fifty-five adolescents that underwent gastroduodenoscopy were divided into three groups: NL (n=19) for normal controls, HP (n=15) for patients with H. pylori, and IDA (n=21) for patients with H. pylori gastritis and coexisting iron-deficiency anemia. Histopathologic features were graded from null to marked on the basis of the Updated Sydney System. The gastric mucosal levels of lactoferrin were measured by immunoassay. Immunohistochemical technique was used to allow identification of the location and quantification of the lactoferrin expression. RESULTS: Lactoferrin levels in the antrum increased significantly, in proportion to, H. pylori density, polymorphonuclear cell infiltration, and chronic inflammation in the histologic specimens. Patients in the HP and IDA groups showed significantly increased mucosal levels of lactoferrin compared with that observed in the normal group (p=0.0001). The lactoferrin level in IDA group tended to be higher than that in the HP group (p=0.2614). The major sites of lactoferrin expression by immunohistochemistry were in glands and neutrophils within epithelium. Lactoferrin was stained weakly in NL, and strongly in HP and IDA. CONCLUSION: The lactoferrin sequestration in the gastric mucosa of IDA was remarkable, and this finding seems to give a clue that leads to the clarification of the mechanism by which H. pylori infection contributes to iron-deficiency anemia.
Adolescent
;
Anemia, Iron-Deficiency*
;
Biopsy
;
Epithelium
;
Gastric Mucosa*
;
Gastritis
;
Helicobacter pylori*
;
Helicobacter*
;
Humans
;
Immunoassay
;
Immunohistochemistry
;
Inflammation
;
Iron*
;
Lactoferrin*
;
Neutrophils
7.Effect of TGF-beta(1) and Chitosan-TGF-beta(1) Conjugate on Collagenase Induced Arthritis of the Knee in Rabbits.
Eui Chan CHANG ; Kwang Sup SONG ; Ho Jung JUNG ; Young Uk PARK ; Mi Kyung KIM
Journal of the Korean Knee Society 2006;18(2):219-228
PURPOSE; To evaluate the effects of the chitosan-TGF-beta(1) conjugate and TGF-beta(1) on osteoarthritic rabbit cartilage induced by collagenase type II. MATERIALS AND METHODS; Chemical arthritis was induced in right knee of 15 rabbits by injection of collagenase type II (4 mg/mL, 0.25 cc) twice at day 1 and 4, and then each 5 rabbits were treated by intra-articular injection of TGF-beta(1) (15 ng/mL, 1 mL, group I), chitosan-TGF-beta(1) conjugate (Chitosan: 5.8 g/mL, TGF-beta(1): 15 ng/mL, group II) and PBS (1 mL, group III) at 10 days later in the same knees. The appearance of the injected knee joints and lameness were observed weekly. The articular cartilage and synovium obtained at 4 weeks were analysed by gross findings (India ink), histological examinations (H&E, Safrainin O) and evaluation through the Kikuchi score. RESULT; The osteoarthritic sign about knee joints was the most severe at 1 weeks after the initiation of collagenase injections, but there wasere no difference of 3 groups in osteoarthritic sign and lameness was most severe in group 3. Group 2 showed the most superior results in gross findings using india ink and the these results were more prominent in the evaluation of histological scoring (average scores of each group I:14+/-2.7, II:10.3+/-1.2, III:20.3+/-3.7). CONCLUSION; These results might suggest that, in the rabbit osteoarthritic knee model induced by collagenase, Chitosan-TGF-beta(1) conjugate is more effective than only TGF-beta(1) in inhibiting cartilage degeneration.
Arthritis*
;
Cartilage
;
Cartilage, Articular
;
Collagenases*
;
India
;
Injections, Intra-Articular
;
Ink
;
Knee Joint
;
Knee*
;
Osteoarthritis
;
Rabbits*
;
Synovial Membrane
8.A Case of Thyroid Abscsess in Subacute Thyroiditis During Glucocorticoid Therapy.
