We report a case of morphea profunda in a 21-year-old male who had diffuse brown sclerotic plaques on his extremities. Laboratory findings showed peripheral eosinophilia and an increased titers for anti-DNA and anti-nuclear antibodies. Histopathologic findings showed diffuse fibrosis and a thickening of the lower dermis and subcutaneous tissue. He has been treated with hydroxychloroquine 400mg per day and the sclerosis of the skin improved.
Antibodies ; Dermis ; Eosinophilia ; Extremities ; Fibrosis ; Humans ; Hydroxychloroquine ; Male ; Scleroderma, Localized* ; Sclerosis ; Skin ; Subcutaneous Tissue ; Young Adult

No abstract available.
CREST Syndrome* ; Nifedipine

We report. herein a case of pruritic urticatial papules and plaques of pregnancy in a Z8-year-old primigravida. She had the urticarial papules and plaques on the abdomen and thighs, which developed at 30th week of pregnancy. She was treated with topical fluorinated steroid and chlorpheniramine, 6mg/ day. The itching sensation was relieved within 24 hours after the therapy and the skin lesions resolved after delivery.
Abdomen ; Chlorpheniramine ; Pregnancy* ; Pruritus ; Sensation ; Skin ; Thigh

Primary localized cutaneous amyloidosis comprises macular, papular and rare nodular amyloidosis. Macular and papular amyloidosis are considered as different manifestations of the same disease process and can occur in the same patient, which is known as biphasic amyloidosis. Although most cases of primary cutaneous amyloidosis occur sporadically, some cases have been reported to have familial incidence with papular, biphasic or rarely macular amyloidosis. We report a case of a family in which a mother and her son have brown hyperkeratotic pruritic papules on both upper and lower extremities. The skin lesions initially began as macules on the shins in the second or third decade, but gradually spread with increasing papules and pigmentation. They had no kind of manifestation suggesting systemic amyloidosis. A skin biopsy specimen disclosed amyloid deposition in papillary dermis.
Amyloidosis* ; Biopsy ; Dermis ; Humans ; Incidence ; Lower Extremity ; Mothers ; Pigmentation ; Plaque, Amyloid ; Skin

Primary localized cutaneous amyloidosis comprises macular, papular and rare nodular amyloidosis. Macular and papular amyloidosis are considered as different manifestations of the same disease process and can occur in the same patient, which is known as biphasic amyloidosis. Although most cases of primary cutaneous amyloidosis occur sporadically, some cases have been reported to have familial incidence with papular, biphasic or rarely macular amyloidosis. We report a case of a family in which a mother and her son have brown hyperkeratotic pruritic papules on both upper and lower extremities. The skin lesions initially began as macules on the shins in the second or third decade, but gradually spread with increasing papules and pigmentation. They had no kind of manifestation suggesting systemic amyloidosis. A skin biopsy specimen disclosed amyloid deposition in papillary dermis.
Amyloidosis* ; Biopsy ; Dermis ; Humans ; Incidence ; Lower Extremity ; Mothers ; Pigmentation ; Plaque, Amyloid ; Skin

In temporal clear corneal incision cataract surgery, it is essential to change the equipment and personnel between right eye and left eye. To obtain an advantages of clear corneal incision without going through the hassles and same effect of postoperative astigmatism and visual acuity, we sat at 10 o`clock orientation on patient`s head(right handed surgeon)and performed lateral clear corneal incision on the right eye and medial clear corneal incision on the left eye. Temporal clear corneal incision in right eye(Group 1)and medial clear corneal incision in left eye(Group 2)were performed in randomly selected 20 eyes in each group by one surgeon between June 1997 and October 1997 at Dongguk University Medical Center. Preoperative corneal astigmatism , surgically induced corneal astigmatism and changes of visual acuity were analyzed at 1 week, 2 weeks, 4 weeks, 2 months, 3 and 6 months postoperatively using corneal videokeratography(EYESYS Technology)and visual acuity chart projector(Topcon ACP-7). Postoperative uncorrected visual acuities were 20/40 or better in 75%(15 eyes)in group 1 and 70%(14 eyes)in group 2. In preoperative corneal astigmatism, there was no statistical significance between the two groups (P>0.05)(Group 1: 0.58+/-0.28D, Group 2: 0.59 +/-0.17D). In surgically induced corneal astigmatism, we found there was statistically significant difference between the two groups(P<0.05)(Group 1: 1. 26+/-0.61D, Group 2: 1. 64+/-0.34D)at 1 week postoperatively, but at 6months postoperatively, there was no statistically significant difference between the two groups(P>0.05)(Group 1: 0.87+/-0.59D, Group 2: 1. 14+/-0.58D). In conclusion, medial clear corneal incision did not need to change the personnel and equipment from case to case and the nose didn`t get in the way in medial approach. We consider that medial clear corneal incision is recommendable procedure because there were no significant differences in postoperative visual acuity and surgically induced astigmatism at 6 months postoperatively between the two groups.
Academic Medical Centers ; Astigmatism ; Cataract* ; Hand ; Nose ; Visual Acuity

