1.Progression of renal diseases and antihypertensive treatment.
Korean Journal of Medicine 2004;66(2):108-119
No abstract available.
2.Progression of renal diseases and antihypertensive treatment.
Korean Journal of Medicine 2004;66(1):4-10
No abstract availalbe.
3.Retraction: Asp 280 residue is important in the activity of the Escherichia coli leader peptidase.
Mee Sook SUNG ; Kwang Sook PARK
Experimental & Molecular Medicine 1999;31(4):217-217
No abstract available.
4.Effects of Hantaan Virus and IFN-gammaon Induction of Surface ICAM-1 in Primary Cultured Buman Nasal Epithelial Cells and Human Lung Fibroblasts.
Journal of the Korean Society of Virology 1998;28(4):317-325
The primary culture of human nasal epithelial cells was performed using the inferior nasal turbinate tissues, and infected with Hantaan virus to examine the hypothesis of airborne transmission of Hantaan virus in humans. The primary culture cells were identified as epithelial cells by morphologic and immunologic analyses. The viral antigens were detected in the primary human nasal epithelial cells infected with Hantaan virus by immunofluorescence staining. The ICAM-1 induction by Hantaan virus or IFN-gammawas examined in the primary human nasal epithelial cells and human lung fibroblasts (WI-38). Hantaan virus induced the surface ICAM-1 in Wl-38 cells in a time-dependent manner, and IFN-gammainduced the surface ICAM-1 in a dose-dependent manner in HNEC and WI-38 cells. These results revealed that the human nasal epithelial cells are susceptible to Hantaan viral infection supporting the hypothesis of airborne transmission of Hantaan virus in humans. The human lung fibroblasts also might have an important role in the pathogenesis of Hantaan virus through the induction of ICAM-1.
Antigens, Viral
;
Epithelial Cells*
;
Fibroblasts*
;
Fluorescent Antibody Technique
;
Hantaan virus*
;
Humans*
;
Intercellular Adhesion Molecule-1*
;
Lung*
;
Turbinates
5.Immunohistochemical Study on Cytokeratin Expression in Tracheal Epithelium of Human Fetus.
Kwang Soo OH ; Kwang Il NAM ; Sung Sik PARK ; Sung Sik PARK
Korean Journal of Physical Anthropology 1996;9(1):55-67
Trachea is lined by a pseudostratified epithelium which usually expresses a complex mixture of stratified as well as simple epithelial-type cytokeratins. In the present work, the cytokeratin expressions was studied immunohistochemically in the tracheal epithelium and gland of human fetus at 14, 26 and 32 weeks of gestation. The primary antibodies used were CK7, 8, 10, 14, 18, AE8, 5D3, MNFl16 and AE3. In PAS-hematoxylin stain, the tracheal eithelium was composed of pseudostratified ciliated columnar type and consisted of surface, intermediate and basal layers regardless of gestational ages. The PAS positive cells, however, were decreased in number in proportion to gestational ages. The tracheal gland was not fully differentiated at 14 weeks of gestation, and had well differentiated secretory portions consisting mucous and serous cells at 26 and 32 weeks of gestation. The mucous cells and luminal border of the duct were positive for PAS stain. The tracheal eithelium showed different immunoreactivity between cartilageous and membranous portions. In general, CK7 and 5D3 were expressed in surface cells, AE8 in intermediate cells, and MNFl16 and AE3 in the cells of all layers. At 14 weeks of gestation, the tracheal epithelium immunoreacted for CK7, AE8, 5D3, MNFl16 and AE3. The premordium of tracheal gland was positive for 5D3, MNFl16 and AE3. The tracheal epithelium at 26 and 32 weeks of gestation showed same staining properties to those at 14 weeks of gestation. The duct cells at 26 weeks of gestation were immunoreactive for CK7, 8, 14, 18, AE8, 5D3, MNFl16 and AE3, and those at 32 weeks of gestation were immunoreactive for CK7, 14, 5D3, MNFl16 and AE3. The acinar cells at 26 and 32 weeks of gestation were positively stained for CK7, 8, 18, 5D3, MNFl16 and AE3. These results suggest that CK7 and 5D3 may serve as useful markers for mature cilated cells, AE8 (CKl3) for immature ciliated cells, and CKl4 for duct cells in tracheal epithelium and gland.