Soon Jib YOO ; Bong Yun CHA ; Kwang Woo LEE ; Ho Young SON ; Sung Koo KANG ; Young Hwan KIM ; Mi Ja KANG ; Seung Hyeon KO ; Ki Uk CHANG
Journal of Korean Society of Endocrinology 1997;12(3):468-472
Subacute thyroiditis is a frequent benign thyroid disease associated with previous viral upper respiratory tract infection. Known complications of this disease are long-standing subclinical hypothyroidism, persistent anterior neck pain and rarely Graves disease. In general, thyroid abscess is an uncommon disease because of anatomic isolation of the gland and its rich system of drainage for blood and lymph. Especially, development of thyroid abscess in subacute thyroiditis is extremely rare phenomenan, but significant bad outcomes can be resulted. Its clinical BACKGROUND containes immune-suppressed state, anatomic defect, presence of underlying other thyroid disease and of non-thyroidal infectious foci. We experienced a case of subacute thyroiditis complicated with streptococcal thyroid abscess during glucocorticoid therapy. The patient was a 19-year-old female who was admitted due to anterior neck pain for 1 month. Typical subacute thyroiditis was suggested from initial laboratory findings including CBC, erythrocyte sedimentation rate, serum T3, T4, TSH levels, thyroid scan & thyroid uptake. But during oral prednisolone therapy, unexpected bacterial thyroid abscess was developed. We report this unusual case with review of literatures.
Abscess
;
Blood Sedimentation
;
Drainage
;
Female
;
Graves Disease
;
Humans
;
Hypothyroidism
;
Neck Pain
;
Prednisolone
;
Respiratory Tract Infections
;
Thyroid Diseases
;
Thyroid Gland*
;
Thyroiditis, Subacute*
;
Young Adult
9.Plate and Screw Removal after Orthognathic Surgery, under Intravenous Sedation with Dexmedetomidine and Pethidine
Hee Jea KANG ; Jong Ryoul KIM ; Si Yeob KIM ; Tea Sung CHOI ; Kwang Uk CHANG
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons 2012;34(4):260-266
0.05). Amnesia during local injection was observed in eight patients (34.8%). Compared with the preoperative anxiety score, the intraoperative anxiety score was decreased.CONCLUSION: In this study, we found cardiovascular and respiratory stability in intravenous sedation using dexmedetomidine with pethidine, in plate and screw removal, after orthognathic surgery. Furthemore, intravenous sedation using dexmedetomidine with pethidine shows adequate analgesic and sedative effects.]]>
Amnesia
;
Anxiety
;
Arterial Pressure
;
Blood Pressure
;
Dexmedetomidine
;
Heart Rate
;
Humans
;
Hypnotics and Sedatives
;
Meperidine
;
Orthognathic Surgery
;
Oxygen
10.The Learning Curve for Biplane Medial Open Wedge High Tibial Osteotomy in 100 Consecutive Cases Assessed Using the Cumulative Summation Method
Do Kyung LEE ; Kwang Kyoun KIM ; Chang Uk HAM ; Seok Tae YUN ; Byung Kag KIM ; Kwang Jun OH
The Journal of Korean Knee Society 2018;30(4):303-310
PURPOSE: The purpose of this study was to investigate whether surgical experience could improve surgical competency in medial open wedge high tibial osteotomy (MOWHTO). MATERIALS AND METHODS: One hundred consecutive cases of MOWHTO were performed with preoperative planning using the Miniaci method. Surgical errors were defined as under- or overcorrection, excessive posterior slope change, or the presence of a lateral hinge fracture. Each of these treatment failures was separately evaluated using the cumulative summation test for learning curve (LC-CUSUM). RESULTS: The LC-CUSUM showed competency in prevention of undercorrection, excessive posterior slope change, and lateral hinge fracture after 27, 47, and 42 procedures, respectively. However, the LC-CUSUM did not signal achievement of competency in prevention of overcorrection after 100 procedures. Furthermore, the failure rate for overcorrection showed an increasing tendency as surgical experience increased. CONCLUSIONS: Surgical experience may improve the surgeon’s competency in prevention of undercorrection, excessive posterior slope change, and lateral hinge fracture. However, it may not help reduce the incidence of overcorrection even after performance of 100 cases of MOWHTO over a period of 6 years.
Incidence
;
Knee
;
Learning Curve
;
Learning
;
Medical Errors
;
Methods
;
Osteoarthritis
;
Osteotomy
;
Treatment Failure