Isolated rupture of the posterior capsule caused by blunt ocular trauma is rarely reported and is usually detected incidentally during surgery for the associated cataract. We report a case of isolated posterior capsule rupture detected during cataract surgery in a 33-year-old man who had traumatic cataract. In this case, the ruptured posterior capsule had relatively large defect in size(5x5 mm)with thickened and fibrosed edge and vitreous opacity existed. The surgical management of this case consisted of phacoemulsification with PC-IOL implantation and pars plana vitrectomy. During surgery, although the posterior capsule rupture was large, further rupture of the capsule was prevented by the fibrosed edge which tightened the margin ofthe ruptured capsule, and so PC-IOL implantation could be possible securely.
Adult ; Cataract ; Humans ; Phacoemulsification ; Rupture* ; Vitrectomy

BACKGROUND: Chronic cutaneous lupus erythematosus(CCLE) is a well-known disease entity. But there has been no data about its clinical behavior and histopathologic features in Korea. OBJECTIVES: This study was conducted to elucidate the clinical, laboratory, and histopathologic features of CCLE, and the relationship between CCLE and SLE. MATERIALS AND METHODS: We investigated 48 cases of CCLE that visited the department of dermatology at the Seoul National University Hospital from January 1990 to June 1997. Medical records and biopsy slides were reviewed.
Biopsy ; Dermatology ; Korea ; Lupus Erythematosus, Cutaneous* ; Medical Records ; Seoul

No abstract available.
Korea* ; Lung Neoplasms* ; Lung*

BACKGROUND: Cord blood transplantation has generated much enthusiasm because of the low incidence of GVHD(graft-versus-host disease), even in HLA(Human Leukocyte Antigen) mismatched situations, owing to intrinsic defects in mature T cell functions, and human cord blood is a constantly and easily obtainable source for hematopoietic stem cell. This study was undertaken to elucidate the possible mechanisms of low GVHD incidence observed when cord blood is used for stem cell transplantation. Based on current knowledge of the phenotypic correlates with functional subtypes of peripheral blood lymphocytes, we evaluated lymphocyte subpopulation in cord blood. METHODS: The 25 cord blood and 20 peripheral blood of adult control were included in this study. Monoclonal antibodies(MAb) conjugated with fluorescein-isothiocynate(FITC), phycoerythrin(PE) were used in this study. Heparinized whole blood was stained with mAbs using the whole blood lysis method. We used FACScan flow cytometer with argon laser tuned at 488 nm. Analysis was done by either Simulset or lysis II research software. RESULT: 1) The means of WBC and lymphocyte content were higher in cord blood than in adult blood(p<0.05). 2) The overall percentages of cord blood T(CD3+) cells, B(CD19+) cells, NK(natural killer)(CD16+/CD56+) cells were not different from adult controls. 3) The CD4+ : CD8+ ratio of cord blood was higher than thar of adult controls(2.7 in cord bloods versus 1.8 in adults). 4) The majority of the cord blood cells, both CD4+ and CD8+, co-expressed the CD45RA+ (naive) molecule. 5) The CD57, an antigen present on a subpopulation of NK cells, is absent in cord blood. CONCLUSION: We determined that cord blood contained mainly naive T lymphocytes to be predominantly suppressor cells. We found reduced alloproliferative, allostimulatory and allocytotoxic capacity of cord blood lymphocytes. Therefore, the GVHD may be less readily induced in cord blood transplantation, even in the face of HLA difference.
Adult ; Argon ; Fetal Blood* ; Hematopoietic Stem Cells ; Heparin ; Humans ; Incidence ; Killer Cells, Natural ; Leukocytes ; Lymphocyte Subsets* ; Lymphocytes* ; Phenotype ; Stem Cell Transplantation ; T-Lymphocytes