Acinar Cells
;
Antibodies
;
Epithelium*
;
Fetus*
;
Gestational Age
;
Humans*
;
Immunohistochemistry
;
Keratins*
;
Phenobarbital
;
Pregnancy
;
Trachea
6.Clinical Significance of Transperineal Duplex Doppler Ultrasonography in the Diagnosis of Arteriogenic Impotence.
Gun Pyung KIM ; Kwang Sung PARK ; Soo Bang RYU
Korean Journal of Urology 2000;41(11):1384-1388
No abstract available.
Diagnosis*
;
Female
;
Impotence, Vasculogenic*
;
Male
;
Ultrasonography, Doppler, Duplex*
7.Alteration of Insulin-like Growth Factor ( IGF ) -I and IGP-Binding Proteins in Renal Development and Regeneration.
Dae Yeol LEE ; Sung Kwang PARK ; Gou Young KOH
Journal of the Korean Society of Pediatric Nephrology 1999;3(2):109-116
The effect of Roentgen rays on carcinoma of the cervix has long been of great interest to both radiologists and gynecologists. Since most cervical carcinomas are treated by irradiation, any additional knowledge either concerning the radiosensitivity of cervical tumors or their ultimate prognosis would be of value. The vaginal smear is considered to be one of convenient and rapid methods to study the effects of radiation on cervical malignancy. We observed morphologic changes in 297 cytologic preparations obtained from 60 patients who had underwent irradiation for cancer of the cervix. With the morphologic parameters such as cytoplasmic vacuolization, cytoplasmic basophilia, multinucleated giant cell formation, polymorphonuclear leucocytes (PMNL) sticking and postradiation dysplasia, we analyzed the findings in relation to the follow up time interval. The most common effect was the cytoplasmic vacuolization with basophilia of basaloid cells, which were noted in more than 90% of followed patients. The multinucleated giant cell formation and PMNL stickering were noted in 38 cases(63%) and 48 cases(80% ) respectively. The differential diagnosis of postradiation dysplasia from recurrent or persistent carcinoma, reparative atypical cells, and regressing tumor cells was difficult and further study seems to be needed to clarify the more accurate morphologic features and biologic behavior.
Cervix Uteri
;
Cytoplasm
;
Diagnosis, Differential
;
Female
;
Follow-Up Studies
;
Giant Cells
;
Humans
;
Pancreas
;
Prognosis
;
Radiation Tolerance
;
Regeneration*
;
Uterine Cervical Neoplasms
;
Vaginal Smears
8.Growth Expectation in Children: Leg Length Discrepancy Related with Bone Tumor in Children.
Sung Taek JUNG ; Kwang Cheul JEONG ; Hyeong Won PARK
The Journal of the Korean Bone and Joint Tumor Society 2011;17(1):1-10
The main goals of treatment of malignant bone tumor are the prolongation of life survival and the improvement of quality of life. In growing children, however, leg length discrepancy (LLD) is one of major problem in the treatment of malignant bone tumors. Therefore, the precise understanding of growth in children is essential, and the prediction of LLD is critical in deciding the time and options of surgery. In addition, to use the adequate method of growth expectation, periodic follow-up and collaboration with patient's parents are needed.
Child
;
Cooperative Behavior
;
Humans
;
Leg
;
Life Support Care
;
Parents
;
Quality of Life
10.A Case Dermal Melanocyte Hamartoma.
Jin Gon JANG ; Sung Hyun PARK ; Kwang Hoon LEE
Korean Journal of Dermatology 1988;26(6):956-959
A 26-year-old man presented with a bluish speckled patch on the dorsum of the left hand. It had apperaed at birth as a bluish spot. Since adolescence the lesion extended and at the time of visiting hospital it covered the most part of the dorsum of the left hand and even some palmar aspect. The histopathological and ultrastructural examination revealed numerous dermal melanocytes, mainly in the upper dermis. Clinically and pathologically, the patient was diagnosed as having dermal melanocyte hamartoma, a distinct type of dermal melanocytosis.
Adolescent
;
Adult
;
Dermis
;
Hamartoma*
;
Hand
;
Humans
;
Melanocytes*
;
Parturition